RU2756318C2 - Мутеины липокалина 2 человека с аффинностью в отношении глипикана-3 (gpc3) - Google Patents

Мутеины липокалина 2 человека с аффинностью в отношении глипикана-3 (gpc3) Download PDF

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RU2756318C2
RU2756318C2 RU2017135605A RU2017135605A RU2756318C2 RU 2756318 C2 RU2756318 C2 RU 2756318C2 RU 2017135605 A RU2017135605 A RU 2017135605A RU 2017135605 A RU2017135605 A RU 2017135605A RU 2756318 C2 RU2756318 C2 RU 2756318C2
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Марлон Хиннер
Андреа Аллерсдорфер
Рачида Сихам Бел Айба
Михаэла АЛЁ
Александер Виденман
Габриеле МАЧИНЕР
Мартин Хюльсмейер
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ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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RU2017135605A 2015-05-18 2016-05-18 Мутеины липокалина 2 человека с аффинностью в отношении глипикана-3 (gpc3) RU2756318C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15167922 2015-05-18
EP15167922.2 2015-05-18
PCT/EP2016/061058 WO2016184875A1 (en) 2015-05-18 2016-05-18 Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3)

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RU2017135605A RU2017135605A (ru) 2019-06-18
RU2017135605A3 RU2017135605A3 (cg-RX-API-DMAC7.html) 2019-11-13
RU2756318C2 true RU2756318C2 (ru) 2021-09-29

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US (2) US10273275B2 (cg-RX-API-DMAC7.html)
EP (1) EP3298029A1 (cg-RX-API-DMAC7.html)
JP (2) JP6942060B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180008649A (cg-RX-API-DMAC7.html)
CN (2) CN114456252A (cg-RX-API-DMAC7.html)
AU (1) AU2016262838B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017020961A2 (cg-RX-API-DMAC7.html)
CA (1) CA2982034A1 (cg-RX-API-DMAC7.html)
MX (1) MX2017014730A (cg-RX-API-DMAC7.html)
RU (1) RU2756318C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201707872WA (cg-RX-API-DMAC7.html)
WO (1) WO2016184875A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201706605B (cg-RX-API-DMAC7.html)

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BR112017020434A2 (pt) 2015-05-04 2018-06-26 Pieris Pharmaceuticals Gmbh polipeptídeos de fusão, molécula de ácido nucleico, célula hospedeira, método para produzir um polipeptídeo de fusão, usos do polipeptídeo de fusão, métodos para ativar as vias de sinalização, para coestimular células, para induzir a proliferação de linfócitos t, para direcionar o agrupamento de cd137, para induzir uma resposta local de células t, para induzir uma resposta local de células nk e para induzir a produção de il-2
DK3292137T3 (da) 2015-05-04 2022-10-17 Pieris Pharmaceuticals Gmbh Proteiner specifikke for cd137
KR20180008649A (ko) 2015-05-18 2018-01-24 피어이스 파마슈티컬즈 게엠베하 글리피칸-3(gpc3)에 대해 친화도를 갖는 인간 리포칼린 2의 뮤테인
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TW201725212A (zh) 2015-12-10 2017-07-16 第一三共股份有限公司 特異性於降鈣素基因相關胜肽的新穎蛋白
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SG11201707872WA (en) 2017-10-30
RU2017135605A3 (cg-RX-API-DMAC7.html) 2019-11-13
ZA201706605B (en) 2020-05-27
MX2017014730A (es) 2018-06-28
KR20180008649A (ko) 2018-01-24
US20180141988A1 (en) 2018-05-24
JP2021184725A (ja) 2021-12-09
US10273275B2 (en) 2019-04-30
AU2016262838B2 (en) 2020-10-08
AU2016262838A1 (en) 2018-01-04
CA2982034A1 (en) 2016-11-24
BR112017020961A2 (pt) 2018-07-10
US20190309037A1 (en) 2019-10-10
EP3298029A1 (en) 2018-03-28
WO2016184875A1 (en) 2016-11-24
JP2018519802A (ja) 2018-07-26
JP6942060B2 (ja) 2021-09-29
RU2017135605A (ru) 2019-06-18
CN107787327B (zh) 2022-02-08
CN107787327A (zh) 2018-03-09
JP7217783B2 (ja) 2023-02-03
US10787491B2 (en) 2020-09-29
CN114456252A (zh) 2022-05-10

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