RU93043620A - Агенты для мечения, включающие конъюгаты бороновой кислоты - Google Patents

Агенты для мечения, включающие конъюгаты бороновой кислоты

Info

Publication number
RU93043620A
RU93043620A RU93043620/04A RU93043620A RU93043620A RU 93043620 A RU93043620 A RU 93043620A RU 93043620/04 A RU93043620/04 A RU 93043620/04A RU 93043620 A RU93043620 A RU 93043620A RU 93043620 A RU93043620 A RU 93043620A
Authority
RU
Russia
Prior art keywords
labeling agents
boronic acid
agents including
hemoglobin
including conjugates
Prior art date
Application number
RU93043620/04A
Other languages
English (en)
Other versions
RU2076127C1 (ru
Inventor
Франтцен Франк
Сундрехаген Эрлинг
Original Assignee
Эксиз Рисерч АС
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909024775A external-priority patent/GB9024775D0/en
Application filed by Эксиз Рисерч АС filed Critical Эксиз Рисерч АС
Publication of RU93043620A publication Critical patent/RU93043620A/ru
Application granted granted Critical
Publication of RU2076127C1 publication Critical patent/RU2076127C1/ru

Links

Claims (1)

  1. Предложены агенты для мечения, представляющие собой небелковые конъюгаты бороновой кислоты, имеющие максимум поглощения не менее чем при 600 нм, причем указанная метка обеспечивается, например, азиновым, трифенилметановым, цианиновым или фталоцианиновым красителем. Метки такого типа являются полезными для оценки и количественного определения цис-диолов, таких, как гликозилированный гемоглобин, за счет практически полного отсутствия перекрывания со спектром гемоглобина. Оксазиновые и тиазиновые красители, имеющие подобные характеристики поглощения и содержащие другие активированные фрагменты, подобным образом являются полезными агентами для мечения, особенно в присутствии гемоглобина.
RU9193043620A 1990-11-14 1991-11-13 Небелковые конъюгатные соединения бороновой кислоты и способ их получения RU2076127C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9024775.0 1990-11-14
GB909024775A GB9024775D0 (en) 1990-11-14 1990-11-14 Chemical compounds
PCT/EP1991/002160 WO1992008722A1 (en) 1990-11-14 1991-11-13 Labelling agents comprising boronic acid conjugates

Publications (2)

Publication Number Publication Date
RU93043620A true RU93043620A (ru) 1996-12-27
RU2076127C1 RU2076127C1 (ru) 1997-03-27

Family

ID=10685377

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9193043620A RU2076127C1 (ru) 1990-11-14 1991-11-13 Небелковые конъюгатные соединения бороновой кислоты и способ их получения

Country Status (16)

