SE450052B - Anordning for materieoverforing mellan gas, vetska och/eller fast fas, serskilt for blandning och separation vid immunanalyser - Google Patents
Anordning for materieoverforing mellan gas, vetska och/eller fast fas, serskilt for blandning och separation vid immunanalyserInfo
- Publication number
- SE450052B SE450052B SE8104446A SE8104446A SE450052B SE 450052 B SE450052 B SE 450052B SE 8104446 A SE8104446 A SE 8104446A SE 8104446 A SE8104446 A SE 8104446A SE 450052 B SE450052 B SE 450052B
- Authority
- SE
- Sweden
- Prior art keywords
- liquid
- mixer
- separator
- separation
- lidex
- Prior art date
Links
- 238000002156 mixing Methods 0.000 title claims description 59
- 238000000926 separation method Methods 0.000 title claims description 58
- 239000007791 liquid phase Substances 0.000 title claims description 28
- 238000012546 transfer Methods 0.000 title claims description 23
- 239000007790 solid phase Substances 0.000 title claims description 14
- 239000000463 material Substances 0.000 title claims description 10
- 238000004458 analytical method Methods 0.000 title description 17
- 239000007788 liquid Substances 0.000 claims description 42
- 239000012071 phase Substances 0.000 claims description 34
- 238000007789 sealing Methods 0.000 claims description 15
- 230000009969 flowable effect Effects 0.000 claims description 2
- 230000009467 reduction Effects 0.000 claims description 2
- 239000012528 membrane Substances 0.000 description 80
- 238000000034 method Methods 0.000 description 60
- WJOHZNCJWYWUJD-IUGZLZTKSA-N Fluocinonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)C)[C@@]2(C)C[C@@H]1O WJOHZNCJWYWUJD-IUGZLZTKSA-N 0.000 description 49
- 238000002474 experimental method Methods 0.000 description 30
- 230000004888 barrier function Effects 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 15
- 239000000203 mixture Substances 0.000 description 15
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 14
- 229960005156 digoxin Drugs 0.000 description 14
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 14
- 238000003127 radioimmunoassay Methods 0.000 description 14
- 238000005119 centrifugation Methods 0.000 description 13
- 230000033001 locomotion Effects 0.000 description 13
- 230000008569 process Effects 0.000 description 13
- 239000003153 chemical reaction reagent Substances 0.000 description 12
- 239000007789 gas Substances 0.000 description 11
- 210000002966 serum Anatomy 0.000 description 11
- 239000007787 solid Substances 0.000 description 11
- 239000000725 suspension Substances 0.000 description 11
- 239000002245 particle Substances 0.000 description 10
- 239000012137 tryptone Substances 0.000 description 10
- 238000001223 reverse osmosis Methods 0.000 description 9
- 230000009871 nonspecific binding Effects 0.000 description 8
- 241000588724 Escherichia coli Species 0.000 description 7
- 238000003018 immunoassay Methods 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000001179 sorption measurement Methods 0.000 description 6
- 229920002684 Sepharose Polymers 0.000 description 5
- 239000003463 adsorbent Substances 0.000 description 5
- 239000003708 ampul Substances 0.000 description 5
- 239000000470 constituent Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229920001971 elastomer Polymers 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 230000003204 osmotic effect Effects 0.000 description 5
- 239000005060 rubber Substances 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000003610 charcoal Substances 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000700 radioactive tracer Substances 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000004760 aramid Substances 0.000 description 2
