SA516370523B1 - مركبات نشطة علاجيًا وطرق استخدامها - Google Patents

مركبات نشطة علاجيًا وطرق استخدامها Download PDF

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Publication number
SA516370523B1
SA516370523B1 SA516370523A SA516370523A SA516370523B1 SA 516370523 B1 SA516370523 B1 SA 516370523B1 SA 516370523 A SA516370523 A SA 516370523A SA 516370523 A SA516370523 A SA 516370523A SA 516370523 B1 SA516370523 B1 SA 516370523B1
Authority
SA
Saudi Arabia
Prior art keywords
compound
diffraction pattern
amino
treatment
trifluoromethyl
Prior art date
Application number
SA516370523A
Other languages
Arabic (ar)
English (en)
Inventor
وانج جيانمينج
شينكين ديفيد
تانج زهين
في. اجريستا سامويل
جو شونج-هوي
جوو ليتينج
يانج هوا
زهوو يان
زهانج يانفينج
Original Assignee
اجيوس فارماسوتيكالز، انك.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2013/081170 external-priority patent/WO2015018060A1/en
Application filed by اجيوس فارماسوتيكالز، انك. filed Critical اجيوس فارماسوتيكالز، انك.
Publication of SA516370523B1 publication Critical patent/SA516370523B1/ar

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
SA516370523A 2013-08-02 2016-02-01 مركبات نشطة علاجيًا وطرق استخدامها SA516370523B1 (ar)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361861884P 2013-08-02 2013-08-02
PCT/CN2013/081170 WO2015018060A1 (en) 2013-08-09 2013-08-09 Crystalline forms of therapeutically active compounds and use thereof
US201461939098P 2014-02-12 2014-02-12
US201461975448P 2014-04-04 2014-04-04
US201462011948P 2014-06-13 2014-06-13
PCT/US2014/049469 WO2015017821A2 (en) 2013-08-02 2014-08-01 Therapeutically active compounds and their methods of use

Publications (1)

Publication Number Publication Date
SA516370523B1 true SA516370523B1 (ar) 2019-01-10

Family

ID=52432592

Family Applications (1)

Application Number Title Priority Date Filing Date
SA516370523A SA516370523B1 (ar) 2013-08-02 2016-02-01 مركبات نشطة علاجيًا وطرق استخدامها

Country Status (21)

Country Link
US (5) US9738625B2 (enExample)
EP (3) EP3932408A1 (enExample)
JP (3) JP6742905B2 (enExample)
CN (3) CN110386922A (enExample)
AU (2) AU2014295938B2 (enExample)
BR (1) BR112016002287A2 (enExample)
CA (1) CA2919382A1 (enExample)
CL (2) CL2016000263A1 (enExample)
EA (1) EA030428B1 (enExample)
ES (1) ES2886211T3 (enExample)
IL (2) IL243833A0 (enExample)
MX (2) MX389250B (enExample)
MY (1) MY177994A (enExample)
NI (1) NI201600022A (enExample)
PE (1) PE20160840A1 (enExample)
PH (1) PH12016500164B1 (enExample)
SA (1) SA516370523B1 (enExample)
SG (2) SG11201600479WA (enExample)
TW (2) TWI666208B (enExample)
UA (1) UA121021C2 (enExample)
WO (1) WO2015017821A2 (enExample)

