JP6742905B2 - 治療活性のある化合物及びその使用方法 - Google Patents

治療活性のある化合物及びその使用方法 Download PDF

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JP6742905B2
JP6742905B2 JP2016531940A JP2016531940A JP6742905B2 JP 6742905 B2 JP6742905 B2 JP 6742905B2 JP 2016531940 A JP2016531940 A JP 2016531940A JP 2016531940 A JP2016531940 A JP 2016531940A JP 6742905 B2 JP6742905 B2 JP 6742905B2
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compound
dose
idh2
crystalline form
treatment
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Japanese (ja)
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JP2016527279A5 (enExample
JP2016527279A (ja
Inventor
ブイ．アグレスタ サムエル
ブイ．アグレスタ サムエル
グ チョング‐フイ
グ チョング‐フイ
スチェンケイン デビッド
スチェンケイン デビッド
ヤング フア
ヤング フア
グオ リトイング
グオ リトイング
タング ズヘン
タング ズヘン
ワング ジアンミング
ワング ジアンミング
ズハング ヤンフェング
ズハング ヤンフェング
ズホウ ヤン
ズホウ ヤン
Original Assignee
アギオス ファーマシューティカルス，インコーポレーテッド
アギオス ファーマシューティカルス，インコーポレーテッド
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Priority claimed from PCT/CN2013/081170 external-priority patent/WO2015018060A1/en
Application filed by アギオス ファーマシューティカルス，インコーポレーテッド, アギオス ファーマシューティカルス，インコーポレーテッド filed Critical アギオス ファーマシューティカルス，インコーポレーテッド
Publication of JP2016527279A publication Critical patent/JP2016527279A/ja
Publication of JP2016527279A5 publication Critical patent/JP2016527279A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
JP2016531940A 2013-08-02 2014-08-01 治療活性のある化合物及びその使用方法 Active JP6742905B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361861884P 2013-08-02 2013-08-02
US61/861,884 2013-08-02
PCT/CN2013/081170 WO2015018060A1 (en) 2013-08-09 2013-08-09 Crystalline forms of therapeutically active compounds and use thereof
CNPCT/CN2013/081170 2013-08-09
US201461939098P 2014-02-12 2014-02-12
US61/939,098 2014-02-12
US201461975448P 2014-04-04 2014-04-04
US61/975,448 2014-04-04
US201462011948P 2014-06-13 2014-06-13
US62/011,948 2014-06-13
PCT/US2014/049469 WO2015017821A2 (en) 2013-08-02 2014-08-01 Therapeutically active compounds and their methods of use

Related Child Applications (1)

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JP2019082794A Division JP2019142930A (ja) 2013-08-02 2019-04-24 治療活性のある化合物及びその使用方法

Publications (3)

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JP2016527279A JP2016527279A (ja) 2016-09-08
JP2016527279A5 JP2016527279A5 (enExample) 2017-09-07
JP6742905B2 true JP6742905B2 (ja) 2020-08-19

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JP2016531940A Active JP6742905B2 (ja) 2013-08-02 2014-08-01 治療活性のある化合物及びその使用方法
JP2019082794A Withdrawn JP2019142930A (ja) 2013-08-02 2019-04-24 治療活性のある化合物及びその使用方法
JP2021123814A Pending JP2021176893A (ja) 2013-08-02 2021-07-29 治療活性のある化合物及びその使用方法

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JP2021123814A Pending JP2021176893A (ja) 2013-08-02 2021-07-29 治療活性のある化合物及びその使用方法

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US (6) US9738625B2 (enExample)
EP (3) EP3027193A4 (enExample)
JP (3) JP6742905B2 (enExample)
CN (3) CN110372670B (enExample)
AU (2) AU2014295938B2 (enExample)
BR (1) BR112016002287A2 (enExample)
CA (1) CA2919382A1 (enExample)
CL (2) CL2016000263A1 (enExample)
EA (1) EA030428B1 (enExample)
ES (1) ES2886211T3 (enExample)
IL (2) IL243833A0 (enExample)
MX (2) MX389250B (enExample)
MY (1) MY177994A (enExample)
NI (1) NI201600022A (enExample)
PE (1) PE20160840A1 (enExample)
PH (1) PH12016500164B1 (enExample)
SA (1) SA516370523B1 (enExample)
SG (2) SG11201600479WA (enExample)
TW (2) TWI666208B (enExample)
UA (1) UA121021C2 (enExample)
WO (1) WO2015017821A2 (enExample)