- 229920003235 aromatic polyamide Polymers 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 238000010612 desalination reaction Methods 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 239000011152 fibreglass Substances 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000016507 interphase Effects 0.000 description 2
- 238000000622 liquid--liquid extraction Methods 0.000 description 2
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical compound CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 description 1
- 239000004953 Aliphatic polyamide Substances 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical class COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 102000003946 Prolactin Human genes 0.000 description 1
- 108010057464 Prolactin Proteins 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229920003231 aliphatic polyamide Polymers 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- UOCJDOLVGGIYIQ-PBFPGSCMSA-N cefatrizine Chemical group S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)[C@H](N)C=2C=CC(O)=CC=2)CC=1CSC=1C=NNN=1 UOCJDOLVGGIYIQ-PBFPGSCMSA-N 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000000909 electrodialysis Methods 0.000 description 1
- 238000005370 electroosmosis Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- 238000001423 gas--liquid extraction Methods 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000003014 ion exchange membrane Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000008384 membrane barrier Effects 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004001 molecular interaction Effects 0.000 description 1
- 238000004810 partition chromatography Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005597 polymer membrane Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000008400 supply water Substances 0.000 description 1
- FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- CZPRKINNVBONSF-UHFFFAOYSA-M zinc;dioxido(oxo)phosphanium Chemical compound [Zn+2].[O-][P+]([O-])=O CZPRKINNVBONSF-UHFFFAOYSA-M 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/022—Filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0415—Solvent extraction of solutions which are liquid in combination with membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D33/00—Filters with filtering elements which move during the filtering operation
- B01D33/01—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons
- B01D33/015—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with flat filtering elements
- B01D33/0183—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with flat filtering elements supported
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/025—Reverse osmosis; Hyperfiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/08—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/087—Single membrane modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/04—Specific sealing means
- B01D2313/041—Gaskets or O-rings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/06—Submerged-type; Immersion type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/02—Elements in series
- B01D2317/025—Permeate series
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/52—Physical parameters
- G01N2030/524—Physical parameters structural properties
- G01N2030/527—Physical parameters structural properties sorbent material in form of a membrane
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A20/00—Water conservation; Efficient water supply; Efficient water use
- Y02A20/124—Water desalination
