SE516272C2 - Metoder och kit för analytdetektion mha proximitets-probning - Google Patents

Metoder och kit för analytdetektion mha proximitets-probning

Info

Publication number
SE516272C2
SE516272C2 SE0000538A SE0000538A SE516272C2 SE 516272 C2 SE516272 C2 SE 516272C2 SE 0000538 A SE0000538 A SE 0000538A SE 0000538 A SE0000538 A SE 0000538A SE 516272 C2 SE516272 C2 SE 516272C2
Authority
SE
Sweden
Prior art keywords
analyte
binding
proximity
nucleic acid
ligation
Prior art date
Application number
SE0000538A
Other languages
English (en)
Swedish (sv)
Other versions
SE0000538D0 (sv
SE0000538L (sv
Inventor
Ulf Landegren
Simon Fredriksson
Original Assignee
Ulf Landegren
Simon Fredriksson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ulf Landegren, Simon Fredriksson filed Critical Ulf Landegren
Priority to SE0000538A priority Critical patent/SE516272C2/sv
Publication of SE0000538D0 publication Critical patent/SE0000538D0/xx
Priority to CA002400384A priority patent/CA2400384A1/fr
Priority to EP01906476A priority patent/EP1255861B1/fr
Priority to PCT/SE2001/000341 priority patent/WO2001061037A1/fr
Priority to AU34300/01A priority patent/AU783644B2/en
Priority to AT01906476T priority patent/ATE402269T1/de
Priority to JP2001559873A priority patent/JP4804691B2/ja
Priority to DE60134957T priority patent/DE60134957D1/de
Publication of SE0000538L publication Critical patent/SE0000538L/xx
Publication of SE516272C2 publication Critical patent/SE516272C2/sv

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SE0000538A 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning SE516272C2 (sv)

Priority Applications (8)

Application Number Priority Date Filing Date Title
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning
CA002400384A CA2400384A1 (fr) 2000-02-18 2001-02-16 Procedes et trousses de detection de proximite
EP01906476A EP1255861B1 (fr) 2000-02-18 2001-02-16 Procedes et trousses de detection de proximite
PCT/SE2001/000341 WO2001061037A1 (fr) 2000-02-18 2001-02-16 Procedes et trousses de detection de proximite
AU34300/01A AU783644B2 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
AT01906476T ATE402269T1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest
JP2001559873A JP4804691B2 (ja) 2000-02-18 2001-02-16 近接プロービング方法およびキット
DE60134957T DE60134957D1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning

Publications (3)

Publication Number Publication Date
SE0000538D0 SE0000538D0 (sv) 2000-02-18
SE0000538L SE0000538L (sv) 2001-08-19
SE516272C2 true SE516272C2 (sv) 2001-12-10

Family

ID=20278505

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning

Country Status (8)

