MX3007E - IMPROVED PROCEDURE FOR MAKING A MONOLITHIC ACTIVE AGENT DISPENSER - Google Patents

IMPROVED PROCEDURE FOR MAKING A MONOLITHIC ACTIVE AGENT DISPENSER

Info

Publication number
MX3007E
MX3007E MX001433U MX143375U MX3007E MX 3007 E MX3007 E MX 3007E MX 001433 U MX001433 U MX 001433U MX 143375 U MX143375 U MX 143375U MX 3007 E MX3007 E MX 3007E
Authority
MX
Mexico
Prior art keywords
active agent
making
dispersion
agent dispenser
polymeric matrix
Prior art date
Application number
MX001433U
Other languages
Spanish (es)
Inventor
Alan S Michaels
Felix Theeuwes
Richard W Baker
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of MX3007E publication Critical patent/MX3007E/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un procedimiento mejorado para hacer un dispensador monolítico de agente activo, del tipo que comprende una dispersión de agente activo, tal como una droga, en forma de partículas sólidas, en una matriz polimérica y que comprende los pasos de formar una dispersión del agente activo en forma de partículas sólidas en dicha matriz, y transformar la dispersión en un cuerpo conformado adaptado para colocarse en el ambiente de utilización del dispositivo, caracterizado por el paso adicional de separar el agente activo en forma de partículas sólidas de la superficie de dicho cuerpo, mediante lavado del cuerpo en un líquido que es inerte con respecto a la matriz polimérica, para formar una capa desprovista de agente activo en la matriz polimérica, ahuecada por la remoción del agente activo sólido en forma de partículas de la misma, y porque el espesor de dicha capa desprovista de agente activo es, por lo menos, aproximadamente del 5 por ciento del espesor global del cuerpo.The present invention relates to an improved process for making a monolithic active agent dispenser, of the type comprising a dispersion of active agent, such as a drug, in the form of solid particles, in a polymeric matrix and comprising the steps of forming a dispersion of the active agent in the form of solid particles in said matrix, and transforming the dispersion into a shaped body adapted to be placed in the environment of use of the device, characterized by the additional step of separating the active agent in the form of solid particles from the surface of said body, by washing the body in a liquid that is inert with respect to the polymeric matrix, to form a layer devoid of active agent in the polymeric matrix, hollowed out by the removal of the solid active agent in the form of particles thereof , and because the thickness of said layer devoid of active agent is at least approximately 5 percent of the glo bal of the body.

MX001433U 1974-06-07 1975-06-06 IMPROVED PROCEDURE FOR MAKING A MONOLITHIC ACTIVE AGENT DISPENSER MX3007E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US477297A US3923939A (en) 1974-06-07 1974-06-07 Process for improving release kinetics of a monolithic drug delivery device

Publications (1)

Publication Number Publication Date
MX3007E true MX3007E (en) 1980-01-28

Family

ID=23895337

Family Applications (1)

Application Number Title Priority Date Filing Date
MX001433U MX3007E (en) 1974-06-07 1975-06-06 IMPROVED PROCEDURE FOR MAKING A MONOLITHIC ACTIVE AGENT DISPENSER

Country Status (10)

Country Link
US (1) US3923939A (en)
JP (1) JPS6043327B2 (en)
CA (1) CA1047403A (en)
CH (1) CH611160A5 (en)
DE (1) DE2525061C2 (en)
FR (1) FR2273515A1 (en)
GB (1) GB1477545A (en)
IT (1) IT1036192B (en)
MX (1) MX3007E (en)
SE (1) SE405803B (en)

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US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
US4432964A (en) * 1981-08-24 1984-02-21 Alza Corporation Topical composition containing steroid in two forms released independently from polymeric carrier
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US4557925A (en) * 1982-07-08 1985-12-10 Ab Ferrosan Membrane-coated sustained-release tablets and method
US4478818A (en) * 1982-12-27 1984-10-23 Alza Corporation Ocular preparation housing steroid in two different therapeutic forms
US4564364A (en) * 1983-05-26 1986-01-14 Alza Corporation Active agent dispenser
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US4624848A (en) * 1984-05-10 1986-11-25 Ciba-Geigy Corporation Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
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US4704282A (en) * 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
US4629619A (en) * 1984-09-05 1986-12-16 Ab Ferrosan Membrane-coated sustained-release tablets and method
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US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
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US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US5071656A (en) * 1987-03-05 1991-12-10 Alza Corporation Delayed onset transdermal delivery device
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US4917895A (en) * 1987-11-02 1990-04-17 Alza Corporation Transdermal drug delivery device
US4837027A (en) * 1987-11-09 1989-06-06 Alza Corporation Transdermal drug delivery device
US4781924A (en) * 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US5229148A (en) * 1989-04-19 1993-07-20 Wm. Wrigley Jr. Company Method of combining active ingredients with polyvinyl acetates
US4978537A (en) * 1989-04-19 1990-12-18 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5198251A (en) * 1989-04-19 1993-03-30 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5154939A (en) * 1989-04-19 1992-10-13 Wm. Wrigley Jr. Company Use of salt to improve extrusion encapsulation of chewing gum ingredients
US5165944A (en) * 1989-04-19 1992-11-24 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5108762A (en) * 1989-04-19 1992-04-28 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5091186A (en) * 1989-08-15 1992-02-25 Cygnus Therapeutic Systems Biphasic transdermal drug delivery device
US5124157A (en) * 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
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Also Published As

Publication number Publication date
DE2525061C2 (en) 1985-08-22
CH611160A5 (en) 1979-05-31
JPS6043327B2 (en) 1985-09-27
SE405803B (en) 1979-01-08
IT1036192B (en) 1979-10-30
GB1477545A (en) 1977-06-22
FR2273515B1 (en) 1980-02-15
US3923939A (en) 1975-12-02
DE2525061A1 (en) 1976-01-02
JPS5112920A (en) 1976-01-31
FR2273515A1 (en) 1976-01-02
CA1047403A (en) 1979-01-30
SE7506099L (en) 1975-12-08

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