UA121021C2 - Терапевтично активні сполуки і способи їх застосування - Google Patents

Терапевтично активні сполуки і способи їх застосування Download PDF

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Publication number
UA121021C2
UA121021C2 UAA201601999A UAA201601999A UA121021C2 UA 121021 C2 UA121021 C2 UA 121021C2 UA A201601999 A UAA201601999 A UA A201601999A UA A201601999 A UAA201601999 A UA A201601999A UA 121021 C2 UA121021 C2 UA 121021C2
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UA
Ukraine
Prior art keywords
compound
dose
profile
temperature
treatment
Prior art date
Application number
UAA201601999A
Other languages
English (en)
Ukrainian (uk)
Inventor
Семюел В. Агреста
Чун-Хой ГУ
Девід Шенкейн
Девид Шенкейн
Хуа ЯН
Літін Го
Литин Го
Чжень Тан
Цзяньмін Ван
Цзяньмин Ван
Яньфен Чжан
Янь ЧЖОУ
Original Assignee
Аджіос Фармасьютікалз, Інк.
Аджиос Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2013/081170 external-priority patent/WO2015018060A1/en
Application filed by Аджіос Фармасьютікалз, Інк., Аджиос Фармасьютикалз, Инк. filed Critical Аджіос Фармасьютікалз, Інк.
Publication of UA121021C2 publication Critical patent/UA121021C2/uk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
UAA201601999A 2013-08-02 2014-08-01 Терапевтично активні сполуки і способи їх застосування UA121021C2 (uk)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361861884P 2013-08-02 2013-08-02
PCT/CN2013/081170 WO2015018060A1 (en) 2013-08-09 2013-08-09 Crystalline forms of therapeutically active compounds and use thereof
US201461939098P 2014-02-12 2014-02-12
US201461975448P 2014-04-04 2014-04-04
US201462011948P 2014-06-13 2014-06-13
PCT/US2014/049469 WO2015017821A2 (en) 2013-08-02 2014-08-01 Therapeutically active compounds and their methods of use

Publications (1)

Publication Number Publication Date
UA121021C2 true UA121021C2 (uk) 2020-03-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201601999A UA121021C2 (uk) 2013-08-02 2014-08-01 Терапевтично активні сполуки і способи їх застосування

Country Status (21)

Country Link
US (5) US9738625B2 (enExample)
EP (3) EP3566706B1 (enExample)
JP (3) JP6742905B2 (enExample)
CN (3) CN110386922A (enExample)
AU (2) AU2014295938B2 (enExample)
BR (1) BR112016002287A2 (enExample)
CA (1) CA2919382A1 (enExample)
CL (2) CL2016000263A1 (enExample)
EA (1) EA030428B1 (enExample)
ES (1) ES2886211T3 (enExample)
IL (2) IL243833A0 (enExample)
MX (2) MX394658B (enExample)
MY (1) MY177994A (enExample)
NI (1) NI201600022A (enExample)
PE (1) PE20160840A1 (enExample)
PH (1) PH12016500164B1 (enExample)
SA (1) SA516370523B1 (enExample)
SG (2) SG10201709187TA (enExample)
TW (2) TWI701242B (enExample)
UA (1) UA121021C2 (enExample)
WO (1) WO2015017821A2 (enExample)