- Y02A20/131—Reverse-osmosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Water Supply & Treatment (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
- Extraction Or Liquid Replacement (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL60645A IL60645A (en) | 1980-07-21 | 1980-07-21 | Method and device for mass transfer and separation through selective barriers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8104446L SE8104446L (sv) | 1982-01-22 |
| SE450052B true SE450052B (sv) | 1987-06-01 |
Family
ID=11051975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8104446A SE450052B (sv) | 1980-07-21 | 1981-07-20 | Anordning for materieoverforing mellan gas, vetska och/eller fast fas, serskilt for blandning och separation vid immunanalyser |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US4832850A (enExample) |
| JP (1) | JPS5775105A (enExample) |
| AU (1) | AU555404B2 (enExample) |
| BE (1) | BE889565A (enExample) |
| BR (1) | BR8104653A (enExample) |
| CA (1) | CA1168836A (enExample) |
| DE (1) | DE3126926A1 (enExample) |
| FR (1) | FR2486813B1 (enExample) |
| GB (1) | GB2080699B (enExample) |
| IL (1) | IL60645A (enExample) |
| IT (1) | IT1167798B (enExample) |
| NL (1) | NL8102995A (enExample) |
| SE (1) | SE450052B (enExample) |
| ZA (1) | ZA813768B (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL63363A (en) * | 1981-07-20 | 1986-08-31 | Cais Michael | Non-centrifugation method for immunoassay of materials |
| IL66551A (en) * | 1982-08-15 | 1985-11-29 | Cais Michael | Method for moving-bed chromatography and device therefor |
| US4891134A (en) * | 1988-01-25 | 1990-01-02 | Abbott Laboratories | Sample filtration device |
| US4892654A (en) * | 1989-03-15 | 1990-01-09 | Nickerson Mark A | Trapping assembly |
| US5376337A (en) * | 1990-12-18 | 1994-12-27 | Seymour; Eugene H. | Saliva sampling device and sample adequacy system |
| US5501841A (en) * | 1991-11-14 | 1996-03-26 | Artchem, Inc. | Connection-type treatment system for micro solution and method of treatment |
| US5268150A (en) * | 1991-12-18 | 1993-12-07 | Corning Incorporated | Concentrator/extractor apparatus having a hydrophobic membrane |
| US5658463A (en) * | 1993-03-05 | 1997-08-19 | Strategic Diagnostics, Inc. | Process for extraction of analytes from solid and materials and filtration |
| US5494646A (en) * | 1993-04-14 | 1996-02-27 | Seymour; Eugene H. | Sampling device and sample adequacy system |
| US6103127A (en) | 1993-06-08 | 2000-08-15 | Cortex Biochem, Inc. | Methods for removing hazardous organic molecules from liquid waste |
| JPH09500826A (ja) * | 1993-07-30 | 1997-01-28 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 向流多相液体分離のための装置 |
| USD369214S (en) | 1994-12-02 | 1996-04-23 | Nason Frederic L | Plunger for specimen filtration device |
| US5549816A (en) * | 1995-10-31 | 1996-08-27 | Hach Company | Re-usable piston filter system |
| US5788863A (en) * | 1995-12-13 | 1998-08-04 | Becton Dickinson And Company | Apparatus and method for conducting an assay using reverse flow through a membrane |
| US5744709A (en) * | 1996-04-25 | 1998-04-28 | University Of Florida | Measurement of specific interfacial areas of immiscible fluid interfaces in flow systems |
| GB9720821D0 (en) * | 1997-10-02 | 1997-12-03 | Brebner Graham C | Hand operated press water filter |
| AU1821700A (en) * | 1998-11-18 | 2000-06-05 | Orchid Biosciences, Inc. | One-step nucleic acid dipstick device with movable membrane |
| SE0102921D0 (sv) * | 2001-08-30 | 2001-08-30 | Astrazeneca Ab | Pharmaceutically useful compounds |
| CA2455345C (en) | 2001-05-31 | 2009-08-25 | Pall Corporation | Well for processing a fluid |
| AU2003259794A1 (en) * | 2002-08-14 | 2004-03-03 | Rensselaer Polytechnic Institute | Model for microfiltration of poly-disperse suspensions |
