SE0201778D0 - Process for the manufacture of quinoline derivatives - Google Patents
Process for the manufacture of quinoline derivativesInfo
- Publication number
- SE0201778D0 SE0201778D0 SE0201778A SE0201778A SE0201778D0 SE 0201778 D0 SE0201778 D0 SE 0201778D0 SE 0201778 A SE0201778 A SE 0201778A SE 0201778 A SE0201778 A SE 0201778A SE 0201778 D0 SE0201778 D0 SE 0201778D0
- Authority
- SE
- Sweden
- Prior art keywords
- manufacture
- quinoline derivatives
- formula
- quinoline
- chaineded
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0201778A SE0201778D0 (sv) | 2002-06-12 | 2002-06-12 | Process for the manufacture of quinoline derivatives |
RU2005100054/04A RU2291861C2 (ru) | 2002-06-12 | 2003-05-14 | Способ получения производных хинолина |
EP03725956A EP1511732B9 (en) | 2002-06-12 | 2003-05-14 | Process for the manufacture of quinoline derivatives |
BRPI0311674-3A BR0311674A (pt) | 2002-06-12 | 2003-05-14 | processo para a preparação de compostos |
YUP-1076/04A RS51021B (sr) | 2002-06-12 | 2003-05-14 | Postupak za dobijanje derivata hinolina |
MEP-2008-656A ME00435B (me) | 2002-06-12 | 2003-05-14 | Postupak za dobijanje derivata hinolina |
NZ536768A NZ536768A (en) | 2002-06-12 | 2003-05-14 | Process for the manufacture of quinoline carboxamide derivatives using an alkane or cycloalkane solvent |
SI200330688T SI1511732T1 (sl) | 2002-06-12 | 2003-05-14 | Postopek za pripravo kinolinskih derivatov |
ES03725956T ES2278160T3 (es) | 2002-06-12 | 2003-05-14 | Procedimiento para la fabricacion de derivados de quinolina. |
DE60310554T DE60310554T2 (de) | 2002-06-12 | 2003-05-14 | Verfahren zur herstellung von chinolinderivaten |
DK03725956T DK1511732T5 (da) | 2002-06-12 | 2003-05-14 | Fremgangsmåde til fremstilling af quinolinderivater |
CNB038135310A CN100418950C (zh) | 2002-06-12 | 2003-05-14 | 制备喹啉衍生物的方法 |
PL373817A PL210259B1 (pl) | 2002-06-12 | 2003-05-14 | Sposób wytwarzania pochodnych chinoliny |
MXPA04012276A MXPA04012276A (es) | 2002-06-12 | 2003-05-14 | Proceso para la elaboracion de derivados de quinolina. |
UA20041109639A UA78310C2 (en) | 2002-06-12 | 2003-05-14 | Method for preparing quinolin derivatives |
CA2487329A CA2487329C (en) | 2002-06-12 | 2003-05-14 | Process for the manufacture of quinoline derivatives |
PT03725956T PT1511732E (pt) | 2002-06-12 | 2003-05-14 | Processo para o fabrico de derivados quinolina |
JP2004513257A JP4584709B2 (ja) | 2002-06-12 | 2003-05-14 | キノリン誘導体の製造工程 |
KR1020047020088A KR100979216B1 (ko) | 2002-06-12 | 2003-05-14 | 퀴놀린 유도체의 제조 방법 |
AU2003228195A AU2003228195B2 (en) | 2002-06-12 | 2003-05-14 | Process for the manufacture of quinoline derivatives |
AT03725956T ATE348814T1 (de) | 2002-06-12 | 2003-05-14 | Verfahren zur herstellung von chinolinderivaten |
PCT/SE2003/000780 WO2003106424A1 (en) | 2002-06-12 | 2003-05-14 | Process for the manufacture of quinoline derivatives |
IL165155A IL165155A (en) | 2002-06-12 | 2004-11-11 | A process to create a history of quinoline |
