RU2749437C2 - Ингибиторы протеинкиназ, их способ получения и медицинское применение - Google Patents
Ингибиторы протеинкиназ, их способ получения и медицинское применение Download PDFInfo
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- RU2749437C2 RU2749437C2 RU2018122864A RU2018122864A RU2749437C2 RU 2749437 C2 RU2749437 C2 RU 2749437C2 RU 2018122864 A RU2018122864 A RU 2018122864A RU 2018122864 A RU2018122864 A RU 2018122864A RU 2749437 C2 RU2749437 C2 RU 2749437C2
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- Prior art keywords
- compound
- fluoro
- alkyl
- hydrogen
- amino
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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- Y02P20/50—Improvements relating to the production of bulk chemicals
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Landscapes
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- Plural Heterocyclic Compounds (AREA)
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| US11440912B2 (en) | 2017-10-27 | 2022-09-13 | Fresenius Kabi Oncology Ltd | Process for the preparation of ribociclib and its salts |
| BR112020015431A2 (pt) | 2018-02-15 | 2020-12-08 | Nuvation Bio Inc. | Compostos heterocíclicos como inibidores de quinase |
| WO2019170055A1 (zh) * | 2018-03-05 | 2019-09-12 | 上海海和药物研究开发有限公司 | 具有cdk4/6激酶抑制活性的化合物、其药用组合物和用途 |
| SG11202108004VA (en) * | 2019-01-29 | 2021-08-30 | Beta Pharma Inc | 2h-indazole derivatives as therapeutic agents for brain cancers and brain metastases |
| EP3988545A1 (en) * | 2019-06-21 | 2022-04-27 | Gan & Lee Pharmaceuticals Co., Ltd. | Methods for preparing cdk4/6 inhibitor and salt and intermediate thereof |
| AR119184A1 (es) * | 2019-06-21 | 2021-12-01 | Gan & Lee Pharmaceuticals | Sales de un compuesto, formas cristalinas de las sales y método de preparación y uso de las mismas |
| WO2022042738A1 (zh) * | 2020-08-31 | 2022-03-03 | 甘李药业股份有限公司 | 一种含cdk4/6抑制剂的药物组合物 |
| CN116583283A (zh) * | 2020-09-21 | 2023-08-11 | 普莱鲁德疗法有限公司 | Cdk抑制剂及其作为药物的用途 |
| US12129262B2 (en) | 2020-12-18 | 2024-10-29 | Prelude Therapeutics Incorporated | CDK inhibitors and their use as pharmaceuticals |
| CN112390793B (zh) * | 2021-01-19 | 2021-04-27 | 中国药科大学 | Cdk6/dyrk2双靶点抑制剂及其制备方法和应用 |
| WO2022218247A1 (zh) * | 2021-04-12 | 2022-10-20 | 甘李药业股份有限公司 | 作为cdk4/6抑制剂的氘代化合物 |
| WO2022242563A1 (zh) * | 2021-05-17 | 2022-11-24 | 甘李药业股份有限公司 | 一种cdk4/6抑制剂的医药用途 |
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| CN118339157A (zh) * | 2021-12-24 | 2024-07-12 | 江苏恒瑞医药股份有限公司 | 氢化吲哚类化合物、其制备方法及其在医药上的应用 |
| CN115093397B (zh) * | 2022-06-07 | 2023-09-05 | 自贡市第三人民医院 | 一种用于治疗肿瘤的化合物、合成方法及应用 |
| CN117658987A (zh) * | 2022-09-08 | 2024-03-08 | 上海深势唯思科技有限责任公司 | 作为plk1抑制剂的化合物及其制备方法和用途 |
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| WO2005076854A2 (en) * | 2004-02-04 | 2005-08-25 | Smithkline Beecham Corporation | Pyrimidinone compounds useful as kinase inhibitors |
| CN102007124A (zh) * | 2008-02-15 | 2011-04-06 | 里格尔制药公司 | 嘧啶-2-胺化合物及其作为jak激酶抑制剂的用途 |
| EA201170872A1 (ru) * | 2008-12-22 | 2011-12-30 | Эли Лилли Энд Компани | Ингибиторы протеинкиназы |
| WO2013173506A2 (en) * | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| RU2504545C2 (ru) * | 2008-05-16 | 2014-01-20 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы jnk |
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- 2016-11-28 CN CN201680064053.7A patent/CN108290864B/zh active Active
- 2016-11-28 JP JP2018546737A patent/JP6921101B2/ja not_active Expired - Fee Related
- 2016-11-28 DK DK16869945.2T patent/DK3385262T3/da active
- 2016-11-28 CN CN202111217526.1A patent/CN113956238B/zh active Active
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- 2016-11-28 UA UAA201806447A patent/UA124001C2/uk unknown
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- 2016-11-28 AU AU2016365366A patent/AU2016365366B2/en not_active Ceased
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- 2016-11-28 BR BR112018010879-0A patent/BR112018010879A2/pt not_active Application Discontinuation
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