SE500702C2 - Sätt och anordning för optisk analys av prov separerade i tunna kapillärer - Google Patents
Sätt och anordning för optisk analys av prov separerade i tunna kapillärerInfo
- Publication number
- SE500702C2 SE500702C2 SE9201089A SE9201089A SE500702C2 SE 500702 C2 SE500702 C2 SE 500702C2 SE 9201089 A SE9201089 A SE 9201089A SE 9201089 A SE9201089 A SE 9201089A SE 500702 C2 SE500702 C2 SE 500702C2
- Authority
- SE
- Sweden
- Prior art keywords
- capillary
- separation
- detector
- sample components
- components
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
- G01N30/6082—Construction of the column body transparent to radiation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9201089A SE500702C2 (sv) | 1992-04-07 | 1992-04-07 | Sätt och anordning för optisk analys av prov separerade i tunna kapillärer |
US08/313,319 US5627643A (en) | 1992-04-07 | 1993-04-07 | Method and detector for separation processes |
DE69321480T DE69321480T2 (de) | 1992-04-07 | 1993-04-07 | Verfahren und detektor für trennungsprozesse |
EP93908259A EP0666982B1 (fr) | 1992-04-07 | 1993-04-07 | Procede et detecteur pour processus de separation |
AT93908259T ATE172030T1 (de) | 1992-04-07 | 1993-04-07 | Verfahren und detektor für trennungsprozesse |
JP05517383A JP3127238B2 (ja) | 1992-04-07 | 1993-04-07 | 分離プロセスのための方法および検出器 |
PCT/SE1993/000305 WO1993020435A1 (fr) | 1992-04-07 | 1993-04-07 | Procede et detecteur pour processus de separation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9201089A SE500702C2 (sv) | 1992-04-07 | 1992-04-07 | Sätt och anordning för optisk analys av prov separerade i tunna kapillärer |
Publications (3)
Publication Number | Publication Date |
---|---|
SE9201089D0 SE9201089D0 (sv) | 1992-04-07 |
SE9201089L SE9201089L (sv) | 1993-10-08 |
SE500702C2 true SE500702C2 (sv) | 1994-08-15 |
Family
ID=20385875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9201089A SE500702C2 (sv) | 1992-04-07 | 1992-04-07 | Sätt och anordning för optisk analys av prov separerade i tunna kapillärer |
Country Status (7)
Country | Link |
---|---|
US (1) | US5627643A (fr) |
EP (1) | EP0666982B1 (fr) |
JP (1) | JP3127238B2 (fr) |
AT (1) | ATE172030T1 (fr) |
DE (1) | DE69321480T2 (fr) |
SE (1) | SE500702C2 (fr) |
WO (1) | WO1993020435A1 (fr) |
Families Citing this family (60)
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US6485625B1 (en) | 1995-05-09 | 2002-11-26 | Curagen Corporation | Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments |
US6017434A (en) | 1995-05-09 | 2000-01-25 | Curagen Corporation | Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
BR9710054A (pt) | 1996-06-28 | 2000-01-11 | Caliper Techn Corp | Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio. |
US5871628A (en) * | 1996-08-22 | 1999-02-16 | The University Of Texas System | Automatic sequencer/genotyper having extended spectral response |
JP3077609B2 (ja) * | 1996-10-31 | 2000-08-14 | 株式会社島津製作所 | マイクロチップ電気泳動方法及び装置 |
CA2284164A1 (fr) * | 1997-03-14 | 1998-09-17 | Paul D. Taylor | Affichage de separations polyonucleotidiques sous la forme d'un arrangement de bandes |
AU2021099A (en) * | 1997-12-30 | 1999-07-19 | Caliper Technologies Corporation | Software for the display of chromatographic separation data |
