SA518391121B1 - 18f مثبطات موسومة بواسطة (psma) في مستضد الغشاء الخاص بالبروستاتا واستخدامها كعوامل تصوير تشخيصي لحالات سرطان البروستاتا - Google Patents
18f مثبطات موسومة بواسطة (psma) في مستضد الغشاء الخاص بالبروستاتا واستخدامها كعوامل تصوير تشخيصي لحالات سرطان البروستاتاInfo
- Publication number
- SA518391121B1 SA518391121B1 SA518391121A SA518391121A SA518391121B1 SA 518391121 B1 SA518391121 B1 SA 518391121B1 SA 518391121 A SA518391121 A SA 518391121A SA 518391121 A SA518391121 A SA 518391121A SA 518391121 B1 SA518391121 B1 SA 518391121B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- imaging agents
- psma
- prostate cancer
- prostate
- specific membrane
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
مثبطات موسومة بواسطة 18F في مستضد الغشاء الخاص بالبروستاتا (PSMA) واستخدامها كعوامل تصوير تشخيصي لحالات سرطان البروستاتا 18F-TAGGED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) AND THEIR USE AS IMAGING AGENTS FOR PROSTATE CANCER الملخـــص يتعلق الاختراع الحالي بوجه عام بمجال الأدوية المشعة (radiopharmaceuticals) وباستخدامها في الطب النووي nuclear medicine كمتتبعات tracers وعوامل تصوير تشخيصي imaging agents لحالات مرضية متنوعة various disease states من سرطان البروستاتا (prostate cancer). شكل.1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15002800 | 2015-09-30 | ||
| EP16164090 | 2016-04-06 | ||
| EP16182764 | 2016-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA518391121B1 true SA518391121B1 (ar) | 2021-05-30 |
Family
ID=57121178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA518391121A SA518391121B1 (ar) | 2015-09-30 | 2018-03-15 | 18f مثبطات موسومة بواسطة (psma) في مستضد الغشاء الخاص بالبروستاتا واستخدامها كعوامل تصوير تشخيصي لحالات سرطان البروستاتا |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US10815200B2 (ar) |
| EP (2) | EP3805250A1 (ar) |
| JP (1) | JP6824971B2 (ar) |
| KR (1) | KR102233726B1 (ar) |
| CN (1) | CN108026144B (ar) |
| AU (1) | AU2016333334B2 (ar) |
| BR (1) | BR112018005899A2 (ar) |
| CA (1) | CA2996330A1 (ar) |
| CL (1) | CL2018000604A1 (ar) |
| CO (1) | CO2018003726A2 (ar) |
| CU (1) | CU24524B1 (ar) |
| CY (1) | CY1123790T1 (ar) |
| DK (1) | DK3356385T3 (ar) |
| EA (1) | EA037512B1 (ar) |
| ES (1) | ES2844586T3 (ar) |
| GE (1) | GEP20207106B (ar) |
| HR (1) | HRP20210183T1 (ar) |
| HU (1) | HUE053064T2 (ar) |
| IL (1) | IL258378B (ar) |
| LT (1) | LT3356385T (ar) |
| MX (1) | MX2018004050A (ar) |
| MY (1) | MY197061A (ar) |
| NZ (1) | NZ739770A (ar) |
| PE (1) | PE20181350A1 (ar) |
| PH (1) | PH12018500701A1 (ar) |
| PL (1) | PL3356385T3 (ar) |
| RS (1) | RS61394B1 (ar) |
| SA (1) | SA518391121B1 (ar) |
| SI (1) | SI3356385T1 (ar) |
| TN (1) | TN2018000089A1 (ar) |
| WO (1) | WO2017054907A1 (ar) |
| ZA (1) | ZA201801024B (ar) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7231536B2 (ja) | 2016-08-10 | 2023-03-01 | キャンサー ターゲテッド テクノロジー エルエルシー | キレート化されたｐｓｍａ阻害剤 |
| DE102016122273B4 (de) | 2016-11-18 | 2018-06-21 | Abx Advanced Biochemical Compounds Gmbh | Präkursoren für die Radiofluorierung |
| EP3544960A1 (en) * | 2016-11-23 | 2019-10-02 | Cancer Targeted Technology LLC | Albumin-binding psma inhibitors |
| CN110272468B (zh) * | 2019-05-14 | 2020-12-08 | 上海益泰医药科技有限公司 | 一种前列腺特异性膜抗原小分子抑制剂及其放射性核素配合物的制备及应用 |
| CN111253465A (zh) * | 2020-03-03 | 2020-06-09 | 复旦大学附属肿瘤医院 | 一种psma结合剂及其用途 |
| AU2022216463A1 (en) | 2021-02-08 | 2023-08-17 | Stichting Radboud Universitair Medisch Centrum | Psma-targeting ligands for multimodal applications |
| JPWO2023008556A1 (ar) * | 2021-07-30 | 2023-02-02 | ||
| WO2023030434A1 (zh) * | 2021-09-01 | 2023-03-09 | 天津恒瑞医药有限公司 | 前列腺特异性膜抗原的抑制剂及其医药用途 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60020962T2 (de) | 1999-04-28 | 2006-05-24 | Georgetown University | Liganden für metabotropische Glutamat-Rezeptoren |
