JP7012725B2 - アセチルサリチル酸リジン・グリシン粒子の改良された合成 - Google Patents

アセチルサリチル酸リジン・グリシン粒子の改良された合成 Download PDF

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JP7012725B2
JP7012725B2 JP2019533172A JP2019533172A JP7012725B2 JP 7012725 B2 JP7012725 B2 JP 7012725B2 JP 2019533172 A JP2019533172 A JP 2019533172A JP 2019533172 A JP2019533172 A JP 2019533172A JP 7012725 B2 JP7012725 B2 JP 7012725B2
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lysine
glycine
acetylsalicylic acid
solution
mixture
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JP2020514261A (ja
JP2020514261A5 (enExample
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カールハインツ ノッカー，
ラルフ ツゥーゼ，
ドゥミトロ オストロフスキー，
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アスピエアー ゲーエムベーハー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/26—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing carboxyl groups by reaction with HCN, or a salt thereof, and amines, or from aminonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2019533172A 2016-12-23 2017-12-22 アセチルサリチル酸リジン・グリシン粒子の改良された合成 Active JP7012725B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16206723 2016-12-23
EP16206723.5 2016-12-23
PCT/EP2017/084369 WO2018115434A1 (en) 2016-12-23 2017-12-22 Improved synthesis of lysine acetylsalicylate · glycine particles

Publications (3)

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JP2020514261A JP2020514261A (ja) 2020-05-21
JP2020514261A5 JP2020514261A5 (enExample) 2021-01-28
JP7012725B2 true JP7012725B2 (ja) 2022-01-28

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JP2019533172A Active JP7012725B2 (ja) 2016-12-23 2017-12-22 アセチルサリチル酸リジン・グリシン粒子の改良された合成

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Country Link
US (1) US10882811B2 (enExample)
EP (1) EP3558920B1 (enExample)
JP (1) JP7012725B2 (enExample)
CN (1) CN110114333B (enExample)
AU (1) AU2017383071B2 (enExample)
CA (1) CA3044137C (enExample)
DK (1) DK3558920T3 (enExample)
ES (1) ES2877856T3 (enExample)
PT (1) PT3558920T (enExample)
RU (1) RU2764573C2 (enExample)
WO (1) WO2018115434A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113105326A (zh) * 2021-03-24 2021-07-13 海南卓华制药有限公司 赖氨匹林的制备方法及应用
AU2023205426A1 (en) 2022-01-05 2024-06-13 Aspiair Gmbh Improved synthesis of lysine acetylsalicylate · glycine particles

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004507463A (ja) 2000-07-18 2004-03-11 バイエル　アクチェンゲゼルシャフト ｏ−アセチルサリチル酸と塩基性アミノ酸との安定塩
JP2008526774A (ja) 2005-01-03 2008-07-24 リュイ ジェイ． ユー， アミノ炭水化物およびアミノ酸のｏ−アセチルサリチル誘導体を含む組成物
JP2008542316A (ja) 2005-06-02 2008-11-27 バイエル・ヘルスケア・アクチェンゲゼルシャフト ｏ−アセチルサリチル酸の塩基性アミノ酸との塩およびグリシンの安定な活性化合物複合体
JP2011509928A (ja) 2008-01-14 2011-03-31 アクティファエロ ゲーエムベーハー ウィルス感染を治療するためのアセチルサリチル酸塩を使用する方法
WO2017109037A1 (en) 2015-12-22 2017-06-29 Ventaleon Gmbh Treatment of moderate to severe influenza