| WO2009021197A2 (en) | 2007-08-08 | 2009-02-12 | O'brien Paul W | Portable drinking water purification device |
| US7790117B2 (en) | 2008-03-21 | 2010-09-07 | Scientific Plastic Products, Inc. | Filter vial |
| US8394268B2 (en) * | 2008-08-08 | 2013-03-12 | Miracle Straw Corporation, Inc. | Double chamber water purification device |
| WO2010045502A2 (en) | 2008-10-15 | 2010-04-22 | O'brien Paul W | Protable drinking water purification device |
| US8425771B2 (en) | 2009-07-24 | 2013-04-23 | Miracle Straw Corporation, Inc. | Double chamber water purification device |
| US8313644B2 (en) * | 2010-01-13 | 2012-11-20 | OZOlab | Bottle with an integrated filtration assembly that is manually operated using a plunger |
| WO2012135264A1 (en) * | 2011-03-29 | 2012-10-04 | Emd Millipore Corporation | Method and device for centrifugation and filtration |
| CN102326869B (zh) * | 2011-05-12 | 2013-04-03 | 陈志平 | 电子雾化吸入器的雾化嘴 |
| EP2744583A1 (en) * | 2011-08-15 | 2014-06-25 | Mekorot Water Company Ltd. | A method for manipulating a membrane element within a pressure vessel |
| US8322539B1 (en) * | 2012-03-02 | 2012-12-04 | Scientific Plastic Products, Inc. | Filter vial |
| US9333447B2 (en) * | 2012-10-19 | 2016-05-10 | Warsaw Orthopedic, Inc. | Filtration device |
| EP2725094A1 (en) * | 2012-10-29 | 2014-04-30 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Epithelial tissue model |
| US12350627B2 (en) | 2013-02-28 | 2025-07-08 | Aqua Membranes, Inc. | Permeate flow patterns |
| US9358508B2 (en) * | 2013-04-25 | 2016-06-07 | Lockheed Martin Corporation | Dryer and water recovery/purification unit employing graphene oxide or perforated graphene monolayer membranes |
| US20150076069A1 (en) * | 2013-09-13 | 2015-03-19 | Scientific Plastic Products, Inc. | Filter vial with limited piston stroke |
| WO2015070712A1 (en) * | 2013-11-14 | 2015-05-21 | Abon Biopharm (Hangzhou) Co., Ltd. | A device and method for using the device |
| US9921125B2 (en) * | 2014-03-27 | 2018-03-20 | Nxp Usa, Inc. | Leak detector using capacitance sensor |
| EP3128331A4 (en) * | 2014-03-31 | 2017-08-23 | Nikon Corporation | Supporting device and inspection method |
| US9568404B2 (en) | 2014-05-16 | 2017-02-14 | Junyu Mai | Method and apparatus for biomolecule analysis |
| DE102015216241A1 (de) | 2015-08-25 | 2017-03-02 | Bbi-Biotech Gmbh | Behälter und Verfahren zur Filtration einer Suspension |
| FR3047909B1 (fr) * | 2016-02-23 | 2018-03-23 | Thomas Boudier | Dispositif d'extraction et de filtration-compression |
| IL265376B2 (en) | 2016-09-20 | 2024-08-01 | Aqua Membranes Llc | Permeate flow patterns |
| US11040311B2 (en) | 2016-11-19 | 2021-06-22 | Aqua Membranes Inc. | Interference patterns for spiral wound elements |
| WO2018190937A1 (en) | 2017-04-12 | 2018-10-18 | Aqua Membranes Llc | Graded spacers for filtration wound elements |
| WO2018194911A1 (en) | 2017-04-20 | 2018-10-25 | Aqua Membranes Llc | Non-nesting, non-deforming patterns for spiral-wound elements |
| WO2018195367A1 (en) | 2017-04-20 | 2018-10-25 | Aqua Membranes Llc | Mixing-promoting spacer patterns for spiral-wound elements |
| CN111344053A (zh) | 2017-10-13 | 2020-06-26 | 阿夸曼布拉尼斯公司 | 螺旋缠绕元件的桥支撑件和减少的进给间隔件 |
| US12128334B2 (en) * | 2018-09-05 | 2024-10-29 | Kin Mun Chin | Filter press with threadably advanced filtrate receiving plunger |
| JP7667081B2 (ja) | 2019-01-27 | 2025-04-22 | アクア メンブレインズ，インコーポレイテッド | 複合膜 |
| US12303838B2 (en) | 2019-08-06 | 2025-05-20 | Aqua Membranes, Inc. | Preferred flow paths for spiral-wound elements |
| WO2021049163A1 (ja) * | 2019-09-09 | 2021-03-18 | 株式会社村田製作所 | 濃縮装置及び濃縮方法 |
