SA94150010B1 - طريقة وتركيبات لعلاج الألم باستخدام روبيفاكين ropivacaine - Google Patents
طريقة وتركيبات لعلاج الألم باستخدام روبيفاكين ropivacaine Download PDFInfo
- Publication number
- SA94150010B1 SA94150010B1 SA94150010A SA94150010A SA94150010B1 SA 94150010 B1 SA94150010 B1 SA 94150010B1 SA 94150010 A SA94150010 A SA 94150010A SA 94150010 A SA94150010 A SA 94150010A SA 94150010 B1 SA94150010 B1 SA 94150010B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- ropivacaine
- aforementioned
- present
- formulation
- pain
- Prior art date
Links
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 title claims abstract description 33
- 229960001549 ropivacaine Drugs 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims description 12
- 239000000203 mixture Substances 0.000 title claims description 10
- 208000002193 Pain Diseases 0.000 title claims description 9
- 238000009472 formulation Methods 0.000 title claims 6
- 150000003839 salts Chemical class 0.000 claims abstract description 3
- 238000001802 infusion Methods 0.000 claims description 14
- 229960001813 ropivacaine hydrochloride Drugs 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 10
- 229960003150 bupivacaine Drugs 0.000 description 10
- 230000001953 sensory effect Effects 0.000 description 10
- 239000003589 local anesthetic agent Substances 0.000 description 6
- 238000001356 surgical procedure Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229960005015 local anesthetics Drugs 0.000 description 3
- 230000001144 postural effect Effects 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000003444 anaesthetic effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005470 impregnation Methods 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 210000002414 leg Anatomy 0.000 description 2
- 229960005181 morphine Drugs 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010002942 Apathy Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000001951 dura mater Anatomy 0.000 description 1
- 230000001432 effect on motor function Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003137 locomotive effect Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 229940127240 opiate Drugs 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 229940124583 pain medication Drugs 0.000 description 1
- 229940124641 pain reliever Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- KQTLORDYYALRNH-UHFFFAOYSA-M sodium;hydroxide;dihydrate Chemical compound O.O.[OH-].[Na+] KQTLORDYYALRNH-UHFFFAOYSA-M 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE19939302218A SE9302218D0 (sv) | 1993-06-28 | 1993-06-28 | New use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA94150010B1 true SA94150010B1 (ar) | 2006-04-04 |
Family
ID=20390432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA94150010A SA94150010B1 (ar) | 1993-06-28 | 1994-06-14 | طريقة وتركيبات لعلاج الألم باستخدام روبيفاكين ropivacaine |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US5670524A (zh) |
| EP (1) | EP0706395B1 (zh) |
| JP (1) | JP3725541B2 (zh) |
| CN (1) | CN1074918C (zh) |
| AT (1) | ATE216237T1 (zh) |
| BR (1) | BR9406865A (zh) |
| CA (1) | CA2165446C (zh) |
| CZ (1) | CZ283300B6 (zh) |
| DE (2) | DE69430427T2 (zh) |
| DK (1) | DK0706395T3 (zh) |
| EE (1) | EE03205B1 (zh) |
| ES (1) | ES2099048T3 (zh) |
| FI (1) | FI956269A0 (zh) |
| GR (1) | GR970300013T1 (zh) |
| HK (1) | HK1010344A1 (zh) |
