GB1503116A - Sustained release drug delivery devices - Google Patents

Sustained release drug delivery devices

Info

Publication number
GB1503116A
GB1503116A GB2809376A GB2809376A GB1503116A GB 1503116 A GB1503116 A GB 1503116A GB 2809376 A GB2809376 A GB 2809376A GB 2809376 A GB2809376 A GB 2809376A GB 1503116 A GB1503116 A GB 1503116A
Authority
GB
United Kingdom
Prior art keywords
pharmaceutical
polymer
environment
release
soluble substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2809376A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of GB1503116A publication Critical patent/GB1503116A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The device for delayed pharmaceutical release is used in an aqueous environment in the human or animal body. It essentially releases the pharmaceutical by diffusion. It displays an integral solid structure of such a shape and size that it can be introduced into the environment in which it is to be used and can be held there. It consists of a mixture which contains a non-ionic pharmaceutical, a polymer and, in addition, 0.1 to 15% by weight of a soluble substance with osmotic activity. The pharmaceutical has a solubility in water of from 200 to 10,000 ppm. The polymer is permeable to water and to the pharmaceutical, is insoluble in the aqueous environment at least for the duration of the pharmaceutical release and is impermeable to the soluble substance. The soluble substance is in the form of single depots which have a number average diameter of 1 to 250 mu m which are dispersed in the polymer so that they are surrounded essentially singly by a polymer layer. When the device is introduced into the aqueous environment, the depots absorb water and rupture the surrounding polymer layers. This results in a network of mutually connected pores inside the device. There is thus an in situ enlargement of the surface area on which the pharmaceutical can be released from the polymer to the environment. This in situ enlargement of the surface area increases the rate of release of the pharmaceutical from the device.
GB2809376A 1975-07-28 1976-07-06 Sustained release drug delivery devices Expired GB1503116A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59979575A 1975-07-28 1975-07-28

Publications (1)

Publication Number Publication Date
GB1503116A true GB1503116A (en) 1978-03-08

Family

ID=24401120

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2809376A Expired GB1503116A (en) 1975-07-28 1976-07-06 Sustained release drug delivery devices

Country Status (8)

Country Link
JP (1) JPS5215810A (en)
CA (1) CA1083041A (en)
CH (1) CH623232A5 (en)
DE (1) DE2633987A1 (en)
FR (1) FR2319380A1 (en)
GB (1) GB1503116A (en)
IT (1) IT1069521B (en)
SE (1) SE7608161L (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080330A2 (en) * 1981-11-18 1983-06-01 Stc Plc Composite materials
WO1997037640A2 (en) * 1996-04-05 1997-10-16 Alza Corporation Uniform drug delivery therapy
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048710B (en) * 1979-05-07 1983-03-09 Alza Corp Osmotically driven fluid dispenser
JPS60139222U (en) * 1984-02-28 1985-09-14 株式会社東芝 foldable recorder
DE19537090A1 (en) * 1995-10-05 1997-04-10 Lohmann Therapie Syst Lts Osmotic device for the continuous release of active substances into the fluids of the gastrointestinal tract

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892842A (en) * 1971-09-01 1975-07-01 Alza Corp Intrauterine contraceptive device for releasing steroid having double bond functionality
GB1425550A (en) * 1973-04-25 1976-02-18 Alza Corp Device for releasing active agent and process for producing the same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080330A2 (en) * 1981-11-18 1983-06-01 Stc Plc Composite materials
EP0080330A3 (en) * 1981-11-18 1983-07-13 Standard Telephones And Cables Public Limited Company Composite materials
WO1997037640A2 (en) * 1996-04-05 1997-10-16 Alza Corporation Uniform drug delivery therapy
WO1997037640A3 (en) * 1996-04-05 1997-11-13 Alza Corp Uniform drug delivery therapy
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same

Also Published As

Publication number Publication date
IT1069521B (en) 1985-03-25
FR2319380B1 (en) 1978-11-17
JPS5215810A (en) 1977-02-05
CA1083041A (en) 1980-08-05
CH623232A5 (en) 1981-05-29
FR2319380A1 (en) 1977-02-25
DE2633987A1 (en) 1977-02-10
SE7608161L (en) 1977-01-29

Similar Documents

Publication Publication Date Title
CA1047403A (en) Process for making a monolithic drug delivery device
Sungthongjeen et al. Design and evaluation of floating multi-layer coated tablets based on gas formation
CA1107197A (en) Controlled-release compositions for administration of thereapeutic agents to ruminants
US4016880A (en) Osmotically driven active agent dispenser
IT1201136B (en) TABLET FOR PHARMACEUTICAL USE SUITABLE FOR THE RELEASE OF SUBSTANCES OF ACTIVE SUBSTANCES
KR900701274A (en) Dosage formulations reduce the likelihood of abuse
ATE206613T1 (en) MEDICINAL DELIVERY SYSTEM WITH BURST RELEASE OF PARTICLES
IE64047B1 (en) Dispensing device containing a hydrophobic medium
CA2375714A1 (en) Delayed total release two pulse gastrointestinal drug delivery system
IE781163L (en) Sustained release of veterinary medicaments
JPS584574B2 (en) Solid zero order emitter
JPS596843B2 (en) Manufacturing method of drug supply body
KR900011486A (en) Dispenser operated by hydrogel
KR102226652B1 (en) Abuse and misuse deterrent transdermal systems
DE69331806D1 (en) MULTIPARTICLE MEDICINE DISPENSING SYSTEM WITH STROKE RELEASE
ES8603749A1 (en) Release devices.
SE459847B (en) OSMOTIC SYSTEM WITH IMMEDIATE MEDICINE AVAILABILITY
CZ49389A3 (en) Floating peroral therapeutic system
GB1503116A (en) Sustained release drug delivery devices
Elkheshen et al. In vitro and in vivo evaluation of floating controlled release dosage forms of verapamil hydrochloride
GB1414812A (en) Device for sustained release of drugs and like active agents
ES2026727T3 (en) INTRA-RUMIAL DEVICE FOR THE ADMINISTRATION OF DRUGS.
JPH0124126B2 (en)
IE35992B1 (en) Device for insertion into the reproductive tract and metho
DE3688355D1 (en) SOLID BODY WITH COVERED CORE.

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee