SE7506099L - PROCEDURE FOR THE MANUFACTURE OF A DRUG DELIVERY DEVICE - Google Patents

PROCEDURE FOR THE MANUFACTURE OF A DRUG DELIVERY DEVICE

Info

Publication number
SE7506099L
SE7506099L SE7506099A SE7506099A SE7506099L SE 7506099 L SE7506099 L SE 7506099L SE 7506099 A SE7506099 A SE 7506099A SE 7506099 A SE7506099 A SE 7506099A SE 7506099 L SE7506099 L SE 7506099L
Authority
SE
Sweden
Prior art keywords
active agent
delivery device
agent
procedure
manufacture
Prior art date
Application number
SE7506099A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE405803B (en
Inventor
A S Michaels
F Theeuwes
R W Baker
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of SE7506099L publication Critical patent/SE7506099L/en
Publication of SE405803B publication Critical patent/SE405803B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A process for improving the release kinetics of a monolithic active agent delivery device comprising a shaped body of a dispersion of particulate active agent, such as a drug, with a polymer matrix, such as ethylene/vinylacetate copolymer, by substantially reducing the initial burst of active agent from the device when it is placed in its environment of use. The process involves prior to placing the body in its use environment removing, such as by water washing, the particulate drug from the exterior surface of the body to form an agent depleted layer of polymer matrix voided by the removal of the agent, the thickness of the layer being at least 5% of the overall body thickness.
SE7506099A 1974-06-07 1975-05-28 PROCEDURE FOR MANUFACTURING AN ACTIVE RELEASE DEVICE SE405803B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US477297A US3923939A (en) 1974-06-07 1974-06-07 Process for improving release kinetics of a monolithic drug delivery device

Publications (2)

Publication Number Publication Date
SE7506099L true SE7506099L (en) 1975-12-08
SE405803B SE405803B (en) 1979-01-08

Family

ID=23895337

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7506099A SE405803B (en) 1974-06-07 1975-05-28 PROCEDURE FOR MANUFACTURING AN ACTIVE RELEASE DEVICE

Country Status (10)