| HU (1) | HU218949B (zh) |
| IL (1) | IL110006A (zh) |
| IS (1) | IS4174A (zh) |
| LT (1) | LT3449B (zh) |
| LV (1) | LV12918B (zh) |
| MY (1) | MY119360A (zh) |
| NO (1) | NO955313L (zh) |
| NZ (1) | NZ268110A (zh) |
| PH (1) | PH31258A (zh) |
| PL (1) | PL175518B1 (zh) |
| PT (1) | PT706395E (zh) |
| RU (1) | RU2152215C1 (zh) |
| SA (1) | SA94150010B1 (zh) |
| SE (1) | SE9302218D0 (zh) |
| SG (1) | SG49078A1 (zh) |
| SK (1) | SK280111B6 (zh) |
| TW (1) | TW285640B (zh) |
| WO (1) | WO1995000148A1 (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9302218D0 (sv) * | 1993-06-28 | 1993-06-28 | Ab Astra | New use |
| BR9802536A (pt) * | 1997-07-21 | 1999-07-20 | Darwin Discovery Ltd | Método para anestesiar um paciente humano antes de cirurgias |
| US20060270708A1 (en) * | 2005-05-25 | 2006-11-30 | Navinta Llc | Novel process for preparation of isotonic aqueous injection of ropivacaine |
| US8920843B2 (en) * | 2007-11-07 | 2014-12-30 | Svip5 Llc | Slow release of organic salts of local anesthetics for pain relief |
| CA2871821C (en) | 2012-05-10 | 2021-01-12 | Painreform Ltd. | Depot formulations of a local anesthetic and methods for preparation thereof |
| JP2016508956A (ja) * | 2012-05-10 | 2016-03-24 | セリックスビオ プライヴェート リミテッド | 局所疼痛の治療のための組成物と治療法 |
| US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
| US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
| EP2961734B1 (en) | 2013-02-28 | 2018-09-26 | Dermira, Inc. | Glycopyrrolate salts |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE40994T1 (de) * | 1983-08-01 | 1989-03-15 | Astra Laekemedel Ab | L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung. |
| SE9302218D0 (sv) * | 1993-06-28 | 1993-06-28 | Ab Astra | New use |
-
1993
- 1993-06-28 SE SE19939302218A patent/SE9302218D0/xx unknown
-
1994
- 1994-05-26 DE DE69430427T patent/DE69430427T2/de not_active Expired - Lifetime
- 1994-05-26 CZ CZ953364A patent/CZ283300B6/cs not_active IP Right Cessation
- 1994-05-26 NZ NZ268110A patent/NZ268110A/xx not_active IP Right Cessation
- 1994-05-26 PT PT94919912T patent/PT706395E/pt unknown
- 1994-05-26 AT AT94919912T patent/ATE216237T1/de not_active IP Right Cessation
- 1994-05-26 SG SG1996005829A patent/SG49078A1/en unknown
- 1994-05-26 DK DK94919912T patent/DK0706395T3/da active
- 1994-05-26 US US08/256,319 patent/US5670524A/en not_active Expired - Lifetime
- 1994-05-26 HU HU9503692A patent/HU218949B/hu not_active IP Right Cessation
- 1994-05-26 PL PL94312198A patent/PL175518B1/pl not_active IP Right Cessation
- 1994-05-26 WO PCT/SE1994/000496 patent/WO1995000148A1/en active IP Right Grant
- 1994-05-26 CA CA002165446A patent/CA2165446C/en not_active Expired - Fee Related
- 1994-05-26 JP JP50268795A patent/JP3725541B2/ja not_active Expired - Fee Related
- 1994-05-26 BR BR9406865A patent/BR9406865A/pt not_active Application Discontinuation
- 1994-05-26 ES ES94919912T patent/ES2099048T3/es not_active Expired - Lifetime
- 1994-05-26 RU RU96101169/14A patent/RU2152215C1/ru not_active IP Right Cessation
- 1994-05-26 DE DE0706395T patent/DE706395T1/de active Pending
- 1994-05-26 CN CN94192664A patent/CN1074918C/zh not_active Expired - Fee Related
- 1994-05-26 SK SK1646-95A patent/SK280111B6/sk not_active IP Right Cessation
- 1994-05-26 EP EP94919912A patent/EP0706395B1/en not_active Expired - Lifetime
- 1994-06-01 TW TW083105008A patent/TW285640B/zh not_active IP Right Cessation
