RU94045250A - Способы получения 2-перфторалкил-3-оксазолин-5-она промежуточные соединения - Google Patents

Способы получения 2-перфторалкил-3-оксазолин-5-она промежуточные соединения

Info

Publication number
RU94045250A
RU94045250A RU94045250/04A RU94045250A RU94045250A RU 94045250 A RU94045250 A RU 94045250A RU 94045250/04 A RU94045250/04 A RU 94045250/04A RU 94045250 A RU94045250 A RU 94045250A RU 94045250 A RU94045250 A RU 94045250A
Authority
RU
Russia
Prior art keywords
perfluoroalkyl
preparing
oxazoline
processes
intermediate product
Prior art date
Application number
RU94045250/04A
Other languages
English (en)
Other versions
RU2134262C1 (ru
Inventor
Камесваран Венкатараман
Us]
Original Assignee
Американ Цианамид Компани (US)
Американ Цианамид Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/175,845 external-priority patent/US5426225A/en
Priority claimed from US08/175,822 external-priority patent/US5659046A/en
Application filed by Американ Цианамид Компани (US), Американ Цианамид Компани filed Critical Американ Цианамид Компани (US)
Publication of RU94045250A publication Critical patent/RU94045250A/ru
Application granted granted Critical
Publication of RU2134262C1 publication Critical patent/RU2134262C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/42—One oxygen atom attached in position 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Предложен способ получения 2-перфторалкил-3-оксазолин-5-онового соединения, включающий реакцию аминонитрила с перфторацилирующим агентом в присутствии растворителя для образования промежуточного продукта перфторалканоиламинонитрила и циклирование промежуточного продукта в присутствии кислоты и, по крайней мере, одного молярного эквивалента воды.

Claims (1)

  1. Предложен способ получения 2-перфторалкил-3-оксазолин-5-онового соединения, включающий реакцию аминонитрила с перфторацилирующим агентом в присутствии растворителя для образования промежуточного продукта перфторалканоиламинонитрила и циклирование промежуточного продукта в присутствии кислоты и, по крайней мере, одного молярного эквивалента воды.
RU94045250A 1993-12-30 1994-12-28 Способы получения 2-перфторалкил-3-оксазолин-5-она, промежуточные соединения RU2134262C1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/175,845 US5426225A (en) 1993-12-30 1993-12-30 Perfluoroalkanoyl aminonitriles
US08/175,822 1993-12-30
US08/175,845 1993-12-30
US08/175822 1993-12-30
US08/175,822 US5659046A (en) 1993-12-30 1993-12-30 Method for the preparation of 2-perfluoroalkyl-3-oxazolin-5-one
US08/175845 1993-12-30

Publications (2)

Publication Number Publication Date
RU94045250A true RU94045250A (ru) 1996-10-27
RU2134262C1 RU2134262C1 (ru) 1999-08-10

Family

ID=26871609

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94045250A RU2134262C1 (ru) 1993-12-30 1994-12-28 Способы получения 2-перфторалкил-3-оксазолин-5-она, промежуточные соединения

Country Status (20)

Country Link
EP (1) EP0662475B1 (ru)
JP (1) JP3848382B2 (ru)
KR (1) KR950017977A (ru)
CN (1) CN1053661C (ru)
AT (1) ATE165824T1 (ru)
AU (1) AU681727B2 (ru)
BR (1) BR9405302A (ru)
CA (1) CA2139190A1 (ru)
CZ (1) CZ286680B6 (ru)
DE (1) DE69410073T2 (ru)
DK (1) DK0662475T3 (ru)
ES (1) ES2116508T3 (ru)
HU (1) HU214085B (ru)
IL (1) IL112159A (ru)
RU (1) RU2134262C1 (ru)
SG (1) SG47670A1 (ru)
SK (1) SK279970B6 (ru)
TW (1) TW318843B (ru)
UA (1) UA41890C2 (ru)
ZA (1) ZA9410405B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453508A (en) * 1994-10-11 1995-09-26 American Cyanamid Company Manufacture of 4-aryl-2-perfluoroalkyl-3-oxazolin-5-one from arylglycine
TW369525B (en) * 1996-06-28 1999-09-11 American Cyanamid Co A process for the manufacture of 2-aryl-5-perfluoroalkylpyrrole derivatives and intermediates useful thereof
KR20010053263A (ko) 1999-04-28 2001-06-25 모치즈키 노부히코 아미드화합물의 제조방법
KR20020077414A (ko) 2000-02-04 2002-10-11 니혼노야쿠가부시키가이샤 퍼플루오로이소프로필벤젠 유도체
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5030735A (en) * 1990-07-31 1991-07-09 American Cyanamid Company Process for the preparation of insecticidal, acaricidal and nematicidal 2-aryl-5-(trifluoromethyl) pyrrole compounds
DE4236400A1 (de) * 1992-10-28 1994-05-05 Bayer Ag N-Phenylacetaminonitrile

Also Published As

Publication number Publication date
ZA9410405B (en) 1995-09-22
SG47670A1 (en) 1998-04-17
EP0662475A2 (en) 1995-07-12
CZ318894A3 (en) 1995-08-16
IL112159A (en) 1999-07-14
JP3848382B2 (ja) 2006-11-22
SK157994A3 (en) 1995-07-11
RU2134262C1 (ru) 1999-08-10
CN1053661C (zh) 2000-06-21
CN1107148A (zh) 1995-08-23
AU681727B2 (en) 1997-09-04
ATE165824T1 (de) 1998-05-15
CA2139190A1 (en) 1995-07-01
EP0662475B1 (en) 1998-05-06
HU214085B (en) 1997-12-29
UA41890C2 (ru) 2001-10-15
AU8184394A (en) 1995-07-06
ES2116508T3 (es) 1998-07-16
DE69410073T2 (de) 1998-09-03
HUT72162A (en) 1996-03-28
IL112159A0 (en) 1995-03-15
JPH07252239A (ja) 1995-10-03
KR950017977A (ko) 1995-07-22
HU9403832D0 (en) 1995-02-28
CZ286680B6 (en) 2000-06-14
DK0662475T3 (da) 1998-06-02
EP0662475A3 (en) 1995-07-19
SK279970B6 (sk) 1999-06-11
TW318843B (ru) 1997-11-01
DE69410073D1 (de) 1998-06-10
BR9405302A (pt) 1995-10-17

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