RU2717677C1 - Налмефен, налтрексон или их производные для применения в лечении (не)алкогольного стеатогепатита или неалкогольной жировой болезни печени - Google Patents

Налмефен, налтрексон или их производные для применения в лечении (не)алкогольного стеатогепатита или неалкогольной жировой болезни печени Download PDF

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RU2717677C1
RU2717677C1 RU2018136387A RU2018136387A RU2717677C1 RU 2717677 C1 RU2717677 C1 RU 2717677C1 RU 2018136387 A RU2018136387 A RU 2018136387A RU 2018136387 A RU2018136387 A RU 2018136387A RU 2717677 C1 RU2717677 C1 RU 2717677C1
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Russia
Prior art keywords
compound
formula
alcoholic
nash
alcoholic steatohepatitis
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RU2018136387A
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English (en)
Russian (ru)
Inventor
Эдвин Ск Ву
Питер Дж.С. ЧИУ
Мэй Мэй-Чи ХСУ
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Тайваньж Фармасьютикалс Со., Лтд.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2018136387A 2016-04-22 2017-04-20 Налмефен, налтрексон или их производные для применения в лечении (не)алкогольного стеатогепатита или неалкогольной жировой болезни печени RU2717677C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662326435P 2016-04-22 2016-04-22
US62/326,435 2016-04-22
US201662395436P 2016-09-16 2016-09-16
US62/395,436 2016-09-16
PCT/US2017/028529 WO2017184819A1 (en) 2016-04-22 2017-04-20 Nalmefene, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease

Publications (1)

Publication Number Publication Date
RU2717677C1 true RU2717677C1 (ru) 2020-03-25

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RU2018136387A RU2717677C1 (ru) 2016-04-22 2017-04-20 Налмефен, налтрексон или их производные для применения в лечении (не)алкогольного стеатогепатита или неалкогольной жировой болезни печени

Country Status (10)

Country Link
US (1) US10045977B2 (cg-RX-API-DMAC7.html)
EP (1) EP3445363A1 (cg-RX-API-DMAC7.html)
JP (1) JP2019514872A (cg-RX-API-DMAC7.html)
KR (1) KR20180129909A (cg-RX-API-DMAC7.html)
CN (2) CN117137917A (cg-RX-API-DMAC7.html)
AU (1) AU2017253228B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018071705A2 (cg-RX-API-DMAC7.html)
CA (1) CA3021788C (cg-RX-API-DMAC7.html)
RU (1) RU2717677C1 (cg-RX-API-DMAC7.html)
WO (1) WO2017184819A1 (cg-RX-API-DMAC7.html)

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WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
ES2860423T3 (es) 2014-05-28 2021-10-05 Childrens Hospital Med Ct Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
JP6963882B2 (ja) 2016-05-05 2021-11-10 チルドレンズ ホスピタル メディカル センター 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物
CN109475626A (zh) * 2016-07-14 2019-03-15 儿童医院医疗中心 治疗纤维化的方法
EP3534907A4 (en) 2016-11-04 2020-06-24 Children's Hospital Medical Center COMPOSITIONS AND METHODS FOR TREATING HEPATIC DISEASE
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
CA3077442A1 (en) 2017-10-10 2019-04-18 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
WO2019126626A1 (en) 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
SG11202100533VA (en) 2018-07-26 2021-02-25 Childrens Hospital Med Ct Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
KR20230073125A (ko) 2021-11-18 2023-05-25 (주)인벤티지랩 난용성 약물을 포함하는 마이크로 입자의 제조 방법
AU2022394933A1 (en) 2021-11-18 2024-05-09 Inventage Lab Inc. Sustained-release injectable composition containing naltrexone and method for preparing same

Citations (5)

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RU2090190C1 (ru) * 1990-06-04 1997-09-20 Алко Лтд, Орион-Ихтюмя Ой Способ лечения алкоголизма
US20090169508A1 (en) * 2003-05-16 2009-07-02 Jenkin Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
CN102048733A (zh) * 2010-12-23 2011-05-11 武汉同源药业有限公司 盐酸纳美芬的医药用途
RU2561871C2 (ru) * 2010-03-31 2015-09-10 Ак Кимя Итхалат-Ихрацат Ве Санайии А.С. Антагонист опиоидных рецепторов (налтрексон) для использования в терапии герпесного опоясывающего лишая
US20150335638A1 (en) * 2009-07-16 2015-11-26 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof

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US7923454B2 (en) * 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
MXPA04011327A (es) 2002-05-17 2005-08-15 Jenken Biosciences Inc Opioides y compuestos similares a opioides y usos de los mismos.
JP6246895B2 (ja) * 2013-04-22 2017-12-13 カディラ・ヘルスケア・リミテッド 非アルコール性脂肪性肝疾患(nafld)のための新規組成物
EP3416619A2 (en) * 2016-02-18 2018-12-26 Immune Therapeutics, Inc. Method for inducing a sustained immune response

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RU2090190C1 (ru) * 1990-06-04 1997-09-20 Алко Лтд, Орион-Ихтюмя Ой Способ лечения алкоголизма
US20090169508A1 (en) * 2003-05-16 2009-07-02 Jenkin Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US20150335638A1 (en) * 2009-07-16 2015-11-26 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
RU2561871C2 (ru) * 2010-03-31 2015-09-10 Ак Кимя Итхалат-Ихрацат Ве Санайии А.С. Антагонист опиоидных рецепторов (налтрексон) для использования в терапии герпесного опоясывающего лишая
CN102048733A (zh) * 2010-12-23 2011-05-11 武汉同源药业有限公司 盐酸纳美芬的医药用途

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Also Published As

Publication number Publication date
CN109069503A (zh) 2018-12-21
CN117137917A (zh) 2023-12-01
WO2017184819A1 (en) 2017-10-26
KR20180129909A (ko) 2018-12-05
CA3021788C (en) 2021-08-03
BR112018071705A2 (pt) 2019-02-19
AU2017253228A8 (en) 2019-01-17
AU2017253228A1 (en) 2018-09-27
AU2017253228B2 (en) 2020-04-09
EP3445363A1 (en) 2019-02-27
US20170304294A1 (en) 2017-10-26
CA3021788A1 (en) 2017-10-26
JP2019514872A (ja) 2019-06-06
US10045977B2 (en) 2018-08-14

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