GB1554048A - Prostacyclin derivatives - Google Patents
Prostacyclin derivativesInfo
- Publication number
- GB1554048A GB1554048A GB21363/77A GB2136377A GB1554048A GB 1554048 A GB1554048 A GB 1554048A GB 21363/77 A GB21363/77 A GB 21363/77A GB 2136377 A GB2136377 A GB 2136377A GB 1554048 A GB1554048 A GB 1554048A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- compounds
- formula
- image
- reaction product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003815 prostacyclins Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- RJADQDXZYFCVHV-JQMWNLLFSA-N 5-[(2s,4r,5r,6ar)-5-hydroxy-4-[(e,3s)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-2h-cyclopenta[b]furan-2-yl]pentanoic acid Chemical class O1[C@@H](CCCCC(O)=O)CC2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@H]21 RJADQDXZYFCVHV-JQMWNLLFSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052753 mercury Inorganic materials 0.000 abstract 1
- 229940100892 mercury compound Drugs 0.000 abstract 1
- 150000002731 mercury compounds Chemical class 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Analogues of 5,6-dihydroprostacyclin of the formula <IMAGE> in which the substituents are defined in claim 1, are prepared. These compounds are obtained by halogenating and cyclising a compound of the formula <IMAGE> and subsequently reductively dehalogenating the reaction product, with the formation of the desired ether, or by converting the said compound LXII into a corresponding mercury compound and then subjecting the reaction product to the removal of mercury by reduction. The compounds which are obtained may be used for the same pharmacological purposes as the known prostaglandins.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69140076A | 1976-06-01 | 1976-06-01 | |
| US69139976A | 1976-06-01 | 1976-06-01 | |
| US78814677A | 1977-04-19 | 1977-04-19 | |
| US78814777A | 1977-04-19 | 1977-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1554048A true GB1554048A (en) | 1979-10-17 |
Family
ID=27505431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB21363/77A Expired GB1554048A (en) | 1976-06-01 | 1977-05-20 | Prostacyclin derivatives |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5936912B2 (en) |
| AU (1) | AU508891B2 (en) |
| BE (1) | BE855224A (en) |
| CA (1) | CA1196632A (en) |
| CH (1) | CH640847A5 (en) |
| DE (1) | DE2724555A1 (en) |
| FR (1) | FR2353543B1 (en) |
| GB (1) | GB1554048A (en) |
| IE (1) | IE45604B1 (en) |
| IL (1) | IL52099A (en) |
| MX (1) | MX4813E (en) |
| NL (1) | NL7705991A (en) |
| SE (3) | SE436744B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001010433A1 (en) * | 1999-08-05 | 2001-02-15 | Teijin Limited | Neuropathy improvers containing nitrogenous compounds as the active ingredient |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL51189A (en) * | 1976-02-04 | 1985-08-30 | Upjohn Co | Prostaglandin analogs |
| FI71138C (en) * | 1976-12-31 | 1986-11-24 | Erba Farmitalia | FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ACTIVE BISYCLISKA PROSTAGLANDINER |
| AU524786B2 (en) * | 1977-03-07 | 1982-10-07 | The Upjohn Company | Prostacyclins |
| DE2743283A1 (en) * | 1977-09-27 | 1979-04-05 | Hoechst Ag | NEW PROSTACYCLIN ANALOG |
| DE2811950A1 (en) * | 1978-03-18 | 1979-12-13 | Hoechst Ag | NEW PROSTACYCLIN ANALOGS |
| US4237060A (en) | 1979-03-23 | 1980-12-02 | Hoffmann-La Roche Inc. | Prostacyclin analogs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH629493A5 (en) * | 1976-05-11 | 1982-04-30 | Wellcome Found | Processes for preparing novel prostaglandin derivatives |
-
1977
- 1977-04-10 MX MX77100668U patent/MX4813E/en unknown
- 1977-05-11 AU AU25086/77A patent/AU508891B2/en not_active Ceased
- 1977-05-16 IL IL52099A patent/IL52099A/en unknown
- 1977-05-20 GB GB21363/77A patent/GB1554048A/en not_active Expired
- 1977-05-25 CA CA000279106A patent/CA1196632A/en not_active Expired