Country Link
EP (1) EP1255861B1 (fr)
JP (1) JP4804691B2 (fr)
AT (1) ATE402269T1 (fr)
AU (1) AU783644B2 (fr)
CA (1) CA2400384A1 (fr)
DE (1) DE60134957D1 (fr)
SE (1) SE516272C2 (fr)
WO (1) WO2001061037A1 (fr)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
US7595202B2 (en) 2001-04-23 2009-09-29 Teruyuki Nagamune Analysis method using reporter (label) intermolecular interaction
ATE365211T1 (de) * 2001-08-20 2007-07-15 Regenesis Bioremediation Produ Biosensor für kleinmolekulare analyten
GB0212544D0 (en) * 2002-05-30 2002-07-10 Microsens Biophage Ltd Methods for detection of target molecules and molecular interactions
WO2003029489A1 (fr) * 2001-10-03 2003-04-10 Iseao Technologies Limited Procedes permettant de detecter des molecules cibles et des interactions moleculaires
WO2003044231A1 (fr) * 2001-11-23 2003-05-30 Simon Fredriksson Procede et kit pour le sondage de proximite au moyen de sondes de proximite polyvalentes
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US7977048B2 (en) 2004-01-13 2011-07-12 Pathogenetix, Inc. Detection and quantification of analytes in solution using polymers
US7595160B2 (en) 2004-01-13 2009-09-29 U.S. Genomics, Inc. Analyte detection using barcoded polymers
JP2007524410A (ja) * 2004-01-23 2007-08-30 リングヴィテ エーエス ポリヌクレオチドライゲーション反応の改良
WO2005123963A2 (fr) 2004-06-14 2005-12-29 The Board Of Trustees Of The Leland Stanford Junior University Procedes et compositions destines a la detection d'analytes au moyen de sondes de proximite
DK1842226T3 (da) † 2004-11-03 2010-10-18 Iris Molecular Diagnostics Inc Homogen analytpåvisning
EP1904648A4 (fr) * 2005-07-06 2010-03-10 Uppsala Uni Projekt Ab Procédé de localisation de molécules associées à un acide nucléique et modifications
EP1762627A1 (fr) 2005-09-09 2007-03-14 Qiagen GmbH Procédé pour l'activation d'acides nucléiques pour effectuer une réaction d'une polymérase
WO2007044903A2 (fr) * 2005-10-11 2007-04-19 Stratagene California Essais de detection de signaux binaires
WO2007054515A1 (fr) * 2005-11-14 2007-05-18 Boehringer Ingelheim Vetmedica Gmbh Procede pour detecter des microorganismes
CN101374965B (zh) * 2006-01-17 2013-08-14 私募蛋白质体公司 测试样品的多元化分析
GB0605584D0 (en) * 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
WO2007117444A2 (fr) * 2006-03-31 2007-10-18 Yinghe Hu Détection de protéines au moyen d'aptamères
EP3305915B1 (fr) * 2006-08-01 2022-01-26 Applied Biosystems, LLC Détection d'analytes et d'acides nucléiques
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
US20110136099A1 (en) 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US8975026B2 (en) 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
GB0918712D0 (en) * 2009-10-26 2009-12-09 Axis Shield Diagnostics Ltd An assay
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
US20120004132A1 (en) * 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
EP2627781B1 (fr) 2010-10-15 2017-02-22 Olink Bioscience AB Methodes de gamme dynamique
US20130323729A1 (en) * 2010-10-29 2013-12-05 Olink Ab Proximity Ligation Technology for Western Blot Applications
EP2466310A1 (fr) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Supports et procédés de détection de cassures à double brin
ES2632768T3 (es) 2011-01-17 2017-09-15 Life Technologies Corporation Flujo de trabajo para la detección de ligandos empleando ácidos nucleicos
EP3263703B1 (fr) 2011-01-17 2020-04-22 Life Technologies Corporation Ligature enzymatique d'acides nucléiques
WO2012106385A2 (fr) 2011-01-31 2012-08-09 Apprise Bio, Inc. Procédés d'identification de multiples épitopes dans des cellules
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
US11560585B2 (en) 2011-01-31 2023-01-24 Roche Sequencing Solutions, Inc. Methods of identifying multiple epitopes in cells
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
US9029086B2 (en) * 2012-01-26 2015-05-12 Masood Kamali Moghaddam Detection of single and multimodal analytes
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
WO2014076209A1 (fr) 2012-11-14 2014-05-22 Olink Ab Procédé d'amplification par rca localisée
