SE0004245D0 - Novel compounds and their use - Google Patents

Novel compounds and their use

Info

Publication number
SE0004245D0
SE0004245D0 SE0004245A SE0004245A SE0004245D0 SE 0004245 D0 SE0004245 D0 SE 0004245D0 SE 0004245 A SE0004245 A SE 0004245A SE 0004245 A SE0004245 A SE 0004245A SE 0004245 D0 SE0004245 D0 SE 0004245D0
Authority
SE
Sweden
Prior art keywords
novel compounds
sub
compound
general formula
novel
Prior art date
Application number
SE0004245A
Other languages
English (en)
Swedish (sv)
Inventor
Bjoern Nilsson
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Priority to SE0004245A priority Critical patent/SE0004245D0/xx
Publication of SE0004245D0 publication Critical patent/SE0004245D0/xx
Priority to PL01361690A priority patent/PL361690A1/xx
Priority to EA200300593A priority patent/EA006552B1/ru
Priority to US09/989,358 priority patent/US6593330B2/en
Priority to CA002448729A priority patent/CA2448729A1/en
Priority to CNB2006100917213A priority patent/CN100451016C/zh
Priority to MXPA03004390A priority patent/MXPA03004390A/es
Priority to JP2002542784A priority patent/JP4387103B2/ja
Priority to NZ525700A priority patent/NZ525700A/xx
Priority to EP01996532A priority patent/EP1335907B1/en
Priority to AU2426602A priority patent/AU2426602A/xx
Priority to PCT/SE2001/002569 priority patent/WO2002040456A1/en
Priority to KR1020037006824A priority patent/KR100846339B1/ko
Priority to CNB018204058A priority patent/CN1267424C/zh
Priority to IL15570201A priority patent/IL155702A0/xx
Priority to BR0115400-1A priority patent/BR0115400A/pt
Priority to NZ536688A priority patent/NZ536688A/en
Priority to YU39803A priority patent/YU39803A/sh
Priority to AT01996532T priority patent/ATE470662T1/de
Priority to DE60142355T priority patent/DE60142355D1/de
Priority to AU2002224266A priority patent/AU2002224266B2/en
Priority to IL155702A priority patent/IL155702A/en
Priority to ZA200303599A priority patent/ZA200303599B/en
Priority to NO20032252A priority patent/NO325181B1/no
Priority to US10/618,868 priority patent/US7247633B2/en
Priority to HK04104869A priority patent/HK1061855A1/xx
Priority to ZA200504675A priority patent/ZA200504675B/en
Priority to HK07106358.6A priority patent/HK1099292A1/xx
Priority to JP2009148822A priority patent/JP2009280587A/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE0004245A 2000-11-20 2000-11-20 Novel compounds and their use SE0004245D0 (sv)

Priority Applications (29)

