RU2764573C2 - Улучшенный синтез частиц ацетилсалицилата лизина ⋅ глицина - Google Patents

Улучшенный синтез частиц ацетилсалицилата лизина ⋅ глицина Download PDF

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RU2764573C2
RU2764573C2 RU2019115337A RU2019115337A RU2764573C2 RU 2764573 C2 RU2764573 C2 RU 2764573C2 RU 2019115337 A RU2019115337 A RU 2019115337A RU 2019115337 A RU2019115337 A RU 2019115337A RU 2764573 C2 RU2764573 C2 RU 2764573C2
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Russia
Prior art keywords
glycine
lysine
acetylsalicylic acid
mixture
solution
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RU2019115337A
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English (en)
Russian (ru)
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RU2019115337A3 (enExample
RU2019115337A (ru
Inventor
Карлхайнц НОККЕР
Ральф ЦУЗЕ
Дмитро ОСТРОВСКИЙ
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АспиЭйр ГмбХ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/26—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing carboxyl groups by reaction with HCN, or a salt thereof, and amines, or from aminonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2019115337A 2016-12-23 2017-12-22 Улучшенный синтез частиц ацетилсалицилата лизина ⋅ глицина RU2764573C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16206723 2016-12-23
EP16206723.5 2016-12-23
PCT/EP2017/084369 WO2018115434A1 (en) 2016-12-23 2017-12-22 Improved synthesis of lysine acetylsalicylate · glycine particles

Publications (3)

Publication Number Publication Date
RU2019115337A RU2019115337A (ru) 2021-02-01
RU2019115337A3 RU2019115337A3 (enExample) 2021-03-12
RU2764573C2 true RU2764573C2 (ru) 2022-01-18

Family

ID=57680128

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019115337A RU2764573C2 (ru) 2016-12-23 2017-12-22 Улучшенный синтез частиц ацетилсалицилата лизина ⋅ глицина

Country Status (11)

Country Link
US (1) US10882811B2 (enExample)
EP (1) EP3558920B1 (enExample)
JP (1) JP7012725B2 (enExample)
CN (1) CN110114333B (enExample)
AU (1) AU2017383071B2 (enExample)
CA (1) CA3044137C (enExample)
DK (1) DK3558920T3 (enExample)
ES (1) ES2877856T3 (enExample)
PT (1) PT3558920T (enExample)
RU (1) RU2764573C2 (enExample)
WO (1) WO2018115434A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113105326A (zh) * 2021-03-24 2021-07-13 海南卓华制药有限公司 赖氨匹林的制备方法及应用
AU2023205426A1 (en) 2022-01-05 2024-06-13 Aspiair Gmbh Improved synthesis of lysine acetylsalicylate · glycine particles

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005782A2 (de) * 2000-07-18 2002-01-24 Bayer Aktiengesellschaft Stabile salze von o-acetylsalicylsäure mit basischen aminosäuren
WO2009089822A2 (de) * 2008-01-14 2009-07-23 Activaero Gmbh Verwendung eines acetylsalicylsäuresalzes zur behandlung viraler infektionen
RU2433995C2 (ru) * 2005-06-02 2011-11-20 Байер Шеринг Фарма Акциенгезельшафт Стабильный биологически активный комплекс солей о-ацетилсалициловой кислоты с основными аминокислотами и глицина

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2101867A (en) 1934-08-18 1937-12-14 Clemmy O Miller Manufacture of water-soluble, storage-stable acetylsalicylic acid products
FR1295304A (fr) 1956-05-07 1962-06-08 Equilibre Biolog L Nouveau sel de l'acide acétyl-salicylique et son procédé de préparation
US3392195A (en) 1963-09-09 1968-07-09 Galat Alexander Amino acid derivatives
ES385222A1 (es) 1970-11-05 1973-04-01 Liade Sa Lab Procedimiento de obtencion de una sal soluble del acido a- cetil salicilico.
JPS5610110A (en) 1979-07-06 1981-02-02 Green Cross Corp:The Acetyl salicylate salt preparation for injection
US4446132A (en) 1982-03-11 1984-05-01 Dynatech Laboratories Incorporated Nontoxic aspirin composition
FR2611501B1 (fr) 1987-03-04 1991-12-06 Corbiere Jerome Nouvelles compositions pharmaceutiques pour la voie buccale a base d'acetylsalielylate de lysine et leur procede d'obtention
CN1043138C (zh) * 1992-05-22 1999-04-28 安徽省蚌埠安宝药厂 赖氨匹林的制造方法
DE10202019A1 (de) * 2002-01-18 2003-07-24 Bayer Ag Stabile Salze von o-Acetylsalicylsäure mit basischen Aminosäuren II
US20060166901A1 (en) 2005-01-03 2006-07-27 Yu Ruey J Compositions comprising O-acetylsalicyl derivatives of aminocarbohydrates and amino acids
DE102005049293A1 (de) 2005-10-15 2007-04-26 Bayer Healthcare Ag Kombinationspräparate von Salzen oder o-Acetylsalicylsäure
FR2965261B1 (fr) * 2009-09-30 2012-10-26 Holis Technologies Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue par ce procede
FR2973370B1 (fr) 2011-03-29 2013-05-03 Holis Technologies Procede a faible cout pour la preparation d'un acide o-acetylsalicyclique et d'un acide amine basique
CN102503845A (zh) * 2011-09-28 2012-06-20 广州普星药业有限公司 一种dl-赖氨酸阿司匹林盐的制备方法及其应用
ITMI20121144A1 (it) 2012-06-28 2013-12-29 Dipharma Francis Srl Procedimento per la preparazione di un sale di un farmaco antinfiammatorio non steroideo
FR3021654B1 (fr) 2014-05-28 2016-06-24 Unither Pharmaceuticals Procede de preparation d'un sel d'acide acetylsalicylique et d'un acide amine basique
DK3393517T3 (da) * 2015-12-22 2021-11-01 Aspiair Gmbh Acetylsalicylsyre til anvendelse til behandling af moderat til alvorlig influenza

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005782A2 (de) * 2000-07-18 2002-01-24 Bayer Aktiengesellschaft Stabile salze von o-acetylsalicylsäure mit basischen aminosäuren
RU2433995C2 (ru) * 2005-06-02 2011-11-20 Байер Шеринг Фарма Акциенгезельшафт Стабильный биологически активный комплекс солей о-ацетилсалициловой кислоты с основными аминокислотами и глицина
WO2009089822A2 (de) * 2008-01-14 2009-07-23 Activaero Gmbh Verwendung eines acetylsalicylsäuresalzes zur behandlung viraler infektionen

Also Published As

Publication number Publication date
EP3558920B1 (en) 2021-04-07
PT3558920T (pt) 2021-06-09
CA3044137A1 (en) 2018-06-28
DK3558920T3 (da) 2021-07-05
WO2018115434A1 (en) 2018-06-28
ES2877856T3 (es) 2021-11-17
RU2019115337A3 (enExample) 2021-03-12
AU2017383071A1 (en) 2019-06-06
JP7012725B2 (ja) 2022-01-28
AU2017383071B2 (en) 2021-04-29
CN110114333A (zh) 2019-08-09
CN110114333B (zh) 2022-12-02
JP2020514261A (ja) 2020-05-21
RU2019115337A (ru) 2021-02-01
EP3558920A1 (en) 2019-10-30
US20190322610A1 (en) 2019-10-24
US10882811B2 (en) 2021-01-05
CA3044137C (en) 2021-06-15

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