ZA200409430A ZA200409430B (en) | 2002-06-12 | 2004-11-23 | Process for the manufacture of quinoline derivatives. |
IS7550A IS2975B (is) | 2002-06-12 | 2004-11-24 | Aðferð til framleiðslu á kvínólín-afleiðum |
NO20045703A NO329162B1 (no) | 2002-06-12 | 2004-12-29 | Fremgangsmate ved fremstilling av quinolin-derivater |
HRP20050028AA HRP20050028B1 (hr) | 2002-06-12 | 2005-01-11 | Postupak za proizvodnju derivata kinolina |
CY20071100295T CY1107555T1 (el) | 2002-06-12 | 2007-03-01 | Μεθοδος για την βιομηχανικη παρασκευη παραγωγων κινολινης |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0201778A SE0201778D0 (sv) | 2002-06-12 | 2002-06-12 | Process for the manufacture of quinoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0201778D0 true SE0201778D0 (sv) | 2002-06-12 |
Family
ID=20288148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0201778A SE0201778D0 (sv) | 2002-06-12 | 2002-06-12 | Process for the manufacture of quinoline derivatives |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP1511732B9 (me) |
JP (1) | JP4584709B2 (me) |
KR (1) | KR100979216B1 (me) |
CN (1) | CN100418950C (me) |
AT (1) | ATE348814T1 (me) |
AU (1) | AU2003228195B2 (me) |
BR (1) | BR0311674A (me) |
CA (1) | CA2487329C (me) |
CY (1) | CY1107555T1 (me) |
DE (1) | DE60310554T2 (me) |
DK (1) | DK1511732T5 (me) |
ES (1) | ES2278160T3 (me) |
HR (1) | HRP20050028B1 (me) |
IL (1) | IL165155A (me) |
IS (1) | IS2975B (me) |
ME (1) | ME00435B (me) |
MX (1) | MXPA04012276A (me) |
NO (1) | NO329162B1 (me) |
NZ (1) | NZ536768A (me) |
PL (1) | PL210259B1 (me) |
PT (1) | PT1511732E (me) |
RS (1) | RS51021B (me) |
RU (1) | RU2291861C2 (me) |
SE (1) | SE0201778D0 (me) |
SI (1) | SI1511732T1 (me) |
UA (1) | UA78310C2 (me) |
WO (1) | WO2003106424A1 (me) |
ZA (1) | ZA200409430B (me) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0400235D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New composition containing quinoline compounds |
US8314124B2 (en) | 2004-02-06 | 2012-11-20 | Active Biotech Ab | Crystalline salts of quinoline compounds and methods for preparing them |
CN103333107A (zh) | 2005-10-19 | 2013-10-02 | 泰华制药工业有限公司 | 拉奎尼莫钠晶体及其制备方法 |
BRPI0713694A2 (pt) * | 2006-06-12 | 2012-10-30 | Teva Pharma | composição farmacêutica, processo para preparar composição farmacêutica, embalagens vedada, métodos para tratar um indivìduo afligido com uma forma de esclerose múltipla, e para aliviar um sintoma de esclerose múltipla em um indivìduo afligido com uma forma de esclerose múltipla, e, uso da composição farmacêutica |
BRPI0719590A2 (pt) | 2006-11-28 | 2014-01-21 | Valeant Pharmaceuticals Int | Análogos de retigabina 1,4 diamino bicíclica como modulares de canal de potássio |
EP2682120B1 (en) | 2007-12-20 | 2016-08-03 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
NZ591315A (en) | 2008-09-03 | 2012-08-31 | Teva Pharma | 2-oxo-1,2-dihydro-quinoline modulators of immune function |
EP2376456A2 (en) * | 2008-12-17 | 2011-10-19 | Actavis Group Ptc Ehf | Highly pure laquinimod or a pharmaceutically acceptable salt thereof |
