SA518400501B1 - مركبات [8- (فنيل سلفونيل)-3، 8-ديازا ثنائي سيكلو [3. 2. 1] أوكتـ-3-يل] ميثانون (1h-1، 2، 3-تريازول-4-يل) - Google Patents
مركبات [8- (فنيل سلفونيل)-3، 8-ديازا ثنائي سيكلو [3. 2. 1] أوكتـ-3-يل] ميثانون (1h-1، 2، 3-تريازول-4-يل)Info
- Publication number
- SA518400501B1 SA518400501B1 SA518400501A SA518400501A SA518400501B1 SA 518400501 B1 SA518400501 B1 SA 518400501B1 SA 518400501 A SA518400501 A SA 518400501A SA 518400501 A SA518400501 A SA 518400501A SA 518400501 B1 SA518400501 B1 SA 518400501B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- compounds
- disorders
- phenylsulfonyl
- triazol
- diazabicyclo
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
يتعلق الاختراع الحالي بـمركبات [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanone بالصيغة العامة (I): حيث يكون كل من R1, R2, R3, R4 و R5 كما عرف هنا، وطرق لتحضير المركبات المذكورة، ومركبات وسيطة مفيدة لتحضير المركبات المذكورة، تراكيب صيدلية وتوليفات تشمل المركبات المذكورة واستخدام المركبات المذكورة لتصنيع التراكيب الصيدلية للمعالجة أو الوقاية من اضطرابات، تحديدا اضطرابات خاصة بأمراض النساء، اضطرابات فرط التكاثر، اضطرابات أيضية، أو اضطرابات التهابية في صورة عامل منفرد أو في توليفة مع مكونات فعالة أخرى.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16171538 | 2016-05-26 | ||
| EP16178891 | 2016-07-11 | ||
| PCT/EP2017/062359 WO2017202817A1 (en) | 2016-05-26 | 2017-05-23 | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl] (1h-1,2,3-triazol-4-yl)methanones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA518400501B1 true SA518400501B1 (ar) | 2022-01-16 |
Family
ID=58765840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA518400501A SA518400501B1 (ar) | 2016-05-26 | 2018-11-25 | مركبات [8- (فنيل سلفونيل)-3، 8-ديازا ثنائي سيكلو [3. 2. 1] أوكتـ-3-يل] ميثانون (1h-1، 2، 3-تريازول-4-يل) |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US10167293B2 (ar) |
| EP (1) | EP3464288B1 (ar) |
| JP (1) | JP6918020B2 (ar) |
| KR (2) | KR102509150B1 (ar) |
| CN (4) | CN114702503B (ar) |
| AU (1) | AU2017269871B2 (ar) |
| BR (1) | BR112018074381B1 (ar) |
| CA (1) | CA3025420A1 (ar) |
| CY (1) | CY1123955T1 (ar) |
| DK (1) | DK3464288T3 (ar) |
| ES (1) | ES2856964T3 (ar) |
| HR (1) | HRP20210424T1 (ar) |
| HU (1) | HUE053438T2 (ar) |
| IL (1) | IL262982B (ar) |
| LT (1) | LT3464288T (ar) |
| MX (1) | MX2018014541A (ar) |
| PE (1) | PE20190204A1 (ar) |
| PL (1) | PL3464288T3 (ar) |
| RS (1) | RS61520B1 (ar) |
| SA (1) | SA518400501B1 (ar) |
| SG (1) | SG11201809469QA (ar) |
| SI (1) | SI3464288T1 (ar) |
| TW (1) | TWI738782B (ar) |
| UY (1) | UY37262A (ar) |
| WO (1) | WO2017202817A1 (ar) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201825478A (zh) * | 2016-12-19 | 2018-07-16 | 德商拜耳製藥公司 | ［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮 |
| JP7178075B2 (ja) * | 2018-03-22 | 2022-11-25 | 株式会社ユニバーサルコーポレーション | Ａｋｒ１ｃ３選択的阻害剤及びその用途 |
| CN110183455B (zh) * | 2019-06-18 | 2021-04-20 | 中国医科大学 | 氮杂双环[3.2.1]辛-3-酮类化合物及其制备方法与其用途 |
| WO2021000862A1 (zh) | 2019-07-01 | 2021-01-07 | 深圳艾欣达伟医药科技有限公司 | Akr1c3抑制剂及医药用途 |
| UY38806A (es) * | 2019-08-01 | 2021-02-26 | Novartis Ag | Compuestos inhibidores tricíclicos de kars dependientes de akr1c3, composiciones y sus usos |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429104A (zh) | 1998-03-11 | 2003-07-09 | 内部研究股份有限公司 | 5型和3型17β－羟基类固醇脱氢酶的抑制剂及其用法 |
| EP1990335A4 (en) * | 2006-03-02 | 2009-11-11 | Astellas Pharma Inc | 17-BETA-HSD-type-5 INHIBITOR |
| WO2007103456A2 (en) | 2006-03-06 | 2007-09-13 | Trimeris, Inc. | Piperazine and piperidine biaryl derivatives |
| MX2008012064A (es) | 2006-03-23 | 2008-12-17 | Amgen Inc | Compuestos de amida 1-fenilsulfonil-diaza-heterociclica y sus usos como moduladores de hidroxiesteroide deshidrogenadas. |
