SE7702640L - Sett att framstella 5-(1,1-difenyl-3-(5 eller 6-hydroxi-2-azabicyklo-(2,2,2)okt-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoler och dermed beslektade foreningar - Google Patents

Sett att framstella 5-(1,1-difenyl-3-(5 eller 6-hydroxi-2-azabicyklo-(2,2,2)okt-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoler och dermed beslektade foreningar

Info

Publication number
SE7702640L
SE7702640L SE7702640A SE7702640A SE7702640L SE 7702640 L SE7702640 L SE 7702640L SE 7702640 A SE7702640 A SE 7702640A SE 7702640 A SE7702640 A SE 7702640A SE 7702640 L SE7702640 L SE 7702640L
Authority
SE
Sweden
Prior art keywords
oxadiazoles
azabicyclo
diphenyl
oct
propyl
Prior art date
Application number
SE7702640A
Other languages
English (en)
Swedish (sv)
Inventor
G W Adelstein
A Karim
C H Yen
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of SE7702640L publication Critical patent/SE7702640L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SE7702640A 1976-03-10 1977-03-09 Sett att framstella 5-(1,1-difenyl-3-(5 eller 6-hydroxi-2-azabicyklo-(2,2,2)okt-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoler och dermed beslektade foreningar SE7702640L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/665,609 US4013668A (en) 1976-03-10 1976-03-10 5-(1,1-diphenyl-3-(5- or 6-hydroxy-2-azabicyclo(2.2.2)oct-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoles and related compounds

Publications (1)

Publication Number Publication Date
SE7702640L true SE7702640L (sv) 1977-09-11

Family

ID=24670819

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7702640A SE7702640L (sv) 1976-03-10 1977-03-09 Sett att framstella 5-(1,1-difenyl-3-(5 eller 6-hydroxi-2-azabicyklo-(2,2,2)okt-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoler och dermed beslektade foreningar

Country Status (17)

Country Link
US (1) US4013668A (nl)
JP (1) JPS5951955B2 (nl)
AT (1) AT350559B (nl)
AU (1) AU505650B2 (nl)
BE (1) BE852252A (nl)
CA (1) CA1078386A (nl)
CH (1) CH627467A5 (nl)
DE (1) DE2710242A1 (nl)
DK (1) DK103777A (nl)
ES (1) ES456687A1 (nl)
FR (1) FR2343740A2 (nl)
GB (1) GB1524653A (nl)
IE (1) IE44639B1 (nl)
NL (1) NL7702537A (nl)
NZ (1) NZ183540A (nl)
SE (1) SE7702640L (nl)
ZA (1) ZA771428B (nl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0241180A (ja) * 1988-07-29 1990-02-09 Shinji Kanda 耐火避難用カプセル
US5242930A (en) * 1991-02-11 1993-09-07 Merck Sharp & Dohme Ltd. Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5667773A (en) * 1996-03-12 1997-09-16 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
EP1615646B2 (en) * 2003-04-08 2022-07-27 Progenics Pharmaceuticals, Inc. Pharmaceutical formulations containing methylnaltrexone
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
PL2565195T3 (pl) 2007-03-29 2015-10-30 Wyeth Llc Obwodowy receptor opioidowy i jego antagoniści oraz ich zastosowania
TWI553009B (zh) 2007-03-29 2016-10-11 普吉尼製藥公司 末梢性類鴉片受體拮抗劑及其用途
AU2008233133B2 (en) 2007-03-29 2014-03-27 Progenics Pharmaceuticals, Inc. Crystal forms of (R) -N-methylnaltrexone bromide and uses thereof
KR101581480B1 (ko) 2008-02-06 2015-12-30 프로제닉스 파머슈티컬스, 인코포레이티드 (ｒ),(ｒ)-2,2'-비스-메틸날트렉손의 제조법 및 용도
WO2010029313A1 (en) * 2008-09-11 2010-03-18 Summit Corporation Plc. Antiinfective compounds
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917615A (en) * 1974-04-01 1975-11-04 Searle & Co 1,1-Diaryl-1-oxadiazol-alkylamines