US6156576A (en) * | 1998-03-06 | 2000-12-05 | The Regents Of The University Of California | Fast controllable laser lysis of cells for analysis |
US6335201B1 (en) * | 1998-03-06 | 2002-01-01 | The Regents Of The University Of California | Method and apparatus for detecting enzymatic activity using molecules that change electrophoretic mobility |
US6740497B2 (en) * | 1998-03-06 | 2004-05-25 | The Regents Of The University Of California | Method and apparatus for detecting cancerous cells using molecules that change electrophoretic mobility |
US6096205A (en) * | 1998-05-13 | 2000-08-01 | The Regents Of The University Of California | Hand portable thin-layer chromatography system |
ATE425448T1 (de) | 1998-05-16 | 2009-03-15 | Applera Corp | Optisches gerät insbesondere zur überwachung von dns-polymerasekettenreaktionen |
US7498164B2 (en) | 1998-05-16 | 2009-03-03 | Applied Biosystems, Llc | Instrument for monitoring nucleic acid sequence amplification reaction |
US6818437B1 (en) | 1998-05-16 | 2004-11-16 | Applera Corporation | Instrument for monitoring polymerase chain reaction of DNA |
US6529835B1 (en) | 1998-06-25 | 2003-03-04 | Caliper Technologies Corp. | High throughput methods, systems and apparatus for performing cell based screening assays |
US7155344B1 (en) | 1998-07-27 | 2006-12-26 | Caliper Life Sciences, Inc. | Distributed database for analytical instruments |
US6498497B1 (en) * | 1998-10-14 | 2002-12-24 | Caliper Technologies Corp. | Microfluidic controller and detector system with self-calibration |
JP2000283960A (ja) * | 1999-03-31 | 2000-10-13 | Shimadzu Corp | マイクロチップ電気泳動装置 |
US6353475B1 (en) | 1999-07-12 | 2002-03-05 | Caliper Technologies Corp. | Light source power modulation for use with chemical and biochemical analysis |
JP2001033427A (ja) * | 1999-07-16 | 2001-02-09 | Hitachi Software Eng Co Ltd | 電気泳動方法及び電気泳動装置 |
US6888951B1 (en) | 1999-08-23 | 2005-05-03 | Nagaoka & Co., Ltd. | Methods and apparatus for analyzing operational and analyte data acquired from optical disc |
US6556923B2 (en) | 2000-01-26 | 2003-04-29 | Caliper Technologies Corp. | Software for high throughput microfluidic systems |
GB0019496D0 (en) * | 2000-08-08 | 2000-09-27 | Diamond Optical Tech Ltd | System and method |
GB0019499D0 (en) * | 2000-08-08 | 2000-09-27 | Diamond Optical Tech Ltd | system and method |
GB0019500D0 (en) * | 2000-08-08 | 2000-09-27 | Diamond Optical Tech Ltd | System and method |
US7033475B2 (en) * | 2000-10-25 | 2006-04-25 | Shimadzu Corporation | Electrophoretic apparatus |
WO2002044695A1 (fr) * | 2000-11-16 | 2002-06-06 | Burstein Technologies, Inc. | Methodes et appareils destines a la detection et au denombrement de lymphocytes utilisant des biodisques optiques |
US20030003464A1 (en) * | 2000-11-27 | 2003-01-02 | Phan Brigitte C. | Dual bead assays including optical biodiscs and methods relating thereto |
US20040248093A1 (en) * | 2000-11-27 | 2004-12-09 | Coombs James Howard | Magneto-optical bio-discs and systems including related methods |
US20020172980A1 (en) * | 2000-11-27 | 2002-11-21 | Phan Brigitte Chau | Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems |
US6800438B2 (en) * | 2000-12-28 | 2004-10-05 | Xerox Corporation | Imager for DNA sequencer |
US6942773B1 (en) * | 2001-01-26 | 2005-09-13 | The Regents Of The University Of California | Particle sizer and DNA sequencer |
