RU2709841C1 - Method of reparative processes stimulation in animals after osteosynthesis - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: invention refers to medicine, namely to veterinary science, and can be used for postoperative therapy of animals after osteosynthesis. During postoperative therapy, once a day, intramuscular administrations of officinal solutions of dimedrol are introduced intramuscularly at dose of 3.0 mg/kg of body weight and analgin in amount of 0.03 g/kg for 4 days; ascorbic acid – 2.0 mg/kg of body weight for 7 days; lincomycin hydrochloride – 10.0 mg/kg of body weight for 7 days; calcium gluconate – 1–5 ml per animal for 7 days and tetravit – 0.05 ml/kg of body weight every 7 days 5 injections. 72 hours after the operation, azoxiveth is additionally introduced intramuscularly in dose of 0.3 mg per 1 kg of live weight once day 5 times with interval of 48 hours.

EFFECT: method provides reduced length of treatment, reduced amount of used antibiotics due to intramuscular introduction of azoxiveth.

1 cl, 1 tbl, 2 ex

Description

The invention relates to veterinary postoperative therapy, namely, to the treatment of animals after bone fractures. Most effective is its use after osteosynthesis.

Esobel is a biologically active, anti-inflammatory drug - a water-soluble dry extract of silt sulfide mud. This drug has antioxidant properties mainly due to the content of highly polar lipids. The main trace elements of Esobela are Cu, Mn, Ag, Co, P, Zn. Currently, esobela electrophoresis in people with injuries of the musculoskeletal system, including fractures, has been tested and applied as an additional therapy [Saratikov, A.S. New hepatoprotective and anti-inflammatory drugs of peloids. / A.S. Saratikov et al. / - Tomsk: Publishing House Tom. University, 2004. - S. 15, 123, 150].

The main disadvantage of this method is that it requires extensive hydration of the skin at the site of bone fracture during electrophoresis. This is unacceptable, especially in the first time after surgery, for the regeneration of soft tissues connected by skin sutures. Extensive tactile action at the fracture site causes pain with the manifestation of animal anxiety. In addition, a significant number of components are included in the composition of Esobela, which in certain conditions may limit its use.

Moreover, despite a well-developed operational technique, a careful regimen of pharmacological protection during surgery and the whole range of effects accompanying surgical treatment, the disease itself can lead to the appearance of disorders, and in many cases to a distortion of the immune defense reactions. Therefore, the additional use of a drug with only antioxidant properties in general postoperative therapy is not quite enough, since the pharmacological correction of immune deficiency in the postoperative period in animals requires the use of an immunomodulator, which also determines the effectiveness of surgical treatment.

General postoperative therapy is also known, including the minimum number of drugs necessary for the full rehabilitation of the body after osteosynthesis of injured animals. After surgery, all animals are injected intramuscularly with official solutions of diphenhydramine at the rate of 3.0 mg / kg body weight and dipyrone (0.03 g / kg) for 4 days; ascorbic acid - 2.0 mg / kg body weight for 7 days; lincomycin hydrochloride - 10.0 mg / kg body weight for 7 days; calcium gluconate - 1-5 ml per animal for 7 days and tetravita - 0.05 ml / kg body weight with an interval of 7 days 5 injections [Sakhno, N.V. Optimization of reparative osteogenesis in bone injuries in small domestic animals: Diss. ... doctor. vet. sciences / N.V. Sahno. - Moscow, 2012. - S. 77].

The main disadvantage of this therapy is that it does not include the full amount of drugs necessary to optimize the course of the postoperative period in animals.

The objective of the invention is to reduce the consolidation of bone fragments after osteosynthesis.

The problem is achieved due to the fact that in the known method, which consists in the use of general postoperative therapy, in which after the operation, once a day, intravenous administration of official solutions of diphenhydramine is administered at the rate of 3.0 mg / kg body weight and dipyrone (0.03 g / kg) within 4 days; ascorbic acid - 2.0 mg / kg body weight for 7 days; lincomycin hydrochloride - 10.0 mg / kg body weight for 7 days; calcium gluconate - 1-5 ml per animal for 7 days and tetravita - 0.05 ml / kg body weight with an interval of 7 days 5 injections, according to the invention, 72 hours after the operation, an additional 0.3 mg of intramuscular injection of azoxivet is administered per 1 kg of live weight once a day 5 times with an interval of 48 hours.

To prevent complications in the postoperative period and reduce the time of consolidation of fragments due to the increase in immunocompetent cells per unit area of tissue, the speedy removal of detritus of bone and soft tissue wounds and the laying of a full regenerate, it is advisable to prescribe azoxivet to animals.

