ES2069914T3 - Agentes marcadores que comprenden conjugados de acidos boronicos. - Google Patents
Agentes marcadores que comprenden conjugados de acidos boronicos.Info
- Publication number
- ES2069914T3 ES2069914T3 ES91920019T ES91920019T ES2069914T3 ES 2069914 T3 ES2069914 T3 ES 2069914T3 ES 91920019 T ES91920019 T ES 91920019T ES 91920019 T ES91920019 T ES 91920019T ES 2069914 T3 ES2069914 T3 ES 2069914T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- haemoglobin
- boronic acid
- acid conjugates
- labelling agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003795 chemical substances by application Substances 0.000 title abstract 4
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002372 labelling Methods 0.000 abstract 3
- 238000010521 absorption reaction Methods 0.000 abstract 2
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 238000000862 absorption spectrum Methods 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000001007 phthalocyanine dye Substances 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
- 239000001016 thiazine dye Substances 0.000 abstract 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 abstract 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Nanotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Luminescent Compositions (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE PRESENTAN AGENTES ETIQUETADORES QUE COMPRENDEN CONJUGADOS DE ACIDO BORICO NO PROTEINACEOS QUE TIENEN UNA ABSORCION MAXIMA NO MENOR DE 600 NM, DICHA ETIQUETA SE OBTIENE MEDIANTE UN COLORANTE DE POR EJEMPLO AZINA, TRIFENILMETANO, CIANINA O FTALOCIANINA, LOS AGENTES SON UTILES EN LA ESTIMACION Y CUANTIFICACION DE CISDIOLES TALES COMO LA HEMOGLOBINA GLICOSILADA, EN VIRTUD DE LA SUBSTANCIALMENTE TOTAL AUSENCIA DE SUPERPOSICION CON EL ESPECTRO DE ABSORCION DE LA HEMOGLOBINA. LOS COLORANTES DE OXACINA Y TIACINA, QUE EXHIBEN SIMILARES CARACTERISTICAS DE ABSORCION Y QUE CONTIENEN OTRAS MOLECULAS ACTIVADAS SON SIMILARMENTE UTILES COMO AGENTES ETIQUETADORES, ESPECIALMENTE EN LA PRESENCIA DE HEMOGLOBINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909024775A GB9024775D0 (en) | 1990-11-14 | 1990-11-14 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2069914T3 true ES2069914T3 (es) | 1995-05-16 |
Family
ID=10685377
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91920019T Expired - Lifetime ES2069914T3 (es) | 1990-11-14 | 1991-11-13 | Agentes marcadores que comprenden conjugados de acidos boronicos. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5739318A (es) |
EP (1) | EP0557357B1 (es) |
JP (1) | JP2761494B2 (es) |
AT (1) | ATE120195T1 (es) |
AU (1) | AU666294B2 (es) |
CA (1) | CA2096251C (es) |
DE (1) | DE69108403T2 (es) |
DK (1) | DK0557357T3 (es) |
ES (1) | ES2069914T3 (es) |
FI (1) | FI105549B (es) |
GB (1) | GB9024775D0 (es) |
HU (1) | HU216635B (es) |
NO (1) | NO304691B1 (es) |
PL (1) | PL176747B1 (es) |
RU (1) | RU2076127C1 (es) |
WO (1) | WO1992008722A1 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0596700A1 (en) * | 1992-11-03 | 1994-05-11 | Hewlett-Packard Company | Cis-diol detection method and solid supports |
EP0617288B1 (en) * | 1993-03-19 | 2002-05-02 | Novartis AG | Long emission wavelength chemiluminescent compounds and their use in test assays |
US5395752A (en) * | 1993-03-19 | 1995-03-07 | Ciba Corning Diagnostics Corp. | Long emission wavelength chemiluminescent compounds and their use in test assays |
ES2158085T3 (es) * | 1994-01-28 | 2001-09-01 | Prolinx Inc | Complejos de acido fenilboronico. |
US5744627A (en) * | 1994-01-28 | 1998-04-28 | Prolinx, Inc. | Boronic compound complexing reagents and complexes |
