RU93043620A - Агенты для мечения, включающие конъюгаты бороновой кислоты - Google Patents
Агенты для мечения, включающие конъюгаты бороновой кислотыInfo
- Publication number
- RU93043620A RU93043620A RU93043620/04A RU93043620A RU93043620A RU 93043620 A RU93043620 A RU 93043620A RU 93043620/04 A RU93043620/04 A RU 93043620/04A RU 93043620 A RU93043620 A RU 93043620A RU 93043620 A RU93043620 A RU 93043620A
- Authority
- RU
- Russia
- Prior art keywords
- labeling agents
- boronic acid
- agents including
- hemoglobin
- including conjugates
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title claims 3
- 238000002372 labelling Methods 0.000 title claims 3
- ZADPBFCGQRWHPN-UHFFFAOYSA-N OBO Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title claims 2
- 102000001554 Hemoglobins Human genes 0.000 claims 3
- 108010054147 Hemoglobins Proteins 0.000 claims 3
- 238000010521 absorption reaction Methods 0.000 claims 2
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2H-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 claims 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M CHEMBL593252 Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N Phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 claims 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N Triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 claims 1
- 239000001007 phthalocyanine dye Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 239000001016 thiazine dye Substances 0.000 claims 1
Claims (1)
- Предложены агенты для мечения, представляющие собой небелковые конъюгаты бороновой кислоты, имеющие максимум поглощения не менее чем при 600 нм, причем указанная метка обеспечивается, например, азиновым, трифенилметановым, цианиновым или фталоцианиновым красителем. Метки такого типа являются полезными для оценки и количественного определения цис-диолов, таких, как гликозилированный гемоглобин, за счет практически полного отсутствия перекрывания со спектром гемоглобина. Оксазиновые и тиазиновые красители, имеющие подобные характеристики поглощения и содержащие другие активированные фрагменты, подобным образом являются полезными агентами для мечения, особенно в присутствии гемоглобина.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9024775.0 | 1990-11-14 | ||
GB909024775A GB9024775D0 (en) | 1990-11-14 | 1990-11-14 | Chemical compounds |
PCT/EP1991/002160 WO1992008722A1 (en) | 1990-11-14 | 1991-11-13 | Labelling agents comprising boronic acid conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93043620A true RU93043620A (ru) | 1996-12-27 |
RU2076127C1 RU2076127C1 (ru) | 1997-03-27 |
Family
ID=10685377
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU9193043620A RU2076127C1 (ru) | 1990-11-14 | 1991-11-13 | Небелковые конъюгатные соединения бороновой кислоты и способ их получения |
Country Status (16)
Country | Link |
---|---|
US (1) | US5739318A (ru) |
EP (1) | EP0557357B1 (ru) |
JP (1) | JP2761494B2 (ru) |
AT (1) | ATE120195T1 (ru) |
AU (1) | AU666294B2 (ru) |
CA (1) | CA2096251C (ru) |
DE (1) | DE69108403T2 (ru) |
DK (1) | DK0557357T3 (ru) |
ES (1) | ES2069914T3 (ru) |
FI (1) | FI105549B (ru) |
GB (1) | GB9024775D0 (ru) |
HU (1) | HU216635B (ru) |
NO (1) | NO304691B1 (ru) |
PL (1) | PL176747B1 (ru) |
RU (1) | RU2076127C1 (ru) |
WO (1) | WO1992008722A1 (ru) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0596700A1 (en) * | 1992-11-03 | 1994-05-11 | Hewlett-Packard Company | Cis-diol detection method and solid supports |
