SE421426B - Sett att framstella en unik kristallinisk polymorf form av alfa-fluor-11beta, 21-dihydroxi-16alfa, 17alfa-isopropylendioxi-1,4-dien-3,20-dion - Google Patents

Sett att framstella en unik kristallinisk polymorf form av alfa-fluor-11beta, 21-dihydroxi-16alfa, 17alfa-isopropylendioxi-1,4-dien-3,20-dion

Info

Publication number
SE421426B
SE421426B SE7605927A SE7605927A SE421426B SE 421426 B SE421426 B SE 421426B SE 7605927 A SE7605927 A SE 7605927A SE 7605927 A SE7605927 A SE 7605927A SE 421426 B SE421426 B SE 421426B
Authority
SE
Sweden
Prior art keywords
isopropylendioxy
16alfa
17alfa
crystallinic
11beta
Prior art date
Application number
SE7605927A
Other languages
English (en)
Swedish (sv)
Other versions
SE7605927L (sv
Inventor
J H Fried
R E Jones
G T Haringer
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of SE7605927L publication Critical patent/SE7605927L/
Publication of SE421426B publication Critical patent/SE421426B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
SE7605927A 1975-05-27 1976-05-25 Sett att framstella en unik kristallinisk polymorf form av alfa-fluor-11beta, 21-dihydroxi-16alfa, 17alfa-isopropylendioxi-1,4-dien-3,20-dion SE421426B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58130075A 1975-05-27 1975-05-27
US58130175A 1975-05-27 1975-05-27

Publications (2)

Publication Number Publication Date
SE7605927L SE7605927L (sv) 1976-11-28
SE421426B true SE421426B (sv) 1981-12-21

Family

ID=27078279

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7605927A SE421426B (sv) 1975-05-27 1976-05-25 Sett att framstella en unik kristallinisk polymorf form av alfa-fluor-11beta, 21-dihydroxi-16alfa, 17alfa-isopropylendioxi-1,4-dien-3,20-dion

Country Status (15)

Country Link
JP (1) JPS51144719A (cs)
AT (1) AT357702B (cs)
AU (1) AU506080B2 (cs)
CA (1) CA1075228A (cs)
DE (2) DE2624924C2 (cs)
ES (1) ES448220A1 (cs)
FR (1) FR2361900A1 (cs)
GB (1) GB1525181A (cs)
HK (1) HK8580A (cs)
IL (1) IL49652A (cs)
MX (1) MX3864E (cs)
MY (1) MY8000275A (cs)
NL (1) NL191234C (cs)
NZ (1) NZ180946A (cs)
SE (1) SE421426B (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE883381A (fr) * 1979-05-21 1980-11-20 Syntex Corp Procede de preparation d'une modification cristalline de flunisolide
EP0039369B1 (en) * 1980-05-02 1983-06-15 Schering Corporation Beclomethasone ester solvates, process for their preparation, and preparation of a formulation
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4782047A (en) * 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
EP0437451B1 (en) * 1988-10-05 1993-06-09 The Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
PT835098E (pt) * 1995-06-27 2002-12-31 Boehringer Ingelheim Pharma Nova composicao farmaceutica estavel para a producao de aerossois sem gas propulsante
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
TR200102563T2 (tr) * 1999-03-03 2002-04-22 Optinose As Burundan aktarım cihazı.
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
AU2000250701B2 (en) 2000-05-22 2004-07-01 Chiesi Farmaceutici S.P.A. Stable pharmaceutical solution formulations for pressurised metered dose inhalers
PT1273292E (pt) 2001-07-02 2004-10-29 Chiesi Farma Spa Formulacao optimizada de tobramicina para aerossolizacao
JP5238779B2 (ja) * 2003-04-25 2013-07-17 ロート製薬株式会社 点鼻剤
JP4632687B2 (ja) * 2003-04-25 2011-02-16 ロート製薬株式会社 点鼻剤
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
JP6473134B2 (ja) * 2013-03-15 2019-02-20 メディシス ファーマシューティカル コーポレイション フルニソリドの局所用組成物および治療方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) 1964-03-24 Chioacyl
BE585432A (fr) * 1958-12-08 1960-06-08 American Cyanamid Co Stéroïdes fluorés.
US3282791A (en) * 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) * 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
FR2038105A1 (fr) * 1969-04-01 1971-01-08 Syntex Corp Composition anti-inflammatoire locale et son mode d'utilisation
GB1429184A (en) * 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
DE2332663C2 (de) * 1973-06-23 1986-07-31 Schering AG, 1000 Berlin und 4709 Bergkamen Verwendung von Kortikoid-Wirkstoffen zur Inhalationstherapie
US3934013A (en) * 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Also Published As

Publication number Publication date
DE2624924A1 (de) 1977-12-15
CA1075228A (en) 1980-04-08
SE7605927L (sv) 1976-11-28
DE2661037C2 (cs) 1989-04-06
FR2361900A1 (fr) 1978-03-17
FR2361900B1 (cs) 1979-04-13
AU506080B2 (en) 1979-12-13
AT357702B (de) 1980-07-25
JPS6247880B2 (cs) 1987-10-09
JPS51144719A (en) 1976-12-13
IL49652A0 (en) 1976-07-30
NZ180946A (en) 1978-07-28
GB1525181A (en) 1978-09-20
NL7605699A (nl) 1976-11-30
MX3864E (es) 1981-08-26
ATA388376A (de) 1979-12-15
HK8580A (en) 1980-03-14
ES448220A1 (es) 1977-11-01
IL49652A (en) 1979-05-31
DE2624924C2 (de) 1986-11-27
NL191234C (nl) 1995-04-03
MY8000275A (en) 1980-12-31
AU1430176A (en) 1977-12-01
NL191234B (nl) 1994-11-01

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