ES2886211T3 - Compuestos terapéuticamente activos y sus métodos de uso - Google Patents
Compuestos terapéuticamente activos y sus métodos de uso Download PDFInfo
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- ES2886211T3 ES2886211T3 ES19177845T ES19177845T ES2886211T3 ES 2886211 T3 ES2886211 T3 ES 2886211T3 ES 19177845 T ES19177845 T ES 19177845T ES 19177845 T ES19177845 T ES 19177845T ES 2886211 T3 ES2886211 T3 ES 2886211T3
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- trifluoromethyl
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
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| US201361861884P | 2013-08-02 | 2013-08-02 | |
| PCT/CN2013/081170 WO2015018060A1 (en) | 2013-08-09 | 2013-08-09 | Crystalline forms of therapeutically active compounds and use thereof |
| US201461939098P | 2014-02-12 | 2014-02-12 | |
| US201461975448P | 2014-04-04 | 2014-04-04 | |
| US201462011948P | 2014-06-13 | 2014-06-13 |
Publications (1)
| Publication Number | Publication Date |
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| ES2886211T3 true ES2886211T3 (es) | 2021-12-16 |
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| ES19177845T Active ES2886211T3 (es) | 2013-08-02 | 2014-08-01 | Compuestos terapéuticamente activos y sus métodos de uso |
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| JP (3) | JP6742905B2 (enExample) |
| CN (3) | CN110386922A (enExample) |
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| CL (2) | CL2016000263A1 (enExample) |
| EA (1) | EA030428B1 (enExample) |
| ES (1) | ES2886211T3 (enExample) |
| IL (2) | IL243833A0 (enExample) |
| MX (2) | MX394658B (enExample) |
| MY (1) | MY177994A (enExample) |
| NI (1) | NI201600022A (enExample) |
| PE (1) | PE20160840A1 (enExample) |
| PH (1) | PH12016500164B1 (enExample) |
| SA (1) | SA516370523B1 (enExample) |
| SG (2) | SG10201709187TA (enExample) |
| TW (2) | TWI701242B (enExample) |
| UA (1) | UA121021C2 (enExample) |
| WO (1) | WO2015017821A2 (enExample) |
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| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CN110386922A (zh) | 2013-08-02 | 2019-10-29 | 安吉奥斯医药品有限公司 | 治疗活性化合物及其使用方法 |
| EP3200800A1 (en) | 2014-09-29 | 2017-08-09 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CA2975506A1 (en) | 2015-02-04 | 2016-08-11 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2016177347A1 (en) * | 2015-05-07 | 2016-11-10 | Teligene Ltd | Heterocyclic compounds as idh2 inhibitors |
| KR102303011B1 (ko) | 2015-07-30 | 2021-09-16 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 1,3,5-트라이아진 유도체 및 이의 사용 방법 |
| CA2993615A1 (en) | 2015-08-05 | 2017-02-09 | Agios Pharmaceuticals, Inc. | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
| WO2017066611A1 (en) * | 2015-10-15 | 2017-04-20 | Celgene Corporation | Combination therapy for treating malignancies |
| BR112018007304A2 (pt) | 2015-10-15 | 2018-10-23 | Agios Pharmaceuticals Inc | terapia de combinação para tratamento de malignidades |
| CN107207469B (zh) * | 2015-10-21 | 2018-09-25 | 纽弗姆制药有限公司 | 用于治疗血液恶性肿瘤的氘代化合物以及其组合物和方法 |
| CA3007218A1 (en) | 2015-12-04 | 2017-06-08 | Agios Pharmaceuticals, Inc. | Methods of treatment of malignancies |
| WO2017140758A1 (en) | 2016-02-19 | 2017-08-24 | Debiopharm International S.A. | Derivatives of 2-amino-4-(2-oxazolidinon-3-yl)-pyrimidine fused with a five-membered heteroaromatic ring in 5,6-position which are useful for the treatment of various cancers |