Application Number Priority Date Filing Date Title
SE0004245A SE0004245D0 (sv) 2000-11-20 2000-11-20 Novel compounds and their use
AU2002224266A AU2002224266B2 (en) 2000-11-20 2001-11-20 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5HT-2 receptor
KR1020037006824A KR100846339B1 (ko) 2000-11-20 2001-11-20 세로토닌 5ｈｔ-2 수용체의 아고니스트 또는안타고니스트로서의 피페라지닐피라진 화합물
IL15570201A IL155702A0 (en) 2000-11-20 2001-11-20 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5-ht2 receptor
US09/989,358 US6593330B2 (en) 2000-11-20 2001-11-20 Compounds and their use
CA002448729A CA2448729A1 (en) 2000-11-20 2001-11-20 Piperazinyl and piperidyl substituted heterocyclic compounds
CNB2006100917213A CN100451016C (zh) 2000-11-20 2001-11-20 作为5-羟色胺5ht-2受体的激动剂或拮抗剂的哌嗪基嘧啶化合物
MXPA03004390A MXPA03004390A (es) 2000-11-20 2001-11-20 Compuestos de piperazinilpirazina utiles como un agonista o antagonista del receptor 5ht-2 de serotonina.
JP2002542784A JP4387103B2 (ja) 2000-11-20 2001-11-20 セロトニン５ｈｔ−２レセプターのアゴニストまたはアンタゴニストとしてのピペラジニルピラジン化合物
NZ525700A NZ525700A (en) 2000-11-20 2001-11-20 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5HT-2 receptor
EP01996532A EP1335907B1 (en) 2000-11-20 2001-11-20 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor
AU2426602A AU2426602A (en) 2000-11-20 2001-11-20 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor
PCT/SE2001/002569 WO2002040456A1 (en) 2000-11-20 2001-11-20 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor
PL01361690A PL361690A1 (en) 2000-11-20 2001-11-20 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor
CNB018204058A CN1267424C (zh) 2000-11-20 2001-11-20 作为5－羟色胺5ht－2受体的激动剂或拮抗剂的哌嗪基吡嗪化合物
EA200300593A EA006552B1 (ru) 2000-11-20 2001-11-20 Соединения пиперазинилпиразинов в качестве агонистов или антагонистов серотонин 5-ht2 рецептора
BR0115400-1A BR0115400A (pt) 2000-11-20 2001-11-20 Compostos de piperazinilpirazina atuando como agonistas ou antagonistas do receptor 5ht-2 de serotonina
NZ536688A NZ536688A (en) 2000-11-20 2001-11-20 Piperazinylpyrazine compounds as agonists or antagonists of serotonin 5HT-2 receptors
YU39803A YU39803A (sh) 2000-11-20 2001-11-20 Jedinjenja piperazinilpirazina kao agonisti ili antagonisti serotonin 5ht-2-receptora
AT01996532T ATE470662T1 (de) 2000-11-20 2001-11-20 Piperazinylpyrazinverbindungen als agonisten oder antagonisten am serotonin-5ht-2-rezeptor
DE60142355T DE60142355D1 (de) 2000-11-20 2001-11-20 Piperazinylpyrazinverbindungen als agonisten oder antagonisten am serotonin-5ht-2-rezeptor
IL155702A IL155702A (en) 2000-11-20 2003-05-01 Piprazinylpirazine compounds, pharmaceutical preparations containing them and their uses in the drug drug treatment of serotonin-related medical conditions
ZA200303599A ZA200303599B (en) 2000-11-20 2003-05-09 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5HT-2 receptor.
NO20032252A NO325181B1 (no) 2000-11-20 2003-05-19 Piperazinylpyrazinforbindelser som agonist eller antagonist av serotonin 5HT-2-reseptor
US10/618,868 US7247633B2 (en) 2000-11-20 2003-07-14 Pyrimidine compounds and their use
HK04104869A HK1061855A1 (en) 2000-11-20 2004-07-06 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor
ZA200504675A ZA200504675B (en) 2000-11-20 2005-06-08 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5HT-2 receptor
HK07106358.6A HK1099292A1 (en) 2000-11-20 2007-06-13 Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor
JP2009148822A JP2009280587A (ja) 2000-11-20 2009-06-23 セロトニン５ｈｔ−２レセプターのアゴニストまたはアンタゴニストとしてのピペラジニルピラジン化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0004245A SE0004245D0 (sv) 2000-11-20 2000-11-20 Novel compounds and their use

Publications (1)

Publication Number Publication Date
SE0004245D0 true SE0004245D0 (sv) 2000-11-20

Family

ID=20281886

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0004245A SE0004245D0 (sv) 2000-11-20 2000-11-20 Novel compounds and their use

Country Status (6)

