DK3356385T3 - 18f-taggede inhibitorer af prostataspecifik membranantigen (psma) og deres anvendelse til billededannelsesforbindelser til prostatakræft - Google Patents
18f-taggede inhibitorer af prostataspecifik membranantigen (psma) og deres anvendelse til billededannelsesforbindelser til prostatakræft Download PDFInfo
- Publication number
- DK3356385T3 DK3356385T3 DK16778680.5T DK16778680T DK3356385T3 DK 3356385 T3 DK3356385 T3 DK 3356385T3 DK 16778680 T DK16778680 T DK 16778680T DK 3356385 T3 DK3356385 T3 DK 3356385T3
- Authority
- DK
- Denmark
- Prior art keywords
- prostate
- taged
- psma
- imagination
- inhibitors
- Prior art date
Links
- 0 CCC1C(CC(*C2)*C2=C(C)C=*(C)CC)*1 Chemical compound CCC1C(CC(*C2)*C2=C(C)C=*(C)CC)*1 0.000 description 3
- OYDJFSZPTZNANQ-UHFFFAOYSA-N CC1CC#CC1 Chemical compound CC1CC#CC1 OYDJFSZPTZNANQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15002800 | 2015-09-30 | ||
| EP16164090 | 2016-04-06 | ||
| EP16182764 | 2016-08-04 | ||
| PCT/EP2016/001573 WO2017054907A1 (en) | 2015-09-30 | 2016-09-19 | 18f-tagged inhibitors of prostate specific membrane antigen (psma) and their use as imaging agents for prostate cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3356385T3 true DK3356385T3 (da) | 2021-02-15 |
Family
ID=57121178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16778680.5T DK3356385T3 (da) | 2015-09-30 | 2016-09-19 | 18f-taggede inhibitorer af prostataspecifik membranantigen (psma) og deres anvendelse til billededannelsesforbindelser til prostatakræft |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US10815200B2 (da) |
| EP (2) | EP3805250A1 (da) |
| JP (1) | JP6824971B2 (da) |
| KR (1) | KR102233726B1 (da) |
| CN (1) | CN108026144B (da) |
| AU (1) | AU2016333334B2 (da) |
| BR (1) | BR112018005899A2 (da) |
| CA (1) | CA2996330A1 (da) |
| CL (1) | CL2018000604A1 (da) |
| CO (1) | CO2018003726A2 (da) |
| CU (1) | CU24524B1 (da) |
| CY (1) | CY1123790T1 (da) |
| DK (1) | DK3356385T3 (da) |
| EA (1) | EA037512B1 (da) |
| ES (1) | ES2844586T3 (da) |
| GE (1) | GEP20207106B (da) |
| HR (1) | HRP20210183T1 (da) |
| HU (1) | HUE053064T2 (da) |
| IL (1) | IL258378B (da) |
| LT (1) | LT3356385T (da) |
| MX (1) | MX2018004050A (da) |
| MY (1) | MY197061A (da) |
| NZ (1) | NZ739770A (da) |
| PE (1) | PE20181350A1 (da) |
| PH (1) | PH12018500701A1 (da) |
| PL (1) | PL3356385T3 (da) |
| RS (1) | RS61394B1 (da) |
| SA (1) | SA518391121B1 (da) |
| SI (1) | SI3356385T1 (da) |
| TN (1) | TN2018000089A1 (da) |
| WO (1) | WO2017054907A1 (da) |
| ZA (1) | ZA201801024B (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017311510B2 (en) | 2016-08-10 | 2021-11-18 | Cancer Targeted Technology Llc | Chelated PSMA inhibitors |
| DE102016122273B4 (de) * | 2016-11-18 | 2018-06-21 | Abx Advanced Biochemical Compounds Gmbh | Präkursoren für die Radiofluorierung |
| CA3043619A1 (en) * | 2016-11-23 | 2018-05-31 | Cancer Targeted Technology Llc | Albumin-binding psma inhibitors |
| CN110272468B (zh) * | 2019-05-14 | 2020-12-08 | 上海益泰医药科技有限公司 | 一种前列腺特异性膜抗原小分子抑制剂及其放射性核素配合物的制备及应用 |
| CN111253465A (zh) * | 2020-03-03 | 2020-06-09 | 复旦大学附属肿瘤医院 | 一种psma结合剂及其用途 |
| WO2022167681A1 (en) | 2021-02-08 | 2022-08-11 | Stichting Radboud Universitair Medisch Centrum | Psma-targeting ligands for multimodal applications |
| WO2023008556A1 (ja) * | 2021-07-30 | 2023-02-02 | 国立大学法人大阪大学 | 放射標識された化合物およびその用途 |