US5594151A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexing reagents derived from aminosalicylic acid |
US5852178A (en) * | 1994-01-28 | 1998-12-22 | Prolinx, Inc. | Phenylboronic acid complexing reagents for conjugating biologically active molecules |
US5777148A (en) * | 1994-01-28 | 1998-07-07 | Prolinx, Inc. | Boronic compound complexing reagents and highly stable complexes |
US5623055A (en) * | 1994-01-28 | 1997-04-22 | Prolinx, Inc. | Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation |
US5847192A (en) * | 1994-01-28 | 1998-12-08 | Prolinx, Inc. | Boronic compound complexing reagents and complexes |
US5837878A (en) * | 1994-01-28 | 1998-11-17 | Prolinx, Inc. | Boronic compound complexing reagents and highly stable complexes |
US5594111A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexes for bioconjugate preparation |
US5880279A (en) * | 1995-07-31 | 1999-03-09 | Chevron U.S.A. Inc. | Cobalt dihalodihydroxydisulfophthalocyanines |
US6075126A (en) | 1996-08-05 | 2000-06-13 | Prolinx, Inc. | Phenyldiboronic acid reagents and complexes |
US6156884A (en) | 1996-08-05 | 2000-12-05 | Prolinx, Inc. | Bifunctional boronic compound complexing reagents and complexes |
DE19843094A1 (de) | 1998-09-21 | 2000-03-23 | Roche Diagnostics Gmbh | Verfahren zur Bestimmung von glykiertem Hämoglobin |
AU4024500A (en) * | 1999-03-24 | 2000-10-09 | Princeton Separations | Chemically reactive plane-rigidized cyanine dyes and their derivatives |
CA2419238A1 (en) * | 2000-08-16 | 2002-02-21 | University Of Alberta | Non-pressurized methods for the preparation of conjugated solid supports for boronic acids |
EP1213328A1 (de) * | 2000-12-08 | 2002-06-12 | Evotec OAI AG | Oxazinderivate |
EP1535967B1 (de) * | 2000-09-06 | 2011-08-03 | Evotec AG | Verfahren zur gezielten Markierung mittels affinitätsmarkierter Detektionsmarker |
US6653141B2 (en) | 2000-12-05 | 2003-11-25 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing method and device |
US7470420B2 (en) | 2000-12-05 | 2008-12-30 | The Regents Of The University Of California | Optical determination of glucose utilizing boronic acid adducts |
US6627177B2 (en) | 2000-12-05 | 2003-09-30 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
US7195923B2 (en) * | 2001-01-31 | 2007-03-27 | Scripps Laboratories, Inc. | Ratiometric determination of glycated protein |
GB0110053D0 (en) * | 2001-04-24 | 2001-06-13 | Axis Shield Asa | Assay |
AU2002314957A1 (en) * | 2001-06-06 | 2002-12-16 | Proteologics, Inc. | Methods and compositions related to tagging of membrane surface proteins |
US6858592B2 (en) | 2001-06-29 | 2005-02-22 | Genzyme Corporation | Aryl boronic acids for treating obesity |
US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
US7390670B2 (en) * | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
US7427129B2 (en) * | 2004-02-04 | 2008-09-23 | Hewlett-Packard Development Company, L.P. | Boronic acid containing dyes to improve permanence of images |
CN101541813B (zh) * | 2006-11-30 | 2013-07-31 | 医药及科学传感器公司 | 耐氧化的指示剂分子 |
GB0903348D0 (en) * | 2009-02-27 | 2009-04-08 | Pharmalucia Ltd | Compounds and methods relating thereto |
ES2915263T3 (es) | 2011-06-17 | 2022-06-21 | Roche Diagnostics Hematology Inc | Solución y procedimiento para el histoprocesamiento de muestras biológicas |
GB201215571D0 (en) | 2012-08-31 | 2012-10-17 | Axis Shield Asa | Assay method |
EP3375777A1 (en) * | 2017-03-15 | 2018-09-19 | MIKROCHEM spol. s.r.o. | Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4496722A (en) * | 1981-05-01 | 1985-01-29 | The Children's Medical Center Corporation | Reporter compounds |