Country Link
US (2) US6593330B2 (zh)
CN (1) CN100451016C (zh)
EA (1) EA006552B1 (zh)
SE (1) SE0004245D0 (zh)
YU (1) YU39803A (zh)
ZA (2) ZA200303599B (zh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
US6989392B2 (en) * 2002-06-18 2006-01-24 Abbott Laboratories 2-Aminoquinolines as melanin concentrating hormone receptor antagonists
CA2493667C (en) * 2002-08-08 2010-04-27 Amgen Inc. Vanilloid receptor ligands and their use in treatments
CA2514656A1 (en) * 2003-01-31 2004-08-12 Pfizer Products Inc. 5ht7 antagonists and inverse agonists
US20080146583A1 (en) * 2003-05-15 2008-06-19 Pfizer Inc Treatment of Incontinence
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
US20040235856A1 (en) * 2003-04-25 2004-11-25 Pfizer Inc Treatment of incontinence
US7795266B2 (en) * 2003-09-25 2010-09-14 Helton David R Tetrahydroindolone derivatives for treament of neurological conditions
MY139645A (en) * 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
CA2556239A1 (en) 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
KR100635053B1 (ko) * 2005-06-21 2006-10-16 도레이새한 주식회사 전자부품용 접착테이프
GT200500317A (es) * 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
WO2006089311A1 (en) * 2005-02-15 2006-08-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
MX2007012082A (es) * 2005-03-31 2007-11-20 Pfizer Prod Inc Derivados de ciclopentapiridina y tetrahidroquinolina.
EP1877400A1 (en) * 2005-04-15 2008-01-16 Amgen, Inc Vanilloid receptor ligands and their use in treatments
AR054849A1 (es) * 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
US20070225279A1 (en) * 2006-03-24 2007-09-27 Wyeth Therapeutic combinations for the treatment of depression
EP1998781A2 (en) * 2006-03-24 2008-12-10 Wyeth a Corporation of the State of Delaware Treatment of pain
CN101506172A (zh) * 2006-07-14 2009-08-12 辉瑞产品公司 （7S）-7-[（5-氟-2-甲基-苄基）氧基]-2-[（2R）-2-甲基哌嗪-1-基]-6，7-二氢-5H-环戊烷并[b]吡啶的酒石酸盐
CL2008002777A1 (es) * 2007-09-21 2010-01-22 Wyeth Corp Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario.
WO2009062134A1 (en) * 2007-11-09 2009-05-14 Cenomed Biosciences, Llc Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperazine compounds
US20090264443A1 (en) * 2008-04-18 2009-10-22 David Helton Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
MY158927A (en) 2008-06-12 2016-11-30 Janssen Pharmaceutica Nv Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine h4 receptor
US20110003796A1 (en) * 2009-07-06 2011-01-06 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet) Method for the treatment of psychic disorders