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EP3200800A1 (en) 2014-09-29 2017-08-09 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
CA2975506A1 (en) 2015-02-04 2016-08-11 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2016177347A1 (en) * 2015-05-07 2016-11-10 Teligene Ltd Heterocyclic compounds as idh2 inhibitors
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BR112018007304A2 (pt) 2015-10-15 2018-10-23 Agios Pharmaceuticals Inc terapia de combinação para tratamento de malignidades
CN107207469B (zh) * 2015-10-21 2018-09-25 纽弗姆制药有限公司 用于治疗血液恶性肿瘤的氘代化合物以及其组合物和方法
CA3007218A1 (en) 2015-12-04 2017-06-08 Agios Pharmaceuticals, Inc. Methods of treatment of malignancies
WO2017140758A1 (en) 2016-02-19 2017-08-24 Debiopharm International S.A. Derivatives of 2-amino-4-(2-oxazolidinon-3-yl)-pyrimidine fused with a five-membered heteroaromatic ring in 5,6-position which are useful for the treatment of various cancers
JP6930991B2 (ja) * 2016-02-26 2021-09-01 セルジーン コーポレイション 血液学的悪性腫瘍及び固形腫瘍の治療のためのidh2阻害剤
WO2018026894A1 (en) 2016-08-03 2018-02-08 Celgene Corporation Methods of treatment of myelodysplastic syndrome
JP7093764B2 (ja) * 2016-08-03 2022-06-30 セルジーン コーポレイション 骨髄異形成症候群の治療方法
KR102498693B1 (ko) 2016-09-07 2023-02-10 셀진 코포레이션 정제 조성물
WO2018133856A1 (zh) * 2017-01-22 2018-07-26 正大天晴药业集团股份有限公司 1,3,5-三嗪衍生物的盐及其晶体、它们的制备方法、药物组合物和用途
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CN109467538A (zh) 2017-09-07 2019-03-15 和记黄埔医药(上海)有限公司 环烯烃取代的杂芳环类化合物及其用途
US20220017489A1 (en) 2018-11-02 2022-01-20 Celgene Corporation Solid dispersions for treatment of cancer
WO2020092894A1 (en) 2018-11-02 2020-05-07 Celgene Corporation Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol
US20220017490A1 (en) 2018-11-02 2022-01-20 Celgene Corporation Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof
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CN114773320A (zh) * 2022-05-29 2022-07-22 重庆医科大学 1,3,5-三嗪化合物及其制备方法和用途

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Also Published As

Publication number Publication date
PH12016500164A1 (en) 2016-04-25
US10730854B2 (en) 2020-08-04
SG10201709187TA (en) 2017-12-28
AU2018247242A1 (en) 2018-11-01
CN110386922A (zh) 2019-10-29
AU2014295938B2 (en) 2018-07-19
CL2016000263A1 (es) 2016-08-19
JP6742905B2 (ja) 2020-08-19
US20180370951A1 (en) 2018-12-27
US9738625B2 (en) 2017-08-22
SG11201600479WA (en) 2016-02-26
PH12016500164B1 (en) 2023-11-08
SA516370523B1 (ar) 2019-01-10
MX394658B (es) 2025-03-24
EP3027193A2 (en) 2016-06-08
CA2919382A1 (en) 2015-02-05
EA030428B1 (ru) 2018-08-31
US20240132474A1 (en) 2024-04-25
MX2016001361A (es) 2016-06-14
CN110372670A (zh) 2019-10-25
US10093654B2 (en) 2018-10-09
AU2018247242B2 (en) 2020-03-12
ES2886211T3 (es) 2021-12-16
CN105916507A (zh) 2016-08-31
JP2021176893A (ja) 2021-11-11
IL243833A0 (en) 2016-04-21
EA201690322A1 (ru) 2016-07-29
IL270347B (en) 2021-08-31
TW201524971A (zh) 2015-07-01
US20170305885A1 (en) 2017-10-26
MY177994A (en) 2020-09-28
WO2015017821A2 (en) 2015-02-05
EP3027193A4 (en) 2017-04-26
JP2016527279A (ja) 2016-09-08
NZ716226A (en) 2021-08-27
JP2019142930A (ja) 2019-08-29
BR112016002287A2 (pt) 2017-08-01
CN110372670B (zh) 2023-04-07
PE20160840A1 (es) 2016-09-22
EP3566706A1 (en) 2019-11-13
AU2014295938A1 (en) 2016-02-18
EP3932408A1 (en) 2022-01-05
US20210155603A1 (en) 2021-05-27
WO2015017821A3 (en) 2015-04-09
CL2017002240A1 (es) 2018-04-20
NI201600022A (es) 2016-03-16
TWI666208B (zh) 2019-07-21
MX2020011397A (es) 2022-08-05
US20160194305A1 (en) 2016-07-07
MX389250B (es) 2025-03-20
EP3566706B1 (en) 2021-07-14
TWI701242B (zh) 2020-08-11
TW201932455A (zh) 2019-08-16

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