SE430885B - Oxytocin-derivat - Google Patents
Oxytocin-derivatInfo
- Publication number
- SE430885B SE430885B SE8002222A SE8002222A SE430885B SE 430885 B SE430885 B SE 430885B SE 8002222 A SE8002222 A SE 8002222A SE 8002222 A SE8002222 A SE 8002222A SE 430885 B SE430885 B SE 430885B
- Authority
- SE
- Sweden
- Prior art keywords
- oxytocin
- derivatives
- mpa
- tyr
- uterine
- Prior art date
Links
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 title claims description 39
- 229960001723 oxytocin Drugs 0.000 claims description 34
- 101800000989 Oxytocin Proteins 0.000 claims description 25
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims description 25
- 230000008602 contraction Effects 0.000 claims description 12
- 210000004291 uterus Anatomy 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 claims description 5
- 230000002269 spontaneous effect Effects 0.000 claims description 5
- -1 3-mercaptopropionyl Chemical group 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 108700042769 prolyl-leucyl-glycine Proteins 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 24
- 102400000050 Oxytocin Human genes 0.000 description 24
- 230000000694 effects Effects 0.000 description 19
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 239000000556 agonist Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 7
- 241000700159 Rattus Species 0.000 description 7
- 239000005557 antagonist Substances 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000037396 body weight Effects 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 229920005654 Sephadex Polymers 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000012507 Sephadex™ Substances 0.000 description 3
- 230000003042 antagnostic effect Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000000754 myometrium Anatomy 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000012891 Ringer solution Substances 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 description 2
- 108010004977 Vasopressins Proteins 0.000 description 2
- 102000002852 Vasopressins Human genes 0.000 description 2
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000012173 estrus Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000012453 sprague-dawley rat model Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229960003726 vasopressin Drugs 0.000 description 2
- BJFIDCADFRDPIO-DZCXQCEKSA-N (2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloeicos-4-yl]-oxomethyl]-2-pyrrolidinecarboxamide Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](N)CSSC1 BJFIDCADFRDPIO-DZCXQCEKSA-N 0.000 description 1
- NDBNSZKHDMXOJE-UHFFFAOYSA-N 3-benzylsulfanylpropanoic acid Chemical compound OC(=O)CCSCC1=CC=CC=C1 NDBNSZKHDMXOJE-UHFFFAOYSA-N 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 108010048179 Lypressin Proteins 0.000 description 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 description 1
- 206010036600 Premature labour Diseases 0.000 description 1
- 206010046823 Uterine spasm Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000001270 agonistic effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 230000006957 competitive inhibition Effects 0.000 description 1
- 230000009615 deamination Effects 0.000 description 1
- 238000006481 deamination reaction Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000009802 hysterectomy Methods 0.000 description 1
- 229960003837 lypressin Drugs 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 208000026440 premature labor Diseases 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000006965 reversible inhibition Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- SLZHLQUFNFXTHB-UHFFFAOYSA-M sodium;5-butan-2-yl-5-ethyl-2-sulfanylidenepyrimidin-3-ide-4,6-dione Chemical compound [Na+].CCC(C)C1(CC)C([O-])=NC(=S)NC1=O SLZHLQUFNFXTHB-UHFFFAOYSA-M 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 230000003191 uterotonic effect Effects 0.000 description 1
- 238000011121 vaginal smear Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8002222A SE430885B (sv) | 1980-03-24 | 1980-03-24 | Oxytocin-derivat |
| US06/238,715 US4402942A (en) | 1980-03-24 | 1981-02-27 | Oxytocin derivatives |
| CH140781A CH646139A5 (de) | 1980-03-24 | 1981-03-03 | Oxytocin-derivate. |
| GB8106843A GB2074582B (en) | 1980-03-24 | 1981-03-04 | Oxytocin-derivatives |