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3253989A (en) 1963-02-11 1966-05-31 American Cyanamid Co Process for producing anorexia
DE2202385A1 (de) 1972-01-19 1973-07-26 Boehringer Mannheim Gmbh Nitrofuran-derivate
US4081542A (en) 1975-04-21 1978-03-28 Merck & Co., Inc. Piperazinylpyrazines
US4078063A (en) 1976-09-24 1978-03-07 Merck & Co., Inc. Piperazinylpyridines
US4686220A (en) 1985-12-19 1987-08-11 American Cyanamid Company Substituted 2-[b-substituted-amino)-ethylamino]-1,4-naphthalenediones for treating asthma, allergic diseases and inflammation in warm-blooded animals
EP0799617A3 (en) 1986-02-24 1997-11-12 Mitsui Petrochemical Industries, Ltd. Therapeutic agent for neurological diseases
EP0330263A1 (en) 1988-02-25 1989-08-30 Merck & Co. Inc. Piperazinylalkylpyrimidines as hypoglycemic agents
US4954502A (en) 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
ES2061953T3 (es) 1988-11-24 1994-12-16 Akzo Nv Un procedimiento para preparar una composicion farmaceutica.
IE911774A1 (en) 1990-06-11 1991-12-18 Akzo Nv Pyridinylpiperazine derivatives
EP0572863A1 (de) 1992-06-05 1993-12-08 F. Hoffmann-La Roche Ag ZNS Pyrazinoindole
JPH0665203A (ja) 1992-06-25 1994-03-08 Elf Sanofi ピペラジンのヘテロ環誘導体
EP0580465A1 (fr) 1992-06-25 1994-01-26 Sanofi Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
GB9313913D0 (en) 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
TW334423B (en) 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
TW270114B (zh) 1993-10-22 1996-02-11 Hoffmann La Roche
JPH07300474A (ja) 1994-05-02 1995-11-14 Asahi Chem Ind Co Ltd テトラハイドロキノキサリン誘導体およびその用途
KR100232341B1 (ko) 1994-10-13 2000-07-01 디. 제이. 우드 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물
JP3560986B2 (ja) 1997-01-13 2004-09-02 山之内製薬株式会社 ５―ｈｔ２ｃ受容体作用薬及びアミノアルキルインダゾール誘導体
DK0863136T3 (da) 1997-02-25 2004-02-02 Akzo Nobel Nv Azetidin- og pyrrolidinderivater
FR2761071B1 (fr) 1997-03-20 1999-12-03 Synthelabo Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
AU727654B2 (en) 1997-06-13 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Tricyclic pyrazole derivative
GB9718833D0 (en) 1997-09-04 1997-11-12 Merck Sharp & Dohme Therapeutic agents
WO1999058490A2 (en) 1998-05-08 1999-11-18 Akzo Nobel N.V. Novel aryl-hydro naphthalenal kanamines
GB9819032D0 (en) 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds IV
GB9819033D0 (en) 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds VI
GB9819020D0 (en) 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds III
GB9819019D0 (en) 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds II
GB9819035D0 (en) 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
US6673799B1 (en) 1998-09-22 2004-01-06 Yamanouchi Pharmaceutical Co. Ltd. Cyanophenyl derivative
GB9820767D0 (en) 1998-09-23 1998-11-18 Cerebrus Ltd Chemical compounds VIII
EP1140940A1 (en) 1998-12-17 2001-10-10 American Home Products Corporation 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)qinoxalin-5(6h)one derivates being 5ht2c agonists
FR2788772B1 (fr) 1999-01-26 2001-03-02 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2619800A (en) 1999-01-27 2000-08-18 Eli Lilly And Company Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists
GB9902047D0 (en) 1999-01-29 1999-03-17 Cerebrus Ltd Chemical compounds XI
AU772446B2 (en) 1999-02-24 2004-04-29 F. Hoffmann-La Roche Ag 3-phenylpyridine derivatives and their use as NK-1 receptor antagonists
WO2000076984A2 (en) 1999-05-21 2000-12-21 Biovitrum Ab Novel compounds, their use and preparation
DE60014083T2 (de) 1999-06-15 2006-03-02 Bristol-Myers Squibb Pharma Co., Wilmington Substituierte heterocyclylkondensierte gamma carboline
PT1204654E (pt) 1999-07-29 2003-11-28 Lilly Co Eli Benzofurilpiperazinas agonistas do receptor 5-ht2c da serotonina
EP1204658B1 (en) 1999-07-29 2003-05-07 Eli Lilly And Company Benzofurylpiperazine serotonin agonists
EP1204660B1 (en) 1999-07-29 2004-10-20 Eli Lilly And Company Serotonergic benzothiophenes
DK1204659T3 (da) 1999-07-29 2004-04-05 Lilly Co Eli Serotonerge benzofuraner
GB9918962D0 (en) 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxii
GB9918965D0 (en) 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
WO2001077001A2 (en) 2000-04-11 2001-10-18 Sandia Corporation Microelectromechanical apparatus for elevating and tilting a platform

Also Published As

Publication number Publication date
YU39803A (sh) 2006-05-25
CN100451016C (zh) 2009-01-14
ZA200303599B (en) 2005-06-09
US7247633B2 (en) 2007-07-24
US6593330B2 (en) 2003-07-15
US20040014767A1 (en) 2004-01-22
US20020147200A1 (en) 2002-10-10
EA006552B1 (ru) 2006-02-24
EA200300593A1 (ru) 2003-10-30
ZA200504675B (en) 2006-05-31
CN1876648A (zh) 2006-12-13

Similar Documents

Publication Publication Date Title
SE0004245D0 (sv) Novel compounds and their use
ATE270817T1 (de) Fungizide
RS51444B (sr) JEDINJENJA KOJA SADRŽE LAKTAM I NJIHOVI DERIVATI KAO INHIBITORI FAKTORA Xa
DK1377593T3 (da) 2-Amino-propanolderivater
ATE403429T1 (de) Spiropyrazol-verbindungen
PT1109812E (pt) Pirrolobenzodiazepinas
ID29076A (id) Kombinasi senyawa aktif fungisida
GB9929552D0 (en) Compounds
GB0114185D0 (en) Compounds
AU2001266575A1 (en) Chemical compounds
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
SE9903290D0 (sv) Novel compounds
DK1204659T3 (da) Serotonerge benzofuraner
UA83266C2 (en) Oxazole derivatives of tetracyclines
ATE287403T1 (de) 6-phenylbenzonaphthyidine
ATE280169T1 (de) Serotonerge benzothiophene
DE60121048D1 (de) PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
GB0011071D0 (en) Organic compounds
CY1110139T1 (el) Γλυκοπεπτιδικα αντιβιοτικα