Azoxivet belongs to the group of immunomodulating agents. Azoximera bromide, which is part of azoxivet, helps to restore immune responses in secondary immunodeficiency conditions caused by infections of various etiologies, injuries, burns, malignant neoplasms, complications after surgery or the use of chemotherapeutic agents, including cytostatics, steroid hormones. Along with the immunomodulatory effect, azoxivet has a pronounced detoxification and antioxidant activity, which is determined by the structure and high molecular nature of the components of the drug. Increases the resistance of cell membranes to the cytotoxic effect of drugs and chemicals, reduces their toxicity. Azoxivet is used in animals of various types and ages for the correction of immunity as mono-and complex therapy of acute and chronic infectious diseases of bacterial, viral or fungal etiology; in case of poisoning, acute allergic and toxic-allergic conditions; during and after chemo- and radiation therapy of tumors; to reduce the nephro- and hepatotoxic effects of drugs; in order to prevent complications in the postoperative period; to increase resistance to adverse environmental factors [http://www.vetlek.ru/directions/?id=1081 [Electronic resource]. - Date of appeal: 03/05/2016].

Studies were performed on 2 groups of dogs with 6 goals in each and 2 groups of cats with the same number of individuals. All animals underwent osteosynthesis on damaged long tubular bones of the extremities using both intramedullary fixators and bone. It was necessary to find out the effectiveness of complex postoperative therapy, which consisted of general therapy and the additional use of immunomodulators using the example of azoxivet.

Dogs of the control group were treated according to a known method using general therapy drugs. Dogs of the experimental group were treated in addition to the known method using individually azoxivet intramuscularly at a dose of 0.3 mg / kg of body weight.

Cats of the control group were treated according to a known method using general therapy drugs. Cats of the experimental group were treated in addition to the known method using individually azoxivet intramuscularly at a dose of 0.3 mg / kg of body weight.

Example 1. Dogs and cats of control groups immediately after the operation was assigned a general course of drugs according to the known method, used simultaneously intramuscularly 24 hours after surgery. This included the official solutions of diphenhydramine at the rate of 3.0 mg / kg body weight and dipyrone (0.03 g / kg) for 4 days; ascorbic acid - 2.0 mg / kg body weight for 7 days; lincomycin hydrochloride - 10.0 mg / kg body weight for 7 days; calcium gluconate - 1-5 ml per animal for 7 days and tetravit - 0.05 ml / kg body weight with an interval of 7 days 5 injections.

Example 2. Dogs and cats of the experimental groups were treated according to the same scheme, but 72 hours after surgery, in addition to general therapy, and then at the same time azoxivet was used at a dose of 0.3 mg per 1 kg of live weight once a day in a 5-course introductions every other day.

In case of delayed osteosynthesis due to the instability of the general condition of the animal after injury, it is possible to use azoxivet before the planned operation for osteosynthesis. So, to prevent complications in the postoperative period, azoxivet is prescribed to animals already 2-3 days before the proposed operation, and longer after 72 hours after the operation - 4 times with an interval of 48 hours.

The application of the proposed method of stimulation of reparative processes in animals after osteosynthesis allows:

- use, along with the immunomodulatory effect of the drug included in the additional therapy, its pronounced detoxification and antioxidant activity;

- achieving the full volume of drugs necessary to optimize the course of the postoperative period in animals;

- reduce the number of complications in the postoperative period;

- reduce the time of consolidation of fragments;

- reduce the use of antibiotics.

The use of azoxivet in complex therapy can increase efficiency and reduce the duration of treatment, thereby reducing the use of antibiotics. The results of treatment of these groups of dogs and cats are presented in table. 1.

Table 1.

As you can see, the therapeutic effectiveness of the additional and simultaneous application of immunomodulators to the general postoperative therapy after osteosynthesis is significantly higher than from the treatment of animals by a known method.

So, the use of azoxivet allows you to restore support function in dogs and cats after osteosynthesis on average 6 days earlier compared to the known method. The long-term results after osteosynthesis were tracked, which made it possible to verify the high therapeutic effect of the additional use of azoxivet, there were no postoperative complications. The results obtained indicate the need for widespread implementation of the proposed method in practice.

The proposed method of stimulating the reparative processes in animals after osteosynthesis was successfully applied when performing operations in 28 animals (goats, dogs, cats) at the Oryol State Agrarian University Veterinary Diagnostic Center and at the Russian Friendship University Federal Clinical Veterinary Department peoples. "

Claims (1)

A method of stimulating reparative processes in animals after osteosynthesis, which consists in the use of general postoperative therapy, in which, after an operation, once a day, official injected diphenhydramine solutions of diphenhydramine are administered intramuscularly at a rate of 3.0 mg / kg body weight and 0.03 g / kg analginum within 4 days; ascorbic acid - 2.0 mg / kg body weight for 7 days; lincomycin hydrochloride - 10.0 mg / kg body weight for 7 days; calcium gluconate - 1-5 ml per animal for 7 days and tetravita - 0.05 ml / kg body weight with an interval of 7 days of 5 injections, characterized in that, 72 hours after the operation, an additional 0.3 mg of intramuscular injection of azoxivet is administered mg per 1 kg of live weight once a day 5 times with an interval of 48 hours.