SE435930B - Forfarande for framstellning av ett spirooxazolidindionderivat av vinkaleukoblastin - Google Patents

Forfarande for framstellning av ett spirooxazolidindionderivat av vinkaleukoblastin

Info

Publication number
SE435930B
SE435930B SE7713587A SE7713587A SE435930B SE 435930 B SE435930 B SE 435930B SE 7713587 A SE7713587 A SE 7713587A SE 7713587 A SE7713587 A SE 7713587A SE 435930 B SE435930 B SE 435930B
Authority
SE
Sweden
Prior art keywords
compound
salt
pharmaceutically acceptable
parenteral
acceptable salt
Prior art date
Application number
SE7713587A
Other languages
English (en)
Swedish (sv)
Other versions
SE7713587L (sv
Inventor
J C Miller
G E Gutowski
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SE7713587L publication Critical patent/SE7713587L/xx
Publication of SE435930B publication Critical patent/SE435930B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
SE7713587A 1976-12-06 1977-11-30 Forfarande for framstellning av ett spirooxazolidindionderivat av vinkaleukoblastin SE435930B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/747,575 US4096148A (en) 1976-12-06 1976-12-06 Oxazolidinedione derivatives of Vinca alkaloids

Publications (2)

Publication Number Publication Date
SE7713587L SE7713587L (sv) 1978-06-07
SE435930B true SE435930B (sv) 1984-10-29

Family

ID=25005690

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7713586A SE436036B (sv) 1976-12-06 1977-11-30 Analogiforfarande for framstellning av oxazolidindionderivat av vinkaalkaloider
SE7713587A SE435930B (sv) 1976-12-06 1977-11-30 Forfarande for framstellning av ett spirooxazolidindionderivat av vinkaleukoblastin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7713586A SE436036B (sv) 1976-12-06 1977-11-30 Analogiforfarande for framstellning av oxazolidindionderivat av vinkaalkaloider

Country Status (31)

Country Link
US (1) US4096148A (no)
JP (1) JPS5371100A (no)
AR (1) AR218467A1 (no)
AT (2) AT353987B (no)
AU (1) AU513936B2 (no)
BE (1) BE861417A (no)
BG (2) BG33437A3 (no)
CA (2) CA1082180A (no)
CH (2) CH632516A5 (no)
CS (2) CS195344B2 (no)
DD (2) DD134228A5 (no)
DE (1) DE2753791A1 (no)
DK (2) DK145001C (no)
ES (2) ES464765A1 (no)
FR (1) FR2372839A1 (no)
GB (1) GB1590649A (no)
GR (2) GR67244B (no)
HK (1) HK57281A (no)
HU (2) HU180724B (no)
IE (1) IE46105B1 (no)
IL (1) IL53506A (no)
MX (1) MX4326E (no)
MY (1) MY8200176A (no)
NL (1) NL7713336A (no)
NZ (1) NZ185818A (no)
PL (2) PL110671B1 (no)
PT (2) PT67342B (no)
RO (2) RO75391A (no)
SE (2) SE436036B (no)
SU (2) SU865127A3 (no)
ZA (1) ZA777237B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU181874B (en) * 1977-08-08 1983-11-28 Lilly Co Eli Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine
US4357334A (en) * 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
US4362664A (en) * 1980-12-29 1982-12-07 Eli Lilly And Company Vinblastine oxazolidinedione disulfides and related compounds
GR81790B (no) * 1983-04-29 1984-12-12 Omnichem Sa
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT649883A (no) * 1960-05-24
HU165986B (no) * 1973-02-16 1974-12-28
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
US4012390A (en) * 1974-10-16 1977-03-15 Eli Lilly And Company Vinblastinoic acid

