SE432705B - Forfarande for framstellning av ett terapeutiskt avgivningssystem - Google Patents
Forfarande for framstellning av ett terapeutiskt avgivningssystemInfo
- Publication number
- SE432705B SE432705B SE7805660A SE7805660A SE432705B SE 432705 B SE432705 B SE 432705B SE 7805660 A SE7805660 A SE 7805660A SE 7805660 A SE7805660 A SE 7805660A SE 432705 B SE432705 B SE 432705B
- Authority
- SE
- Sweden
- Prior art keywords
- groups
- copolyester
- drug
- ester units
- chain ester
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 9
- 230000001225 therapeutic effect Effects 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title description 2
- 239000003814 drug Substances 0.000 claims description 39
- 229940079593 drug Drugs 0.000 claims description 38
- 229920001634 Copolyester Polymers 0.000 claims description 32
- 239000004014 plasticizer Substances 0.000 claims description 15
- 229920001577 copolymer Polymers 0.000 claims description 11
- -1 1,4-butylene groups Chemical group 0.000 claims description 10
- 239000012633 leachable Substances 0.000 claims description 7
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 229920005682 EO-PO block copolymer Polymers 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 150000002009 diols Chemical class 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
- CSJDCSCTVDEHRN-UHFFFAOYSA-N methane;molecular oxygen Chemical compound C.O=O CSJDCSCTVDEHRN-UHFFFAOYSA-N 0.000 claims description 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 2
- 229920001169 thermoplastic Polymers 0.000 claims description 2
- 239000004416 thermosoftening plastic Substances 0.000 claims description 2
- 125000004185 ester group Chemical group 0.000 claims 6
- 229920006236 copolyester elastomer Polymers 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 description 9
- 150000002148 esters Chemical group 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 229920001451 polypropylene glycol Polymers 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 229920001983 poloxamer Polymers 0.000 description 4
- 239000007787 solid Substances 0.000 description 3
- YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 description 2
- WSQZNZLOZXSBHA-UHFFFAOYSA-N 3,8-dioxabicyclo[8.2.2]tetradeca-1(12),10,13-triene-2,9-dione Chemical compound O=C1OCCCCOC(=O)C2=CC=C1C=C2 WSQZNZLOZXSBHA-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 2
- 239000013043 chemical agent Substances 0.000 description 2
- QMQBBUPJKANITL-MYXGOWFTSA-N dextropropoxyphene hydrochloride Chemical compound [H+].[Cl-].C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 QMQBBUPJKANITL-MYXGOWFTSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 239000004945 silicone rubber Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 1
- YKFROQCFVXOUPW-UHFFFAOYSA-N 4-(methylthio) aniline Chemical compound CSC1=CC=C(N)C=C1 YKFROQCFVXOUPW-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 229920003345 Elvax® Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229920011453 Hytrel® 4056 Polymers 0.000 description 1
- 229920010966 Hytrel® 5526 Polymers 0.000 description 1
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000003619 algicide Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- 235000019987 cider Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 229940089536 indocin Drugs 0.000 description 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229960001416 pilocarpine Drugs 0.000 description 1
- 229960001963 pilocarpine nitrate Drugs 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229940072690 valium Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/009—Sachets, pouches characterised by the material or function of the envelope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/799,854 US4127127A (en) | 1977-05-23 | 1977-05-23 | Therapeutic systems made from certain segmented copolyesters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7805660L SE7805660L (sv) | 1978-11-24 |
| SE432705B true SE432705B (sv) | 1984-04-16 |
Family