Country Link
US (1) US5739318A (ru)
EP (1) EP0557357B1 (ru)
JP (1) JP2761494B2 (ru)
AT (1) ATE120195T1 (ru)
AU (1) AU666294B2 (ru)
CA (1) CA2096251C (ru)
DE (1) DE69108403T2 (ru)
DK (1) DK0557357T3 (ru)
ES (1) ES2069914T3 (ru)
FI (1) FI105549B (ru)
GB (1) GB9024775D0 (ru)
HU (1) HU216635B (ru)
NO (1) NO304691B1 (ru)
PL (1) PL176747B1 (ru)
RU (1) RU2076127C1 (ru)
WO (1) WO1992008722A1 (ru)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596700A1 (en) * 1992-11-03 1994-05-11 Hewlett-Packard Company Cis-diol detection method and solid supports
ATE217087T1 (de) * 1993-03-19 2002-05-15 Novartis Ag Chemilumineszierende derivate mit langer emissionswellenlänge und ihre verwendung in assays
US5395752A (en) * 1993-03-19 1995-03-07 Ciba Corning Diagnostics Corp. Long emission wavelength chemiluminescent compounds and their use in test assays
US5594151A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
CZ220196A3 (en) * 1994-01-28 1996-12-11 Prolinx Inc Bioconjugate complexes
US5623055A (en) * 1994-01-28 1997-04-22 Prolinx, Inc. Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation
US5847192A (en) * 1994-01-28 1998-12-08 Prolinx, Inc. Boronic compound complexing reagents and complexes
US5744627A (en) * 1994-01-28 1998-04-28 Prolinx, Inc. Boronic compound complexing reagents and complexes
US5777148A (en) * 1994-01-28 1998-07-07 Prolinx, Inc. Boronic compound complexing reagents and highly stable complexes
US5837878A (en) * 1994-01-28 1998-11-17 Prolinx, Inc. Boronic compound complexing reagents and highly stable complexes
US5852178A (en) * 1994-01-28 1998-12-22 Prolinx, Inc. Phenylboronic acid complexing reagents for conjugating biologically active molecules
US5880279A (en) * 1995-07-31 1999-03-09 Chevron U.S.A. Inc. Cobalt dihalodihydroxydisulfophthalocyanines
US6075126A (en) * 1996-08-05 2000-06-13 Prolinx, Inc. Phenyldiboronic acid reagents and complexes
US6156884A (en) * 1996-08-05 2000-12-05 Prolinx, Inc. Bifunctional boronic compound complexing reagents and complexes
DE19843094A1 (de) * 1998-09-21 2000-03-23 Roche Diagnostics Gmbh Verfahren zur Bestimmung von glykiertem Hämoglobin
WO2000056933A1 (en) * 1999-03-24 2000-09-28 Princeton Separations Chemically reactive plane-rigidized cyanine dyes and their derivatives
US20040039129A1 (en) * 2000-08-16 2004-02-26 Hall Dennis G. Non-pressurized methods for the preparation of conjugrated solid supports for boronic acids
EP1213328A1 (de) * 2000-12-08 2002-06-12 Evotec OAI AG Oxazinderivate
ATE287430T1 (de) * 2000-09-06 2005-02-15 Evotec Ag Oxazinderivate
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US6653141B2 (en) 2000-12-05 2003-11-25 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing method and device
US6627177B2 (en) * 2000-12-05 2003-09-30 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof
US7195923B2 (en) * 2001-01-31 2007-03-27 Scripps Laboratories, Inc. Ratiometric determination of glycated protein
GB0110053D0 (en) * 2001-04-24 2001-06-13 Axis Shield Asa Assay
AU2002314957A1 (en) * 2001-06-06 2002-12-16 Proteologics, Inc. Methods and compositions related to tagging of membrane surface proteins
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US7390670B2 (en) * 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US7427129B2 (en) * 2004-02-04 2008-09-23 Hewlett-Packard Development Company, L.P. Boronic acid containing dyes to improve permanence of images
BRPI0721056B8 (pt) * 2006-11-30 2019-11-19 Sensors For Medicine And Science Inc moléculas indicadoras resistentes a oxidação
GB0903348D0 (en) * 2009-02-27 2009-04-08 Pharmalucia Ltd Compounds and methods relating thereto
EP2721391B1 (en) 2011-06-17 2022-04-06 Roche Diagnostics Hematology, Inc. Solution and method for histoprocessing of biological samples
GB201215571D0 (en) 2012-08-31 2012-10-17 Axis Shield Asa Assay method
EP3375777A1 (en) * 2017-03-15 2018-09-19 MIKROCHEM spol. s.r.o. Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496722A (en) * 1981-05-01 1985-01-29 The Children's Medical Center Corporation Reporter compounds
EP0319620A1 (en) * 1987-12-10 1989-06-14 Viomedics Inc. Novel oxazines-ureas and thiazine urea chromophors
US4830786A (en) * 1986-02-27 1989-05-16 Syntex (U.S.A.) Inc. Squaraine dyes
DE3720736A1 (de) * 1987-06-23 1989-01-05 Erwin Dr Schleicher Verfahren, reagenzien und ausruestung zur einfachen bestimmung von nicht-enzymatisch glykosylierten proteinen in koerperfluessigkeiten
US4861728A (en) * 1987-07-24 1989-08-29 Becton, Dickinson And Company Immunoassay of glycosylated hemoglobin using a labeled boron reagent
EP0310361A3 (en) * 1987-09-30 1989-05-24 Beckman Instruments, Inc. Tridentate conjugate and method of use thereof
DE3827340A1 (de) * 1988-08-12 1990-02-15 Hoechst Ag Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen
DE3840452A1 (de) * 1988-12-01 1990-06-07 Hoechst Ag (beta)-amino-boronsaeure-derivate
DE3843605A1 (de) * 1988-12-23 1990-06-28 Hoechst Ag Wasserloesliche faserreaktive farbstoffe, verfahren zu ihrer herstellung und ihre verwendung
NO890029D0 (no) * 1989-01-04 1989-01-04 Axis Research Nye modifiserte peptider og proteiner for in vitro diagnoser (diabetes).
JPH02226070A (ja) * 1989-02-27 1990-09-07 Fuji Photo Film Co Ltd 糖タンパク質の定量方法
US5071531A (en) * 1989-05-01 1991-12-10 Soane Technologies, Inc. Casting of gradient gels
DE59004049D1 (de) * 1989-05-10 1994-02-10 Hoechst Ag Wasserlösliche faserreaktive farbstoffe, verfahren zu ihrer herstellung und ihre verwendung.
EP0455225B1 (en) * 1990-05-01 1995-03-29 Nacalai Tesque, Inc. Method for measuring the percentage of glycation of a particular protein