US6856390B2 (en) | 2001-07-25 | 2005-02-15 | Applera Corporation | Time-delay integration in electrophoretic detection systems |
US7280207B2 (en) * | 2001-07-25 | 2007-10-09 | Applera Corporation | Time-delay integration in a flow cytometry system |
US7265833B2 (en) * | 2001-07-25 | 2007-09-04 | Applera Corporation | Electrophoretic system with multi-notch filter and laser excitation source |
US20030129665A1 (en) * | 2001-08-30 | 2003-07-10 | Selvan Gowri Pyapali | Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems |
WO2003021222A2 (fr) * | 2001-08-31 | 2003-03-13 | Burstein Technologies, Inc. | Ensembles a couche de capture destines a des analyses cellulaires, comportant des disques d'analyse optiques, et procedes correspondants |
US20030113925A1 (en) * | 2001-09-07 | 2003-06-19 | Gordon John Francis | Nuclear morphology based identification and quantification of white blood cell types using optical bio-disc systems |
CA2468041A1 (fr) * | 2001-11-20 | 2003-05-30 | Burstein Technologies, Inc. | Biodisques optiques et circuits fluidiques utilises pour l'analyse de cellules et methodes correspondantes |
US7179357B2 (en) * | 2002-10-25 | 2007-02-20 | Beckman Coulter, Inc. | Serial sample injection in capillary electrophoresis |
US20070042433A1 (en) * | 2003-03-26 | 2007-02-22 | Jianxin Bao | Neuregulin protein regulation of synaptic proteins |
US20040204866A1 (en) * | 2003-04-09 | 2004-10-14 | Allington Robert W. | Method and apparatus to enhance the signal to noise ratio in chromatography |
US6909091B2 (en) | 2003-05-30 | 2005-06-21 | Nanosep Ab | Separation and analysis of sample components |
IL160869A0 (en) * | 2004-03-15 | 2004-08-31 | Dnr Imaging System Ltd | Integrated system for real time gel electrophoresis running and documenting |
TWI251079B (en) * | 2004-06-15 | 2006-03-11 | Univ Nat Cheng Kung | Inspection chip and the manufacturing method thereof |
US7935479B2 (en) | 2004-07-19 | 2011-05-03 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
US7846676B2 (en) | 2004-07-19 | 2010-12-07 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
FR2879293B1 (fr) | 2004-12-13 | 2007-04-06 | Total France Sa | Procede pour l'analyse de la composition en hydrocarbures de produits petroliers liquides. |
FR2880426B1 (fr) * | 2004-12-30 | 2007-04-06 | Total France Sa | Procede et dispositif pour la determination du point de fumee des hydrocarbures |
CN100394172C (zh) * | 2005-01-25 | 2008-06-11 | 中国科学院化学研究所 | 显微毛细管电泳仪 |
WO2007035864A2 (fr) * | 2005-09-20 | 2007-03-29 | Cell Biosciences, Inc. | Standards, procedes et ensembles d'electrophorese |
EP2049233A4 (fr) | 2006-07-10 | 2011-08-31 | Convergent Bioscience Ltd | Procédé et appareil permettant de sélectionner et d'extraire précisément un élément focalisé dans des micro-canaux réalisés par focalisation isoélectrique |
US10107782B2 (en) * | 2008-01-25 | 2018-10-23 | ProteinSimple | Method to perform limited two dimensional separation of proteins and other biologicals |
AU2010257118B2 (en) | 2009-06-04 | 2014-08-28 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for DNA analysis |
EP2513635A4 (fr) | 2009-12-18 | 2017-06-28 | FPInnovations | Analyseur de macropolluants en ligne et procédé |