Also Published As

Publication number Publication date
GR67243B (no) 1981-06-25
SU843753A3 (ru) 1981-06-30
BE861417A (fr) 1978-06-02
ATA868877A (de) 1979-05-15
CH634076A5 (de) 1983-01-14
ES464765A1 (es) 1979-01-01
MX4326E (es) 1982-03-24
DK541177A (da) 1978-06-07
IL53506A (en) 1981-09-13
SU865127A3 (ru) 1981-09-15
NL7713336A (nl) 1978-06-08
AU513936B2 (en) 1981-01-15
RO75391A (ro) 1980-11-30
BG33436A3 (en) 1983-02-15
PL110671B1 (en) 1980-07-31
CA1082180A (en) 1980-07-22
HK57281A (en) 1981-11-27
SE7713586L (sv) 1978-06-07
GR67244B (no) 1981-06-25
AU3123077A (en) 1979-06-14
HU180725B (en) 1983-04-29
IE46105B1 (en) 1983-02-23
PL106522B1 (pl) 1979-12-31
IL53506A0 (en) 1978-03-10
DD134228A5 (de) 1979-02-14
SE436036B (sv) 1984-11-05
DK541077A (da) 1978-06-07
DK144916B (da) 1982-07-05
ZA777237B (en) 1979-07-25
PL202660A1 (pl) 1978-08-28
RO74137A (ro) 1981-08-30
PL202659A1 (pl) 1978-12-04
IE46105L (en) 1978-06-06
GB1590649A (en) 1981-06-03
PT67343A (en) 1977-12-01
DE2753791A1 (de) 1978-06-08
DK145001B (da) 1982-07-26
PT67342B (en) 1979-04-26
NZ185818A (en) 1979-12-11
JPS625160B2 (no) 1987-02-03
SE7713587L (sv) 1978-06-07
US4096148A (en) 1978-06-20
HU180724B (en) 1983-04-29
PT67342A (en) 1977-12-01
JPS5371100A (en) 1978-06-24
BG33437A3 (bg) 1983-02-15
CS195344B2 (en) 1980-01-31
ES464764A1 (es) 1979-01-01
FR2372839A1 (fr) 1978-06-30
DD134227A5 (de) 1979-02-14
DK145001C (da) 1982-12-27
CA1103664A (en) 1981-06-23
DK144916C (da) 1982-12-06
FR2372839B1 (no) 1981-11-06
PT67343B (en) 1979-04-26
ATA868777A (de) 1980-08-15
DE2753791C2 (no) 1990-08-02
AR218467A1 (es) 1980-06-13
AT353987B (de) 1979-12-10
CS195343B2 (en) 1980-01-31
AT361638B (de) 1981-03-25
MY8200176A (en) 1982-12-31
CH632516A5 (de) 1982-10-15

Similar Documents

Publication Publication Date Title
US4166810A (en) Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
IE921148A1 (en) Anti-tumor and anti-psoriatic agents
US5446047A (en) Camptothecin analogues
SE435930B (sv) Forfarande for framstellning av ett spirooxazolidindionderivat av vinkaleukoblastin
US6403636B1 (en) Xanthone compounds, their preparation and use as medicament
JP3076672B2 (ja) キノリン誘導体のフマル酸塩
Koeksal et al. Synthesis, Analgesic and Antiinflammatory properties of certain 5‐/6‐Acyl‐3‐(4‐substituted‐1‐piperazinylmethyl)‐2‐benzoxazolinones Derivatives
HU180722B (en) Process for preparing dimeric indole-dihydro-indole-carboxamide derivatives
US4746665A (en) Nitro derivatives of vinblastine-type bisindoles, and pharmaceutical compositions containing them
GB2086884A (en) Cytostatic Compounds
US4160767A (en) Vinca alkaloid intermediates
USRE30560E (en) Oxazolidinedione derivatives of Vinca alkaloids
EP0205168B1 (en) Furfuryl derivatives of vinblastine-type bis-indoles, a process for preparing same and pharmaceutical compositions containing them
US5043336A (en) Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
HU225989B1 (en) 20-(s)-camptothecin derivatives substituted at position 5, process for their preparation, their use and pharmaceutical compositions containing the same compounds
CN115850284B (zh) 一类8-氟-9-脂肪胺取代色胺酮衍生物、其制备方法及应用
CN112745331B (zh) 一种青藤碱生物素标记探针及其制备方法和用途
KR810000494B1 (ko) 빈카 알카로이드의 옥사졸리딘 디온 유도체의 제조방법
US4757077A (en) Bis-indole derivatives and pharmaceutical compositions containing them
SE444684B (sv) Forfarande for framstellning av 4-desacetylderivat av vinkristin och leurosidin
PL90467B1 (no)

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 7713587-9

Effective date: 19901019

Format of ref document f/p: F