ATE217087T1 (de) * | 1993-03-19 | 2002-05-15 | Novartis Ag | Chemilumineszierende derivate mit langer emissionswellenlänge und ihre verwendung in assays |
US5395752A (en) * | 1993-03-19 | 1995-03-07 | Ciba Corning Diagnostics Corp. | Long emission wavelength chemiluminescent compounds and their use in test assays |
US5594151A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexing reagents derived from aminosalicylic acid |
US5594111A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexes for bioconjugate preparation |
CZ220196A3 (en) * | 1994-01-28 | 1996-12-11 | Prolinx Inc | Bioconjugate complexes |
US5623055A (en) * | 1994-01-28 | 1997-04-22 | Prolinx, Inc. | Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation |
US5847192A (en) * | 1994-01-28 | 1998-12-08 | Prolinx, Inc. | Boronic compound complexing reagents and complexes |
US5744627A (en) * | 1994-01-28 | 1998-04-28 | Prolinx, Inc. | Boronic compound complexing reagents and complexes |
US5777148A (en) * | 1994-01-28 | 1998-07-07 | Prolinx, Inc. | Boronic compound complexing reagents and highly stable complexes |
US5837878A (en) * | 1994-01-28 | 1998-11-17 | Prolinx, Inc. | Boronic compound complexing reagents and highly stable complexes |
US5852178A (en) * | 1994-01-28 | 1998-12-22 | Prolinx, Inc. | Phenylboronic acid complexing reagents for conjugating biologically active molecules |
US5880279A (en) * | 1995-07-31 | 1999-03-09 | Chevron U.S.A. Inc. | Cobalt dihalodihydroxydisulfophthalocyanines |
US6075126A (en) * | 1996-08-05 | 2000-06-13 | Prolinx, Inc. | Phenyldiboronic acid reagents and complexes |
US6156884A (en) * | 1996-08-05 | 2000-12-05 | Prolinx, Inc. | Bifunctional boronic compound complexing reagents and complexes |
DE19843094A1 (de) * | 1998-09-21 | 2000-03-23 | Roche Diagnostics Gmbh | Verfahren zur Bestimmung von glykiertem Hämoglobin |
WO2000056933A1 (en) * | 1999-03-24 | 2000-09-28 | Princeton Separations | Chemically reactive plane-rigidized cyanine dyes and their derivatives |
US20040039129A1 (en) * | 2000-08-16 | 2004-02-26 | Hall Dennis G. | Non-pressurized methods for the preparation of conjugrated solid supports for boronic acids |
EP1213328A1 (de) * | 2000-12-08 | 2002-06-12 | Evotec OAI AG | Oxazinderivate |
ATE287430T1 (de) * | 2000-09-06 | 2005-02-15 | Evotec Ag | Oxazinderivate |
US7470420B2 (en) * | 2000-12-05 | 2008-12-30 | The Regents Of The University Of California | Optical determination of glucose utilizing boronic acid adducts |
US6653141B2 (en) | 2000-12-05 | 2003-11-25 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing method and device |
US6627177B2 (en) * | 2000-12-05 | 2003-09-30 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
US7195923B2 (en) * | 2001-01-31 | 2007-03-27 | Scripps Laboratories, Inc. | Ratiometric determination of glycated protein |
GB0110053D0 (en) * | 2001-04-24 | 2001-06-13 | Axis Shield Asa | Assay |
AU2002314957A1 (en) * | 2001-06-06 | 2002-12-16 | Proteologics, Inc. | Methods and compositions related to tagging of membrane surface proteins |
US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
US6858592B2 (en) | 2001-06-29 | 2005-02-22 | Genzyme Corporation | Aryl boronic acids for treating obesity |
US7390670B2 (en) * | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
US7427129B2 (en) * | 2004-02-04 | 2008-09-23 | Hewlett-Packard Development Company, L.P. | Boronic acid containing dyes to improve permanence of images |
BRPI0721056B8 (pt) * | 2006-11-30 | 2019-11-19 | Sensors For Medicine And Science Inc | moléculas indicadoras resistentes a oxidação |