Country Link
US (1) US3923939A (en)
JP (1) JPS6043327B2 (en)
CA (1) CA1047403A (en)
CH (1) CH611160A5 (en)
DE (1) DE2525061C2 (en)
FR (1) FR2273515A1 (en)
GB (1) GB1477545A (en)
IT (1) IT1036192B (en)
MX (1) MX3007E (en)
SE (1) SE405803B (en)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177256A (en) * 1973-04-25 1979-12-04 Alza Corporation Osmotic bursting drug delivery device
US4145408A (en) * 1976-08-16 1979-03-20 The Procter & Gamble Company Controlled release article
HU174057B (en) * 1976-09-17 1979-10-28 Richter Gedeon Vegyeszet Coating material for the regulated release of the active substance in biologically active preparations and process for preparing such preparations with regulated release of the active substance
US4190642A (en) * 1978-04-17 1980-02-26 Alza Corporation Ocular therapeutic system for dispensing a medication formulation
US4156604A (en) * 1978-09-15 1979-05-29 Minnesota Mining And Manufacturing Company Controlled delivery of corrosion inhibitors for silver recovery cartridges
US4333850A (en) * 1979-06-15 1982-06-08 Borg-Warner Corporation Filled polymer composition for automatic addition of a corrosion inhibitor to a coolant system
US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
US4432964A (en) * 1981-08-24 1984-02-21 Alza Corporation Topical composition containing steroid in two forms released independently from polymeric carrier
DE3218150C2 (en) * 1982-05-14 1986-09-25 Akzo Gmbh, 5600 Wuppertal Active substance-containing body for long-term release and process for its production
JPS5931701A (en) * 1982-08-16 1984-02-20 Nitto Electric Ind Co Ltd Membrane containing liquid active substance and its preparation
US4557925A (en) * 1982-07-08 1985-12-10 Ab Ferrosan Membrane-coated sustained-release tablets and method
US4478818A (en) * 1982-12-27 1984-10-23 Alza Corporation Ocular preparation housing steroid in two different therapeutic forms
US4564364A (en) * 1983-05-26 1986-01-14 Alza Corporation Active agent dispenser
GB8331546D0 (en) * 1983-11-25 1984-01-04 Exxon Research Engineering Co Polymeric compositions
US4624848A (en) * 1984-05-10 1986-11-25 Ciba-Geigy Corporation Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
US4725439A (en) * 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4704282A (en) * 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
US4629619A (en) * 1984-09-05 1986-12-16 Ab Ferrosan Membrane-coated sustained-release tablets and method
US4629620A (en) * 1984-09-05 1986-12-16 Ab Ferrosan Membrane-coated sustained-release tablets and method
US4874366A (en) * 1984-12-03 1989-10-17 Baxter Internatiional Inc. Housing enabling passive mixing of a beneficial agent with a diluent
DE3585530D1 (en) * 1984-12-03 1992-04-09 Baxter Int ADMINISTRATIVE ARRANGEMENT FOR MEDICINAL PRODUCTS FOR PREVENTING LOCAL AND SYSTEMIC TOXICITY.
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
US4898733A (en) * 1985-11-04 1990-02-06 International Minerals & Chemical Corp. Layered, compression molded device for the sustained release of a beneficial agent
ES2028074T3 (en) * 1986-06-13 1992-07-01 Alza Corporation ACTIVATION BY MOISTURE OF A TRANSDERMIC PHARMACY SUPPLY SYSTEM.
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US5071656A (en) * 1987-03-05 1991-12-10 Alza Corporation Delayed onset transdermal delivery device
DE3743945A1 (en) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg DEVICE FOR DELIVERING SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
US4917895A (en) * 1987-11-02 1990-04-17 Alza Corporation Transdermal drug delivery device
US4837027A (en) * 1987-11-09 1989-06-06 Alza Corporation Transdermal drug delivery device
US4781924A (en) * 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US5154939A (en) * 1989-04-19 1992-10-13 Wm. Wrigley Jr. Company Use of salt to improve extrusion encapsulation of chewing gum ingredients
US5108762A (en) * 1989-04-19 1992-04-28 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5198251A (en) * 1989-04-19 1993-03-30 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US4978537A (en) * 1989-04-19 1990-12-18 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5165944A (en) * 1989-04-19 1992-11-24 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5229148A (en) * 1989-04-19 1993-07-20 Wm. Wrigley Jr. Company Method of combining active ingredients with polyvinyl acetates
US5091186A (en) * 1989-08-15 1992-02-25 Cygnus Therapeutic Systems Biphasic transdermal drug delivery device
US5124157A (en) 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
AU639645B2 (en) * 1989-10-10 1993-07-29 Wm. Wrigley Jr. Company Gradual release structures made from fiber spinning techniques
JPH03287525A (en) * 1990-04-03 1991-12-18 Toichi Chikuma Applicable analgesic tool
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
JPH0421521U (en) * 1990-06-14 1992-02-24
US5128155A (en) * 1990-12-20 1992-07-07 Wm. Wrigley Jr. Company Flavor releasing structures for chewing gum
US5271736A (en) * 1991-05-13 1993-12-21 Applied Medical Research Collagen disruptive morphology for implants
WO1993013758A1 (en) * 1992-01-13 1993-07-22 Pfizer Inc. Preparation of tablets of increased strength
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5962011A (en) * 1993-12-06 1999-10-05 Schering-Plough Healthcare Products, Inc. Device for delivery of dermatological ingredients
US5633000A (en) * 1994-06-23 1997-05-27 Axxia Technologies Subcutaneous implant
US5819742A (en) * 1996-11-06 1998-10-13 Family Health International Vaginal device for preventing conception or the transmission of sexually transmitted diseases, or both
PT949905E (en) * 1996-12-20 2001-12-28 Alza Corp DELAYED EFFECT INJECTABLE GEL COMPOSITION AND PROCESS FOR THEIR PREPARATION
US6039968A (en) * 1997-06-24 2000-03-21 Hoechst Marion Roussel Intravaginal drug delivery device
US6110500A (en) * 1998-03-25 2000-08-29 Temple University Coated tablet with long term parabolic and zero-order release kinetics
US20050175959A1 (en) * 2000-03-14 2005-08-11 Coll Partners Ltd. System for the controlled delivery of an active material to a dental site
IL135061A0 (en) * 2000-03-14 2001-05-20 Ahron Jodaikin Strategic targeted fluoridation and chemical treatment of teeth
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
MXPA03002871A (en) * 2000-09-29 2004-12-06 Johnson & Johnson Coated medical devices.
WO2003041685A1 (en) * 2001-11-14 2003-05-22 Alza Corporation Injectable depot composition
NZ533436A (en) 2001-11-14 2007-10-26 Alza Corp Catheter injectable depot compositons and uses thereof
PT2561860T (en) * 2002-05-31 2018-05-08 Titan Pharmaceuticals Inc Implantable polymeric device for sustained release of buprenorphine
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CN1684663A (en) 2002-07-31 2005-10-19 阿尔萨公司 Injectable multimodal polymer depot compositions and uses thereof
AU2002359397B2 (en) 2002-07-31 2009-01-29 Durect Corporation Injectable depot compositions and uses thereof
CN102772357B (en) 2003-03-31 2014-12-31 泰坦医药品公司 Implantable polymeric device for sustained release of dopamine agonist
US7850453B2 (en) * 2007-08-08 2010-12-14 Coll Partners Ltd. Reshapable device for fixation at a dental site
USRE48948E1 (en) * 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
WO2010096822A2 (en) * 2009-02-23 2010-08-26 Qlt Plug Delivery, Inc. Lacrimal implants and related methods
US20110129516A1 (en) * 2009-10-30 2011-06-02 Aton Pharma, Inc. Ocular drug delivery devices
US9138308B2 (en) 2010-02-03 2015-09-22 Apollo Endosurgery, Inc. Mucosal tissue adhesion via textured surface
US9205577B2 (en) * 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
CN102971018B (en) * 2010-05-11 2016-02-03 阿勒根公司 Porogen composition, Preparation method and use
US9668844B2 (en) 2013-11-06 2017-06-06 Colldent Y.A Ltd Device for fixation at a dental site
WO2015088990A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
KR20220140711A (en) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 Reduced Impurity Sustained Release Drug Delivery Systems and Related Methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3402240A (en) * 1957-06-25 1968-09-17 Pfizer & Co C Medicinal tablet and process of making same
US3639583A (en) * 1968-06-28 1972-02-01 Goodrich Co B F Biocidal elastomeric compositions
US3700380A (en) * 1970-10-01 1972-10-24 Tecna Corp Surface or lining compatible with blood or other tissue
GB1412983A (en) * 1971-11-30 1975-11-05 Debell & Richardson Method of producing porous plastic materials
FR2183546B1 (en) * 1972-05-10 1975-06-20 Servier Lab
JPS49118827A (en) * 1973-03-27 1974-11-13
JPS506709A (en) * 1973-05-18 1975-01-23