ID=25176936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7805660A SE432705B (sv) | 1977-05-23 | 1978-05-17 | Forfarande for framstellning av ett terapeutiskt avgivningssystem |
Country Status (10)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4246904A (en) * | 1979-01-29 | 1981-01-27 | American Cyanamid Company | Surgical suture derived from segmented polyether-ester block copolymers |
| USRE32770E (en) * | 1978-08-14 | 1988-10-25 | American Cyanamid Company | Surgical suture derived from segmented polyether-ester block copolymers |
| IN151798B (US06312121-20011106-C00033.png) * | 1978-12-08 | 1983-07-30 | Ethicon Inc | |
| US4314561A (en) * | 1979-01-29 | 1982-02-09 | American Cyanamid Company | Surgical suture derived from segmented polyether-ester block copolymers |
| US4235236A (en) * | 1979-02-12 | 1980-11-25 | Alza Corporation | Device for dispensing drug by combined diffusional and osmotic operations |
| US4473370A (en) * | 1981-09-14 | 1984-09-25 | Weiss Jeffrey N | Protective eye shield |
| FR2513243B1 (US06312121-20011106-C00033.png) * | 1981-09-24 | 1983-11-18 | Commissariat Energie Atomique | |
| US4502976A (en) * | 1982-10-25 | 1985-03-05 | Bend Research, Inc. | Water soluble polyesters |
| US4619652A (en) * | 1982-12-23 | 1986-10-28 | Alza Corporation | Dosage form for use in a body mounted pump |
| GB8309993D0 (en) * | 1983-04-13 | 1983-05-18 | Smith & Nephew Ass | Surgical adhesive dressing |
| US4588580B2 (en) * | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
| EP0200213B1 (en) * | 1985-05-02 | 1992-07-22 | Ciba-Geigy Ag | Hydrogels with increased organic solvent soluble active agent loading capacity, their preparation and the use thereof |
| US4666704A (en) * | 1985-05-24 | 1987-05-19 | International Minerals & Chemical Corp. | Controlled release delivery system for macromolecules |
| US4873086A (en) * | 1986-03-03 | 1989-10-10 | Ciba-Geigy Corporation | Hydrogels with increased organic solvent soluble active agent loading capacity, their preparation and the use thereof |
| US4959217A (en) * | 1986-05-22 | 1990-09-25 | Syntex (U.S.A.) Inc. | Delayed/sustained release of macromolecules |
| GB8622046D0 (en) * | 1986-09-12 | 1986-10-22 | Reckitt & Colmann Prod Ltd | Emanator for volatile liquids |
| US4906475A (en) * | 1988-02-16 | 1990-03-06 | Paco Pharmaceutical Services | Estradiol transdermal delivery system |
| US5702716A (en) * | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5487897A (en) | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
| AU2605592A (en) | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5411737A (en) * | 1991-10-15 | 1995-05-02 | Merck & Co., Inc. | Slow release syneresing polymeric drug delivery device |
| DE4137290A1 (de) * | 1991-11-13 | 1993-05-19 | Bayer Ag | Wirkstoffhaltige formkoerper auf basis thermoplastisch verarbeitbarer elastomerer copolyester, verfahren zu ihrer herstellung und verwendung zur kontrolle von schaedlingen |
| US5681873A (en) * | 1993-10-14 | 1997-10-28 | Atrix Laboratories, Inc. | Biodegradable polymeric composition |
| WO1996000389A1 (de) * | 1994-06-24 | 1996-01-04 | Ciba-Geigy Ag | Verfahren zur bestimmung der wirkstoff-freisetzung von festen oder halbfesten darreichungsformen zur anwendung bei mensch und tier |
| US8226598B2 (en) | 1999-09-24 | 2012-07-24 | Tolmar Therapeutics, Inc. | Coupling syringe system and methods for obtaining a mixed composition |
| US6626870B1 (en) | 2000-03-27 | 2003-09-30 | Artix Laboratories, Inc. | Stoppering method to maintain sterility |
| US20090292013A1 (en) * | 2004-12-14 | 2009-11-26 | Caroline Sautter | In-Situ Forming Implant for Animals |
| US20060291981A1 (en) * | 2005-06-02 | 2006-12-28 | Viola Frank J | Expandable backspan staple |
| US20090258061A1 (en) * | 2007-10-15 | 2009-10-15 | Johnson & Johnson | Once-a-day replacement transdermal administration of fentanyl |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3948262A (en) * | 1969-04-01 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
| US3993073A (en) * | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
