RU2769251C2 - Комбинированная терапия для лечения гепатоцеллюлярной карциномы - Google Patents

Комбинированная терапия для лечения гепатоцеллюлярной карциномы Download PDF

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RU2769251C2
RU2769251C2 RU2019108259A RU2019108259A RU2769251C2 RU 2769251 C2 RU2769251 C2 RU 2769251C2 RU 2019108259 A RU2019108259 A RU 2019108259A RU 2019108259 A RU2019108259 A RU 2019108259A RU 2769251 C2 RU2769251 C2 RU 2769251C2
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pharmaceutically acceptable
amino
inhibitor
cdk
pyrimidin
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RU2019108259A
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Russian (ru)
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RU2019108259A3 (OSRAM
RU2019108259A (ru
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Ананд СЕЛВАРАДЖ
Питер Смит
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Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2019108259A 2016-08-23 2017-08-23 Комбинированная терапия для лечения гепатоцеллюлярной карциномы RU2769251C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662378455P 2016-08-23 2016-08-23
US62/378,455 2016-08-23
PCT/US2017/048183 WO2018039324A1 (en) 2016-08-23 2017-08-23 Combination therapies for the treatment of hepatocellular carcinoma

Publications (3)

Publication Number Publication Date
RU2019108259A RU2019108259A (ru) 2020-09-25
RU2019108259A3 RU2019108259A3 (OSRAM) 2020-11-24
RU2769251C2 true RU2769251C2 (ru) 2022-03-29

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RU2019108259A RU2769251C2 (ru) 2016-08-23 2017-08-23 Комбинированная терапия для лечения гепатоцеллюлярной карциномы

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Country Link
US (1) US20190175598A1 (OSRAM)
EP (1) EP3503923B1 (OSRAM)
JP (1) JP7190425B2 (OSRAM)
KR (1) KR102466192B1 (OSRAM)
CN (1) CN109803684B (OSRAM)
AU (1) AU2017315357B2 (OSRAM)
BR (1) BR112019003722A2 (OSRAM)
CA (1) CA3034875C (OSRAM)
ES (1) ES2966469T3 (OSRAM)
IL (1) IL264950B2 (OSRAM)
MX (1) MX2019002115A (OSRAM)
RU (1) RU2769251C2 (OSRAM)
SG (1) SG11201901472TA (OSRAM)
WO (1) WO2018039324A1 (OSRAM)

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EP4309656A3 (en) 2018-05-14 2024-02-28 Pfizer Inc. Oral solution formulation
TW202128173A (zh) * 2019-10-09 2021-08-01 美商G1治療公司 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療
WO2021230886A1 (en) * 2020-05-15 2021-11-18 Eisai R&D Management Co., Ltd. A method for treating cancer with an oral dosage form of an fgfr4 inhibitor
WO2023232012A1 (zh) 2022-05-30 2023-12-07 石药集团中奇制药技术（石家庄）有限公司 用于治疗癌症的药物组合和药物组合物
TW202523318A (zh) * 2023-11-30 2025-06-16 大陸商石藥集團中奇製藥技術（石家莊）有限公司 聯合治療腫瘤的藥物

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Also Published As

Publication number Publication date
WO2018039324A1 (en) 2018-03-01
JP7190425B2 (ja) 2022-12-15
CN109803684B (zh) 2022-08-23
JP2019528302A (ja) 2019-10-10
RU2019108259A3 (OSRAM) 2020-11-24
BR112019003722A2 (pt) 2019-05-28
CA3034875A1 (en) 2018-03-01
RU2019108259A (ru) 2020-09-25
EP3503923A1 (en) 2019-07-03
AU2017315357B2 (en) 2022-12-01
AU2017315357A1 (en) 2019-02-28
KR102466192B1 (ko) 2022-11-14
US20190175598A1 (en) 2019-06-13
MX2019002115A (es) 2019-07-08
IL264950A (en) 2019-05-30
IL264950B1 (en) 2023-09-01
IL264950B2 (en) 2024-01-01
KR20190040996A (ko) 2019-04-19
EP3503923B1 (en) 2023-10-04
ES2966469T3 (es) 2024-04-22
SG11201901472TA (en) 2019-03-28
CA3034875C (en) 2024-05-28
CN109803684A (zh) 2019-05-24

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