SA519410905B1 - مضاعفة إرسال كاشف مستشعر نشط باستخدام إضاءة مهيكلة - Google Patents

مضاعفة إرسال كاشف مستشعر نشط باستخدام إضاءة مهيكلة

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Publication number
SA519410905B1
SA519410905B1 SA519410905A SA519410905A SA519410905B1 SA 519410905 B1 SA519410905 B1 SA 519410905B1 SA 519410905 A SA519410905 A SA 519410905A SA 519410905 A SA519410905 A SA 519410905A SA 519410905 B1 SA519410905 B1 SA 519410905B1
Authority
SA
Saudi Arabia
Prior art keywords
pixel
image sensor
structured illumination
sensor
multiplexing
Prior art date
Application number
SA519410905A
Other languages
English (en)
Inventor
توماس باكير
Original Assignee
.الومينا، إنك
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2019/012404 external-priority patent/WO2019136290A1/en
Application filed by .الومينا، إنك filed Critical .الومينا، إنك
Publication of SA519410905B1 publication Critical patent/SA519410905B1/ar

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/082—Condensers for incident illumination only
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/361—Optical details, e.g. image relay to the camera or image sensor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/42—Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect
    • G02B27/4233—Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect having a diffractive element [DOE] contributing to a non-imaging application
    • G02B27/425—Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect having a diffractive element [DOE] contributing to a non-imaging application in illumination systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0635—Structured illumination, e.g. with grating
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/18—Diffraction gratings
    • G02B5/1866—Transmission gratings characterised by their structure, e.g. step profile, contours of substrate or grooves, pitch variations, materials

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

يتعلق الاختراع الحالي بتوفير نظام تصوير imaging system بالإضاءة المهيكلة structured illumination يستخدم مستشعر صور image sensor (على سبيل المثال، مستشعرًا نشط البيكسلات active pixel sensor) في مستوى نشط لعينة مقولبة patterned sample لزيادة دقة الصورة. يمكن قولبة العينة المصورة و/ أو محاذاتها على مستشعر صور بحيث يكون لكل مستشعر ضوء light sensor (على سبيل المثال، بيكسل pixel) في مستشعر الصور مجموعة مقابلة من السمات المكوَّنة و/ أو المركبة عليه. استجابة للإضاءة، يمكن أن تصدر كل من السمات ضوءًا متألقًا فلوريًا fluorescent light يتم تجميعه بواسطة بيكسل مستشعر الصور. أثناء التصوير، يمكن مضاعفة كل بيكسل في مستشعر الصور مكانيًا باستخدام إضاءة مهيكلة بحيث تتم إضاءة مجموعة فرعية فقط (على سبيل المثال، واحدة أو اثنتين) من سمات المحاذاة على البيكسل بالضوء المهيكل أثناء قراءة صورة. شكل2
SA519410905A 2018-01-08 2019-12-25 مضاعفة إرسال كاشف مستشعر نشط باستخدام إضاءة مهيكلة SA519410905B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862614690P 2018-01-08 2018-01-08
NL2020621A NL2020621B1 (en) 2018-01-08 2018-03-20 Multiplexing of an active sensor detector using structured illumination
PCT/US2019/012404 WO2019136290A1 (en) 2018-01-08 2019-01-04 Multiplexing of an active sensor detector using structured illumination

Publications (1)

Publication Number Publication Date
SA519410905B1 true SA519410905B1 (ar) 2022-09-21

Family

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SA519410905A SA519410905B1 (ar) 2018-01-08 2019-12-25 مضاعفة إرسال كاشف مستشعر نشط باستخدام إضاءة مهيكلة

Country Status (15)

Country Link
US (1) US20190212266A1 (ar)
EP (1) EP3628074A4 (ar)
JP (1) JP7026147B2 (ar)
KR (1) KR102296574B1 (ar)
CN (2) CN209589844U (ar)
AU (1) AU2019205317B2 (ar)
BR (1) BR112019028057A2 (ar)
CA (1) CA3066484C (ar)
IL (1) IL271087A (ar)
MX (1) MX2019014281A (ar)
MY (1) MY201492A (ar)
NL (1) NL2020621B1 (ar)
RU (1) RU2738756C1 (ar)
SA (1) SA519410905B1 (ar)
TW (2) TWI703717B (ar)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201911764VA (en) 2018-01-08 2020-01-30 Illumina Inc High-throughput sequencing with semiconductor-based detection
EP3850336A4 (en) 2018-09-14 2022-02-09 Illumina, Inc. FLOW CELLS AND ASSOCIATED METHODS
US11105745B2 (en) * 2019-10-10 2021-08-31 Visera Technologies Company Limited Biosensor
US11297289B2 (en) * 2019-12-26 2022-04-05 Himax Technologies Limited Structured light projector
US11060138B1 (en) 2020-01-17 2021-07-13 Element Biosciences, Inc. Nucleic acid sequencing systems
US11284045B2 (en) * 2020-04-22 2022-03-22 OmniVision Technologies. Inc. Image sensor with shifted color filter array pattern and bit line pairs
CN112730354B (zh) * 2020-12-14 2022-11-01 南方科技大学 一种结构光成像方法、成像图及在生化检测中的应用
KR20230149293A (ko) * 2021-03-03 2023-10-26 일루미나, 인코포레이티드 픽셀당 다수의 반응 부위를 갖는 센서
KR102320174B1 (ko) * 2021-03-18 2021-11-02 주식회사 하이브비젼 프린지 메트릭 방법을 이용한 표면 검사 시스템
TWI821935B (zh) * 2021-10-14 2023-11-11 大陸商廣州印芯半導體技術有限公司 生物檢測裝置及包含該裝置的生物檢測系統