DE102010048788A1 (de) | 2009-02-13 | 2011-05-19 | Amw Gmbh | Transdermales System mit Immunmodulator |
DE102009008851A1 (de) | 2009-02-13 | 2010-08-19 | Amw Gmbh | Transdermales System mit Immunmodulator |
KR20120045032A (ko) | 2009-07-30 | 2012-05-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 크론병의 치료 |
HUE029983T2 (en) | 2009-08-10 | 2017-04-28 | Teva Pharma | Treatment of BDNF-related diseases with laquinimod |
DE102010026879A1 (de) | 2010-02-11 | 2011-08-11 | AMW GmbH, 83627 | Transdermales System mit Immunmodulator |
PT2542079E (pt) | 2010-03-03 | 2014-07-18 | Teva Pharma | Tratamento da artrite reumatoide com uma combinação de laquinimod e metotrexato |
EA201290837A1 (ru) | 2010-03-03 | 2013-05-30 | Тева Фармасьютикал Индастриз Лтд. | Лечение волчаночного нефрита с применением лаквинимода |
MX2013000332A (es) * | 2010-07-09 | 2013-02-26 | Teva Pharma | 5-cloro-4-hidroxi-1-metil-2-oxo-n-fenil-1,2-dihidroquinolina-3-ca rboxamida, sales y usos de la misma. |
JP5881691B2 (ja) * | 2010-07-09 | 2016-03-09 | アクティブ バイオテック エイビー | キノリン−3−カルボキサミドの製造方法 |
EP3213636A1 (en) | 2010-07-09 | 2017-09-06 | Teva Pharmaceutical Industries, Ltd. | Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
EP2537517A1 (en) * | 2011-06-22 | 2012-12-26 | Active Biotech AB | Deuterium-enriched 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide |
KR20140101333A (ko) | 2011-10-12 | 2014-08-19 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드 및 핑골리모드의 조합을 이용한 다발성 경화증의 치료 |
TW201345527A (zh) | 2012-02-03 | 2013-11-16 | Teva Pharma | 拉喹莫德於治療對第一線抗-TNFα療法無效之克隆氏症患者之用途 |
MX2014009889A (es) | 2012-02-16 | 2014-11-13 | Teva Pharma | N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinoli ncarboxamida, preparacion y usos de los mismos. |
TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-n-苯基-1,2-二氫喹啉-3-甲醯胺 |
TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療gaba媒介之疾病之拉喹莫德(laquinimod) |
CN103626701A (zh) * | 2012-08-28 | 2014-03-12 | 天津药物研究院 | 一种制备喹啉衍生物的方法 |
CN103626702A (zh) * | 2012-08-30 | 2014-03-12 | 天津药物研究院 | 一种制备喹啉酮衍生物的方法 |
US8975279B2 (en) | 2012-11-07 | 2015-03-10 | Teva Pharmaceutical Industries, Ltd. | Amine salts of laquinimod |
KR20150143499A (ko) * | 2013-03-14 | 2015-12-23 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드 나트륨의 결정 및 이의 개선된 제조방법 |
AU2015253330A1 (en) | 2014-04-29 | 2016-12-01 | Teva Pharmaceutical Industries Ltd. | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (RRMS) patients with a high disability status |
US9956212B2 (en) | 2014-09-23 | 2018-05-01 | Active Biotech Ab | Quinoline carboxamides for use in the treatment of multiple myeloma |
KR102525805B1 (ko) | 2014-11-19 | 2023-04-25 | 액티브 바이오테크 에이비 | 백혈병 치료용 퀴놀린 카르복사미드 |
WO2021175924A1 (en) | 2020-03-03 | 2021-09-10 | Active Biotech Ab | Tasquinimod or a pharmaceutically acceptable salt thereof for use in combination therapy |
CN111732540B (zh) * | 2020-07-20 | 2020-11-13 | 湖南速博生物技术有限公司 | 一种罗喹美克的制备方法 |
KR20230043916A (ko) | 2020-07-23 | 2023-03-31 | 에라스무스 유니버시티 메디컬 센터 로테르담 | 골수증식성 신생물의 새로운 치료학적 표적으로서 s100 단백질 |