| CN110801663A (zh) * | 2019-11-27 | 2020-02-18 | 陈龙刚 | 一种生物工程用过滤分离设备 |
| WO2021207256A1 (en) | 2020-04-07 | 2021-10-14 | Aqua Membranes Inc. | Independent spacers and methods |
| CN112915580B (zh) * | 2021-01-12 | 2022-04-01 | 深圳太阳生物科技股份有限公司 | 一种中草药有效成分超临界萃取方法 |
| WO2023129904A2 (en) | 2021-12-28 | 2023-07-06 | Aqua Membranes, Inc. | Spiral element construction yielding enhanced capacity |
| CN115228351B (zh) * | 2022-07-29 | 2023-10-17 | 中南大学 | 一种集成式固液混合-分离装置及其使用方法 |
| ES2997935R1 (es) * | 2023-07-27 | 2025-05-14 | Guasch Francesc Xavier Gimenez | Dispositivo de filtracion para usar sin jeringa y metodo para filtrar y manipular una muestra de fluido que incluye uno o mas analitos detectables y/o cuantificables y usa dicho dispositivo |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2524362A (en) * | 1947-07-19 | 1950-10-03 | Arthur E Smith | Disposable ampoule syringe |
| US3027799A (en) * | 1959-01-26 | 1962-04-03 | Brunswick Corp | Sample space adapters for spectrophotometers and the like |
| US3355098A (en) * | 1964-07-06 | 1967-11-28 | Bioconsultants Inc | Serum separation apparatus and method |
| US3464798A (en) * | 1965-11-16 | 1969-09-02 | Gustave Frederick Kilthau | Ion-exchange or chemical interaction plastic form |
| US3512948A (en) * | 1967-03-23 | 1970-05-19 | Owens Corning Fiberglass Corp | Apparatus for processing heat-softened mineral material |
| US3512940A (en) * | 1968-12-30 | 1970-05-19 | Justin J Shapiro | Test tube filter device |
| US3661265A (en) * | 1970-07-27 | 1972-05-09 | Contemporary Research And Dev | Serum separator type container |
| US3802843A (en) * | 1971-05-28 | 1974-04-09 | American Hospital Supply Corp | Fluid testing apparatus |
| DE2454918B2 (de) * | 1974-11-20 | 1977-02-10 | Walter Sarstedt Kunststoff-Spritzgußwerk, 5223 Nümbrecht | Filtervorrichtung zum trennen von blutfraktionen |
| FR2274918A1 (fr) * | 1974-03-30 | 1976-01-09 | Sarstedt Kunststoff | Dispositif de filtrage pour la separation de fractions de sang |
| US3969250A (en) * | 1975-03-10 | 1976-07-13 | Farr Andrew F | Apparatus for preparing liquid samples for analysis in automatic analyzers |
| US4035150A (en) * | 1975-09-24 | 1977-07-12 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education And Welfare | Test for occult blood in an emulsified aqueous/organic system |
| IL49685A (en) * | 1976-05-31 | 1978-10-31 | Technion Res & Dev Foundation | Specific binding assay method for determining the concentration of materials and reagent means therefor |
| DE2637273B2 (de) * | 1976-08-19 | 1979-02-15 | Walter Sarstedt Kunststoff-Spritzgusswerk, 5223 Nuembrecht | Vorrichtung zum Trennen von Blutfraktionen |
| US4210623A (en) * | 1978-05-01 | 1980-07-01 | Owens-Illinois, Inc. | Fluid collection apparatus |
| IL56839A0 (en) * | 1979-03-11 | 1979-05-31 | Technion Res & Dev Foundation | Improvement in specific binding assay technique |
| IL58943A (en) * | 1979-12-12 | 1983-05-15 | Cais Michael | Method and device for mass transfer operations in immunoassays and other applications |
-
1980
- 1980-07-21 IL IL60645A patent/IL60645A/xx not_active IP Right Cessation
-
1981
- 1981-06-05 AU AU71395/81A patent/AU555404B2/en not_active Ceased
- 1981-06-05 ZA ZA00813768A patent/ZA813768B/xx unknown
- 1981-06-09 CA CA000379382A patent/CA1168836A/en not_active Expired
- 1981-06-09 GB GB8117570A patent/GB2080699B/en not_active Expired
- 1981-06-19 IT IT22446/81A patent/IT1167798B/it active
- 1981-06-22 NL NL8102995A patent/NL8102995A/nl not_active Application Discontinuation
- 1981-07-08 DE DE3126926A patent/DE3126926A1/de active Granted
- 1981-07-09 BE BE0/205360A patent/BE889565A/fr not_active IP Right Cessation
