AU2017383071B2 - Improved synthesis of lysine acetylsalicylate · glycine particles - Google Patents
Improved synthesis of lysine acetylsalicylate · glycine particles Download PDFInfo
- Publication number
- AU2017383071B2 AU2017383071B2 AU2017383071A AU2017383071A AU2017383071B2 AU 2017383071 B2 AU2017383071 B2 AU 2017383071B2 AU 2017383071 A AU2017383071 A AU 2017383071A AU 2017383071 A AU2017383071 A AU 2017383071A AU 2017383071 B2 AU2017383071 B2 AU 2017383071B2
- Authority
- AU
- Australia
- Prior art keywords
- glycine
- lysine
- acetylsalicylic acid
- mixture
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/26—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing carboxyl groups by reaction with HCN, or a salt thereof, and amines, or from aminonitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
- C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
- C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16206723 | 2016-12-23 | ||
| EP16206723.5 | 2016-12-23 | ||
| PCT/EP2017/084369 WO2018115434A1 (en) | 2016-12-23 | 2017-12-22 | Improved synthesis of lysine acetylsalicylate · glycine particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017383071A1 AU2017383071A1 (en) | 2019-06-06 |
| AU2017383071B2 true AU2017383071B2 (en) | 2021-04-29 |
Family
ID=57680128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017383071A Active AU2017383071B2 (en) | 2016-12-23 | 2017-12-22 | Improved synthesis of lysine acetylsalicylate · glycine particles |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10882811B2 (enExample) |
| EP (1) | EP3558920B1 (enExample) |
| JP (1) | JP7012725B2 (enExample) |
| CN (1) | CN110114333B (enExample) |
| AU (1) | AU2017383071B2 (enExample) |
| CA (1) | CA3044137C (enExample) |
| DK (1) | DK3558920T3 (enExample) |
| ES (1) | ES2877856T3 (enExample) |
| PT (1) | PT3558920T (enExample) |
| RU (1) | RU2764573C2 (enExample) |
| WO (1) | WO2018115434A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113105326A (zh) * | 2021-03-24 | 2021-07-13 | 海南卓华制药有限公司 | 赖氨匹林的制备方法及应用 |
| AU2023205426A1 (en) | 2022-01-05 | 2024-06-13 | Aspiair Gmbh | Improved synthesis of lysine acetylsalicylate · glycine particles |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002005782A2 (de) * | 2000-07-18 | 2002-01-24 | Bayer Aktiengesellschaft | Stabile salze von o-acetylsalicylsäure mit basischen aminosäuren |
| WO2009089822A2 (de) * | 2008-01-14 | 2009-07-23 | Activaero Gmbh | Verwendung eines acetylsalicylsäuresalzes zur behandlung viraler infektionen |
| WO2011039432A1 (fr) * | 2009-09-30 | 2011-04-07 | Holis Technologies | Procede de preparation d'un sel d'acide o- acetylsalicylique et d'un acide amine basique ainsi que composition obtenue par ce procede |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2101867A (en) | 1934-08-18 | 1937-12-14 | Clemmy O Miller | Manufacture of water-soluble, storage-stable acetylsalicylic acid products |
| FR1295304A (fr) | 1956-05-07 | 1962-06-08 | Equilibre Biolog L | Nouveau sel de l'acide acétyl-salicylique et son procédé de préparation |
| US3392195A (en) | 1963-09-09 | 1968-07-09 | Galat Alexander | Amino acid derivatives |
| ES385222A1 (es) | 1970-11-05 | 1973-04-01 | Liade Sa Lab | Procedimiento de obtencion de una sal soluble del acido a- cetil salicilico. |
| JPS5610110A (en) | 1979-07-06 | 1981-02-02 | Green Cross Corp:The | Acetyl salicylate salt preparation for injection |
| US4446132A (en) | 1982-03-11 | 1984-05-01 | Dynatech Laboratories Incorporated | Nontoxic aspirin composition |