Also Published As

Publication number Publication date
US3923939A (en) 1975-12-02
DE2525061C2 (en) 1985-08-22
MX3007E (en) 1980-01-28
FR2273515B1 (en) 1980-02-15
DE2525061A1 (en) 1976-01-02
FR2273515A1 (en) 1976-01-02
CH611160A5 (en) 1979-05-31
CA1047403A (en) 1979-01-30
JPS5112920A (en) 1976-01-31
SE405803B (en) 1979-01-08
JPS6043327B2 (en) 1985-09-27
GB1477545A (en) 1977-06-22
IT1036192B (en) 1979-10-30

Similar Documents

Publication Publication Date Title
SE7506099L (en) PROCEDURE FOR THE MANUFACTURE OF A DRUG DELIVERY DEVICE
US3934580A (en) Chemically acting intra-uterine device
KR890003361A (en) Clevoprid-containing skin preparation
GB1374199A (en) Shaped bodies of pullulan and their use
NL7900958A (en) MICROCAPSULES OF POLYVINYL ALCOHOL WITH LIQUID, WATER-INSOLUBLE FILLER AND PROCESS FOR THEIR MANUFACTURE.
IE42604L (en) Pharmaceutical preparation in the form of a foil
FR2331603A1 (en) Absorption mixt. from a polymer and an inorganic material - for use e.g. in disposable napkins which retain moisture even under pressure
IE44353L (en) Controlled release of an active component
ATE81450T1 (en) RELEASED RELEASE PHARMACEUTICAL FORM AND PROCESS FOR PRODUCTION.
JPS52139715A (en) Coated granules of alkali polyacrylate
ES446992A1 (en) Device for releasing active agent and process for producing the same
MX168426B (en) METHOD FOR MANUFACTURING A MEDICAL DEVICE AND THE MANUFACTURED MEDICAL DEVICE
JPS5592312A (en) Suppository containing bronchodilating compound
CA2010225A1 (en) Therapeutic System for the Retarded and Controlled Transdermal or Transmucous Administration of Active Substances (1)
JPS5256187A (en) Process for preparing aqueous dispersions
JPS5540604A (en) Improved local topicum
FR2290250A1 (en) DEVICE FOR PRESSURIZED TANK AND UNDER PRESSURE TANK, IN PARTICULAR FOR TREATMENT OF STRIPS OF TEXTILE MATERIAL
GB1503116A (en) Sustained release drug delivery devices
JPS57139011A (en) Material for releasing physiologically active substance
JPS5279018A (en) Analgesic embrocation
JPS55111895A (en) Filter material for waste liquid treating apparatus
GB1480615A (en) Catamenial device
JPS57136513A (en) Material for controlling release of physiologically active substance
GB924081A (en) Method of treating expanded sponge material to render it hydrophilic and product thereof
JPS574918A (en) Material for feeding physiologically active substance

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 7506099-6

Effective date: 19911209

Format of ref document f/p: F