Similar Documents

Publication Publication Date Title
RU93043620A (ru) Агенты для мечения, включающие конъюгаты бороновой кислоты
CA2096251A1 (en) Labelling agents comprising boronic acid conjugates
DK0656929T3 (da) Anvendelse af forbindelser, som absorberer og/eller fluorescerer i IR-området,som mærkestoffer for væsker
CA2182516A1 (en) Probes labelled with energy transfer coupled dyes
CA2297216A1 (en) Cyanine dyes
CA2142091A1 (en) Process for dyeing keratin-containing fibres
DE59507493D1 (de) Farbstoffmischungen, enthaltend methin- und azofarbstoffe
DE69007176D1 (de) Infrarot-absorbierende trinukleare Cyanin-Farbstoffe für ein Farbstoff-Donor-Element, das bei der Laser-induzierten thermischen Farbstoff-Übertragung verwendet wird.
CA2254413A1 (en) Dye compositions
ITRM950393A0 (it) Coloranti reattici alla ftalocianina di alluminio.
DE59708389D1 (de) Farbstoffzubereitungen, enthaltend methinfarbstoffe
ES2146221T3 (es) Mezclas de colorantes, procedimiento para su obtencion y su empleo.
ATE204224T1 (de) Färben von holzfurnieren mit küpenfarbstoffen
DE59408676D1 (de) Farbstoffmischungen, 1:2-Kobaltkomplexformazanfarbstoffe und deren Verwendung
DE69308187D1 (de) Farbstoffgebendes Element, enthaltend Dicyanovinylanilinfarbstoffe
KR880007861A (ko) 적외선위장 나일론직물의 날염방법
RU95105438A (ru) Способ маркировки жидкостей
KR870004923A (ko) 천연석재의 착색방법
TW265352B (en) Tri-azo black dyes
TH14713EX (th) ซึ่งดูดกลืน และ/หรือ เรืองแสงในบริเวณอินฟราเรด (ir) เป็นสารแสดงเครื่องหมายบ่งบอกสำหรับของเหลว
RU98120387A (ru) Индикаторный пенетрант для цветного метода капиллярной дефектоскопии
KR850006208A (ko) 적외흡수 화합물의 제법
TH26379A (th) "สีย้อมล่วงหน้าแบบใหม่"
DE69122825D1 (de) Triphenodioxazin-Farbstoffe.
TH21238A (th) สีย้อมชนิดอะโซที่ก่อปฏิกิริยาไวที่มีส่วนประกอบสำหรับคัพลิงจากชุด