| TW202313000A (zh) * | 2021-09-01 | 2023-04-01 | 大陸商天津恆瑞醫藥有限公司 | 前列腺特異性膜抗原的抑制劑及其醫藥用途 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5095050B2 (ja) | 1999-04-28 | 2012-12-12 | ジョージタウン ユニバーシティー | 代謝調節型グルタミン酸受容体のリガンド、及び、ＮＡＡＬＡＤａｓｅの阻害剤 |
| CA2451188A1 (en) | 2001-06-25 | 2003-01-03 | Drug Innovation & Design, Incorporated | Exponential pattern recognition based cellular targeting, compositions, methods and anticancer applications |
| DK1472541T3 (da) | 2002-01-10 | 2010-01-25 | Univ Johns Hopkins | Afbildningsmidler og metoder til at afbilde NAALADase og PSMA |
| WO2006093991A1 (en) | 2005-03-02 | 2006-09-08 | The Cleveland Clinic Foundation | Compounds which bind psma and uses thereof |
| JP2010509570A (ja) | 2006-11-03 | 2010-03-25 | パーデュー・リサーチ・ファウンデーション | エクスビボフローサイトメトリーの方法および装置 |
| SI2097111T1 (sl) | 2006-11-08 | 2016-02-29 | Molecular Insight Pharmaceuticals, Inc. | Heterodimeri glutaminske kisline |
| CA2675202C (en) | 2007-01-11 | 2014-09-16 | Immunomedics, Inc. | Methods and compositions for improved f-18 labeling of proteins, peptides and other molecules |
| JP5680409B2 (ja) | 2007-06-26 | 2015-03-04 | ザ ジョンズ ホプキンス ユニバーシティ | 前立腺特異膜抗原（ｐｓｍａ）の標識阻害剤、生物学的評価およびイメージング剤としての使用 |
| AU2008289108C1 (en) * | 2007-08-17 | 2024-05-23 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| SI2644192T1 (sl) | 2007-09-28 | 2017-08-31 | Pfizer Inc. | Ciljanje rakavih celic z uporabo nanodelcev |
| WO2009070302A1 (en) | 2007-11-30 | 2009-06-04 | The Johns Hopkins University | Prostate specific membrane antigen (psma) targeted nanoparticles for therapy of prostate cancer |
| CN102083427B (zh) | 2008-01-09 | 2014-12-10 | 分子洞察制药公司 | 碳酸酐酶ix的抑制剂 |
| RU2494096C2 (ru) | 2008-08-01 | 2013-09-27 | Дзе Джонс Хопкинс Юниверсити | Агенты, связывающиеся с psma, и их применение |
| EP2706057B1 (en) | 2008-12-05 | 2016-04-20 | Molecular Insight Pharmaceuticals, Inc. | Bis(imidazolyl)compounds and radionuclide complexes |
| TW201034691A (en) * | 2008-12-05 | 2010-10-01 | Molecular Insight Pharm Inc | Technetium-and rhenium-bis(heteroaryl) complexes and methods of use thereof |
| EP3964502A1 (en) | 2009-03-19 | 2022-03-09 | The Johns Hopkins University | Psma-targeting compounds and uses thereof |
| GB0905438D0 (en) | 2009-03-30 | 2009-05-13 | Ge Healthcare Ltd | Radiolabelling reagents and methods |
| EP2338892A1 (en) * | 2009-12-18 | 2011-06-29 | Bayer Schering Pharma Aktiengesellschaft | Prostate specific membrane antigen inhibitors |
| GB201020314D0 (en) | 2010-12-01 | 2011-01-12 | Ge Healthcare Ltd | Apoptosis pet imaging agents |
| JP6275484B2 (ja) | 2010-12-06 | 2018-02-07 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | Ｐｓｍａ標的化デンドリマー |
| WO2012166923A2 (en) | 2011-05-31 | 2012-12-06 | Bind Biosciences | Drug loaded polymeric nanoparticles and methods of making and using same |
| JP5843338B2 (ja) | 2011-08-05 | 2016-01-13 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | 放射標識された前立腺特異的膜抗原阻害剤 |
| WO2013028664A1 (en) * | 2011-08-22 | 2013-02-28 | Siemens Medical Solutions Usa, Inc. | Psma imaging agents |
| AU2013369982B2 (en) | 2012-12-28 | 2016-11-17 | Tva (Abc), Llc | Targeted conjugates encapsulated in particles and formulations thereof |
| WO2014127365A1 (en) | 2013-02-15 | 2014-08-21 | Case Western Reserve University | Psma ligands and uses thereof |