| WO2003000201A2 (en) | 2001-06-25 | 2003-01-03 | Drug Innovation & Design, Incorporated | Exponential pattern recognition based cellular targeting, compositions, methods and anticancer applications |
| SI1472541T1 (sl) | 2002-01-10 | 2010-12-31 | Univ Johns Hopkins | Prikazovalni agensi in postopek prikazovanja naaladase ali psma |
| WO2006093991A1 (en) | 2005-03-02 | 2006-09-08 | The Cleveland Clinic Foundation | Compounds which bind psma and uses thereof |
| EP2087337A4 (en) | 2006-11-03 | 2010-09-08 | Purdue Research Foundation | METHOD AND DEVICE FOR EX-VIVO FLOW CYTOMETRY |
| PL3699162T3 (pl) | 2006-11-08 | 2022-10-31 | Molecular Insight Pharmaceuticals, Inc. | Heterodimery kwasu glutaminowego |
| EP2117604B1 (en) | 2007-01-11 | 2017-07-26 | Immunomedics, Inc. | Methods and compositions for improved f-18 labeling of proteins, peptides and other molecules |
| EP2136788B1 (en) | 2007-03-30 | 2011-10-26 | Bind Biosciences, Inc. | Cancer cell targeting using nanoparticles |
| EP3466928A1 (en) | 2007-06-26 | 2019-04-10 | The Johns Hopkins University | Labeled inhibitors of prostate-specific membrane antigen (psma), biological evaluation, and use as imaging agents |
| EP3656403B1 (en) * | 2007-08-17 | 2022-05-11 | Purdue Research Foundation | Preparation process of psma binding ligand-linker conjugates |
| WO2009070302A1 (en) | 2007-11-30 | 2009-06-04 | The Johns Hopkins University | Prostate specific membrane antigen (psma) targeted nanoparticles for therapy of prostate cancer |
| RU2498798C2 (ru) | 2008-01-09 | 2013-11-20 | Моликьюлар Инсайт Фармасьютикалз, Инк. | Ингибиторы карбоангидразы iх |
| EP4089074A1 (en) | 2008-08-01 | 2022-11-16 | The Johns Hopkins University | Psma-binding agents and uses thereof |
| BRPI0922779A8 (pt) | 2008-12-05 | 2018-06-19 | Molecular Insight Pharm Inc | complexos de tecnécio e rênio-bis(heteroarila) e métodos de uso dos mesmos para inibir psma |
| WO2010065899A2 (en) | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
| WO2010108125A2 (en) | 2009-03-19 | 2010-09-23 | The Johns Hopkins University | Psma-targeting compounds and uses thereof |
| GB0905438D0 (en) | 2009-03-30 | 2009-05-13 | Ge Healthcare Ltd | Radiolabelling reagents and methods |
| EP2338892A1 (en) * | 2009-12-18 | 2011-06-29 | Bayer Schering Pharma Aktiengesellschaft | Prostate specific membrane antigen inhibitors |
| GB201020314D0 (en) | 2010-12-01 | 2011-01-12 | Ge Healthcare Ltd | Apoptosis pet imaging agents |
| ES2675320T3 (es) | 2010-12-06 | 2018-07-10 | Molecular Insight Pharmaceuticals, Inc. | Dendrímeros dirigidos a PSMA |
| US20140308363A1 (en) | 2011-05-31 | 2014-10-16 | Bind Therapeutics, Inc. | Drug loaded polymeric nanoparticles and methods of making and using same |
| US8926944B2 (en) | 2011-08-05 | 2015-01-06 | Molecular Insight Pharmaceuticals | Radiolabeled prostate specific membrane antigen inhibitors |
| US10011632B2 (en) * | 2011-08-22 | 2018-07-03 | Siemens Medical Solutions Usa, Inc. | PSMA imaging agents |
| JP6118914B2 (ja) | 2012-12-28 | 2017-04-19 | ターベダ セラピューティクス インコーポレイテッドＴａｒｖｅｄａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 放出制御型の固体ポリマーナノ粒子 |
| WO2014127365A1 (en) | 2013-02-15 | 2014-08-21 | Case Western Reserve University | Psma ligands and uses thereof |
| WO2015004029A1 (en) | 2013-07-08 | 2015-01-15 | Technische Universität München | 18f-labeling of aromatic and heteroaromatic molecules with unprotected carboxylic acid groups |
| US10406246B2 (en) | 2013-10-17 | 2019-09-10 | Deutsches Kresbsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| WO2015057250A1 (en) | 2013-10-18 | 2015-04-23 | Psma Development Company, Llc | Combination therapies with psma ligand conjugates |
