RU95108386A - Способ получения производных 2,6-дихлор-5-фторникотиновой кислоты и ее хлорангидрида - Google Patents

Способ получения производных 2,6-дихлор-5-фторникотиновой кислоты и ее хлорангидрида

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Publication number
RU95108386A
RU95108386A RU95108386/04A RU95108386A RU95108386A RU 95108386 A RU95108386 A RU 95108386A RU 95108386/04 A RU95108386/04 A RU 95108386/04A RU 95108386 A RU95108386 A RU 95108386A RU 95108386 A RU95108386 A RU 95108386A
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RU
Russia
Prior art keywords
acid
chlorination
hydroxyl
formula
dichloro
Prior art date
Application number
RU95108386/04A
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English (en)
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RU2114831C1 (ru
Inventor
Эллен Дженнингс Рекс
Us]
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Варнер-Ламберт Компани (US)
Варнер-Ламберт Компани
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Application filed by Варнер-Ламберт Компани (US), Варнер-Ламберт Компани filed Critical Варнер-Ламберт Компани (US)
Publication of RU95108386A publication Critical patent/RU95108386A/ru
Application granted granted Critical
Publication of RU2114831C1 publication Critical patent/RU2114831C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Предложен способ получения 2,6-дихлор-5-фторникотиновой кислоты и ее хлорангидрида формулы Iгде R - хлор или гидроксил, путем хлорирования производного замещенного 2,6-дигидроксипиридина хлорокиси фосфора при нагревании с последующим охлаждением, разбавления разбавителем и переработки получаемого продукта хлорирования, который заключается в том, что в качестве производного замещенного 2,6-дгидроксипиридина используют соединение общей формулы IIгде R- низший алкил или бензил, хлорирование осуществляют в присутствии литиевого реагента, а переработку продукта хлорирования осуществляют путем выделения соединения формулы I'которые в случае R-гидроксил подвергают взаимодействию с основанием в присутствии воды с последующей экстракцией получаемого раствора растворителем и нейтрализацией кислотой.

Claims (1)

  1. Предложен способ получения 2,6-дихлор-5-фторникотиновой кислоты и ее хлорангидрида формулы I
    Figure 00000001

    где R - хлор или гидроксил, путем хлорирования производного замещенного 2,6-дигидроксипиридина хлорокиси фосфора при нагревании с последующим охлаждением, разбавления разбавителем и переработки получаемого продукта хлорирования, который заключается в том, что в качестве производного замещенного 2,6-дгидроксипиридина используют соединение общей формулы II
    Figure 00000002

    где R1 - низший алкил или бензил, хлорирование осуществляют в присутствии литиевого реагента, а переработку продукта хлорирования осуществляют путем выделения соединения формулы I'
    Figure 00000003

    которые в случае R-гидроксил подвергают взаимодействию с основанием в присутствии воды с последующей экстракцией получаемого раствора растворителем и нейтрализацией кислотой.
RU95108386A 1992-08-20 1993-07-19 Способ получения 2,6-дихлор-5-фторникотиновой кислоты и ее хлорангидрида RU2114831C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/932,452 US5204478A (en) 1992-08-20 1992-08-20 Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride
US932452 1992-08-20

Publications (2)

Publication Number Publication Date
RU95108386A true RU95108386A (ru) 1997-03-20
RU2114831C1 RU2114831C1 (ru) 1998-07-10

Family

ID=25462348

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95108386A RU2114831C1 (ru) 1992-08-20 1993-07-19 Способ получения 2,6-дихлор-5-фторникотиновой кислоты и ее хлорангидрида

Country Status (15)

Country Link
US (1) US5204478A (ru)
EP (1) EP0655998B1 (ru)
JP (1) JP3287845B2 (ru)
KR (1) KR100281313B1 (ru)
AT (1) ATE151754T1 (ru)
AU (1) AU668412B2 (ru)
CA (1) CA2141046C (ru)
CZ (1) CZ286204B6 (ru)
DE (1) DE69309935T2 (ru)
HU (1) HU214908B (ru)
MX (1) MX9305053A (ru)
NZ (1) NZ254628A (ru)
RU (1) RU2114831C1 (ru)
SK (1) SK280982B6 (ru)
WO (1) WO1994004501A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739342A (en) * 1997-03-03 1998-04-14 Abbott Laboratories Process for the preparation of nicotinic acids
US20030129292A1 (en) * 1998-04-02 2003-07-10 Lipton Tomato paste and sauce and process for preparation
PT1436263E (pt) * 2001-10-15 2007-12-17 Lg Life Sciences Ltd Um processo para se preparar um composto beta-cetoéster
US6624307B1 (en) * 2002-03-28 2003-09-23 Isp Investments Inc. Process for producing 2,6-dihydroxy-3,4-dialkylpyridines
WO2004099149A1 (ja) * 2003-05-09 2004-11-18 Asahi Glass Company, Limited ２－クロロ－５－フルオロ－３－置換ピリジンまたはその塩の製造方法
CN113735785B (zh) * 2020-05-28 2023-10-13 南京桦冠生物技术有限公司 3,6-二氯吡嗪-2-甲腈的制备方法
CN114181139B (zh) * 2021-12-27 2023-12-08 四川仁安药业有限责任公司 一种5-卤代烟酸的合成方法
CN114591225B (zh) * 2022-03-02 2024-02-06 河南阿尔法医药科技有限公司 一种可规模化生产2,6-二溴-4-甲基吡啶的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE603365A (fr) * 1960-05-04 1961-09-01 Glaxo Lab Ltd Composés analogues à la griséofulvine et leur préparation
DE3574380D1 (en) * 1984-02-17 1989-12-28 Daiichi Seiyaku Co 1,8-naphthyridine derivatives
EP0333020A3 (en) * 1988-03-18 1991-03-20 Abbott Laboratories Process for the preparation of substituted pyridines

Also Published As

Publication number Publication date
DE69309935D1 (de) 1997-05-22
CZ286204B6 (cs) 2000-02-16
WO1994004501A1 (en) 1994-03-03
CA2141046C (en) 2004-03-23
JP3287845B2 (ja) 2002-06-04
CZ38895A3 (en) 1995-12-13
SK23295A3 (en) 1995-07-11
HU9500490D0 (en) 1995-04-28
NZ254628A (en) 1996-01-26
US5204478A (en) 1993-04-20
EP0655998B1 (en) 1997-04-16
CA2141046A1 (en) 1994-03-03
KR950702965A (ko) 1995-08-23
JPH08500358A (ja) 1996-01-16
AU4682393A (en) 1994-03-15
HU214908B (hu) 1998-07-28
ATE151754T1 (de) 1997-05-15
EP0655998A1 (en) 1995-06-07
AU668412B2 (en) 1996-05-02
SK280982B6 (sk) 2000-10-09
HUT71270A (en) 1995-11-28
MX9305053A (es) 1994-02-28
KR100281313B1 (ko) 2001-02-01
DE69309935T2 (de) 1997-10-23
RU2114831C1 (ru) 1998-07-10

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Effective date: 20060720