SA111320943B1 - مشتقات داي فينيل - أمين: الاستخدامات، وعملية التصنيع والتركيبات الصيدلانية - Google Patents

مشتقات داي فينيل - أمين: الاستخدامات، وعملية التصنيع والتركيبات الصيدلانية Download PDF

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SA111320943B1
SA111320943B1 SA111320943A SA111320943A SA111320943B1 SA 111320943 B1 SA111320943 B1 SA 111320943B1 SA 111320943 A SA111320943 A SA 111320943A SA 111320943 A SA111320943 A SA 111320943A SA 111320943 B1 SA111320943 B1 SA 111320943B1
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Saudi Arabia
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compound
salt
hydrochloride salt
diphenyl
cancer
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SA111320943A
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Arabic (ar)
English (en)
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روزا روديس سولانيس
نيفاتلى جارشيا دومينجويز
بياتريز لوبيز اورتيجا
ميلشور الفاريز دى مون سوتو
انطونيو دى لاهيرا مارتينيز
انا مونوز مونوز
فرانسيسكو ليدو جوميز
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فايس فارما اس ايه
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Application filed by فايس فارما اس ايه filed Critical فايس فارما اس ايه
Publication of SA111320943B1 publication Critical patent/SA111320943B1/ar

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    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
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    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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  • Pyridine Compounds (AREA)
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SA111320943A 2010-11-23 2011-11-23 مشتقات داي فينيل - أمين: الاستخدامات، وعملية التصنيع والتركيبات الصيدلانية SA111320943B1 (ar)

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EP10382314A EP2465498A1 (en) 2010-11-23 2010-11-23 Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions

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SA111320943B1 true SA111320943B1 (ar) 2014-12-09

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US (1) US20130296346A1 (enExample)
EP (2) EP2465498A1 (enExample)
JP (1) JP2014505662A (enExample)
KR (1) KR20130121888A (enExample)
CN (1) CN103313707A (enExample)
AU (1) AU2011333887A1 (enExample)
BR (1) BR112013012665A2 (enExample)
CA (1) CA2818842A1 (enExample)
CL (1) CL2013001445A1 (enExample)
CO (1) CO6771413A2 (enExample)
MA (1) MA34746B1 (enExample)
MX (1) MX2013005761A (enExample)
RU (1) RU2013128602A (enExample)
SA (1) SA111320943B1 (enExample)
UY (1) UY33745A (enExample)
WO (1) WO2012069442A1 (enExample)
ZA (1) ZA201303692B (enExample)

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RS51423B (sr) 2006-03-31 2011-02-28 Janssen Pharmaceutica N.V. Benzoimidazol-2-il pirimidini i pirazini kao modulatori histaminskog h4 receptora
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
JP6038882B2 (ja) * 2011-04-20 2016-12-07 マッパー・リソグラフィー・アイピー・ビー．ブイ． 光ファイバの構成体及びこのような構成体を形成する方法
JO3516B1 (ar) 2013-03-06 2020-07-05 Janssen Pharmaceutica Nv مُعدِّلات بنزإيميدازول-2-يل بيريميدين لمستقبل الهستامين h4
KR101694318B1 (ko) * 2014-10-02 2017-01-09 한국과학기술연구원 신규한 퓨린 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB682160A (en) * 1948-10-18 1952-11-05 Wellcome Found Improvements in and relating to the preparation of substituted aminoalcohols, alkenylamines, aminoalkanes and quaternary salts thereof
US6087346A (en) * 1993-06-23 2000-07-11 Cambridge Neuroscience, Inc. Sigma receptor ligands and the use thereof
US5795756A (en) 1995-12-11 1998-08-18 Johnson; Roger A. Method and compounds for the inhibition of adenylyl cyclase
CA2243330A1 (en) * 1996-01-20 1997-07-24 Ioana Popa Tamoxifen and analogues thereof
DE19756261A1 (de) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
EP1375502B1 (en) 2001-04-05 2007-06-13 Sumitomo Chemical Company, Limited Process for producing 2,6-dihalogenopurine
US20050065171A1 (en) 2003-06-25 2005-03-24 Shakespeare William C. Substituted purine derivatives

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EP2642987A1 (en) 2013-10-02
UY33745A (es) 2012-06-29
US20130296346A1 (en) 2013-11-07
RU2013128602A (ru) 2014-12-27
BR112013012665A2 (pt) 2016-09-06
MA34746B1 (fr) 2013-12-03
WO2012069442A1 (en) 2012-05-31
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EP2465498A1 (en) 2012-06-20
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