CA3021788C - Use of nalmefene in non-alcoholic steatohepatitis - Google Patents
Use of nalmefene in non-alcoholic steatohepatitis Download PDFInfo
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- CA3021788C CA3021788C CA3021788A CA3021788A CA3021788C CA 3021788 C CA3021788 C CA 3021788C CA 3021788 A CA3021788 A CA 3021788A CA 3021788 A CA3021788 A CA 3021788A CA 3021788 C CA3021788 C CA 3021788C
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- compound
- alcoholic
- nash
- alcoholic steatohepatitis
- liver
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/US2017/028529 WO2017184819A1 (en) | 2016-04-22 | 2017-04-20 | Nalmefene, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease |
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| WO2016061464A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intetine using pluripotent stem cells and methods of making and using same |
| JP6963882B2 (ja) | 2016-05-05 | 2021-11-10 | チルドレンズ ホスピタル メディカル センター | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 |
| CN109475626A (zh) * | 2016-07-14 | 2019-03-15 | 儿童医院医疗中心 | 治疗纤维化的方法 |
| EP3534907A4 (en) | 2016-11-04 | 2020-06-24 | Children's Hospital Medical Center | COMPOSITIONS AND METHODS FOR TREATING HEPATIC DISEASE |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
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| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
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| CN102048733B (zh) * | 2010-12-23 | 2011-12-28 | 武汉同源药业有限公司 | 盐酸纳美芬在制备治疗脂肪肝的药物中的用途 |
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|---|---|
| CN109069503A (zh) | 2018-12-21 |
| CN117137917A (zh) | 2023-12-01 |
| WO2017184819A1 (en) | 2017-10-26 |
| KR20180129909A (ko) | 2018-12-05 |
| BR112018071705A2 (pt) | 2019-02-19 |
| RU2717677C1 (ru) | 2020-03-25 |
| AU2017253228A8 (en) | 2019-01-17 |
| AU2017253228A1 (en) | 2018-09-27 |
| AU2017253228B2 (en) | 2020-04-09 |
| EP3445363A1 (en) | 2019-02-27 |
| US20170304294A1 (en) | 2017-10-26 |
| CA3021788A1 (en) | 2017-10-26 |
| JP2019514872A (ja) | 2019-06-06 |
| US10045977B2 (en) | 2018-08-14 |
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