| WO2015004029A1 (en) | 2013-07-08 | 2015-01-15 | Technische Universität München | 18f-labeling of aromatic and heteroaromatic molecules with unprotected carboxylic acid groups |
| US10406246B2 (en) | 2013-10-17 | 2019-09-10 | Deutsches Kresbsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| WO2015057250A1 (en) | 2013-10-18 | 2015-04-23 | Psma Development Company, Llc | Combination therapies with psma ligand conjugates |
| EP3415489A1 (en) * | 2013-10-18 | 2018-12-19 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| CA2930581A1 (en) | 2013-11-14 | 2015-05-21 | Endocyte, Inc. | Compounds for positron emission tomography |
| WO2015143029A1 (en) | 2014-03-18 | 2015-09-24 | The Johns Hopkins University | Psma-based molecular-genetic reporter system |
| AU2015256002B2 (en) | 2014-05-06 | 2020-01-02 | Northwestern University | Metal/radiometal-labeled PSMA inhibitors for PSMA-targeted imaging and radiotherapy |
| WO2016030329A1 (en) | 2014-08-24 | 2016-03-03 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for the production of 18f-labeled active esters and their application exemplified by the preparation of a psma-specific pet-tracer |
| US9956305B2 (en) | 2014-09-08 | 2018-05-01 | Molecular Insight Pharmaceuticals, Inc. | Organ protection in PSMA-targeted radionuclide therapy of prostate cancer |
| EP3011976A1 (en) | 2014-10-20 | 2016-04-27 | Deutsches Krebsforschungszentrum | 18F-tagged inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents |
| WO2016062370A1 (en) * | 2014-10-20 | 2016-04-28 | Deutsches Krebsforschungszentrum | 18f-tagged inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| US10736974B2 (en) | 2014-10-22 | 2020-08-11 | The Johns Hopkins University | Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy |
-
2016
- 2016-09-19 WO PCT/EP2016/001573 patent/WO2017054907A1/en active Application Filing
- 2016-09-19 TN TNP/2018/000089A patent/TN2018000089A1/en unknown
- 2016-09-19 CU CU2018000030A patent/CU24524B1/es unknown
- 2016-09-19 ES ES16778680T patent/ES2844586T3/es active Active
- 2016-09-19 KR KR1020187012228A patent/KR102233726B1/ko active IP Right Grant
- 2016-09-19 AU AU2016333334A patent/AU2016333334B2/en active Active
- 2016-09-19 BR BR112018005899-8A patent/BR112018005899A2/pt active Search and Examination
- 2016-09-19 CN CN201680054882.7A patent/CN108026144B/zh active Active
- 2016-09-19 GE GEAP201614748A patent/GEP20207106B/en unknown
- 2016-09-19 MY MYPI2018700586A patent/MY197061A/en unknown
- 2016-09-19 EA EA201890282A patent/EA037512B1/ru unknown
- 2016-09-19 SI SI201631064T patent/SI3356385T1/sl unknown
- 2016-09-19 PE PE2018000482A patent/PE20181350A1/es unknown
- 2016-09-19 MX MX2018004050A patent/MX2018004050A/es unknown
- 2016-09-19 DK DK16778680.5T patent/DK3356385T3/da active
- 2016-09-19 CA CA2996330A patent/CA2996330A1/en active Pending
- 2016-09-19 EP EP20206516.5A patent/EP3805250A1/en active Pending
- 2016-09-19 LT LTEP16778680.5T patent/LT3356385T/lt unknown
- 2016-09-19 NZ NZ739770A patent/NZ739770A/en unknown
- 2016-09-19 PL PL16778680T patent/PL3356385T3/pl unknown
- 2016-09-19 JP JP2018516512A patent/JP6824971B2/ja active Active
- 2016-09-19 RS RS20210120A patent/RS61394B1/sr unknown
- 2016-09-19 HU HUE16778680A patent/HUE053064T2/hu unknown
- 2016-09-19 EP EP16778680.5A patent/EP3356385B1/en active Active
-
2018
- 2018-02-14 ZA ZA2018/01024A patent/ZA201801024B/en unknown
