SE7608161L - DEVICE FOR DELIVERING MEDICINES DURING AN EXTENDED PERIOD AND A PROCEDURE FOR ITS PREPARATION - Google Patents

DEVICE FOR DELIVERING MEDICINES DURING AN EXTENDED PERIOD AND A PROCEDURE FOR ITS PREPARATION

Info

Publication number
SE7608161L
SE7608161L SE7608161A SE7608161A SE7608161L SE 7608161 L SE7608161 L SE 7608161L SE 7608161 A SE7608161 A SE 7608161A SE 7608161 A SE7608161 A SE 7608161A SE 7608161 L SE7608161 L SE 7608161L
Authority
SE
Sweden
Prior art keywords
pharmaceutical
polymer
environment
release
soluble substance
Prior art date
Application number
SE7608161A
Other languages
Unknown language ( )
Swedish (sv)
Inventor
R M Gale
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of SE7608161L publication Critical patent/SE7608161L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The device for delayed pharmaceutical release is used in an aqueous environment in the human or animal body. It essentially releases the pharmaceutical by diffusion. It displays an integral solid structure of such a shape and size that it can be introduced into the environment in which it is to be used and can be held there. It consists of a mixture which contains a non-ionic pharmaceutical, a polymer and, in addition, 0.1 to 15% by weight of a soluble substance with osmotic activity. The pharmaceutical has a solubility in water of from 200 to 10,000 ppm. The polymer is permeable to water and to the pharmaceutical, is insoluble in the aqueous environment at least for the duration of the pharmaceutical release and is impermeable to the soluble substance. The soluble substance is in the form of single depots which have a number average diameter of 1 to 250 mu m which are dispersed in the polymer so that they are surrounded essentially singly by a polymer layer. When the device is introduced into the aqueous environment, the depots absorb water and rupture the surrounding polymer layers. This results in a network of mutually connected pores inside the device. There is thus an in situ enlargement of the surface area on which the pharmaceutical can be released from the polymer to the environment. This in situ enlargement of the surface area increases the rate of release of the pharmaceutical from the device.
SE7608161A 1975-07-28 1976-07-16 DEVICE FOR DELIVERING MEDICINES DURING AN EXTENDED PERIOD AND A PROCEDURE FOR ITS PREPARATION SE7608161L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59979575A 1975-07-28 1975-07-28

Publications (1)

Publication Number Publication Date
SE7608161L true SE7608161L (en) 1977-01-29

Family

ID=24401120

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7608161A SE7608161L (en) 1975-07-28 1976-07-16 DEVICE FOR DELIVERING MEDICINES DURING AN EXTENDED PERIOD AND A PROCEDURE FOR ITS PREPARATION

Country Status (8)

Country Link
JP (1) JPS5215810A (en)
CA (1) CA1083041A (en)
CH (1) CH623232A5 (en)
DE (1) DE2633987A1 (en)
FR (1) FR2319380A1 (en)
GB (1) GB1503116A (en)
IT (1) IT1069521B (en)
SE (1) SE7608161L (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048710B (en) * 1979-05-07 1983-03-09 Alza Corp Osmotically driven fluid dispenser
GB2109237B (en) * 1981-11-18 1985-12-18 Standard Telephones Cables Ltd Composite materials
JPS60139222U (en) * 1984-02-28 1985-09-14 株式会社東芝 foldable recorder
DE19537090A1 (en) * 1995-10-05 1997-04-10 Lohmann Therapie Syst Lts Osmotic device for the continuous release of active substances into the fluids of the gastrointestinal tract
ZA97976B (en) * 1996-04-05 1997-08-18 Alza Corp Uniform drug delivery theraphy.
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892842A (en) * 1971-09-01 1975-07-01 Alza Corp Intrauterine contraceptive device for releasing steroid having double bond functionality
GB1425550A (en) * 1973-04-25 1976-02-18 Alza Corp Device for releasing active agent and process for producing the same

Also Published As

Publication number Publication date
IT1069521B (en) 1985-03-25
GB1503116A (en) 1978-03-08
JPS5215810A (en) 1977-02-05
FR2319380A1 (en) 1977-02-25
FR2319380B1 (en) 1978-11-17
DE2633987A1 (en) 1977-02-10
CA1083041A (en) 1980-08-05
CH623232A5 (en) 1981-05-29

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