RU93050199A - Дезокситаксолы, способы их получения, промежуточные соединения, фармацевтический препарат - Google Patents

Дезокситаксолы, способы их получения, промежуточные соединения, фармацевтический препарат

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Publication number
RU93050199A
RU93050199A RU93050199/04A RU93050199A RU93050199A RU 93050199 A RU93050199 A RU 93050199A RU 93050199/04 A RU93050199/04 A RU 93050199/04A RU 93050199 A RU93050199 A RU 93050199A RU 93050199 A RU93050199 A RU 93050199A
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RU
Russia
Prior art keywords
formula
alkyl
deoxitaxols
pharmaceuticals
production
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RU93050199/04A
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English (en)
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RU2122545C1 (ru
Inventor
Фарина Витторио
Чен Шу-Хью
Р.Лэнгли Дэвид
Д.Уиттман Марк
Кэнт Джойдип
Вайс Долатрай
Original Assignee
Бристоль-Мейерз Сквибб Компани
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Priority claimed from US07/981,151 external-priority patent/US5272171A/en
Application filed by Бристоль-Мейерз Сквибб Компани filed Critical Бристоль-Мейерз Сквибб Компани
Publication of RU93050199A publication Critical patent/RU93050199A/ru
Application granted granted Critical
Publication of RU2122545C1 publication Critical patent/RU2122545C1/ru

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Claims (1)

  1. Предложено соединение формулы
    Figure 00000001

    в которой R представляет -CORz(Rz -RO - или R); Rg представляет C1 - C6 - алкил, C2 - C6 - алкенил, C2 - C6 - алкинил, C3 - C6 - циклоалкил или радикал формулы - W - Rx (W - связь, C2 - C6 - алкендиил или - (CH2)1 - t = 1 - 6, Rx - нафтил, фенил или гетероарил, кроме того Rx возможно замещен 1 - 3 одинаковыми или различными C1 - C6-алкилами, C1 - C6-алкоксигруппами, галогенами или - CF3; R2 представляет собой - OCOR, H, OH, -OR, - OSOR, - -OCONRoR, -OCONHR, - OCOO(CH2)tR или - OCOOR, R и Ro независимо представляют C1 - C6 алкил, C2 - C6 -алкенил, C3 - C6 - циклоалкил, C2 - C6 - алкинил или фенил, возможно замещенный 1 - 3 одинаковыми или различными C1 - C6 - алкилами, C1 - C6 - алкоксигруппами, галогенами или - CF3. Кроме того, изобретениям даются фармацевтические препараты и промежуточные соединения для получения дезокситаксолов формулы. Дается также способ лечения опухолей млекопитающих с помощью соединений формулы.
RU93050199A 1992-10-01 1993-07-30 7-дезоксипроизводные таксола, производные баккатина, 10-пентафторфенилбаккатин, 7-[(метилтио)карбонотиоилокси]-13-триэтилсилилоксибаккатин, фармацевтическая композиция RU2122545C1 (ru)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US95500892A 1992-10-01 1992-10-01
US07/955008 1992-10-01
US07/955,008 1992-10-01
US07/981151 1992-10-24
US07/981,151 US5272171A (en) 1992-02-13 1992-11-24 Phosphonooxy and carbonate derivatives of taxol
US07/981,151 1992-11-24
US99544392A 1992-12-23 1992-12-23
US07/995443 1992-12-23
US07/995,443 1992-12-23
US99645592A 1992-12-24 1992-12-24
US07/996.455 1992-12-24
US07/996455 1992-12-24
US8070493A 1993-06-28 1993-06-28
US07/080704 1993-06-28
US08/080.704 1993-06-28

Publications (2)

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RU93050199A true RU93050199A (ru) 1996-03-20
RU2122545C1 RU2122545C1 (ru) 1998-11-27

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RU93050199A RU2122545C1 (ru) 1992-10-01 1993-07-30 7-дезоксипроизводные таксола, производные баккатина, 10-пентафторфенилбаккатин, 7-[(метилтио)карбонотиоилокси]-13-триэтилсилилоксибаккатин, фармацевтическая композиция

Country Status (19)

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EP (1) EP0590267B1 (ru)
JP (1) JP3410518B2 (ru)
KR (1) KR100291771B1 (ru)
CN (1) CN1052229C (ru)
AT (1) ATE217305T1 (ru)
AU (1) AU658318B2 (ru)
CA (1) CA2100808A1 (ru)
DE (1) DE69331892T2 (ru)
DK (1) DK0590267T3 (ru)
ES (1) ES2176193T3 (ru)
FI (1) FI111634B (ru)
HU (2) HUT65326A (ru)
IL (3) IL106453A (ru)
MX (1) MX9304581A (ru)
NO (1) NO306404B1 (ru)
NZ (1) NZ248295A (ru)
PL (1) PL173741B1 (ru)
PT (1) PT590267E (ru)
RU (1) RU2122545C1 (ru)

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