| JP6930991B2 (ja) * | 2016-02-26 | 2021-09-01 | セルジーン コーポレイション | 血液学的悪性腫瘍及び固形腫瘍の治療のためのｉｄｈ２阻害剤 |
| WO2018026894A1 (en) | 2016-08-03 | 2018-02-08 | Celgene Corporation | Methods of treatment of myelodysplastic syndrome |
| JP7093764B2 (ja) * | 2016-08-03 | 2022-06-30 | セルジーン コーポレイション | 骨髄異形成症候群の治療方法 |
| KR102498693B1 (ko) | 2016-09-07 | 2023-02-10 | 셀진 코포레이션 | 정제 조성물 |
| WO2018133856A1 (zh) * | 2017-01-22 | 2018-07-26 | 正大天晴药业集团股份有限公司 | 1，3，5-三嗪衍生物的盐及其晶体、它们的制备方法、药物组合物和用途 |
| WO2018204787A1 (en) | 2017-05-05 | 2018-11-08 | Memorial Sloan Kettering Cancer Center | Methods of treatment of myeloproliferative neoplasm |
| MX2019015886A (es) | 2017-06-30 | 2020-09-10 | Celgene Corp | Composiciones y metodos de uso de 2-(4-clorofenil)-n-((2-(2,6-diox opiperidin-3-il)-1-0xoisoindolin-5-il)metil)-2,2-difluoroacetamid a. |
| CN109467538A (zh) | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| US20220017489A1 (en) | 2018-11-02 | 2022-01-20 | Celgene Corporation | Solid dispersions for treatment of cancer |
| WO2020092894A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol |
| US20220017490A1 (en) | 2018-11-02 | 2022-01-20 | Celgene Corporation | Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof |
| WO2021097160A1 (en) | 2019-11-14 | 2021-05-20 | Celgene Corporation | Pediatric formulations for treatment of cancer |
| CN114773320A (zh) * | 2022-05-29 | 2022-07-22 | 重庆医科大学 | 1,3,5-三嗪化合物及其制备方法和用途 |
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| US2390529A (en) | 1942-02-03 | 1945-12-11 | Ernst A H Friedheim | Hydrazino-1,3,5-triazino derivatives of substituted phenylarsenic compounds |
| JPS58186682A (ja) | 1982-04-27 | 1983-10-31 | 日本化薬株式会社 | セルロ−ス又はセルロ−ス含有繊維材料の染色法 |
| DE3512630A1 (de) | 1985-04-06 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Verfahren zum faerben oder bedrucken von cellulosefasern oder cellulosemischfasern |
| DE59106971D1 (de) | 1990-07-12 | 1996-01-11 | Ciba Geigy Ag | Verfahren zur photochemischen und thermischen Stabilisierung von Polyamid-Fasermaterialien. |
| JPH11158073A (ja) | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンａ３拮抗剤 |
| AU5379900A (en) | 1999-06-07 | 2000-12-28 | Shire Biochem Inc. | Thiophene integrin inhibitors |
| WO2003037346A1 (en) * | 2001-10-31 | 2003-05-08 | Cell Therapeutics, Inc. | 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer |
| EP2256108B1 (en) | 2002-07-18 | 2016-03-23 | Janssen Pharmaceutica NV | Substituted triazine kinase inhibitors |
| US8258295B2 (en) | 2007-04-30 | 2012-09-04 | Prometic Biosciences Inc. | Triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives |
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| BRPI1010881A2 (pt) | 2009-06-08 | 2016-05-31 | California Capital Equity Llc | derivados de triazina e suas aplicações terapêuticas. |
| CA2987503C (en) * | 2009-07-07 | 2019-02-26 | Mei Pharma, Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
| UA117451C2 (uk) * | 2012-01-06 | 2018-08-10 | Аджиос Фармасьютікалз, Інк. | Терапевтично активні сполуки і способи їх застосування |
| EP2824099A4 (en) | 2012-03-09 | 2015-11-11 | Carna Biosciences Inc | NOVEL TRIAZINE DERIVATIVE |