WO2014076214A1 (fr) 2012-11-14 2014-05-22 Olink Ab Sondes rca rapporteur et leur utilisation pour détecter des molécules d'acide nucléique
GB201320145D0 (en) 2013-11-14 2014-01-01 Olink Ab Localised RCA-based amplification method using a padlock-probe
GB201321123D0 (en) 2013-11-29 2014-01-15 Linea Ab Q Amplification of circular molecules
GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
CN107110849B (zh) * 2014-12-19 2019-07-26 豪夫迈·罗氏有限公司 在选定的细胞亚群中鉴别多个表位的方法
US20180179576A1 (en) * 2015-03-02 2018-06-28 The Regents Of The University Of California Homogeneous entropy-driven biomolecular assay (heba)
CA2982998A1 (fr) * 2015-04-17 2016-10-20 The Regents Of The University Of California Procedes de detection d'une agglutination et compositions destinees a etre utilisees dans la pratique de ceux-ci
WO2017070309A1 (fr) * 2015-10-20 2017-04-27 Quateris Llc Immuno-essai en sandwich d'adn multiplex (mdisa)
GB201518655D0 (en) * 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
DK4015647T3 (da) 2016-02-26 2023-12-04 Univ Leland Stanford Junior Multiplexeret enkeltmolekyle-RNA-visualisering med et to-sonde-proximetetsligationssystem
EP3472357A4 (fr) * 2016-06-17 2020-01-22 Proximity Biosciences, LLC Procédé de sélection de paires d'aptamères
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
EP3380843B1 (fr) * 2016-10-21 2020-02-12 Zelda Therapeutics Operations Pty Ltd Procédé de pronostic et kits utiles dans ledit procédé
GB201621514D0 (en) 2016-12-16 2017-02-01 Q-Linea Ab Padlock probe detection method
CN111139285A (zh) * 2018-11-02 2020-05-12 深圳华大生命科学研究院 一种高通量检测多个待测样本中不同目的蛋白含量的方法及其专用试剂盒
WO2021034971A1 (fr) * 2019-08-19 2021-02-25 Brickbio, Inc. Procédés et compositions pour une détection et de quantification d'analyte
EP4069731A4 (fr) * 2019-12-03 2024-05-29 Alamar Biosciences, Inc. Dosage immunologique-sandwich lié à un acide nucléique (nulisa)
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
IL296756A (en) 2020-03-27 2022-11-01 Olink Proteomics Ab A method for identifying chemical forms of variable prevalence
GB202004472D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Method for detecting analytes of varying abundance
GB202004469D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Controls for proximity detection assays
GB202017873D0 (en) 2020-11-12 2020-12-30 Olso Unversitetssykehus Hf Method of determining DLBCL prognosis
GB202018503D0 (en) 2020-11-25 2021-01-06 Olink Proteomics Ab Analyte detection method employing concatamers
CN113945720B (zh) * 2021-09-26 2024-08-16 瑞博奥(广州)生物科技股份有限公司 基于核酸适配体探针的pdgf-bb识别方法及检测pdgf-bb的试剂盒
WO2023122345A1 (fr) * 2021-12-23 2023-06-29 California Institute Of Technology Suppression de signaux non spécifiques au moyen d'exonucléases dans une expérience fish
GB202213930D0 (en) 2022-09-23 2022-11-09 Xu Bo Padlock blocking oligonucleotide
WO2024100258A1 (fr) 2022-11-11 2024-05-16 Olink Proteomics Ab Bibliothèque de sondes de proximité et procédé d'utilisation
EP4382534A1 (fr) 2022-12-06 2024-06-12 Biomérieux Peptide synthétique pour l'utilisation dans un dosage immunomoléculaire

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
WO1993006240A1 (fr) * 1991-09-13 1993-04-01 Cytocell Limited Technique d'amplification d'acides nucleiques
US5846709A (en) * 1993-06-15 1998-12-08 Imclone Systems Incorporated Chemical process for amplifying and detecting nucleic acid sequences
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
EP1216417A1 (fr) * 1999-09-28 2002-06-26 Evotec OAI AG Analyse quantitative et de classement par types des particules infracellulaires

Also Published As

Publication number Publication date
EP1255861B1 (fr) 2008-07-23
ATE402269T1 (de) 2008-08-15
JP4804691B2 (ja) 2011-11-02
SE0000538D0 (sv) 2000-02-18
SE0000538L (sv) 2001-08-19
CA2400384A1 (fr) 2001-08-23
DE60134957D1 (de) 2008-09-04
AU783644B2 (en) 2005-11-17
WO2001061037A1 (fr) 2001-08-23
EP1255861A1 (fr) 2002-11-13
JP2003524419A (ja) 2003-08-19
AU3430001A (en) 2001-08-27

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