JP2023522417A - スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節 - Google Patents

スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節 Download PDF

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JP2023522417A
JP2023522417A JP2022564304A JP2022564304A JP2023522417A JP 2023522417 A JP2023522417 A JP 2023522417A JP 2022564304 A JP2022564304 A JP 2022564304A JP 2022564304 A JP2022564304 A JP 2022564304A JP 2023522417 A JP2023522417 A JP 2023522417A
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seq
antibody
cells
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JPWO2021214277A5 (https=
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シャオ，ジーシン
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F Hoffmann La Roche AG
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Publication of JPWO2021214277A5 publication Critical patent/JPWO2021214277A5/ja
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Priority to JP2025119872A priority patent/JP2025157400A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
JP2022564304A 2020-04-24 2021-04-23 スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節 Pending JP2023522417A (ja)

Priority Applications (2)

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JP2025017484A JP2025072512A (ja) 2020-04-24 2025-02-05 スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節
JP2025119872A JP2025157400A (ja) 2020-04-24 2025-07-16 スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節

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EP20171356 2020-04-24
EP20171356.7 2020-04-24
PCT/EP2021/060637 WO2021214277A1 (en) 2020-04-24 2021-04-23 Enzyme and pathway modulation with sulfhydryl compounds and their derivatives

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JP2025017484A Division JP2025072512A (ja) 2020-04-24 2025-02-05 スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節
JP2025119872A Division JP2025157400A (ja) 2020-04-24 2025-07-16 スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節

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JP2023522417A true JP2023522417A (ja) 2023-05-30
JP2023522417A5 JP2023522417A5 (https=) 2023-12-07
JPWO2021214277A5 JPWO2021214277A5 (https=) 2023-12-07

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JP2025017484A Pending JP2025072512A (ja) 2020-04-24 2025-02-05 スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節
JP2025119872A Pending JP2025157400A (ja) 2020-04-24 2025-07-16 スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節

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JP2025119872A Pending JP2025157400A (ja) 2020-04-24 2025-07-16 スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節

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US (2) US20230265204A1 (https=)
EP (2) EP4139349A1 (https=)
JP (3) JP2023522417A (https=)
KR (1) KR20230005172A (https=)
CN (1) CN115427443A (https=)
AR (1) AR121918A1 (https=)
AU (1) AU2021258475A1 (https=)
BR (1) BR112022021203A2 (https=)
CA (1) CA3178472A1 (https=)
CL (2) CL2022002885A1 (https=)
CR (2) CR20220531A (https=)
IL (1) IL296664A (https=)
MX (1) MX2022013173A (https=)
PE (1) PE20230078A1 (https=)
SA (1) SA522441031B1 (https=)
TW (2) TWI908792B (https=)
WO (1) WO2021214277A1 (https=)
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AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3

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SA522441031B1 (ar) 2025-05-15
WO2021214277A1 (en) 2021-10-28
MX2022013173A (es) 2022-11-30
JP2025157400A (ja) 2025-10-15
KR20230005172A (ko) 2023-01-09
IL296664A (en) 2022-11-01
TW202547878A (zh) 2025-12-16
EP4400515A2 (en) 2024-07-17
CR20250142A (es) 2025-10-30
AR121918A1 (es) 2022-07-20
CL2025000038A1 (es) 2025-05-23
ZA202210643B (en) 2023-06-28
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