AU2022208424A1 (en) | 2021-01-18 | 2023-08-24 | Active Biotech Ab | Tasquinimod or a pharmaceutically acceptable salt thereof for use in the treatment of myelodysplastic syndrome |
KR20240012436A (ko) | 2021-05-25 | 2024-01-29 | 액티브 바이오테크 에이비 | 복수의 타스퀴니모드 입자 및 그 용도 |
WO2023275248A1 (en) | 2021-07-02 | 2023-01-05 | Active Biotech Ab | A pharmaceutical product containing tasquinimod and a method for assessing the purity of said product |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE52670B1 (en) * | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
US6077851A (en) * | 1998-04-27 | 2000-06-20 | Active Biotech Ab | Quinoline derivatives |
SE9801474D0 (sv) * | 1998-04-27 | 1998-04-27 | Active Biotech Ab | Quinoline Derivatives |
US6121287A (en) * | 1998-07-15 | 2000-09-19 | Active Biotech Ab | Quinoline derivatives |
SE9802550D0 (sv) * | 1998-07-15 | 1998-07-15 | Active Biotech Ab | Quinoline derivatives |
-
2002
- 2002-06-12 SE SE0201778A patent/SE0201778D0/xx unknown
-
2003
- 2003-05-14 AT AT03725956T patent/ATE348814T1/de active
- 2003-05-14 ME MEP-2008-656A patent/ME00435B/me unknown
- 2003-05-14 JP JP2004513257A patent/JP4584709B2/ja not_active Expired - Lifetime
- 2003-05-14 NZ NZ536768A patent/NZ536768A/en not_active IP Right Cessation
- 2003-05-14 DK DK03725956T patent/DK1511732T5/da active
- 2003-05-14 AU AU2003228195A patent/AU2003228195B2/en not_active Expired
- 2003-05-14 PL PL373817A patent/PL210259B1/pl unknown
- 2003-05-14 RU RU2005100054/04A patent/RU2291861C2/ru not_active IP Right Cessation
- 2003-05-14 CN CNB038135310A patent/CN100418950C/zh not_active Expired - Lifetime
- 2003-05-14 BR BRPI0311674-3A patent/BR0311674A/pt not_active Application Discontinuation
- 2003-05-14 UA UA20041109639A patent/UA78310C2/xx unknown
- 2003-05-14 PT PT03725956T patent/PT1511732E/pt unknown
- 2003-05-14 RS YUP-1076/04A patent/RS51021B/sr unknown
- 2003-05-14 KR KR1020047020088A patent/KR100979216B1/ko active IP Right Grant
- 2003-05-14 EP EP03725956A patent/EP1511732B9/en not_active Expired - Lifetime
- 2003-05-14 ES ES03725956T patent/ES2278160T3/es not_active Expired - Lifetime
- 2003-05-14 DE DE60310554T patent/DE60310554T2/de not_active Expired - Lifetime
- 2003-05-14 MX MXPA04012276A patent/MXPA04012276A/es active IP Right Grant
- 2003-05-14 SI SI200330688T patent/SI1511732T1/sl unknown
- 2003-05-14 WO PCT/SE2003/000780 patent/WO2003106424A1/en active IP Right Grant
- 2003-05-14 CA CA2487329A patent/CA2487329C/en not_active Expired - Lifetime
-
2004
- 2004-11-11 IL IL165155A patent/IL165155A/en active IP Right Grant
- 2004-11-23 ZA ZA200409430A patent/ZA200409430B/xx unknown
- 2004-11-24 IS IS7550A patent/IS2975B/is unknown
- 2004-12-29 NO NO20045703A patent/NO329162B1/no not_active IP Right Cessation
-
2005
- 2005-01-11 HR HRP20050028AA patent/HRP20050028B1/hr not_active IP Right Cessation
-
2007
- 2007-03-01 CY CY20071100295T patent/CY1107555T1/el unknown
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