| US3651014A (en) * | 1969-07-18 | 1972-03-21 | Du Pont | Segmented thermoplastic copolyester elastomers |
| US3766146A (en) * | 1971-03-18 | 1973-10-16 | Du Pont | Segmented thermoplastic copolyester elastomers |
| US3763109A (en) * | 1971-08-19 | 1973-10-02 | Du Pont | Segmented thermoplastic copolyesters |
| US3895103A (en) * | 1971-11-22 | 1975-07-15 | Alza Corp | Intrauterine contraceptive device containing certain pharmaceutically acceptable steroids |
| US3832458A (en) * | 1971-12-06 | 1974-08-27 | River C Foundation | Hydrophilic silicone composition and method |
| US3938515A (en) * | 1971-12-20 | 1976-02-17 | Alza Corporation | Novel drug permeable wall |
| FR2278348A2 (fr) * | 1974-06-28 | 1976-02-13 | Rhone Poulenc Ind | Articles chirurgicaux bioresorbables |
| US3993072A (en) * | 1974-08-28 | 1976-11-23 | Alza Corporation | Microporous drug delivery device |
-
1977
- 1977-05-23 US US05/799,854 patent/US4127127A/en not_active Expired - Lifetime
-
1978
- 1978-05-04 GB GB17687/78A patent/GB1575286A/en not_active Expired
- 1978-05-17 SE SE7805660A patent/SE432705B/sv not_active IP Right Cessation
- 1978-05-19 CA CA303,715A patent/CA1084839A/en not_active Expired
- 1978-05-22 JP JP53060887A patent/JPS6031808B2/ja not_active Expired
- 1978-05-22 IT IT68166/78A patent/IT1108091B/it active
- 1978-05-22 CH CH552478A patent/CH637832A5/de not_active IP Right Cessation
- 1978-05-22 DE DE19782822317 patent/DE2822317A1/de active Granted
- 1978-05-23 AU AU36379/78A patent/AU517497B2/en not_active Expired
- 1978-05-23 FR FR7815207A patent/FR2391721A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CH637832A5 (de) | 1983-08-31 |
| GB1575286A (en) | 1980-09-17 |
| US4127127A (en) | 1978-11-28 |
| IT1108091B (it) | 1985-12-02 |
| FR2391721A1 (fr) | 1978-12-22 |
| JPS6031808B2 (ja) | 1985-07-24 |
| CA1084839A (en) | 1980-09-02 |
| DE2822317A1 (de) | 1978-12-07 |
| IT7868166A0 (it) | 1978-05-22 |
| JPS542317A (en) | 1979-01-09 |
| DE2822317C2 (US06312121-20011106-C00033.png) | 1987-03-12 |
| AU3637978A (en) | 1979-11-29 |
| FR2391721B1 (US06312121-20011106-C00033.png) | 1982-10-15 |
| SE7805660L (sv) | 1978-11-24 |
| AU517497B2 (en) | 1981-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE432705B (sv) | Forfarande for framstellning av ett terapeutiskt avgivningssystem | |
| US5173302A (en) | Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs | |
| CN1812773B (zh) | 基于聚氧乙烯的薄膜及由其制造的药物传递系统 | |
| EP0379044B1 (en) | Breathable backing | |
| US7910641B2 (en) | PH modulated films for delivery of actives | |
| CN101658511B (zh) | 粘合贴剂 | |
| JP2002536118A5 (US06312121-20011106-C00033.png) | ||
| US8790703B2 (en) | Method for producing preparations of substances poorly soluble in water | |
| JPS58134019A (ja) | プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法 | |
| EP1971312A1 (en) | Topical film compositions for delivery of actives | |
| DE602004025159D1 (de) | Matrixzubereitungen für die kontrollierte Darreichung von Arzneistoffen | |
| NZ204643A (en) | Controlled release device containing polymer and acid anhydride | |
| US20070154527A1 (en) | Topical film compositions for delivery of actives | |
| GB2147002A (en) | Microphase separated hydrogels for controlled release of bioactive materials | |
| JPS62265235A (ja) | 射出成形可能な侵食性構成物及び製剤 | |
| CN100430093C (zh) | 温度响应输送系统 | |
| EP1968558B1 (en) | Ph modulated films for delivery of actives | |
| WO2014151915A1 (en) | Continuous single layer film structure including discrete domains | |
| JPH066533B2 (ja) | 含水ゲル貼付剤の基剤 | |
| JPS63146812A (ja) | 経皮投与用貼付剤 | |
| Ishida et al. | Controlled release of vitamin E from thermo-responsive polymeric physico-gel | |
| US20090297585A1 (en) | pH Modulated Films for Delivery of Actives | |
| JP3440284B2 (ja) | 皮膚貼付薬用支持体 | |
| US20100021526A1 (en) | Ph modulated films for delivery of actives | |
| JPH05163110A (ja) | 徐放性フェロモン製剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7805660-3 Effective date: 19941210 Format of ref document f/p: F |
|
| NUG | Patent has lapsed |
Ref document number: 7805660-3 Format of ref document f/p: F |