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2101867A (en) 1934-08-18 1937-12-14 Clemmy O Miller Manufacture of water-soluble, storage-stable acetylsalicylic acid products
FR1295304A (fr) 1956-05-07 1962-06-08 Equilibre Biolog L Nouveau sel de l'acide acétyl-salicylique et son procédé de préparation
US3392195A (en) 1963-09-09 1968-07-09 Galat Alexander Amino acid derivatives
ES385222A1 (es) 1970-11-05 1973-04-01 Liade Sa Lab Procedimiento de obtencion de una sal soluble del acido a- cetil salicilico.
JPS5610110A (en) 1979-07-06 1981-02-02 Green Cross Corp:The Acetyl salicylate salt preparation for injection
US4446132A (en) 1982-03-11 1984-05-01 Dynatech Laboratories Incorporated Nontoxic aspirin composition
FR2611501B1 (fr) 1987-03-04 1991-12-06 Corbiere Jerome Nouvelles compositions pharmaceutiques pour la voie buccale a base d'acetylsalielylate de lysine et leur procede d'obtention
CN1043138C (zh) * 1992-05-22 1999-04-28 安徽省蚌埠安宝药厂 赖氨匹林的制造方法
DE10202019A1 (de) * 2002-01-18 2003-07-24 Bayer Ag Stabile Salze von o-Acetylsalicylsäure mit basischen Aminosäuren II
DE102005049293A1 (de) 2005-10-15 2007-04-26 Bayer Healthcare Ag Kombinationspräparate von Salzen oder o-Acetylsalicylsäure
FR2965261B1 (fr) * 2009-09-30 2012-10-26 Holis Technologies Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue par ce procede
FR2973370B1 (fr) 2011-03-29 2013-05-03 Holis Technologies Procede a faible cout pour la preparation d'un acide o-acetylsalicyclique et d'un acide amine basique
CN102503845A (zh) * 2011-09-28 2012-06-20 广州普星药业有限公司 一种dl-赖氨酸阿司匹林盐的制备方法及其应用
ITMI20121144A1 (it) 2012-06-28 2013-12-29 Dipharma Francis Srl Procedimento per la preparazione di un sale di un farmaco antinfiammatorio non steroideo
FR3021654B1 (fr) 2014-05-28 2016-06-24 Unither Pharmaceuticals Procede de preparation d'un sel d'acide acetylsalicylique et d'un acide amine basique

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004507463A (ja) 2000-07-18 2004-03-11 バイエル　アクチェンゲゼルシャフト ｏ−アセチルサリチル酸と塩基性アミノ酸との安定塩
JP2008526774A (ja) 2005-01-03 2008-07-24 リュイ ジェイ． ユー， アミノ炭水化物およびアミノ酸のｏ−アセチルサリチル誘導体を含む組成物
JP2008542316A (ja) 2005-06-02 2008-11-27 バイエル・ヘルスケア・アクチェンゲゼルシャフト ｏ−アセチルサリチル酸の塩基性アミノ酸との塩およびグリシンの安定な活性化合物複合体
JP2011509928A (ja) 2008-01-14 2011-03-31 アクティファエロ ゲーエムベーハー ウィルス感染を治療するためのアセチルサリチル酸塩を使用する方法
WO2017109037A1 (en) 2015-12-22 2017-06-29 Ventaleon Gmbh Treatment of moderate to severe influenza

Also Published As

Publication number Publication date
EP3558920B1 (en) 2021-04-07
PT3558920T (pt) 2021-06-09
CA3044137A1 (en) 2018-06-28
DK3558920T3 (da) 2021-07-05
WO2018115434A1 (en) 2018-06-28
ES2877856T3 (es) 2021-11-17
RU2019115337A3 (enExample) 2021-03-12
AU2017383071A1 (en) 2019-06-06
AU2017383071B2 (en) 2021-04-29
CN110114333A (zh) 2019-08-09
CN110114333B (zh) 2022-12-02
JP2020514261A (ja) 2020-05-21
RU2019115337A (ru) 2021-02-01
RU2764573C2 (ru) 2022-01-18
EP3558920A1 (en) 2019-10-30
US20190322610A1 (en) 2019-10-24
US10882811B2 (en) 2021-01-05
CA3044137C (en) 2021-06-15

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