CA2814720C (fr) | 2010-10-15 | 2016-12-13 | Lockheed Martin Corporation | Conception optique microfluidique |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
CN102879365A (zh) * | 2012-09-21 | 2013-01-16 | 常州大学 | 一种毛细管电泳荧光检测装置 |
US10031104B2 (en) * | 2014-06-13 | 2018-07-24 | Yes Way Intellectual Holdings, Llc | Mobile micro-lab for chemical analysis of fluids |
Family Cites Families (15)
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DE1800993A1 (de) * | 1968-10-03 | 1970-05-27 | Max Planck Gesellschaft | Verfahren zur automatisierten elektronischen densitometrischen Auswertung von mit Hilfe der sogenannten traegerfreien Elektrophorese getrennten Stoffgemischen |
US4420383A (en) * | 1980-07-10 | 1983-12-13 | Olympus Optical Co., Ltd. | Fractionating method in electrophoreses |
JPS6093339A (ja) * | 1983-10-27 | 1985-05-25 | Olympus Optical Co Ltd | 電気泳動装置 |
SE455646B (sv) | 1984-10-22 | 1988-07-25 | Radians Innova Ab | Fluorescensanordning |
JPH065227B2 (ja) * | 1985-02-27 | 1994-01-19 | オリンパス光学工業株式会社 | 電気泳動装置による総蛋白値の定量方法 |
GB8513538D0 (en) * | 1985-05-29 | 1985-07-03 | Mackay C D | Electrophoresis |
JP2762451B2 (ja) * | 1988-03-31 | 1998-06-04 | アイシン精機株式会社 | 遺伝子物質の電気泳動パターン分析装置 |
DE3812899A1 (de) * | 1988-04-18 | 1989-10-26 | Wilfried Heil | Elektronische kamera zur dokumentation von fluoreszenzmustern auf elektrophoresegelen |
US4927265A (en) * | 1988-04-29 | 1990-05-22 | 501 Microphoretic Systems, Inc. | Detector for fluorescence and absorption spectroscopy |
US5006210A (en) * | 1989-02-06 | 1991-04-09 | Iowa State University Research Foundation, Inc. | Means and method for capillary zone electrophoresis with laser-induced indirect fluorescence detection |
US5141609A (en) * | 1990-11-16 | 1992-08-25 | The Trustees Of The Leland Stanford Junior University | Method and device employing time-delayed integration for detecting sample components after separation |
US5098536A (en) * | 1991-02-01 | 1992-03-24 | Beckman Instruments, Inc. | Method of improving signal-to-noise in electropherogram |
US5162654A (en) * | 1991-02-01 | 1992-11-10 | Wisconsin Alumni Research Foundation | Detection apparatus for electrophoretic gels |
JPH0552810A (ja) * | 1991-08-27 | 1993-03-02 | Hitachi Ltd | 電気泳動装置 |
JP2815506B2 (ja) * | 1992-04-14 | 1998-10-27 | 株式会社日立製作所 | 光検出型電気泳動装置 |
-
1992
- 1992-04-07 SE SE9201089A patent/SE500702C2/sv not_active IP Right Cessation
-
1993
- 1993-04-07 EP EP93908259A patent/EP0666982B1/fr not_active Expired - Lifetime
- 1993-04-07 DE DE69321480T patent/DE69321480T2/de not_active Expired - Fee Related
- 1993-04-07 WO PCT/SE1993/000305 patent/WO1993020435A1/fr active IP Right Grant
- 1993-04-07 JP JP05517383A patent/JP3127238B2/ja not_active Expired - Fee Related
- 1993-04-07 AT AT93908259T patent/ATE172030T1/de not_active IP Right Cessation
- 1993-04-07 US US08/313,319 patent/US5627643A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE172030T1 (de) | 1998-10-15 |
DE69321480T2 (de) | 1999-05-27 |
SE9201089L (sv) | 1993-10-08 |
DE69321480D1 (de) | 1998-11-12 |
JP3127238B2 (ja) | 2001-01-22 |
US5627643A (en) | 1997-05-06 |
WO1993020435A1 (fr) | 1993-10-14 |
JPH07505471A (ja) | 1995-06-15 |
EP0666982A1 (fr) | 1995-08-16 |
EP0666982B1 (fr) | 1998-10-07 |
SE9201089D0 (sv) | 1992-04-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
NUG | Patent has lapsed |