Also Published As

Publication number Publication date
JPS5951955B2 (ja) 1984-12-17
ZA771428B (en) 1978-10-25
AT350559B (de) 1979-06-11
BE852252A (fr) 1977-09-09
US4013668A (en) 1977-03-22
CH627467A5 (de) 1982-01-15
ATA157477A (de) 1978-11-15
ES456687A1 (es) 1978-02-01
DE2710242A1 (de) 1977-09-22
IE44639L (en) 1977-09-10
NL7702537A (nl) 1977-09-13
FR2343740B2 (nl) 1980-06-20
GB1524653A (en) 1978-09-13
IE44639B1 (en) 1982-02-10
AU505650B2 (en) 1979-11-29
FR2343740A2 (fr) 1977-10-07
DK103777A (da) 1977-09-11
AU2302977A (en) 1978-09-14
CA1078386A (en) 1980-05-27
JPS52108999A (en) 1977-09-12
NZ183540A (en) 1980-05-27

Similar Documents

Publication Publication Date Title
SE7702640L (sv) Sett att framstella 5-(1,1-difenyl-3-(5 eller 6-hydroxi-2-azabicyklo-(2,2,2)okt-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoler och dermed beslektade foreningar
NL7711610A (nl) Heparine bevattende liposomen en werkwijze ter bereiding ervan.
NO793530L (no) Toeymykner, samt fremgangsmaate for fremstilling derav
SE413096B (sv) Forfarande for framstellning av 1alfa,24(s)-dihydroxikolekalciferol och/eller 1,24(r)-dihydroxikolekalciferol
SE7505392L (sv) Forfarande for framstellning av penicilliner och cefalosporiner.
FI773784A (fi) Framstaellning av vissa immuna nukleinsyror celldialysat och antikroppar
SE431746B (sv) Forfarande for framstellning av d-fenylglycinamid eller d-fenylglycin och l-fenylglycin
FI790750A (fi) Tillvaratagande av elementsvavel och vaerdemetaller fraon en avrikning av kopparsulfidmalm eller fraon avrikningsavfall
SE7908678L (sv) Sett att tillreda bituminosa blandningar och anordning for settets utforande
SE7508544L (sv) Bensimidazol-derivat och sett att framstella desamma.
SE7703974L (sv) 1,3,4-tiadiazolylderivat till anvendning som herbicider och sett att framstella foreningarna
SE7511438L (sv) 7-hydroxi-ostradioler och sett att framstella desamma
SE7513753L (sv) Forfarande for framstellning av 8,8-disubstituerade-6-metylergoliner och derivat derav
SE7704731L (sv) 1-alkylamino-3-(5-karbocykloalkylaminokarbonyltiazol-2-yloxi)-propan-2-ol-och 5-(5-karbocykloalkylaminokarbonyltiazol-2-yloximetalen)-n-alkyloxazolidinderivat och sett att framstella desamma
SE7711228L (sv) (1-fenyl-2-triazolyl-etyl)-tioeter-derivat till anvendning som fungicider och tillvextregulatorer och sett att framstella foreningarna
SE7607138L (sv) Dl- och 8r-9-fluorprostadiensyraderivat och sett att framstella desamma
PL198445A1 (pl) Srodek grzybobojczy i sposob wytwarzania nowych eterow oksymow
NO156488C (no) Fremgangsmaate for fremstilling av ett eller flere titanklorider.
SE7700705L (sv) 1-legre-alkyl-4,5-dihydro-5-fenyl-2-legre-alkoxikarbonylaminoimidazoler och substituerade fenylderivat derav samt sett att framstella dessa foreningar
SE7603231L (sv) Karbamat av 2-haloergoliner och 2-haloergolener och sett att framstella desamma
FI56872B (fi) Foerfarande foer framstaellning av en bestrykningstalkprodukt i form av en eller flera komponenter
SE426941B (sv) Forfarande for framstellning av 2,6,6-trimetyl-2-cyanometyl-tetrahydropyran och/eller 2-metyl-2-cyanometyl-5-isopropyl-tetrahydrofuran
SE7705156L (sv) Antelminticida och fungicida foreningar
FI792141A (fi) Saett och anordning foer framstaellning av spaon- och fiberplattor eller liknande plattor
SE7708672L (sv) 21,21-dihalosubstituerade 16a,17a-acetonidsteroider och sett att framstella desamma