| DE3108323A DE3108323C2 (de) | 1980-03-24 | 1981-03-05 | 1-Desamino (2-O-alkyltyrosin)-oxytocine und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| NL8101191A NL8101191A (nl) | 1980-03-24 | 1981-03-11 | Oxytocine derivaat; farmaceutisch preparaat; werkwijze voor het tegengaan van spiercontracties van de uterus. |
| BE0/204141A BE887970A (fr) | 1980-03-24 | 1981-03-16 | Nouveaux derives d'ocytocine et compositions pharmaceutiques contenant ces derives |
| FR8105751A FR2482093A1 (fr) | 1980-03-24 | 1981-03-23 | Nouveaux derives d'ocytocine et compositions pharmaceutiques contenant ces derives |
| JP4227581A JPS56150050A (en) | 1980-03-24 | 1981-03-23 | Oxitocin derivative |
| IT20684/81A IT1136574B (it) | 1980-03-24 | 1981-03-24 | Derivati della ossitocina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8002222A SE430885B (sv) | 1980-03-24 | 1980-03-24 | Oxytocin-derivat |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8002222L SE8002222L (sv) | 1981-09-25 |
| SE430885B true SE430885B (sv) | 1983-12-19 |
Family
ID=20340577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8002222A SE430885B (sv) | 1980-03-24 | 1980-03-24 | Oxytocin-derivat |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4402942A (OSRAM) |
| JP (1) | JPS56150050A (OSRAM) |
| BE (1) | BE887970A (OSRAM) |
| CH (1) | CH646139A5 (OSRAM) |
| DE (1) | DE3108323C2 (OSRAM) |
| FR (1) | FR2482093A1 (OSRAM) |
| GB (1) | GB2074582B (OSRAM) |
| IT (1) | IT1136574B (OSRAM) |
| NL (1) | NL8101191A (OSRAM) |
| SE (1) | SE430885B (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3363830D1 (en) * | 1982-12-21 | 1986-07-03 | Ferring Ab | Vasotocin derivatives |
| SE8207277L (sv) * | 1982-12-21 | 1984-06-22 | Ferring Ab | Vasotocin-derivat |
| US4483794A (en) * | 1983-05-10 | 1984-11-20 | Ceskoslovenska Akademie Ved | Analogs of neurohypophysial hormones |
| US4624943A (en) * | 1985-03-20 | 1986-11-25 | Smithkline Beckman Corporation | Aromatic basic-tailed vasopressin antagonists |
| US5225528A (en) * | 1990-02-27 | 1993-07-06 | Merck & Co., Inc. | Cyclic hexapeptide oxytocin antagonists |
| DE4042008A1 (de) * | 1990-12-22 | 1992-06-25 | Schering Ag | Vasopressin-derivate |
| US5830848A (en) * | 1992-10-09 | 1998-11-03 | The Regents Of The University Of California | Method and agents for inducement of endogenous nitric oxide synthase for control and management of labor during pregnancy |
| RU2125062C1 (ru) * | 1997-04-10 | 1999-01-20 | Государственный научный центр вирусологии и биотехнологии "Вектор" | Защищенные производные окситоцина |
| US6909024B1 (en) * | 1999-11-22 | 2005-06-21 | The Dow Chemical Company | Process for the conversion of ethylene to vinyl chloride and novel catalyst compositions useful for such process |
| US6680415B1 (en) | 1999-11-22 | 2004-01-20 | Dow Global Technologies Inc. | Oxyhalogenation process using catalyst having porous rare earth halide support |
| US6933417B1 (en) | 1999-11-22 | 2005-08-23 | Dow Global Technologies Inc. | Process for vinyl chloride manufacture from ethane and ethylene with partial CHl recovery from reactor effluent |
| US6797845B1 (en) | 1999-11-22 | 2004-09-28 | Dow Global Technologies Inc. | Process for vinyl chloride manufacture from ethane and ethylene with immediate HCl recovery from reactor effluent |
| SE0100684D0 (sv) * | 2001-02-28 | 2001-02-28 | Kerstin Uvnaes Moberg | New subject-matter |
| JP4275952B2 (ja) * | 2001-05-23 | 2009-06-10 | ダウ グローバル テクノロジーズ インコーポレイティド | Ｃ３＋炭化水素の酸化的ハロゲン化および任意的な脱水素 |
| US20040152929A1 (en) * | 2002-05-08 | 2004-08-05 | Clarke William D | Process for vinyl chloride manufacture from ethane and ethylene with air feed and alternative hcl processing methods |
| US7722733B2 (en) | 2004-03-29 | 2010-05-25 | Baxter International Inc. | Method for sterile connection of tubing |
| TWI463990B (zh) * | 2009-09-21 | 2014-12-11 | Ferring Bv | 催產素受體促進劑 |
| CA2965759C (en) | 2014-10-31 | 2023-12-12 | Glaxosmithkline Intellectual Property Development Limited | Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials |
| EP4144351A1 (en) | 2016-01-04 | 2023-03-08 | ObsEva S.A. | Hydroxypropylthiazolidine carboxamide derivatives as inhibitors of the prostaglandin f receptor |
| BR112019001047A2 (pt) | 2016-07-21 | 2019-04-30 | ObsEva S.A. | método para tratar um indivíduo submetido à terapia de transferência de embriões e kit |
