SA522441031B1 - تعديل إنزيم ومسار بمركبات سلفهيدرايل ومشتقاتها - Google Patents

تعديل إنزيم ومسار بمركبات سلفهيدرايل ومشتقاتها

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Publication number
SA522441031B1
SA522441031B1 SA522441031A SA522441031A SA522441031B1 SA 522441031 B1 SA522441031 B1 SA 522441031B1 SA 522441031 A SA522441031 A SA 522441031A SA 522441031 A SA522441031 A SA 522441031A SA 522441031 B1 SA522441031 B1 SA 522441031B1
Authority
SA
Saudi Arabia
Prior art keywords
relates
proteins
antibodies
pathway
enzyme
Prior art date
Application number
SA522441031A
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Arabic (ar)
English (en)
Inventor
زهيكسين شاو،
Original Assignee
اف . هوفمان – لا روش ايه جى،
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by اف . هوفمان – لا روش ايه جى، filed Critical اف . هوفمان – لا روش ايه جى،
Publication of SA522441031B1 publication Critical patent/SA522441031B1/ar

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
SA522441031A 2020-04-24 2022-10-24 تعديل إنزيم ومسار بمركبات سلفهيدرايل ومشتقاتها SA522441031B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20171356 2020-04-24
PCT/EP2021/060637 WO2021214277A1 (en) 2020-04-24 2021-04-23 Enzyme and pathway modulation with sulfhydryl compounds and their derivatives

Publications (1)

Publication Number Publication Date
SA522441031B1 true SA522441031B1 (ar) 2025-05-15

Family

ID=70464886

Family Applications (1)

Application Number Title Priority Date Filing Date
SA522441031A SA522441031B1 (ar) 2020-04-24 2022-10-24 تعديل إنزيم ومسار بمركبات سلفهيدرايل ومشتقاتها

Country Status (18)

Country Link
US (2) US20230265204A1 (https=)
EP (2) EP4139349A1 (https=)
JP (3) JP2023522417A (https=)
KR (1) KR20230005172A (https=)
CN (1) CN115427443A (https=)
AR (1) AR121918A1 (https=)
AU (1) AU2021258475A1 (https=)
BR (1) BR112022021203A2 (https=)
CA (1) CA3178472A1 (https=)
CL (2) CL2022002885A1 (https=)
CR (2) CR20220531A (https=)
IL (1) IL296664A (https=)
MX (1) MX2022013173A (https=)
PE (1) PE20230078A1 (https=)
SA (1) SA522441031B1 (https=)
TW (2) TWI908792B (https=)
WO (1) WO2021214277A1 (https=)
ZA (1) ZA202210643B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3

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Also Published As

Publication number Publication date
WO2021214277A1 (en) 2021-10-28
MX2022013173A (es) 2022-11-30
JP2025157400A (ja) 2025-10-15
JP2023522417A (ja) 2023-05-30
KR20230005172A (ko) 2023-01-09
IL296664A (en) 2022-11-01
TW202547878A (zh) 2025-12-16
EP4400515A2 (en) 2024-07-17
CR20250142A (es) 2025-10-30
AR121918A1 (es) 2022-07-20
CL2025000038A1 (es) 2025-05-23
ZA202210643B (en) 2023-06-28
US20250353922A1 (en) 2025-11-20
US20230265204A1 (en) 2023-08-24
EP4139349A1 (en) 2023-03-01
CL2022002885A1 (es) 2023-06-16
EP4400515A3 (en) 2024-10-23
AU2021258475A1 (en) 2022-10-20
BR112022021203A2 (pt) 2022-12-06
CR20220531A (es) 2022-11-28
CA3178472A1 (en) 2021-10-28
JP2025072512A (ja) 2025-05-09
CN115427443A (zh) 2022-12-02
TW202206459A (zh) 2022-02-16
PE20230078A1 (es) 2023-01-11
TWI908792B (zh) 2025-12-21

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