- 1977-05-27 CH CH660877A patent/CH640847A5/en not_active IP Right Cessation
- 1977-05-27 SE SE7706245A patent/SE436744B/en not_active IP Right Cessation
- 1977-05-31 DE DE19772724555 patent/DE2724555A1/en not_active Withdrawn
- 1977-05-31 FR FR7716615A patent/FR2353543B1/en not_active Expired
- 1977-05-31 BE BE178059A patent/BE855224A/en not_active IP Right Cessation
- 1977-06-01 NL NL7705991A patent/NL7705991A/en not_active Application Discontinuation
- 1977-06-01 IE IE1133/77A patent/IE45604B1/en unknown
- 1977-06-01 JP JP52063395A patent/JPS5936912B2/en not_active Expired
-
1978
- 1978-10-26 SE SE7811142A patent/SE432101B/en unknown
-
1982
- 1982-03-16 SE SE8201649A patent/SE8201649L/en not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001010433A1 (en) * | 1999-08-05 | 2001-02-15 | Teijin Limited | Neuropathy improvers containing nitrogenous compounds as the active ingredient |
| US7071359B1 (en) | 1999-08-05 | 2006-07-04 | Teijin Limited | Neuropathy improvers containing nitrogenous compounds as the active ingredient |
Also Published As
| Publication number | Publication date |
|---|---|
| IE45604B1 (en) | 1982-10-06 |
| IL52099A (en) | 1985-03-31 |
| JPS52156854A (en) | 1977-12-27 |
| SE8201649L (en) | 1982-03-16 |
| NL7705991A (en) | 1977-12-05 |
| DE2724555A1 (en) | 1977-12-15 |
| SE432101B (en) | 1984-03-19 |
| CA1196632A (en) | 1985-11-12 |
| IL52099A0 (en) | 1977-07-31 |
| IE45604L (en) | 1977-12-01 |
| CH640847A5 (en) | 1984-01-31 |
| AU2508677A (en) | 1978-11-16 |
| FR2353543A1 (en) | 1977-12-30 |
| SE7811142L (en) | 1978-11-28 |
| SE7706245L (en) | 1977-12-16 |
| MX4813E (en) | 1982-10-19 |
| JPS5936912B2 (en) | 1984-09-06 |
| FR2353543B1 (en) | 1986-02-21 |
| SE436744B (en) | 1985-01-21 |
| BE855224A (en) | 1977-11-30 |
| AU508891B2 (en) | 1980-04-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES459412A1 (en) | Heterocyclic compound | |
| GB2000126B (en) | Preparation of 1,4-diols by hydrolysis-hydrogenation of 2-alkoxytetrahydrofurans | |
| GB1554048A (en) | Prostacyclin derivatives | |
| ES424851A1 (en) | A procedure for preparing piperazine derivatives. (Machine-translation by Google Translate, not legally binding) | |
| JPS5428895A (en) | Dehydration purification of fermentation products | |
| JPS53137908A (en) | Syntheses of monochloropinacolone and cyanopinacolone | |
| JPS5430102A (en) | Carbon-carbon bond formation | |
| JPS51123223A (en) | Process for producing condensation products | |
| GB1540049A (en) | 9,11-bridged prostaglandins | |
| CH614940A5 (en) | Process for the preparation of new terpenoaromatic amidines | |
| JPS5318510A (en) | Preparation of geranyl farnesylacetate | |
| JPS5231615A (en) | Contour compensation circuit | |
| ES526942A0 (en) | A PROCEDURE FOR THE PREPARATION OF 6B-AMINOPENICILLATE FROM 1,1-DIOXOPENICILANOILOXIMETHYL | |
| JPS52114862A (en) | Multistage expansion oil pressure cylinder of dump-car | |
| JPS52148037A (en) | Preparation of per-#-toluylic acid | |
| JPS5223067A (en) | Novel synthesis of 2-aminomethyl-1- ethylpyrrolidine | |
| JPS5242855A (en) | Process for preparation of 7_(2-alkoxycarbonylcyclopentyl+)-5-heptenoi c acid | |
| JPS5239665A (en) | Process for preparing perfluorolactones | |
| GB1498764A (en) | Preparation of prostaglandin intermediates | |
| JPS52131557A (en) | Synthesis of epoxycyclo pentanone derivatives | |
| JPS53119245A (en) | Welding method for pipe circumference of circle not yielding residual stres s | |
| JPS52145793A (en) | Stop tube for stop joint and its preparing | |
| JPS53101716A (en) | Structure of end part of corrugated multilayer | |
| JPS5295610A (en) | Preparation of alpha-thioamino acid derivatives | |
| JPS532476A (en) | Synthesis of 4-substituted-dithio-2-azetidinone derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 48S | Specification amended (sect. 8/1949) | ||
| SP | Amendment (slips) printed | ||
| PCNP | Patent ceased through non-payment of renewal fee |