| WO2020137880A1 (ja) * | 2018-12-27 | 2020-07-02 | 国立大学法人北海道大学 | オキシトシン誘導体及びその使用 |
| EP4025207A1 (en) | 2019-09-03 | 2022-07-13 | ObsEva S.A. | Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage |
| EP4103750A1 (en) | 2020-02-10 | 2022-12-21 | ObsEva S.A. | Biomarkers for oxytocin receptor antagonist therapy |
| WO2022101495A1 (en) | 2020-11-16 | 2022-05-19 | ObsEva S.A. | Compositions and methods for the treatment or prevention of preterm labor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1463865A (fr) * | 1964-07-27 | 1966-07-22 | Ceskoslovenska Akademie Ved | Procédé pour la préparation des dérivés cycliques de peptides ainsi que les produits conformes à ceux obtenus par le présent procédé ou procédé similaire |
| CS194980B1 (en) * | 1976-07-16 | 1979-12-31 | Joseph H Cort | Agent for current induction,fertilization facilitating and milkability increasing at mammals,especially at utility cattle |
-
1980
- 1980-03-24 SE SE8002222A patent/SE430885B/sv not_active IP Right Cessation
-
1981
- 1981-02-27 US US06/238,715 patent/US4402942A/en not_active Expired - Fee Related
- 1981-03-03 CH CH140781A patent/CH646139A5/de not_active IP Right Cessation
- 1981-03-04 GB GB8106843A patent/GB2074582B/en not_active Expired
- 1981-03-05 DE DE3108323A patent/DE3108323C2/de not_active Expired
- 1981-03-11 NL NL8101191A patent/NL8101191A/nl not_active Application Discontinuation
- 1981-03-16 BE BE0/204141A patent/BE887970A/fr not_active IP Right Cessation
- 1981-03-23 FR FR8105751A patent/FR2482093A1/fr active Granted
- 1981-03-23 JP JP4227581A patent/JPS56150050A/ja active Pending
- 1981-03-24 IT IT20684/81A patent/IT1136574B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| SE8002222L (sv) | 1981-09-25 |
| CH646139A5 (de) | 1984-11-15 |
| FR2482093A1 (fr) | 1981-11-13 |
| IT1136574B (it) | 1986-09-03 |
| US4402942A (en) | 1983-09-06 |
| NL8101191A (nl) | 1981-10-16 |
| FR2482093B1 (OSRAM) | 1984-11-09 |
| BE887970A (fr) | 1981-07-16 |
| JPS56150050A (en) | 1981-11-20 |
| GB2074582A (en) | 1981-11-04 |
| IT8120684A0 (it) | 1981-03-24 |
| GB2074582B (en) | 1983-07-06 |
| DE3108323A1 (de) | 1981-12-24 |
| DE3108323C2 (de) | 1983-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE430885B (sv) | Oxytocin-derivat | |
| US5726156A (en) | Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels | |
| Melin et al. | Synthetic antagonists of the myometrial response to vasopressin and oxytocin | |
| US5763404A (en) | Methods for using LHRH antagonists with low histamine release | |
| US5420109A (en) | Cytokine restraining agents | |
| US5786332A (en) | Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels | |
| JP3405460B2 (ja) | ヘプタペプチドオキシトシン類似体 | |
| EP0112809B1 (en) | Vasotocin derivatives | |
| US5480869A (en) | Anti-inflammatory peptide analogs and treatment to inhibit vascular leakage in injured tissues | |
| IE840867L (en) | Peptides | |
| US5106834A (en) | Linear free-sulfhydryl-containing oligopeptide derivatives as antihypertensive agents | |
| US12325760B2 (en) | Inhibitors of NF kappa-B activity for treatment of diseases and disorders | |
| CA2068312A1 (en) | Agent for neutralising the procoagulant activity associated with tumor cells | |
| Melin et al. | Inhibitory effect of O-alkylated analogues of oxytocin and vasopressin on human and rat myometrial activity | |
| KR100244624B1 (ko) | 황체 형성 호르몬 방출 호르몬(lhrh) 길항제 및 이를 함유하는 약제학적 조성물 | |
| CA2072253A1 (en) | Anti-inflammatory peptides and treatment to inhibit vascular leakage in injured tissues | |
| JPS61143399A (ja) | 塩基性ｖ↓１‐バソプレシン拮抗剤 | |
| KR100291304B1 (ko) | 옥시토신 길항제 | |
| KR102417762B1 (ko) | 펜타펩타이드 및 그 용도 | |
| IE912378A1 (en) | Derivatives of pituitary posterior lobe hormones | |
| US4956344A (en) | Method for treatment of lesions in the large intestinal epithelium with a tripeptide | |
| EP0394283B1 (en) | Use of a tripeptide for the preparation of pharmaceutical compositions and a pharmaceutical composition and method | |
| JPS6267100A (ja) | バソプレシン化合物 | |
| SU1083560A1 (ru) | Гептапептид,обладающий способностью ингибировать миотропное действие брадикинина | |
| Freer et al. | Organ selective angiotensin antagonists: sarcosyl1-cysteinyl (S-methyl) 8-angiotensin I |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8002222-1 Effective date: 19890426 Format of ref document f/p: F |