ZA771428B - 5-(1,1-diphenyl-3-(5-or 6-hydroxy-2-azabicyclo(2.2.2)oct-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoles and related compounds - Google Patents
5-(1,1-diphenyl-3-(5-or 6-hydroxy-2-azabicyclo(2.2.2)oct-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoles and related compoundsInfo
- Publication number
- ZA771428B ZA771428B ZA00771428A ZA771428A ZA771428B ZA 771428 B ZA771428 B ZA 771428B ZA 00771428 A ZA00771428 A ZA 00771428A ZA 771428 A ZA771428 A ZA 771428A ZA 771428 B ZA771428 B ZA 771428B
- Authority
- ZA
- South Africa
- Prior art keywords
- oxadiazoles
- azabicyclo
- diphenyl
- oct
- propyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/665,609 US4013668A (en) | 1976-03-10 | 1976-03-10 | 5-(1,1-diphenyl-3-(5- or 6-hydroxy-2-azabicyclo(2.2.2)oct-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoles and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA771428B true ZA771428B (en) | 1978-10-25 |
Family
ID=24670819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA00771428A ZA771428B (en) | 1976-03-10 | 1977-03-09 | 5-(1,1-diphenyl-3-(5-or 6-hydroxy-2-azabicyclo(2.2.2)oct-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoles and related compounds |
Country Status (17)
Country | Link |
---|---|
US (1) | US4013668A (xx) |
JP (1) | JPS5951955B2 (xx) |
AT (1) | AT350559B (xx) |
AU (1) | AU505650B2 (xx) |
BE (1) | BE852252A (xx) |
CA (1) | CA1078386A (xx) |
CH (1) | CH627467A5 (xx) |
DE (1) | DE2710242A1 (xx) |
DK (1) | DK103777A (xx) |
ES (1) | ES456687A1 (xx) |
FR (1) | FR2343740A2 (xx) |
GB (1) | GB1524653A (xx) |
IE (1) | IE44639B1 (xx) |
NL (1) | NL7702537A (xx) |
NZ (1) | NZ183540A (xx) |
SE (1) | SE7702640L (xx) |
ZA (1) | ZA771428B (xx) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0241180A (ja) * | 1988-07-29 | 1990-02-09 | Shinji Kanda | 耐火避難用カプセル |
DE69220258T2 (de) * | 1991-02-11 | 1997-12-18 | Merck Sharp & Dohme | Azabicyclische Verbindungen, diese enthaltende pharmazeutische Zubereitungen und ihre therapeutische Verwendung |
US6190691B1 (en) | 1994-04-12 | 2001-02-20 | Adolor Corporation | Methods for treating inflammatory conditions |
US5962477A (en) * | 1994-04-12 | 1999-10-05 | Adolor Corporation | Screening methods for cytokine inhibitors |
US5849761A (en) | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
US6573282B1 (en) | 1995-09-12 | 2003-06-03 | Adolor Corporation | Peripherally active anti-hyperalgesic opiates |
US5667773A (en) * | 1996-03-12 | 1997-09-16 | Adolor Corporation | Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith |
US6353004B1 (en) | 1997-07-14 | 2002-03-05 | Adolor Coporation | Peripherally acting anti-pruritic opiates |
US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
RU2362560C2 (ru) * | 2003-04-08 | 2009-07-27 | Проджиникс Фармасьютикалз, Инк. | Фармацевтическая препаративная форма |
AR057035A1 (es) * | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
CA2682550C (en) * | 2007-03-29 | 2016-05-17 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
US20100305323A1 (en) | 2007-03-29 | 2010-12-02 | Smolenskaya Valeriya N | Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof |
PE20090700A1 (es) | 2007-03-29 | 2009-07-13 | Progenics Pharm Inc | Compuestos heterociclicos como antagonistas del receptor opioide periferico |
WO2009099411A1 (en) * | 2008-02-06 | 2009-08-13 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
WO2010029313A1 (en) * | 2008-09-11 | 2010-03-18 | Summit Corporation Plc. | Antiinfective compounds |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3917615A (en) * | 1974-04-01 | 1975-11-04 | Searle & Co | 1,1-Diaryl-1-oxadiazol-alkylamines |
-
1976
- 1976-03-10 US US05/665,609 patent/US4013668A/en not_active Expired - Lifetime
-
1977
- 1977-03-09 NZ NZ183540A patent/NZ183540A/xx unknown
- 1977-03-09 ES ES456687A patent/ES456687A1/es not_active Expired
- 1977-03-09 NL NL7702537A patent/NL7702537A/xx not_active Application Discontinuation
- 1977-03-09 SE SE7702640A patent/SE7702640L/xx unknown
- 1977-03-09 DK DK103777A patent/DK103777A/da unknown
- 1977-03-09 AT AT157477A patent/AT350559B/de not_active IP Right Cessation
- 1977-03-09 AU AU23029/77A patent/AU505650B2/en not_active Expired
- 1977-03-09 JP JP52025851A patent/JPS5951955B2/ja not_active Expired
- 1977-03-09 IE IE515/77A patent/IE44639B1/en unknown
- 1977-03-09 CH CH295177A patent/CH627467A5/de not_active IP Right Cessation
- 1977-03-09 ZA ZA00771428A patent/ZA771428B/xx unknown
- 1977-03-09 GB GB10031/77A patent/GB1524653A/en not_active Expired
- 1977-03-09 DE DE19772710242 patent/DE2710242A1/de not_active Withdrawn
- 1977-03-09 CA CA273,594A patent/CA1078386A/en not_active Expired
- 1977-03-09 BE BE175614A patent/BE852252A/xx not_active IP Right Cessation
- 1977-03-10 FR FR7707155A patent/FR2343740A2/fr active Granted
Also Published As
Publication number | Publication date |
---|---|
AT350559B (de) | 1979-06-11 |
AU505650B2 (en) | 1979-11-29 |
NL7702537A (nl) | 1977-09-13 |
JPS52108999A (en) | 1977-09-12 |
ES456687A1 (es) | 1978-02-01 |
GB1524653A (en) | 1978-09-13 |
DE2710242A1 (de) | 1977-09-22 |
CH627467A5 (de) | 1982-01-15 |
DK103777A (da) | 1977-09-11 |
CA1078386A (en) | 1980-05-27 |
US4013668A (en) | 1977-03-22 |
FR2343740A2 (fr) | 1977-10-07 |
NZ183540A (en) | 1980-05-27 |
ATA157477A (de) | 1978-11-15 |
JPS5951955B2 (ja) | 1984-12-17 |
IE44639B1 (en) | 1982-02-10 |
SE7702640L (sv) | 1977-09-11 |
FR2343740B2 (xx) | 1980-06-20 |
BE852252A (fr) | 1977-09-09 |
AU2302977A (en) | 1978-09-14 |
IE44639L (en) | 1977-09-10 |
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