| GEP20237496B (en) * | 2013-10-18 | 2023-04-10 | Deutsches Krebsforsch | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| WO2015073678A1 (en) | 2013-11-14 | 2015-05-21 | Endocyte, Inc. | Compounds for positron emission tomography |
| WO2015143029A1 (en) | 2014-03-18 | 2015-09-24 | The Johns Hopkins University | Psma-based molecular-genetic reporter system |
| JP6749249B2 (ja) | 2014-05-06 | 2020-09-02 | ザ ジョンズ ホプキンズ ユニヴァーシティー | Ｐｓｍａを標的としたイメージング及び放射線治療のための金属／放射性金属標識ｐｓｍａ阻害剤 |
| EP3183236B1 (en) | 2014-08-24 | 2022-04-20 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften | Method for the production of 18f-labeled active esters and their application exemplified by the preparation of a psma-specific pet-tracer |
| US9956305B2 (en) | 2014-09-08 | 2018-05-01 | Molecular Insight Pharmaceuticals, Inc. | Organ protection in PSMA-targeted radionuclide therapy of prostate cancer |
| WO2016062370A1 (en) | 2014-10-20 | 2016-04-28 | Deutsches Krebsforschungszentrum | 18f-tagged inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EP3011976A1 (en) | 2014-10-20 | 2016-04-27 | Deutsches Krebsforschungszentrum | 18F-tagged inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents |
| WO2016065145A2 (en) | 2014-10-22 | 2016-04-28 | The Johns Hopkins University | Psma targeted reversed carbamates and methods of use thereof |
-
2016
- 2016-09-19 BR BR112018005899-8A patent/BR112018005899A2/pt active Search and Examination
- 2016-09-19 RS RS20210120A patent/RS61394B1/sr unknown
- 2016-09-19 HU HUE16778680A patent/HUE053064T2/hu unknown
- 2016-09-19 CN CN201680054882.7A patent/CN108026144B/zh active Active
- 2016-09-19 EP EP20206516.5A patent/EP3805250A1/en active Pending
- 2016-09-19 CA CA2996330A patent/CA2996330A1/en active Pending
- 2016-09-19 JP JP2018516512A patent/JP6824971B2/ja active Active
- 2016-09-19 WO PCT/EP2016/001573 patent/WO2017054907A1/en active Application Filing
- 2016-09-19 PE PE2018000482A patent/PE20181350A1/es unknown
- 2016-09-19 CU CU2018000030A patent/CU24524B1/es unknown
- 2016-09-19 AU AU2016333334A patent/AU2016333334B2/en active Active
- 2016-09-19 GE GEAP201614748A patent/GEP20207106B/en unknown
- 2016-09-19 EP EP16778680.5A patent/EP3356385B1/en active Active
- 2016-09-19 ES ES16778680T patent/ES2844586T3/es active Active
- 2016-09-19 NZ NZ739770A patent/NZ739770A/en unknown
- 2016-09-19 LT LTEP16778680.5T patent/LT3356385T/lt unknown
- 2016-09-19 DK DK16778680.5T patent/DK3356385T3/da active
- 2016-09-19 MX MX2018004050A patent/MX2018004050A/es unknown
- 2016-09-19 KR KR1020187012228A patent/KR102233726B1/ko active IP Right Grant
- 2016-09-19 MY MYPI2018700586A patent/MY197061A/en unknown
- 2016-09-19 PL PL16778680T patent/PL3356385T3/pl unknown
- 2016-09-19 EA EA201890282A patent/EA037512B1/ru unknown
- 2016-09-19 SI SI201631064T patent/SI3356385T1/sl unknown
- 2016-09-19 TN TNP/2018/000089A patent/TN2018000089A1/en unknown
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2018
- 2018-02-14 ZA ZA2018/01024A patent/ZA201801024B/en unknown
- 2018-03-08 US US15/915,978 patent/US10815200B2/en active Active
- 2018-03-08 CL CL2018000604A patent/CL2018000604A1/es unknown
- 2018-03-15 SA SA518391121A patent/SA518391121B1/ar unknown
- 2018-03-26 IL IL258378A patent/IL258378B/en active IP Right Grant
- 2018-03-28 PH PH12018500701A patent/PH12018500701A1/en unknown
- 2018-04-06 CO CONC2018/0003726A patent/CO2018003726A2/es unknown
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2020
- 2020-10-23 US US17/079,013 patent/US20210053922A1/en not_active Abandoned
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2021
- 2021-02-01 CY CY20211100081T patent/CY1123790T1/el unknown
- 2021-02-02 HR HRP20210183TT patent/HRP20210183T1/hr unknown
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2023
- 2023-03-17 US US18/186,043 patent/US20230295092A1/en active Pending
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