SE447106B - Forfarande for framstellning av 10-oxo-10, 11-dihydro-5h-dibens /b,f/azepin-5-karboxamid - Google Patents
Forfarande for framstellning av 10-oxo-10, 11-dihydro-5h-dibens /b,f/azepin-5-karboxamidInfo
- Publication number
- SE447106B SE447106B SE8007597A SE8007597A SE447106B SE 447106 B SE447106 B SE 447106B SE 8007597 A SE8007597 A SE 8007597A SE 8007597 A SE8007597 A SE 8007597A SE 447106 B SE447106 B SE 447106B
- Authority
- SE
- Sweden
- Prior art keywords
- carboxamide
- dihydro
- oxo
- procedure
- dibens
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 10
- ZFXVFMBOFIEPII-UHFFFAOYSA-N 1h-azepine-4-carboxamide Chemical compound NC(=O)C1=CC=CNC=C1 ZFXVFMBOFIEPII-UHFFFAOYSA-N 0.000 title description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 17
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- LXKCVAXDCKLXJE-UHFFFAOYSA-N thiazepine-5-carboxamide Chemical compound S1N=CC=C(C=C1)C(=O)N LXKCVAXDCKLXJE-UHFFFAOYSA-N 0.000 claims 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000007858 starting material Substances 0.000 description 5
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical compound C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 3
- 235000019253 formic acid Nutrition 0.000 description 3
- -1 2-nitro-3-chlorophenyl Chemical group 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 150000007530 organic bases Chemical group 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- GWEHVDNNLFDJLR-UHFFFAOYSA-N 1,3-diphenylurea Chemical compound C=1C=CC=CC=1NC(=O)NC1=CC=CC=C1 GWEHVDNNLFDJLR-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 1
- 241001122315 Polites Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- KPADFPAILITQBG-UHFFFAOYSA-N non-4-ene Chemical compound CCCCC=CCCC KPADFPAILITQBG-UHFFFAOYSA-N 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH970479A CH642950A5 (en) | 1979-10-30 | 1979-10-30 | Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8007597L SE8007597L (sv) | 1981-05-01 |
| SE447106B true SE447106B (sv) | 1986-10-27 |
Family
ID=4354741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8007597A SE447106B (sv) | 1979-10-30 | 1980-10-29 | Forfarande for framstellning av 10-oxo-10, 11-dihydro-5h-dibens /b,f/azepin-5-karboxamid |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5673066A (de) |
| AT (1) | AT375926B (de) |
| CH (1) | CH642950A5 (de) |
| DK (1) | DK457680A (de) |
| ES (1) | ES496332A0 (de) |
| NO (1) | NO153368C (de) |
| SE (1) | SE447106B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0112812D0 (en) * | 2001-05-25 | 2001-07-18 | Portela & Ca Sa | Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom |
| GB2401605A (en) | 2003-05-12 | 2004-11-17 | Portela & Ca Sa | Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof |
| GB2422149A (en) | 2005-01-14 | 2006-07-19 | Portela & Ca Sa | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
| WO2007141798A1 (en) * | 2006-06-07 | 2007-12-13 | Jubilant Organosys Limited | Process for producing oxcarbazepine via an 11-alkoxy-10-halo-dihydroiminostilbene intermediate |
-
1979
- 1979-10-30 CH CH970479A patent/CH642950A5/de not_active IP Right Cessation
-
1980
- 1980-10-28 ES ES496332A patent/ES496332A0/es active Granted
- 1980-10-29 NO NO803229A patent/NO153368C/no unknown
- 1980-10-29 AT AT0531980A patent/AT375926B/de not_active IP Right Cessation
- 1980-10-29 SE SE8007597A patent/SE447106B/sv not_active IP Right Cessation
- 1980-10-29 DK DK457680A patent/DK457680A/da not_active Application Discontinuation
- 1980-10-30 JP JP15152580A patent/JPS5673066A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CH642950A5 (en) | 1984-05-15 |
| ES8200097A1 (es) | 1981-10-16 |
| ATA531980A (de) | 1984-02-15 |
| NO153368C (no) | 1986-03-05 |
| NO153368B (no) | 1985-11-25 |
| JPS5673066A (en) | 1981-06-17 |
| DK457680A (da) | 1981-05-01 |
| SE8007597L (sv) | 1981-05-01 |
| NO803229L (no) | 1981-05-04 |
| AT375926B (de) | 1984-09-25 |
| ES496332A0 (es) | 1981-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0003344B1 (de) | Verfahren zur Herstellung von Fluorbenzolen | |
| KR850000945B1 (ko) | 5-카바모일-10-옥소-10, 11-디하이드로-5H-디벤즈[b, f]-아제핀의 제조방법 | |
| Leuck et al. | The mercuration of naphthalic acids | |
| CH374699A (de) | Verfahren zur Herstellung von Disulfamylanilin-Verbindungen | |
| US3553224A (en) | 1(2h)-pyridine-sulfonates | |
| SE447106B (sv) | Forfarande for framstellning av 10-oxo-10, 11-dihydro-5h-dibens /b,f/azepin-5-karboxamid | |
| Fagan et al. | Cycloadditions and other chemistry of 4-oxygenated pyrazoles | |
| Kapovits et al. | Diaryldiacyloxyspirosulfuranes—I: Syntheses from sulfides with halogenating agents | |
| DE2825313C2 (de) | Verfahren zur Herstellung von Thioindigo-Verbindungen | |
| JPS6087251A (ja) | 置換ベンズアミド誘導体の製造法 | |
| US1765678A (en) | Process for introducing sulphocyanic groups into organic compounds | |
| US4196132A (en) | Continuous flow process for the preparation of o-chloranil from tetrachlorocatechol | |
| JP4159022B2 (ja) | ジホスゲン及びトリホスゲンを使用したジアゾナフトキノンスルホニルクロリドの調製法 | |
| EP0004322A1 (de) | Isochinolinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneimitteln | |
| DE2353580C2 (de) | Verfahren zur Herstellung von o-Acylamino-diarylverbindungen | |
| EP0368225A1 (de) | Hydroxylaminderivate | |
| KR100486320B1 (ko) | 5,11-디히드로-6에이치-디벤즈[비,이]아제핀-6-온의제조방법 | |
| US2238180A (en) | Process for the intramolecular dehydrogenation of aromatic ring systems | |
| SU431163A1 (ru) | Способ получения пирилоцианинов | |
| DE2321332C2 (de) | Verfahren zur Herstellung von 2-Nitro-5-chlor-benzolsulfonsäurechlorid oder von 2-Nitro-5-chlor-benzolsulfonsäure | |
| FI64373B (fi) | Foerfarande foer framstaellning av basiskt substituerade alkylteofyllinderivat | |
| AT239243B (de) | Verfahren zur Herstellung von 2, 3-Dicyan-1, 4-dithia-anthrahydrochinon und -anthrachinon | |
| KR920003172B1 (ko) | 2-아세트아미도 티오펜의 제조방법 | |
| US1810009A (en) | 4'-sulpho-2-benzoyl-5-amino-benzoic acid | |
| CH629775A5 (en) | Process for the direct preparation of N-mono- or N,N-disubstituted 6-amino-benzo[cd]indol-2(1H)-ones |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8007597-1 Effective date: 19880627 Format of ref document f/p: F |