AU2017253228B2 - Nalmefene, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease - Google Patents

Nalmefene, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease Download PDF

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Publication number
AU2017253228B2
AU2017253228B2 AU2017253228A AU2017253228A AU2017253228B2 AU 2017253228 B2 AU2017253228 B2 AU 2017253228B2 AU 2017253228 A AU2017253228 A AU 2017253228A AU 2017253228 A AU2017253228 A AU 2017253228A AU 2017253228 B2 AU2017253228 B2 AU 2017253228B2
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AU
Australia
Prior art keywords
compound
nash
nafld
formula
liver
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AU2017253228A
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English (en)
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AU2017253228A1 (en
AU2017253228A8 (en
Inventor
Peter J. S. Chiu
May Mei-Chi Hsu
Edwin S. C. Wu
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TaiwanJ Pharmaceuticals Co Ltd
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TaiwanJ Pharmaceuticals Co Ltd
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Publication of AU2017253228A8 publication Critical patent/AU2017253228A8/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2017253228A 2016-04-22 2017-04-20 Nalmefene, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease Active AU2017253228B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662326435P 2016-04-22 2016-04-22
US62/326,435 2016-04-22
US201662395436P 2016-09-16 2016-09-16
US62/395,436 2016-09-16
PCT/US2017/028529 WO2017184819A1 (en) 2016-04-22 2017-04-20 Nalmefene, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease

Publications (3)

Publication Number Publication Date
AU2017253228A1 AU2017253228A1 (en) 2018-09-27
AU2017253228A8 AU2017253228A8 (en) 2019-01-17
AU2017253228B2 true AU2017253228B2 (en) 2020-04-09

Family

ID=58668969

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017253228A Active AU2017253228B2 (en) 2016-04-22 2017-04-20 Nalmefene, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease

Country Status (10)

Country Link
US (1) US10045977B2 (enExample)
EP (1) EP3445363A1 (enExample)
JP (1) JP2019514872A (enExample)
KR (1) KR20180129909A (enExample)
CN (2) CN109069503A (enExample)
AU (1) AU2017253228B2 (enExample)
BR (1) BR112018071705A2 (enExample)
CA (1) CA3021788C (enExample)
RU (1) RU2717677C1 (enExample)
WO (1) WO2017184819A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP3712254A1 (en) 2014-05-28 2020-09-23 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
EP3207123A1 (en) 2014-10-17 2017-08-23 Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
WO2017192997A1 (en) 2016-05-05 2017-11-09 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
WO2018013788A1 (en) * 2016-07-14 2018-01-18 Children's Hospital Medical Center Methods for treating fibrosis
EP3534919A4 (en) 2016-11-04 2020-11-11 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
KR102807995B1 (ko) 2016-12-05 2025-05-16 칠드런즈 호스피탈 메디칼 센터 결장 유사장기 및 이를 제조 및 사용하는 방법
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
CA3077442A1 (en) 2017-10-10 2019-04-18 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
WO2019126626A1 (en) 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
SG11202100533VA (en) 2018-07-26 2021-02-25 Childrens Hospital Med Ct Hepato-biliary-pancreatic tissues and methods of making same
WO2020056158A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
CA3141807A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
EP4413977A4 (en) 2021-11-18 2025-11-05 Inventage Lab Inc METHOD FOR PREPARING MICROPARTICLES CONTAINING LOWLY SOLUBLE MEDICINES
AU2022394933A1 (en) 2021-11-18 2024-05-09 Inventage Lab Inc. Sustained-release injectable composition containing naltrexone and method for preparing same

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN102048733A (zh) * 2010-12-23 2011-05-11 武汉同源药业有限公司 盐酸纳美芬的医药用途
US20150335638A1 (en) * 2009-07-16 2015-11-26 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof

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US5086058A (en) * 1990-06-04 1992-02-04 Alko Ltd. Method for treating alcoholism with nalmefene
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
CN103405431B (zh) 2002-05-17 2016-04-13 台湾J药品有限公司 阿片和阿片样化合物及其用途
US8017622B2 (en) * 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
TR201002473A2 (tr) * 2010-03-31 2011-09-21 Mustafa Nevzat �La� Sanay�� A.�. Herpes zoster hastalığının bır opiat reseptör antagonist kullanılarak tedavi yöntemi.
MA38385A1 (fr) * 2013-04-22 2017-09-29 Cadila Healthcare Ltd Nouvelle composition pour la stéatose hépatique non alcoolique (nafld)
EP3939570A1 (en) * 2016-02-18 2022-01-19 Immune Therapeutics, Inc. Naltrexone for treating or preventing autoimmune and inflammatory diseases

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US20150335638A1 (en) * 2009-07-16 2015-11-26 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
CN102048733A (zh) * 2010-12-23 2011-05-11 武汉同源药业有限公司 盐酸纳美芬的医药用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. MOSLEHI ET AL, "Naltrexone attenuates endoplasmic reticulum stress induced hepatic injury in mice", ACTA PHYSIOLOGICA HUNGARICA, HU, (2014-09-01), vol. 101, no. 3, doi:10.1556/APhysiol.101.2014.3.9, ISSN 0231-424X, pages 341 - 352 *
GIOVANNI ADDOLORATO ET AL, "Management of Alcohol Dependence in Patients with Liver Disease", CNS DRUGS, AUCKLAND, NZ, (2013-03-01), vol. 27, no. 4, doi:10.1007/s40263-013-0043-4, ISSN 1172-7047, pages 287 - 299 *

Also Published As

Publication number Publication date
AU2017253228A1 (en) 2018-09-27
KR20180129909A (ko) 2018-12-05
EP3445363A1 (en) 2019-02-27
CA3021788C (en) 2021-08-03
AU2017253228A8 (en) 2019-01-17
JP2019514872A (ja) 2019-06-06
US20170304294A1 (en) 2017-10-26
WO2017184819A1 (en) 2017-10-26
BR112018071705A2 (pt) 2019-02-19
CA3021788A1 (en) 2017-10-26
US10045977B2 (en) 2018-08-14
RU2717677C1 (ru) 2020-03-25
CN109069503A (zh) 2018-12-21
CN117137917A (zh) 2023-12-01

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Free format text: IN VOL 32 , NO 37 , PAGE(S) 5229 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME TAIWANJ PHARMACEUTICALS CO., LTD., APPLICATION NO. 2017253228, UNDER INID (72) ADD CO-INVENTOR WU, EDWIN S. C.

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