SE438153B - Forfarande for framstellning av l-lysyl-n-(2-bensoyl-4-klorfenyl)-n-metylglycinamid med sedativ, muskelrelaxerande och antikonvulsiv verkan - Google Patents

Forfarande for framstellning av l-lysyl-n-(2-bensoyl-4-klorfenyl)-n-metylglycinamid med sedativ, muskelrelaxerande och antikonvulsiv verkan

Info

Publication number
SE438153B
SE438153B SE7902522A SE7902522A SE438153B SE 438153 B SE438153 B SE 438153B SE 7902522 A SE7902522 A SE 7902522A SE 7902522 A SE7902522 A SE 7902522A SE 438153 B SE438153 B SE 438153B
Authority
SE
Sweden
Prior art keywords
benzoyl
acid
lysyl
chlorophenyl
methyl
Prior art date
Application number
SE7902522A
Other languages
English (en)
Swedish (sv)
Other versions
SE7902522L (sv
Inventor
C H Hassall
W H Johnson
A Krohn
C E Smithen
W A Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB36567/74A external-priority patent/GB1517164A/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SE7902522L publication Critical patent/SE7902522L/xx
Publication of SE438153B publication Critical patent/SE438153B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
SE7902522A 1974-08-20 1979-03-20 Forfarande for framstellning av l-lysyl-n-(2-bensoyl-4-klorfenyl)-n-metylglycinamid med sedativ, muskelrelaxerande och antikonvulsiv verkan SE438153B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB36567/74A GB1517164A (en) 1974-08-20 1974-08-20 Substituted-phenyl ketones and a process for the manufacture thereof

Publications (2)

Publication Number Publication Date
SE7902522L SE7902522L (sv) 1979-03-20
SE438153B true SE438153B (sv) 1985-04-01

Family

ID=10389314

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7902522A SE438153B (sv) 1974-08-20 1979-03-20 Forfarande for framstellning av l-lysyl-n-(2-bensoyl-4-klorfenyl)-n-metylglycinamid med sedativ, muskelrelaxerande och antikonvulsiv verkan
SE7902521A SE438152B (sv) 1974-08-20 1979-03-20 Forfarande for framstellning av substituerade fenylketoner med sedativ, muskelrelaxerande och antikonvulsiv verkan

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE7902521A SE438152B (sv) 1974-08-20 1979-03-20 Forfarande for framstellning av substituerade fenylketoner med sedativ, muskelrelaxerande och antikonvulsiv verkan

Country Status (5)

Country Link
JP (1) JPS58150549A (enExample)
BE (1) BE832532A (enExample)
FR (1) FR2315914A1 (enExample)
SE (2) SE438153B (enExample)
ZA (1) ZA755197B (enExample)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1181065A (en) * 1974-08-06 1985-01-15 Kentaro Hirai Dipeptide derivatives and their production

Also Published As

Publication number Publication date
ZA755197B (en) 1976-07-28
JPS58150549A (ja) 1983-09-07
FR2315914B1 (enExample) 1978-11-17
SE7902522L (sv) 1979-03-20
FR2315914A1 (fr) 1977-01-28
SE7902521L (sv) 1979-03-20
SE438152B (sv) 1985-04-01
BE832532A (fr) 1976-02-19
JPS6259120B2 (enExample) 1987-12-09

Similar Documents

Publication Publication Date Title
EP0871653B1 (de) Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
US4016148A (en) Peptide derivatives of phosphonic and phosphinic acids and intermediates therefor
DE69314169T2 (de) Peptide mit eine alphaaminoboronaire gruppe and ihre verwendung als elastasehemmer
JPH0753753B2 (ja) タチキニン由来の新規ぺプチドおよび医薬組成物
SE452326B (sv) Salter av agmatinderivat och farmaceutiska preparat innehallande desamma
WO1996024609A1 (de) Thrombininhibitoren
HU177515B (en) Process for preparing trh analogues
EP0344682B1 (de) Oligopeptide mit zyklischen Prolin-analogen Aminosäuren
EP1220852B1 (en) Substituted diazepans
DE69314911T2 (de) Cis-epoxide Derivate, verwendbar als irreversible HIV-Protease Inhibitoren und Verfahren und Zwischenprodukte zu ihrer Herstellung
DE69313290T2 (de) Laktam-dipeptide mit inhibierender wirkung auf die menschliche leukozytenelastase
US4590178A (en) Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them
DE69426897T2 (de) Antithrombotisch wirkende azacycloalkyl-alkanoyl-peptide und-pseudopeptide
NO784354L (no) Peptidderivater og fremstilling derav
WO1995023810A1 (de) Aminosäurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
IT8148952A1 (it) Amminoglucosidi ammidinati, procedimento per loro preparazione e loro impiego come medicamenti
US4143134A (en) Halo-phosphonopeptides
SE438153B (sv) Forfarande for framstellning av l-lysyl-n-(2-bensoyl-4-klorfenyl)-n-metylglycinamid med sedativ, muskelrelaxerande och antikonvulsiv verkan
DE69519182T2 (de) Azapeptid-Derivate
DE1916481B2 (de) Hydroxylamindenväte und Arzneimittel, die diese Verbindungen enthalten
DE3879191T2 (de) Purin-derivate mit pharmakologischer wirksamkeit.
DE3615512A1 (de) Prolinderivate
EP0069894B1 (de) Optisch aktives Dipeptide, seine pharmazeutisch verträglichen Salze, Verfahren zur Herstellung und diese enthaltende pharmazeutische Präparate
US4187295A (en) Organic compounds
US3749706A (en) Novel dipeptide amide and process for its manufacture

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 7902522-7

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 7902522-7

Format of ref document f/p: F