GB0903348D0 (en) * | 2009-02-27 | 2009-04-08 | Pharmalucia Ltd | Compounds and methods relating thereto |
EP2721391B1 (en) | 2011-06-17 | 2022-04-06 | Roche Diagnostics Hematology, Inc. | Solution and method for histoprocessing of biological samples |
GB201215571D0 (en) | 2012-08-31 | 2012-10-17 | Axis Shield Asa | Assay method |
EP3375777A1 (en) * | 2017-03-15 | 2018-09-19 | MIKROCHEM spol. s.r.o. | Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
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US4496722A (en) * | 1981-05-01 | 1985-01-29 | The Children's Medical Center Corporation | Reporter compounds |
EP0319620A1 (en) * | 1987-12-10 | 1989-06-14 | Viomedics Inc. | Novel oxazines-ureas and thiazine urea chromophors |
US4830786A (en) * | 1986-02-27 | 1989-05-16 | Syntex (U.S.A.) Inc. | Squaraine dyes |
DE3720736A1 (de) * | 1987-06-23 | 1989-01-05 | Erwin Dr Schleicher | Verfahren, reagenzien und ausruestung zur einfachen bestimmung von nicht-enzymatisch glykosylierten proteinen in koerperfluessigkeiten |
US4861728A (en) * | 1987-07-24 | 1989-08-29 | Becton, Dickinson And Company | Immunoassay of glycosylated hemoglobin using a labeled boron reagent |
EP0310361A3 (en) * | 1987-09-30 | 1989-05-24 | Beckman Instruments, Inc. | Tridentate conjugate and method of use thereof |
DE3827340A1 (de) * | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
DE3840452A1 (de) * | 1988-12-01 | 1990-06-07 | Hoechst Ag | (beta)-amino-boronsaeure-derivate |
DE3843605A1 (de) * | 1988-12-23 | 1990-06-28 | Hoechst Ag | Wasserloesliche faserreaktive farbstoffe, verfahren zu ihrer herstellung und ihre verwendung |
NO890029D0 (no) * | 1989-01-04 | 1989-01-04 | Axis Research | Nye modifiserte peptider og proteiner for in vitro diagnoser (diabetes). |
JPH02226070A (ja) * | 1989-02-27 | 1990-09-07 | Fuji Photo Film Co Ltd | 糖タンパク質の定量方法 |
US5071531A (en) * | 1989-05-01 | 1991-12-10 | Soane Technologies, Inc. | Casting of gradient gels |
DE59004049D1 (de) * | 1989-05-10 | 1994-02-10 | Hoechst Ag | Wasserlösliche faserreaktive farbstoffe, verfahren zu ihrer herstellung und ihre verwendung. |
EP0455225B1 (en) * | 1990-05-01 | 1995-03-29 | Nacalai Tesque, Inc. | Method for measuring the percentage of glycation of a particular protein |
-
1990
- 1990-11-14 GB GB909024775A patent/GB9024775D0/en active Pending
-
1991
- 1991-11-13 AT AT91920019T patent/ATE120195T1/de not_active IP Right Cessation
- 1991-11-13 ES ES91920019T patent/ES2069914T3/es not_active Expired - Lifetime
- 1991-11-13 CA CA002096251A patent/CA2096251C/en not_active Expired - Lifetime
- 1991-11-13 DE DE69108403T patent/DE69108403T2/de not_active Expired - Lifetime
- 1991-11-13 WO PCT/EP1991/002160 patent/WO1992008722A1/en active IP Right Grant
- 1991-11-13 EP EP91920019A patent/EP0557357B1/en not_active Expired - Lifetime
- 1991-11-13 AU AU89092/91A patent/AU666294B2/en not_active Ceased
- 1991-11-13 RU RU9193043620A patent/RU2076127C1/ru not_active IP Right Cessation
- 1991-11-13 US US08/050,275 patent/US5739318A/en not_active Expired - Lifetime
- 1991-11-13 JP JP3518099A patent/JP2761494B2/ja not_active Expired - Lifetime
- 1991-11-13 HU HU9301408A patent/HU216635B/hu unknown
- 1991-11-13 DK DK91920019.6T patent/DK0557357T3/da active
- 1991-11-13 PL PL91299064A patent/PL176747B1/pl not_active IP Right Cessation
-
1993
- 1993-05-12 FI FI932149A patent/FI105549B/fi not_active IP Right Cessation
- 1993-05-13 NO NO931746A patent/NO304691B1/no not_active IP Right Cessation
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