JPS5555193A - Novel preparation of penicillanic acid derivative - Google Patents
Novel preparation of penicillanic acid derivativeInfo
- Publication number
- JPS5555193A JPS5555193A JP12742278A JP12742278A JPS5555193A JP S5555193 A JPS5555193 A JP S5555193A JP 12742278 A JP12742278 A JP 12742278A JP 12742278 A JP12742278 A JP 12742278A JP S5555193 A JPS5555193 A JP S5555193A
- Authority
- JP
- Japan
- Prior art keywords
- penicillanic acid
- compound
- hydroxyphenylacetamido
- formula
- azido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound easily, in high efficiency, by treating 6-(α- azido-p-hydroxyphenylacetamido)penicillanic acid with a specific organo-phosphorus compound, and after romoving the objective product from the reaction products, treating the by-products with an aldehyde.
CONSTITUTION: 6-(α-Azido-p-hydroxyphenylacetamido)penicillanic acid is reacted with an organo-phosphorus compound of formula P(R1)3(R1 is allyl or alkoxy), e.g. triallyl phosphine, in a mixture of water and a hydrophilic solvent such as acetonitrile, whereby the reduction and the optical resolution are carried out at the same time to afford the (-) compound of the formula. The (+) compound which is obtained as a by-product, is treated with an aldehyde R2-CHO (R2 is allyl or heterocyclic group), e.g. salicylaldehyde to give 6-[(-)α-amino-p-hydroxyphenylacetamido]penicillanic acid of the formula.
USE: An antibiotic agent which keeps high concentration in blood.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12742278A JPS5555193A (en) | 1978-10-18 | 1978-10-18 | Novel preparation of penicillanic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12742278A JPS5555193A (en) | 1978-10-18 | 1978-10-18 | Novel preparation of penicillanic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5555193A true JPS5555193A (en) | 1980-04-22 |
Family
ID=14959561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12742278A Pending JPS5555193A (en) | 1978-10-18 | 1978-10-18 | Novel preparation of penicillanic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5555193A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5852291A (en) * | 1981-09-22 | 1983-03-28 | Kureha Chem Ind Co Ltd | Penicillin antibiotic derivative and its medicinal preparation |
-
1978
- 1978-10-18 JP JP12742278A patent/JPS5555193A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5852291A (en) * | 1981-09-22 | 1983-03-28 | Kureha Chem Ind Co Ltd | Penicillin antibiotic derivative and its medicinal preparation |
JPS6234038B2 (en) * | 1981-09-22 | 1987-07-24 | Kureha Chemical Ind Co Ltd |
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