| FR2611501B1 (fr) | 1987-03-04 | 1991-12-06 | Corbiere Jerome | Nouvelles compositions pharmaceutiques pour la voie buccale a base d'acetylsalielylate de lysine et leur procede d'obtention |
| CN1043138C (zh) * | 1992-05-22 | 1999-04-28 | 安徽省蚌埠安宝药厂 | 赖氨匹林的制造方法 |
| DE10202019A1 (de) * | 2002-01-18 | 2003-07-24 | Bayer Ag | Stabile Salze von o-Acetylsalicylsäure mit basischen Aminosäuren II |
| US20060166901A1 (en) | 2005-01-03 | 2006-07-27 | Yu Ruey J | Compositions comprising O-acetylsalicyl derivatives of aminocarbohydrates and amino acids |
| DE102005025283A1 (de) * | 2005-06-02 | 2006-12-07 | Bayer Healthcare Ag | Stabiler Wirkstoffkomplex von Salzen der o-Acetylsalicylsäure mit basischen Aminosäuren und Glycin |
| DE102005049293A1 (de) | 2005-10-15 | 2007-04-26 | Bayer Healthcare Ag | Kombinationspräparate von Salzen oder o-Acetylsalicylsäure |
| FR2973370B1 (fr) | 2011-03-29 | 2013-05-03 | Holis Technologies | Procede a faible cout pour la preparation d'un acide o-acetylsalicyclique et d'un acide amine basique |
| CN102503845A (zh) * | 2011-09-28 | 2012-06-20 | 广州普星药业有限公司 | 一种dl-赖氨酸阿司匹林盐的制备方法及其应用 |
| ITMI20121144A1 (it) | 2012-06-28 | 2013-12-29 | Dipharma Francis Srl | Procedimento per la preparazione di un sale di un farmaco antinfiammatorio non steroideo |
| FR3021654B1 (fr) | 2014-05-28 | 2016-06-24 | Unither Pharmaceuticals | Procede de preparation d'un sel d'acide acetylsalicylique et d'un acide amine basique |
| DK3393517T3 (da) * | 2015-12-22 | 2021-11-01 | Aspiair Gmbh | Acetylsalicylsyre til anvendelse til behandling af moderat til alvorlig influenza |
-
2017
- 2017-12-22 ES ES17822689T patent/ES2877856T3/es active Active
- 2017-12-22 PT PT178226890T patent/PT3558920T/pt unknown
- 2017-12-22 RU RU2019115337A patent/RU2764573C2/ru active
- 2017-12-22 JP JP2019533172A patent/JP7012725B2/ja active Active
- 2017-12-22 DK DK17822689.0T patent/DK3558920T3/da active
- 2017-12-22 CN CN201780080190.4A patent/CN110114333B/zh active Active
- 2017-12-22 US US16/472,726 patent/US10882811B2/en active Active
- 2017-12-22 AU AU2017383071A patent/AU2017383071B2/en active Active
- 2017-12-22 EP EP17822689.0A patent/EP3558920B1/en active Active
- 2017-12-22 CA CA3044137A patent/CA3044137C/en active Active
- 2017-12-22 WO PCT/EP2017/084369 patent/WO2018115434A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002005782A2 (de) * | 2000-07-18 | 2002-01-24 | Bayer Aktiengesellschaft | Stabile salze von o-acetylsalicylsäure mit basischen aminosäuren |
| WO2009089822A2 (de) * | 2008-01-14 | 2009-07-23 | Activaero Gmbh | Verwendung eines acetylsalicylsäuresalzes zur behandlung viraler infektionen |
| WO2011039432A1 (fr) * | 2009-09-30 | 2011-04-07 | Holis Technologies | Procede de preparation d'un sel d'acide o- acetylsalicylique et d'un acide amine basique ainsi que composition obtenue par ce procede |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3558920B1 (en) | 2021-04-07 |
| PT3558920T (pt) | 2021-06-09 |
| CA3044137A1 (en) | 2018-06-28 |
| DK3558920T3 (da) | 2021-07-05 |
| WO2018115434A1 (en) | 2018-06-28 |
| ES2877856T3 (es) | 2021-11-17 |
| RU2019115337A3 (enExample) | 2021-03-12 |
| AU2017383071A1 (en) | 2019-06-06 |
| JP7012725B2 (ja) | 2022-01-28 |
| CN110114333A (zh) | 2019-08-09 |
| CN110114333B (zh) | 2022-12-02 |
| JP2020514261A (ja) | 2020-05-21 |
| RU2019115337A (ru) | 2021-02-01 |
| RU2764573C2 (ru) | 2022-01-18 |
| EP3558920A1 (en) | 2019-10-30 |
| US20190322610A1 (en) | 2019-10-24 |
| US10882811B2 (en) | 2021-01-05 |
| CA3044137C (en) | 2021-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: ASPIAIR GMBH Free format text: FORMER APPLICANT(S): VENTALEON GMBH |
|
| FGA | Letters patent sealed or granted (standard patent) |