SE416646B - Forfarande for dehalogenering av en 11a-halogentetracyklin med en fosfin eller ett fosfit - Google Patents

Forfarande for dehalogenering av en 11a-halogentetracyklin med en fosfin eller ett fosfit

Info

Publication number
SE416646B
SE416646B SE7406228A SE7406228A SE416646B SE 416646 B SE416646 B SE 416646B SE 7406228 A SE7406228 A SE 7406228A SE 7406228 A SE7406228 A SE 7406228A SE 416646 B SE416646 B SE 416646B
Authority
SE
Sweden
Prior art keywords
halogentetracycline
dehalogenation
phosphite
phosphine
procedure
Prior art date
Application number
SE7406228A
Other languages
English (en)
Swedish (sv)
Other versions
SE7406228L (ja
Inventor
H Faubl
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE7406228L publication Critical patent/SE7406228L/xx
Publication of SE416646B publication Critical patent/SE416646B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SE7406228A 1973-06-21 1974-05-09 Forfarande for dehalogenering av en 11a-halogentetracyklin med en fosfin eller ett fosfit SE416646B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37230873A 1973-06-21 1973-06-21

Publications (2)

Publication Number Publication Date
SE7406228L SE7406228L (ja) 1974-12-23
SE416646B true SE416646B (sv) 1981-01-26

Family

ID=23467606

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7406228A SE416646B (sv) 1973-06-21 1974-05-09 Forfarande for dehalogenering av en 11a-halogentetracyklin med en fosfin eller ett fosfit

Country Status (30)

Country Link
US (1) US4126639A (ja)
JP (1) JPS5719095B2 (ja)
AT (1) AT337358B (ja)
BE (1) BE815776A (ja)
CA (1) CA1110618A (ja)
CH (1) CH585696A5 (ja)
CS (1) CS175380B2 (ja)
DD (1) DD113893A5 (ja)
DE (1) DE2427420A1 (ja)
DK (1) DK153756C (ja)
ES (1) ES426893A1 (ja)
FI (1) FI58631C (ja)
FR (1) FR2234272B1 (ja)
GB (1) GB1459861A (ja)
HK (1) HK26879A (ja)
HU (1) HU169605B (ja)
IE (1) IE39758B1 (ja)
IL (1) IL44875A (ja)
KE (1) KE2929A (ja)
LU (1) LU70248A1 (ja)
MY (1) MY7900232A (ja)
NL (1) NL179476C (ja)
NO (1) NO146597C (ja)
PH (1) PH10281A (ja)
PL (1) PL89987B1 (ja)
RO (1) RO67373A (ja)
SE (1) SE416646B (ja)
SU (1) SU512698A3 (ja)
YU (1) YU39461B (ja)
ZA (1) ZA743341B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU41093B (en) * 1978-04-12 1986-12-31 Pliva Pharm & Chem Works Process for preparing 6-deoxy-5hydroxy-tetracycline
DK386784A (da) * 1983-08-17 1985-02-18 Hovione Int Ltd Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner
US4987242A (en) * 1988-10-28 1991-01-22 Jagmohan Khanna Hydrogenation catalyst useful in the production of alpha-6-deoxytetracyclines

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2742510A (en) * 1955-06-17 1956-04-17 Kellogg M W Co Process for dehalogenation of organic compounds
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (ja) * 1960-05-23 1966-05-25
US3250809A (en) * 1962-09-06 1966-05-10 Pfizer & Co C 6-deoxy-6-demethyl-6-halomethylene tetracyclines and their 11a-chloro and fluoro derivatives
NL128202C (ja) * 1964-01-21
DE1245360B (de) * 1965-11-17 1967-07-27 Knapsack Ag Verfahren zur Herstellung eines aus 1,2-Dichlorbuten-(2), 1, 3-Dichlorbuten-(2) und 2 ,3-Dichlorbuten-(1) bestehenden Gemisches
US3484483A (en) * 1966-10-31 1969-12-16 Pfizer & Co C Process for producing alpha-6-deoxytetracyclines
US3649700A (en) * 1966-12-20 1972-03-14 Knapsack Ag Process for the dehydrochlorination of chlorinated hydrocarbons
US3444198A (en) * 1967-02-13 1969-05-13 Pfizer & Co C Process for producing alpha-6-deoxytetracyclines
CA942743A (en) * 1970-07-03 1974-02-26 Ivan Villax Process for producing 6-methylenetetracyclines and 6-deoxytetracyclines
GB1349043A (en) * 1971-04-05 1974-03-27 Pliva Pharm & Chem Works Process for the preparation of 6-demethyl-6-deoxy-6-methylene tetracyclines

Also Published As

Publication number Publication date
BE815776A (fr) 1974-12-02
SE7406228L (ja) 1974-12-23
CS175380B2 (ja) 1977-05-31
IL44875A (en) 1977-04-29
KE2929A (en) 1979-03-30
US4126639A (en) 1978-11-21
IE39758B1 (en) 1978-12-20
ES426893A1 (es) 1976-07-16
ATA453674A (de) 1976-10-15
PH10281A (en) 1976-11-05
AT337358B (de) 1977-06-27
NL7407368A (ja) 1974-12-24
HU169605B (ja) 1976-12-28
FI58631B (fi) 1980-11-28
CA1110618A (en) 1981-10-13
CH585696A5 (ja) 1977-03-15
DE2427420C2 (ja) 1987-02-05
MY7900232A (en) 1979-12-31
NL179476C (nl) 1986-09-16
HK26879A (en) 1979-05-04
ZA743341B (en) 1975-05-28
JPS5719095B2 (ja) 1982-04-20
DK153756B (da) 1988-08-29
FI58631C (fi) 1981-03-10
FR2234272B1 (ja) 1977-07-01
GB1459861A (en) 1976-12-31
FI168774A (ja) 1974-12-22
PL89987B1 (ja) 1976-12-31
LU70248A1 (ja) 1975-03-06
DD113893A5 (ja) 1975-07-05
NL179476B (nl) 1986-04-16
RO67373A (ro) 1980-03-15
DK298074A (ja) 1975-02-10
AU6940974A (en) 1975-11-27
IE39758L (en) 1974-12-21
YU39461B (en) 1984-12-31
IL44875A0 (en) 1974-07-31
JPS5019746A (ja) 1975-03-01
NO146597C (no) 1982-11-03
DK153756C (da) 1989-01-09
DE2427420A1 (de) 1975-01-30
SU512698A3 (ru) 1976-04-30
YU151174A (en) 1982-05-31
NO742004L (ja) 1975-01-20
NO146597B (no) 1982-07-26
FR2234272A1 (ja) 1975-01-17

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