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US9694013B2 (en) 2014-09-29 2017-07-04 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
CN107531675A (zh) 2015-02-04 2018-01-02 安吉奥斯医药品有限公司 治疗活性化合物及其使用方法
CN107922354B (zh) * 2015-05-07 2021-05-25 苏州韬略生物科技有限公司 作为idh2抑制剂的杂环化合物
ES2881695T3 (es) * 2015-07-30 2021-11-30 Chia Tai Tianqing Pharmaceutical Group Co Ltd Derivado de 1,3,5-triazina y método de uso del mismo
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EP3362070B1 (en) * 2015-10-15 2021-01-27 Celgene Corporation Combination of a mutant isocitrate dehydrogenase 2 inhibitor with azacitidine and its use for treating acute myelogenous leukemia
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WO2017069878A1 (en) * 2015-10-21 2017-04-27 NeuForm Pharmaceuticals, Inc. Deuterated compounds for treating hematologic malignancies, and compositions and methods thereof
EP3383400B1 (en) * 2015-12-04 2022-01-05 Les Laboratoires Servier Methods of treatment of malignancies
WO2017140758A1 (en) 2016-02-19 2017-08-24 Debiopharm International S.A. Derivatives of 2-amino-4-(2-oxazolidinon-3-yl)-pyrimidine fused with a five-membered heteroaromatic ring in 5,6-position which are useful for the treatment of various cancers
MX390396B (es) 2016-02-26 2025-03-20 Celgene Corp Enasidenib para usarse en leucemia mieloide aguda recidivante o refractaria.
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JP7093764B2 (ja) * 2016-08-03 2022-06-30 セルジーン コーポレイション 骨髄異形成症候群の治療方法
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CN113549056A (zh) * 2017-01-22 2021-10-26 正大天晴药业集团股份有限公司 1,3,5-三嗪衍生物的盐及其晶体、它们的制备方法、药物组合物和用途
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PL3644999T3 (pl) 2017-06-30 2023-05-08 Celgene Corporation Kompozycje i sposoby zastosowania 2-(4-chlorofenylo)-n-((2-(2,6-dioksopiperydyn-3-ylo)-1-oksoizoindolin-5-ylo)metylo)-2,2-difluoroacetamidu
CN109467538A (zh) 2017-09-07 2019-03-15 和记黄埔医药(上海)有限公司 环烯烃取代的杂芳环类化合物及其用途
WO2020092915A1 (en) 2018-11-02 2020-05-07 Celgene Corporation Solid dispersions for treatment of cancer
WO2020092906A1 (en) 2018-11-02 2020-05-07 Celgene Corporation Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof
US12215094B2 (en) * 2018-11-02 2025-02-04 Celgene Corporation Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol
CN115243690A (zh) 2019-11-14 2022-10-25 新基公司 用于治疗癌症的儿科制剂
CN114773320A (zh) * 2022-05-29 2022-07-22 重庆医科大学 1,3,5-三嗪化合物及其制备方法和用途

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US9694013B2 (en) 2014-09-29 2017-07-04 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
CN107531675A (zh) 2015-02-04 2018-01-02 安吉奥斯医药品有限公司 治疗活性化合物及其使用方法

Also Published As

Publication number Publication date
ES2886211T3 (es) 2021-12-16
AU2014295938B2 (en) 2018-07-19
TW201932455A (zh) 2019-08-16
EA030428B1 (ru) 2018-08-31
CN110372670A (zh) 2019-10-25
AU2014295938A1 (en) 2016-02-18
CA2919382A1 (en) 2015-02-05
CL2016000263A1 (es) 2016-08-19
MY177994A (en) 2020-09-28
WO2015017821A2 (en) 2015-02-05
EP3932408A1 (en) 2022-01-05
IL243833A0 (en) 2016-04-21
NI201600022A (es) 2016-03-16
JP2016527279A (ja) 2016-09-08
NZ716226A (en) 2021-08-27
JP2019142930A (ja) 2019-08-29
EA201690322A1 (ru) 2016-07-29
IL270347B (en) 2021-08-31
EP3566706A1 (en) 2019-11-13
UA121021C2 (uk) 2020-03-25
MX389250B (es) 2025-03-20
MX2016001361A (es) 2016-06-14
CN105916507A (zh) 2016-08-31
AU2018247242A1 (en) 2018-11-01
MX2020011397A (es) 2022-08-05
US20210155603A1 (en) 2021-05-27
JP6742905B2 (ja) 2020-08-19
JP2021176893A (ja) 2021-11-11
US20160194305A1 (en) 2016-07-07
PH12016500164A1 (en) 2016-04-25
WO2015017821A3 (en) 2015-04-09
CL2017002240A1 (es) 2018-04-20
SG11201600479WA (en) 2016-02-26
EP3566706B1 (en) 2021-07-14
US10093654B2 (en) 2018-10-09
CN110372670B (zh) 2023-04-07
BR112016002287A2 (pt) 2017-08-01
PE20160840A1 (es) 2016-09-22
TWI666208B (zh) 2019-07-21
MX394658B (es) 2025-03-24
EP3027193A2 (en) 2016-06-08
TW201524971A (zh) 2015-07-01
US20240132474A1 (en) 2024-04-25
EP3027193A4 (en) 2017-04-26
SG10201709187TA (en) 2017-12-28
CN110386922A (zh) 2019-10-29
US20180370951A1 (en) 2018-12-27
TWI701242B (zh) 2020-08-11
US10730854B2 (en) 2020-08-04
AU2018247242B2 (en) 2020-03-12
PH12016500164B1 (en) 2023-11-08
US9738625B2 (en) 2017-08-22
US20170305885A1 (en) 2017-10-26

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