| EP2010180A4 (en) * | 2006-04-21 | 2010-10-13 | Glaxosmithkline Llc | IL-8 RECEPTOR ANTAGONISTS |
| MX2009000513A (es) * | 2006-07-14 | 2009-03-09 | Genelabs Tech Inc | Agentes antivirales. |
| US20090247499A1 (en) | 2006-08-21 | 2009-10-01 | Fletcher Joan M | Sulfonylated piperazines as cannabinoid-1 receptor modulators |
| SG178795A1 (en) * | 2007-02-16 | 2012-03-29 | Pacific Arrow Ltd | Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof |
| US20110065916A1 (en) * | 2007-11-26 | 2011-03-17 | Mark Spyvee | Method of making imidazoazepinone compounds |
| JP5578498B2 (ja) * | 2009-11-10 | 2014-08-27 | 国立大学法人 千葉大学 | 抗癌剤キット及び抗癌剤効果増強剤 |
| DE102011083725A1 (de) | 2011-09-29 | 2013-04-04 | Bayer Pharma AG | Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| EP3078374B1 (en) | 2011-10-17 | 2019-06-19 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
| WO2013142390A1 (en) | 2012-03-21 | 2013-09-26 | Gtx, Inc. | Aldo-keto reductase subfamily 1c3 (akr1c3) inhibitors |
| AU2013289344A1 (en) | 2012-07-10 | 2015-02-05 | Bayer Pharma Aktiengesellschaft | 3-substituted estra-1,3,5(10),16-tetraene derivatives, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments |
| US9890147B2 (en) * | 2012-08-16 | 2018-02-13 | Bayer Pharma Aktiengesellshaft | 2,3-benzodiazepines |
| WO2014039820A1 (en) | 2012-09-07 | 2014-03-13 | Gtx, Inc. | Aldo-keto reductase subfamily 1c3 (akr1c3) inhibitors |
| US9714266B2 (en) | 2013-02-21 | 2017-07-25 | Bayer Pharma Aktiengesellschaft | Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1C3) |
| JP2015020966A (ja) * | 2013-07-18 | 2015-02-02 | 岐阜市 | Ａｋｒ１ｃ３阻害剤 |
| CA2960630A1 (en) * | 2014-09-11 | 2016-03-17 | Bayer Pharma Aktiengesellschaft | 3-nitrogen or sulphur substituted oestra-1,3,5(10),16-tetraene akr1c3 inhibitors |
-
2017
- 2017-05-16 US US15/596,383 patent/US10167293B2/en active Active
- 2017-05-22 TW TW106116812A patent/TWI738782B/zh active
- 2017-05-23 EP EP17725242.6A patent/EP3464288B1/en active Active
- 2017-05-23 CN CN202210300836.8A patent/CN114702503B/zh active Active
- 2017-05-23 ES ES17725242T patent/ES2856964T3/es active Active
- 2017-05-23 SG SG11201809469QA patent/SG11201809469QA/en unknown
- 2017-05-23 CA CA3025420A patent/CA3025420A1/en active Pending
- 2017-05-23 PE PE2018003113A patent/PE20190204A1/es unknown
- 2017-05-23 JP JP2018561608A patent/JP6918020B2/ja active Active
- 2017-05-23 SI SI201730609T patent/SI3464288T1/sl unknown
- 2017-05-23 PL PL17725242T patent/PL3464288T3/pl unknown
- 2017-05-23 DK DK17725242.6T patent/DK3464288T3/da active
- 2017-05-23 RS RS20210281A patent/RS61520B1/sr unknown
- 2017-05-23 AU AU2017269871A patent/AU2017269871B2/en active Active
- 2017-05-23 KR KR1020227007577A patent/KR102509150B1/ko active IP Right Grant
- 2017-05-23 KR KR1020187035345A patent/KR102373202B1/ko active IP Right Grant
- 2017-05-23 WO PCT/EP2017/062359 patent/WO2017202817A1/en unknown
- 2017-05-23 CN CN202210300841.9A patent/CN114699414A/zh active Pending
- 2017-05-23 BR BR112018074381-0A patent/BR112018074381B1/pt active IP Right Grant
- 2017-05-23 HU HUE17725242A patent/HUE053438T2/hu unknown
- 2017-05-23 CN CN201780032131.XA patent/CN109311898B/zh active Active
- 2017-05-23 MX MX2018014541A patent/MX2018014541A/es unknown
- 2017-05-23 LT LTEP17725242.6T patent/LT3464288T/lt unknown
- 2017-05-23 CN CN202210300824.5A patent/CN114699413A/zh active Pending
- 2017-05-26 UY UY0001037262A patent/UY37262A/es not_active Application Discontinuation
-
2018
- 2018-11-13 IL IL262982A patent/IL262982B/en unknown
- 2018-11-25 SA SA518400501A patent/SA518400501B1/ar unknown
-
2021
- 2021-03-11 CY CY20211100212T patent/CY1123955T1/el unknown
- 2021-03-12 HR HRP20210424TT patent/HRP20210424T1/hr unknown
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