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9906929D0 (en) 1999-03-26 1999-05-19 Univ Glasgow Assay system
US7151246B2 (en) * 2001-07-06 2006-12-19 Palantyr Research, Llc Imaging system and methodology
JP2005055219A (ja) 2003-08-07 2005-03-03 Juki Corp マイクロプレートリーダ
JP2007199397A (ja) 2006-01-26 2007-08-09 Nikon Corp 顕微鏡装置
FR2908888B1 (fr) 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
EP2093601B1 (en) 2006-12-12 2013-03-13 Nikon Corporation Microscope device and image processing method
EP2150806A4 (en) * 2007-05-10 2013-01-02 Pacific Biosciences California METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIAL WITH LIMITED AUTOFLUORESCENCE
US8045181B2 (en) * 2009-05-21 2011-10-25 General Electric Company Inspection system and method with multi-image phase shift analysis
US8416400B2 (en) * 2009-06-03 2013-04-09 California Institute Of Technology Wavefront imaging sensor
DE102010062341B4 (de) 2010-12-02 2023-05-17 Carl Zeiss Microscopy Gmbh Vorrichtung zur Erhöhung der Tiefendiskriminierung optisch abbildender Systeme
WO2012118436A1 (en) 2011-03-01 2012-09-07 Applied Precision, Inc. Systems and methods for illumination phase control in fluorescence microscopy
WO2012119094A2 (en) * 2011-03-03 2012-09-07 California Institute Of Technology Light guided pixel
KR101252938B1 (ko) * 2011-04-08 2013-04-12 한국과학기술원 초고해상도 현미경 시스템 및 그 시스템을 이용한 영상 획득 방법
US9285303B2 (en) * 2011-09-06 2016-03-15 Koninklijke Philips N.V. Optical biosensor with a plurality of sensor regions and a detector having a detector plane wherein at least one primary image is mapped onto the whole detector plane
EP2806262A4 (en) * 2012-01-18 2015-09-23 Nikon Corp STRUCTURED LIGHTING DEVICE, LIGHTED MICROSCOPE STRUCTURED DEVICE, AND STRUCTURED LIGHTING METHOD
JP5426751B2 (ja) * 2012-12-28 2014-02-26 未来工業株式会社 配線・配管材支持具
EP2801854B1 (en) * 2013-05-10 2017-07-19 Ruprecht-Karls-Universität Heidelberg Method and apparatus for combination of localization microscopy and structured illumination microscopy
CN110411998B (zh) * 2013-12-10 2022-06-07 伊鲁米那股份有限公司 用于生物或化学分析的生物传感器及其制造方法
WO2015167492A1 (en) * 2014-04-30 2015-11-05 Hewlett-Packard Development Company, L.P. Imaging appratus and methods using diffraction-based illumination
KR20180019500A (ko) * 2015-04-22 2018-02-26 선전 제노리비전 테크놀로지 컴퍼니, 리미티드 생물감지기
CN105043300A (zh) * 2015-05-27 2015-11-11 东莞市盟拓光电科技有限公司 可从多方位对被测物同时投影的三维测量系统
EP4224219A3 (en) * 2016-04-22 2023-08-30 Illumina Inc Photonic stucture-based devices and compositions for use in luminescent imaging of multiple sites within a pixel, and methods of using the same
DE102016007839A1 (de) * 2016-06-28 2017-12-28 Horst Wochnowski Hochauflösendes Verfahren zur Mikroskopie und Nanostrukturierung von Substratoberflächen basierend auf dem SIM-Verfahren (Structured Illumination Microscopy)
CN106770147B (zh) * 2017-03-15 2019-07-19 北京大学 一种结构光照明超分辨显微成像方法

Also Published As

Publication number Publication date
TW201931585A (zh) 2019-08-01
EP3628074A1 (en) 2020-04-01
NZ759669A (en) 2022-03-25
NL2020621B1 (en) 2019-07-15
JP2020531887A (ja) 2020-11-05
KR20200021473A (ko) 2020-02-28
CN110018140A (zh) 2019-07-16
CN209589844U (zh) 2019-11-05
US20190212266A1 (en) 2019-07-11
CN110018140B (zh) 2022-03-22
TWI703717B (zh) 2020-09-01
TWI772850B (zh) 2022-08-01
TW202101753A (zh) 2021-01-01
JP7026147B2 (ja) 2022-02-25
AU2019205317A1 (en) 2019-12-19
MX2019014281A (es) 2021-01-08
IL271087A (en) 2020-01-30
MY201492A (en) 2024-02-27
CA3066484C (en) 2023-02-28
EP3628074A4 (en) 2020-07-22
CA3066484A1 (en) 2019-07-11
KR102296574B1 (ko) 2021-09-01
BR112019028057A2 (pt) 2020-09-01
AU2019205317B2 (en) 2021-04-29
RU2738756C1 (ru) 2020-12-16

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