RU94010864A - Способ получения инсулинсодержащих полимерных гидрогелей - Google Patents
Способ получения инсулинсодержащих полимерных гидрогелейInfo
- Publication number
- RU94010864A RU94010864A RU94010864/14A RU94010864A RU94010864A RU 94010864 A RU94010864 A RU 94010864A RU 94010864/14 A RU94010864/14 A RU 94010864/14A RU 94010864 A RU94010864 A RU 94010864A RU 94010864 A RU94010864 A RU 94010864A
- Authority
- RU
- Russia
- Prior art keywords
- containing polymer
- polymer hydrogels
- producing insulin
- insulin
- ovomukoid
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title claims 4
- 239000000017 hydrogel Substances 0.000 title claims 3
- 238000004519 manufacturing process Methods 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 102000035443 Peptidases Human genes 0.000 claims 2
- 108091005771 Peptidases Proteins 0.000 claims 2
- 229940024999 Proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000003100 immobilizing Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (2)
1. Способ получения инсулинсодержащих полимерных гидрогелей путем иммобилизации инсулина в объеме сшитого полимера, модифицированного ингибитором протеолитических ферментов, отличающийся тем, что в качестве ингибитора протеолитических ферментов используют овомукоид.
2. Способ по п. 1, отличающийся тем, что концентрация овомукоида в сшитом полимере равна 0,2-25 мг/г набухшего в воде гидрогеля.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU9494010864A RU2066551C1 (ru) | 1994-03-23 | 1994-03-23 | Способ получения инсулинсодержащих полимерных гидрогелей |
DK199500287A DK173516B1 (da) | 1994-03-23 | 1995-03-21 | Insulinholdigt polymerpræparat til oral administrering af insulin |
US08/408,076 US5698515A (en) | 1994-03-23 | 1995-03-22 | Insulin-containing polymer composition for oral administration |
DE19510551A DE19510551C2 (de) | 1994-03-23 | 1995-03-23 | Orale Insulinpräparate und ihre Herstellung |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU9494010864A RU2066551C1 (ru) | 1994-03-23 | 1994-03-23 | Способ получения инсулинсодержащих полимерных гидрогелей |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2066551C1 RU2066551C1 (ru) | 1996-09-20 |
RU94010864A true RU94010864A (ru) | 1997-11-10 |
Family
ID=20154065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU9494010864A RU2066551C1 (ru) | 1994-03-23 | 1994-03-23 | Способ получения инсулинсодержащих полимерных гидрогелей |
Country Status (4)
Country | Link |
---|---|
US (1) | US5698515A (ru) |
DE (1) | DE19510551C2 (ru) |
DK (1) | DK173516B1 (ru) |
RU (1) | RU2066551C1 (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9710908A (pt) * | 1996-08-02 | 2000-10-24 | Orex Pharmaceutical Dev Corp | Composição de polìmero contendo proteìna para administração oral |
RU2155602C1 (ru) * | 1999-11-30 | 2000-09-10 | Оао "Куантум Сатис" | Инсулинсодержащее лекарственное средство для перорального применения и способ его получения |
US20030198666A1 (en) | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
US20030220254A1 (en) * | 2002-03-29 | 2003-11-27 | Texas Tech University System | Composition and method for preparation of an oral dual controlled release formulation of a protein and inhibitor |
EP1592438B1 (en) | 2003-01-06 | 2014-02-26 | Emisphere Technologies, Inc. | Night-time oral insulin therapy |
US20050203001A1 (en) | 2004-03-05 | 2005-09-15 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
WO2005063156A1 (en) * | 2003-12-22 | 2005-07-14 | Shear/Kershman Laboratories, Inc. | Oral peptide delivery system with improved bioavailability |
EP1734991A4 (en) * | 2004-04-14 | 2012-10-24 | Avirid Inc | COMPOSITIONS COMPRISING MODIFIED NUCLEASES DIRECTED AGAINST VIRAL NUCLEIC ACIDS AND METHODS OF USE FOR THE PREVENTION AND TREATMENT OF VIRAL DISEASES |
RU2316339C1 (ru) * | 2006-09-13 | 2008-02-10 | Общество С Ограниченной Ответственностью "Концерн О3" | Способ получения препарата инсулина для перорального применения |
UA90013C2 (ru) * | 2008-03-19 | 2010-03-25 | Давид Анатолійович Нога | Фармацевтическая композиция, содержащая инсулин, и способ его получения |
CN101862445A (zh) * | 2009-04-16 | 2010-10-20 | 哈药集团生物工程有限公司 | 一种含有蛋白酶抑制剂的口服胰岛素 |
RU2752509C1 (ru) * | 2020-10-21 | 2021-07-28 | Федеральное государственное бюджетное учреждение науки Ордена Трудового Красного Знамени Институт нефтехимического синтеза им. А.В. Топчиева Российской академии наук (ИНХС РАН) | Способ получения инсулинсодержащей композиции |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4238480A (en) * | 1978-05-19 | 1980-12-09 | Sawyer Philip Nicholas | Method for preparing an improved hemostatic agent and method of employing the same |
IL68769A (en) * | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
US4795436A (en) * | 1983-11-14 | 1989-01-03 | Bio-Mimetics, Inc. | Bioadhesive composition and method of treatment therewith |
DE3604868A1 (de) * | 1986-02-15 | 1987-08-20 | Behringwerke Ag | Insulinderivate, verfahren zu ihrer herstellung und ihre verwendung |
US4849227A (en) * | 1986-03-21 | 1989-07-18 | Eurasiam Laboratories, Inc. | Pharmaceutical compositions |
SU1404513A1 (ru) * | 1986-06-20 | 1988-06-23 | Институт биохимии им.А.Н.Баха | Способ получени овомукоида |
US5340731A (en) * | 1988-07-08 | 1994-08-23 | University Of British Columbia | Method of preparing a B-1,4 glycan matrix containing a bound fusion protein |
US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
DE69328523T2 (de) * | 1992-02-13 | 2000-09-21 | Surmodics, Inc. | Immobilisierung eines chemischen spezies in einer vernetzten matrix |
US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
-
1994
- 1994-03-23 RU RU9494010864A patent/RU2066551C1/ru active
-
1995
- 1995-03-21 DK DK199500287A patent/DK173516B1/da not_active IP Right Cessation
- 1995-03-22 US US08/408,076 patent/US5698515A/en not_active Expired - Fee Related
- 1995-03-23 DE DE19510551A patent/DE19510551C2/de not_active Expired - Fee Related
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