EP0319620A1 (en) * | 1987-12-10 | 1989-06-14 | Viomedics Inc. | Novel oxazines-ureas and thiazine urea chromophors |
US4830786A (en) * | 1986-02-27 | 1989-05-16 | Syntex (U.S.A.) Inc. | Squaraine dyes |
DE3720736A1 (de) * | 1987-06-23 | 1989-01-05 | Erwin Dr Schleicher | Verfahren, reagenzien und ausruestung zur einfachen bestimmung von nicht-enzymatisch glykosylierten proteinen in koerperfluessigkeiten |
US4861728A (en) * | 1987-07-24 | 1989-08-29 | Becton, Dickinson And Company | Immunoassay of glycosylated hemoglobin using a labeled boron reagent |
EP0310361A3 (en) * | 1987-09-30 | 1989-05-24 | Beckman Instruments, Inc. | Tridentate conjugate and method of use thereof |
DE3827340A1 (de) * | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
DE3840452A1 (de) * | 1988-12-01 | 1990-06-07 | Hoechst Ag | (beta)-amino-boronsaeure-derivate |
DE3843605A1 (de) * | 1988-12-23 | 1990-06-28 | Hoechst Ag | Wasserloesliche faserreaktive farbstoffe, verfahren zu ihrer herstellung und ihre verwendung |
NO890029D0 (no) * | 1989-01-04 | 1989-01-04 | Axis Research | Nye modifiserte peptider og proteiner for in vitro diagnoser (diabetes). |
JPH02226070A (ja) * | 1989-02-27 | 1990-09-07 | Fuji Photo Film Co Ltd | 糖タンパク質の定量方法 |
US5071531A (en) * | 1989-05-01 | 1991-12-10 | Soane Technologies, Inc. | Casting of gradient gels |
JPH07113089B2 (ja) * | 1989-05-10 | 1995-12-06 | ヘキスト・アクチェンゲゼルシャフト | 水溶性の繊維反応性染料、その製造方法およびその用途 |
DE69108439T2 (de) * | 1990-05-01 | 1995-07-27 | Nacalai Tesque Inc | Verfahren zur Bestimmung des Glykationsprozentsatzes eines bestimmten Proteins. |
-
1990
- 1990-11-14 GB GB909024775A patent/GB9024775D0/en active Pending
-
1991
- 1991-11-13 US US08/050,275 patent/US5739318A/en not_active Expired - Lifetime
- 1991-11-13 WO PCT/EP1991/002160 patent/WO1992008722A1/en active IP Right Grant
- 1991-11-13 AU AU89092/91A patent/AU666294B2/en not_active Ceased
- 1991-11-13 CA CA002096251A patent/CA2096251C/en not_active Expired - Lifetime
- 1991-11-13 ES ES91920019T patent/ES2069914T3/es not_active Expired - Lifetime
- 1991-11-13 DE DE69108403T patent/DE69108403T2/de not_active Expired - Lifetime
- 1991-11-13 EP EP91920019A patent/EP0557357B1/en not_active Expired - Lifetime
- 1991-11-13 AT AT91920019T patent/ATE120195T1/de not_active IP Right Cessation
- 1991-11-13 HU HU9301408A patent/HU216635B/hu unknown
- 1991-11-13 PL PL91299064A patent/PL176747B1/pl not_active IP Right Cessation
- 1991-11-13 DK DK91920019.6T patent/DK0557357T3/da active
- 1991-11-13 JP JP3518099A patent/JP2761494B2/ja not_active Expired - Lifetime
- 1991-11-13 RU RU9193043620A patent/RU2076127C1/ru not_active IP Right Cessation
-
1993
- 1993-05-12 FI FI932149A patent/FI105549B/fi not_active IP Right Cessation
- 1993-05-13 NO NO931746A patent/NO304691B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5739318A (en) | 1998-04-14 |
FI932149A0 (fi) | 1993-05-12 |
ATE120195T1 (de) | 1995-04-15 |
JPH06502170A (ja) | 1994-03-10 |
NO304691B1 (no) | 1999-02-01 |
DE69108403T2 (de) | 1995-08-17 |
NO931746L (no) | 1993-07-13 |
RU2076127C1 (ru) | 1997-03-27 |
FI932149A (fi) | 1993-06-10 |
DK0557357T3 (da) | 1995-06-12 |
DE69108403D1 (de) | 1995-04-27 |
AU666294B2 (en) | 1996-02-08 |
JP2761494B2 (ja) | 1998-06-04 |
EP0557357A1 (en) | 1993-09-01 |
CA2096251A1 (en) | 1992-05-15 |
HU216635B (hu) | 1999-07-28 |
AU8909291A (en) | 1992-06-11 |
GB9024775D0 (en) | 1991-01-02 |
EP0557357B1 (en) | 1995-03-22 |
CA2096251C (en) | 1999-08-17 |
FI105549B (fi) | 2000-09-15 |
WO1992008722A1 (en) | 1992-05-29 |
HUT64353A (en) | 1993-12-28 |
NO931746D0 (no) | 1993-05-13 |
PL176747B1 (pl) | 1999-07-30 |
HU9301408D0 (en) | 1993-09-28 |
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