- 1994-06-08 IS IS4174A patent/IS4174A/is unknown
- 1994-06-09 PH PH48413A patent/PH31258A/en unknown
- 1994-06-13 IL IL11000694A patent/IL110006A/en not_active IP Right Cessation
- 1994-06-14 SA SA94150010A patent/SA94150010B1/ar unknown
- 1994-06-17 LT LTIP1958A patent/LT3449B/lt not_active IP Right Cessation
- 1994-06-27 MY MYPI94001663A patent/MY119360A/en unknown
- 1994-11-03 EE EE9400347A patent/EE03205B1/xx not_active IP Right Cessation
-
1995
- 1995-12-27 NO NO955313A patent/NO955313L/no not_active Application Discontinuation
- 1995-12-27 FI FI956269A patent/FI956269A0/fi not_active Application Discontinuation
-
1997
- 1997-05-05 US US08/851,062 patent/US5834489A/en not_active Expired - Lifetime
- 1997-05-30 GR GR970300013T patent/GR970300013T1/el unknown
-
1998
- 1998-10-19 HK HK98111303A patent/HK1010344A1/xx not_active IP Right Cessation
-
2002
- 2002-07-15 LV LVP-02-131A patent/LV12918B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Stenseth et al. | Epidural morphine for postoperative pain: experience with 1085 patients | |
| Glynn et al. | Role of spinal noradrenergic system in transmission of pain in patients with spinal cord injury | |
| Klamt et al. | Postoperative analgesic effect of intrathecal neostigmine and its influence on spinal anaesthesia | |
| Johnson | Continuous femoral nerve blockade for analgesia in children with femoral fractures | |
| Khan et al. | Comparison of intrathecal fentanyl and buprenorphine in urological surgery | |
| SA94150010B1 (ar) | طريقة وتركيبات لعلاج الألم باستخدام روبيفاكين ropivacaine | |
| Miller et al. | Fentanyl and diazepam for analgesia and sedation during radiologic special procedures. | |
| PL190896B1 (pl) | Zastosowanie lewobupiwakainy w chirurgii dziecięcej | |
| Celleno et al. | Epidural analgesia during and after cesarean delivery. Comparison of five opioids | |
| Malamed | What's new in local anesthesia? | |
| Ivani et al. | A long‐term continuous infusion via a sciatic catheter in a 3‐year‐old boy | |
| JP2620642B2 (ja) | 麻薬性鎮痛剤とベンゾジアゼピンとを組み合わせて非経口投与した後に観察される平均血圧の低下を拮抗させるための医薬品 | |
| Stoelting | Analgesic action of pentazocine compared with morphine in postoperative pain | |
| Briggs et al. | Morphine: continuous intravenous infusion versus intramuscular injections for postoperative pain relief | |
| JP2001510794A (ja) | レボブピバカインとその使用 | |
| Pitkänen et al. | Comparison of metoclopramide and ondansetron for the prevention of nausea and vomiting after intrathecal morphine | |
| AU692161C (en) | Use of ropivacaine in the manufacture of a pharmaceutical with analgetic effect with minimal motor blockade | |
| Katzen et al. | Nitrous-oxide analgesia for interventional radiologic procedures | |
| Alkattan et al. | Analgesia and anesthesia with epidural Xylazine/Ketamine in donkeys | |
| Slade | Epidural bupivacaine for aortic surgery The effect of dilution on the quality of analgesia | |
| WANGEMAN | Methohexital sodium | |
| Zamir et al. | Comparison of Conventional and Lateral Approach to Supraclavicular Brachial Block. | |
| Bosch et al. | Analgesia after total hip replacement: epidural versus psoas compartment block | |
| Wirinaree Kampitak et al. | Does Adductor Canal Block Have a Synergistic Effect with Local Infiltration Analgesia for Enhancing Ambulation and Improving Analgesia after Total Knee Arthroplasty? | |
| CN109350736A (zh) | 防治运动病、梅尼埃病的药物及心房钠尿肽的医药用途 |