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EP3331866B1 (en) 2015-08-05 2023-07-26 Les Laboratoires Servier Methods of preparing a 6-heteroaryl-1,3,5-triazine-2,4-diol and a 6-heteroaryl-1,3,5-triazine-2,4-diamine
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WO2017140758A1 (en) 2016-02-19 2017-08-24 Debiopharm International S.A. Derivatives of 2-amino-4-(2-oxazolidinon-3-yl)-pyrimidine fused with a five-membered heteroaromatic ring in 5,6-position which are useful for the treatment of various cancers
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JP2019529534A (ja) 2016-09-07 2019-10-17 セルジーン コーポレイション 錠剤組成物
CN113549056A (zh) 2017-01-22 2021-10-26 正大天晴药业集团股份有限公司 1,3,5-三嗪衍生物的盐及其晶体、它们的制备方法、药物组合物和用途
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CN109467538A (zh) 2017-09-07 2019-03-15 和记黄埔医药（上海）有限公司 环烯烃取代的杂芳环类化合物及其用途
US20220017489A1 (en) 2018-11-02 2022-01-20 Celgene Corporation Solid dispersions for treatment of cancer
US20220017490A1 (en) 2018-11-02 2022-01-20 Celgene Corporation Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof
US12215094B2 (en) * 2018-11-02 2025-02-04 Celgene Corporation Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol
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PE20160840A1 (es) 2016-09-22
CL2016000263A1 (es) 2016-08-19
IL270347B (en) 2021-08-31
CN110372670B (zh) 2023-04-07
US20160194305A1 (en) 2016-07-07
MX394658B (es) 2025-03-24
JP2021176893A (ja) 2021-11-11
EP3027193A2 (en) 2016-06-08
EP3027193A4 (en) 2017-04-26
US20260085059A1 (en) 2026-03-26
US9738625B2 (en) 2017-08-22
AU2014295938B2 (en) 2018-07-19
US20180370951A1 (en) 2018-12-27
TWI701242B (zh) 2020-08-11
SG11201600479WA (en) 2016-02-26
AU2018247242A1 (en) 2018-11-01
EP3566706A1 (en) 2019-11-13
PH12016500164A1 (en) 2016-04-25
WO2015017821A3 (en) 2015-04-09
WO2015017821A2 (en) 2015-02-05
AU2018247242B2 (en) 2020-03-12
JP2019142930A (ja) 2019-08-29
CN110386922A (zh) 2019-10-29
EP3932408A1 (en) 2022-01-05
US10093654B2 (en) 2018-10-09
NI201600022A (es) 2016-03-16
EA030428B1 (ru) 2018-08-31
TW201932455A (zh) 2019-08-16
CN110372670A (zh) 2019-10-25
US20210155603A1 (en) 2021-05-27
BR112016002287A2 (pt) 2017-08-01
TW201524971A (zh) 2015-07-01
UA121021C2 (uk) 2020-03-25
MX389250B (es) 2025-03-20
IL243833A0 (en) 2016-04-21
ES2886211T3 (es) 2021-12-16
JP2016527279A (ja) 2016-09-08
EA201690322A1 (ru) 2016-07-29
PH12016500164B1 (en) 2023-11-08
CA2919382A1 (en) 2015-02-05
MX2020011397A (es) 2022-08-05
TWI666208B (zh) 2019-07-21
US20240132474A1 (en) 2024-04-25
SA516370523B1 (ar) 2019-01-10
SG10201709187TA (en) 2017-12-28
CN105916507A (zh) 2016-08-31
NZ716226A (en) 2021-08-27
EP3566706B1 (en) 2021-07-14
AU2014295938A1 (en) 2016-02-18
MY177994A (en) 2020-09-28
US10730854B2 (en) 2020-08-04
MX2016001361A (es) 2016-06-14
US20170305885A1 (en) 2017-10-26
CL2017002240A1 (es) 2018-04-20

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