- 1981-07-20 JP JP56112364A patent/JPS5775105A/ja active Granted
- 1981-07-20 SE SE8104446A patent/SE450052B/sv not_active IP Right Cessation
- 1981-07-20 BR BR8104653A patent/BR8104653A/pt not_active IP Right Cessation
- 1981-07-21 FR FR8114193A patent/FR2486813B1/fr not_active Expired
-
1985
- 1985-12-27 US US06/821,768 patent/US4832850A/en not_active Expired - Lifetime
-
1989
- 1989-01-31 US US07/303,460 patent/US4897193A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BE889565A (fr) | 1981-11-03 |
| ZA813768B (en) | 1982-06-30 |
| IT8122446A0 (it) | 1981-06-19 |
| FR2486813B1 (fr) | 1988-07-15 |
| SE8104446L (sv) | 1982-01-22 |
| US4897193A (en) | 1990-01-30 |
| CA1168836A (en) | 1984-06-12 |
| JPH025443B2 (enExample) | 1990-02-02 |
| US4832850A (en) | 1989-05-23 |
| JPS5775105A (en) | 1982-05-11 |
| DE3126926A1 (de) | 1982-06-03 |
| FR2486813A1 (fr) | 1982-01-22 |
| BR8104653A (pt) | 1982-04-06 |
| IT1167798B (it) | 1987-05-13 |
| GB2080699B (en) | 1984-08-30 |
| DE3126926C2 (enExample) | 1993-08-26 |
| NL8102995A (nl) | 1982-02-16 |
| IL60645A (en) | 1984-02-29 |
| AU555404B2 (en) | 1986-09-25 |
| IL60645A0 (en) | 1980-09-16 |
| AU7139581A (en) | 1982-01-28 |
| GB2080699A (en) | 1982-02-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE450052B (sv) | Anordning for materieoverforing mellan gas, vetska och/eller fast fas, serskilt for blandning och separation vid immunanalyser | |
| CA2550838C (en) | Plasma on demand tube | |
| US3539300A (en) | Body fluid collector and separator having improved flow rate | |
| US10111610B2 (en) | Microscale plasma separator | |
| EP2038657B1 (en) | Assay device and method | |
| CN105683750B (zh) | 用于细胞检测和分离的微流体分拣器 | |
| US10843111B2 (en) | Process of separating blood plasma/serum from whole blood | |
| US8747669B1 (en) | Method and apparatus for the filtration of biological samples | |
| WO1993019831A1 (en) | Blood separation filter assembly and method | |
| JPH0552463B2 (enExample) | ||
| WO2017123668A1 (en) | Separation of cells based on size and affinity using paper microfluidic device | |
| Li et al. | Extraction of plasma from whole blood using a deposited microbead plug (DMBP) in a capillary-driven microfluidic device | |
| CN111433350B (zh) | 从生物样品分离颗粒的方法、系统和过滤单元 | |
| US9903799B2 (en) | Whole blood analytic device and method therefor | |
| Parsons et al. | Comparative study of human red blood cell analysis with three different field-flow fractionation systems | |
| US20070105236A1 (en) | Method of examining blood type and apparatus for examining blood type using the method | |
| CN110585925A (zh) | 定量滤血芯片 | |
| Ali et al. | Design and fabrication of a nano-microfluidic device for blood and cancer cells separation | |
| US4792432A (en) | Method for performing a liquid analysis and an analytical element for use in the method | |
| US10518260B1 (en) | Device for separation of plasma or serum from blood cells and methods of using the device | |
| Blattert et al. | Fabrication and testing of novel blood separation devices based on microchannel bend structures | |
| Riyadh | " DESIGN AND FABRICATION OF BLOOD FILTRATION, PLASMA AND TUMOR CELLS SEPARATION DEVICE | |
| KR850000341Y1 (ko) | 선택장벽을 통한 대량운반 및 분리장치 | |
| Hsiao et al. | Portable self-flowing platform for filtration separation of samples | |
| Khataei et al. | 3D printing in analytical sample preparation Feng Li1, Melisa Rodas Ceballos1, Sepideh Keshan Balavandy1, Jingxi Fan1, Mohammad |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
Ref document number: 8104446-3 Format of ref document f/p: F |
|
| NUG | Patent has lapsed |
Ref document number: 8104446-3 Format of ref document f/p: F |