- 2018-03-08 US US15/915,978 patent/US10815200B2/en active Active
- 2018-03-08 CL CL2018000604A patent/CL2018000604A1/es unknown
- 2018-03-15 SA SA518391121A patent/SA518391121B1/ar unknown
- 2018-03-26 IL IL258378A patent/IL258378B/en active IP Right Grant
- 2018-03-28 PH PH12018500701A patent/PH12018500701A1/en unknown
- 2018-04-06 CO CONC2018/0003726A patent/CO2018003726A2/es unknown
-
2020
- 2020-10-23 US US17/079,013 patent/US20210053922A1/en not_active Abandoned
-
2021
- 2021-02-01 CY CY20211100081T patent/CY1123790T1/el unknown
- 2021-02-02 HR HRP20210183TT patent/HRP20210183T1/hr unknown
-
2023
- 2023-03-17 US US18/186,043 patent/US20230295092A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3397968T3 (da) | Inhibitorer af urea-baseret prostata-specifikt membranantigen (PSMA) til billeddannelse og terapi | |
| DK3925952T3 (da) | Prostataspecifik membranantigen-målrettede højaffinitetsmidler til endoradioterapi af prostatacancer / Prostate-Specific Membrane Antigen Targeted High-Affinity Agents For Endoradiotherapy Of Prostate Cancer | |
| DK3356385T3 (da) | 18f-taggede inhibitorer af prostataspecifik membranantigen (psma) og deres anvendelse til billededannelsesforbindelser til prostatakræft | |
| DK4095130T3 (da) | Mærkede hæmmere af prostataspecifikt membranantigen (psma), deres anvendelse som billeddannelsesmidler og farmaceutiske midler til behandling af prostatacancer | |
| DK3534899T3 (da) | Forbindelser og fremgangsmåder til modulering af interleukin-2-inducerbar t-cellekinase | |
| DK3558997T3 (da) | Aminotriazolopyridinforbindelser og deres anvendelse til behandling af cancer | |
| DK3678668T3 (da) | ENPP1-inhibitorer og deres anvendelse til behandling af kræft | |
| DK3331900T3 (da) | Peptider og kombination af peptider til anvendelse ved immunterapi mod prostatacancer og andre cancere | |
| DK3782639T3 (da) | Sammensætninger og fremgangsmåder til internalisering af enzymer | |
| DK3317284T3 (da) | Benzoxazepin-oxazolidinonforbindelser og fremgangsmåder til anvendelse | |
| DK3280441T3 (da) | Anti-sortilin-antistoffer og fremgangsmåder til anvendelse deraf | |
| DK3295951T3 (da) | Anti-pvrig-antistoffer og fremgangsmåder for anvendelse | |
| DK3285809T3 (da) | Inhibitorer af immunkontrolpunktsmodulatorer til anvendelse i behandling af kræft og infektioner. | |
| DK3152956T4 (da) | Systemer og metoder til kommunikation | |
| DK3215532T3 (da) | Anti-TIM3-antistoffer og fremgangsmåder til anvendelse | |
| DK3557998T3 (da) | Sammensætninger, kompositioner og anvendelsesmetoder | |
| DK3234184T3 (da) | Fremgangsmåder til detektering af cpg-methylering og til diagnosticering af cancer | |
| DK3250610T3 (da) | Fcrn-antistoffer og fremgangsmåder til anvendelse heraf | |
| DK3350201T3 (da) | Manipulerede fytaser og fremgangsmåder til anvendelse af samme | |
| DK3317394T3 (da) | Anordning til opformering af mikrovæv | |
| DK3452485T3 (da) | Arginasehæmmere og deres terapeutiske anvendelser | |
| DK3394065T3 (da) | Tetrahydropyranyl-amino-pyrrolopyrimidinon og fremgangsmåder til anvendelse deraf | |
| DK3177608T3 (da) | Proteinkinase-C-hæmmere og fremgangsmåder til anvendelse deraf | |
| DK3102184T3 (da) | Stabile formuleringer af peptider og fremgangsmåder til fremstilling | |
| DK3200815T3 (da) | Fremgangsmåder og sammensætninger til behandling af cancer |