RU2717677C1 - Налмефен, налтрексон или их производные для применения в лечении (не)алкогольного стеатогепатита или неалкогольной жировой болезни печени - Google Patents
Налмефен, налтрексон или их производные для применения в лечении (не)алкогольного стеатогепатита или неалкогольной жировой болезни печени Download PDFInfo
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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| PCT/US2017/028529 WO2017184819A1 (en) | 2016-04-22 | 2017-04-20 | Nalmefene, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease |
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| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP3712254A1 (en) | 2014-05-28 | 2020-09-23 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| CA2963704A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| US20190247373A1 (en) * | 2016-07-14 | 2019-08-15 | Children's Hospital Medical Center | Methods for treating fibrosis |
| SG11201903697WA (en) | 2016-11-04 | 2019-05-30 | Childrens Hospital Med Ct | Liver organoid compositions and methods of making and using same |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
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| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| US12421500B2 (en) | 2018-07-26 | 2025-09-23 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| JP2021535753A (ja) | 2018-09-12 | 2021-12-23 | チルドレンズ ホスピタル メディカル センター | 造血幹細胞およびその派生体の生成のためのオルガノイド組成物 |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| CA3141814A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| CN114174494A (zh) | 2019-05-31 | 2022-03-11 | 儿童医院医学中心 | 产生和扩增造血干细胞的方法 |
| CA3236690A1 (en) | 2021-11-18 | 2023-05-25 | Ju Hee Kim | Sustained-release injectable composition containing naltrexone and method for preparing same |
| CN118234488A (zh) | 2021-11-18 | 2024-06-21 | 创技公司株式会社 | 包含难溶性药物的微粒的制备方法 |
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- 2017-04-20 AU AU2017253228A patent/AU2017253228B2/en active Active
- 2017-04-20 JP JP2018554716A patent/JP2019514872A/ja active Pending
- 2017-04-20 KR KR1020187031996A patent/KR20180129909A/ko not_active Ceased
- 2017-04-20 US US15/492,198 patent/US10045977B2/en active Active
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| BR112018071705A2 (pt) | 2019-02-19 |
| AU2017253228B2 (en) | 2020-04-09 |
| CN117137917A (zh) | 2023-12-01 |
| US20170304294A1 (en) | 2017-10-26 |
| CA3021788A1 (en) | 2017-10-26 |
| EP3445363A1 (en) | 2019-02-27 |
| AU2017253228A1 (en) | 2018-09-27 |
| AU2017253228A8 (en) | 2019-01-17 |
| KR20180129909A (ko) | 2018-12-05 |
| US10045977B2 (en) | 2018-08-14 |
| CA3021788C (en) | 2021-08-03 |
| WO2017184819A1 (en) | 2017-10-26 |
| CN109069503A (zh) | 2018-12-21 |
| JP2019514872A (ja) | 2019-06-06 |
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