| US9724350B2 (en) | 2013-07-11 | 2017-08-08 | Agios Pharmaceuticals, Inc. | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as IDH2 mutants inhibitors for the treatment of cancer |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| CN110386922A (zh) * | 2013-08-02 | 2019-10-29 | 安吉奥斯医药品有限公司 | 治疗活性化合物及其使用方法 |
| EP3200800A1 (en) * | 2014-09-29 | 2017-08-09 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CA2975506A1 (en) | 2015-02-04 | 2016-08-11 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
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2014
- 2014-08-01 CN CN201910708167.6A patent/CN110386922A/zh active Pending
- 2014-08-01 CA CA2919382A patent/CA2919382A1/en not_active Abandoned
- 2014-08-01 SG SG10201709187TA patent/SG10201709187TA/en unknown
- 2014-08-01 UA UAA201601999A patent/UA121021C2/uk unknown
- 2014-08-01 SG SG11201600479WA patent/SG11201600479WA/en unknown
- 2014-08-01 BR BR112016002287A patent/BR112016002287A2/pt not_active Application Discontinuation
- 2014-08-01 EP EP19177845.5A patent/EP3566706B1/en active Active
- 2014-08-01 EP EP14832505.3A patent/EP3027193A4/en not_active Withdrawn
- 2014-08-01 AU AU2014295938A patent/AU2014295938B2/en active Active
- 2014-08-01 EA EA201690322A patent/EA030428B1/ru not_active IP Right Cessation
- 2014-08-01 US US14/909,451 patent/US9738625B2/en active Active
- 2014-08-01 MX MX2020011397A patent/MX394658B/es unknown
- 2014-08-01 ES ES19177845T patent/ES2886211T3/es active Active
- 2014-08-01 CN CN201480053796.5A patent/CN105916507A/zh active Pending
- 2014-08-01 PH PH1/2016/500164A patent/PH12016500164B1/en unknown
- 2014-08-01 TW TW108110624A patent/TWI701242B/zh active
- 2014-08-01 JP JP2016531940A patent/JP6742905B2/ja active Active
- 2014-08-01 EP EP21178745.2A patent/EP3932408A1/en active Pending
- 2014-08-01 WO PCT/US2014/049469 patent/WO2015017821A2/en not_active Ceased
- 2014-08-01 MX MX2016001361A patent/MX389250B/es unknown
- 2014-08-01 MY MYPI2016700311A patent/MY177994A/en unknown
- 2014-08-01 PE PE2016000214A patent/PE20160840A1/es not_active Application Discontinuation
- 2014-08-01 CN CN201910707312.9A patent/CN110372670B/zh active Active
- 2014-08-01 TW TW103126335A patent/TWI666208B/zh active
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2016
- 2016-01-28 IL IL243833A patent/IL243833A0/en unknown
- 2016-02-01 NI NI201600022A patent/NI201600022A/es unknown
- 2016-02-01 SA SA516370523A patent/SA516370523B1/ar unknown
- 2016-02-02 CL CL2016000263A patent/CL2016000263A1/es unknown
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2017
- 2017-07-13 US US15/649,551 patent/US10093654B2/en active Active
- 2017-09-04 CL CL2017002240A patent/CL2017002240A1/es unknown
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2018
- 2018-09-04 US US16/121,483 patent/US10730854B2/en active Active
- 2018-10-10 AU AU2018247242A patent/AU2018247242B2/en active Active
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2019
- 2019-04-24 JP JP2019082794A patent/JP2019142930A/ja not_active Withdrawn
- 2019-10-31 IL IL270347A patent/IL270347B/en unknown
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2020
- 2020-06-29 US US16/915,936 patent/US20210155603A1/en not_active Abandoned
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2021
- 2021-07-29 JP JP2021123814A patent/JP2021176893A/ja active Pending
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2023
- 2023-05-08 US US18/144,695 patent/US20240132474A1/en not_active Abandoned
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