RU2545450C1 - Method of treating clinical mastitis - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to veterinary and veterinary obstetrics, and can be applied for the treatment of clinical mastitis in cows. For this purpose after evening milking for 4 days, parts of the udder with signs of mastitis are influenced with an alternating magnetic field from the magnetic-therapeutic apparatus AMnp-02 "Solnyshko". The duration of exposure constitutes 10 minutes. Mastoxidine, heated to 40°C, in a dose of 20 ml three days successively, is additionally intracisternally introduced for 3 days running.

EFFECT: method ensures an increase of the treatment efficiency due to the enforcement of mastoxidine action at deep cellular and intra-cellular levels with the acceleration of its penetration in tissues.

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Description

The invention relates to the field of veterinary medicine, to veterinary obstetrics and can be used to treat clinical mastitis of cows using a magnetic field.

A known method of treating patients with chronic catarrhal mastitis of cows using ultrasound. The method includes scoring of the affected lobe with ultrasound with an intensity of 0.9 W / cm ² , a frequency of 880 kHz, an exposure of 10 minutes and intracisternal administration of difurol A at a dose of 10.0 ml for 3 consecutive days. The method has an analgesic effect, promotes resorption of infiltrates, stimulates non-specific resistance factors (V.I. Slobodyanik, V.A. Parikov. The use of ultrasound in chronic mastitis in cows. - M., 1988. - S.12-14).

The disadvantage of this method of treatment is low efficiency, it is 35% -60%.

A known method of treatment, including ultraviolet irradiation using a stationary mercury-quartz lamp "Sollux". The udder is irradiated twice a day for 30-60 minutes. The distance from the lamp to the udder is 60-80 cm. The intensity of the light flux is determined by the thermal sensation of the hand placed on the irradiated part of the body surface of the animal (I. G. Konopeltsev, V. N. Shulyatiev. Inflammation of the udder in cows. Training manual. - Kirov- St. Petersburg. - 2010 .-- S.230-233).

The disadvantage of this method is the long period of treatment and low therapeutic efficacy.

A known method of treatment using low intensity laser radiation LTK "Zorka". It is used externally for the affected lobe in regimen No. 2 in the morning and evening after milking, exposure is 2 minutes. The principle of action is to stimulate the body's own vitality for self-healing (V.P. Inozemtsev, I.I. Balkova, A.G. Nezhdanov. Quantum therapy of cows with metritis and mastitis. Veterinary medicine. - 2000. - No. 10. - S. 9-12).

The disadvantage of this method of treatment is that the effectiveness of laser treatment is 81.9%.

The purpose of the invention: improving the effectiveness of treatment, suppressing the pathogenic microflora of milk, reducing treatment time, as well as reducing the economic costs of treatment.

This goal is achieved by affecting the shares of the udder of animals with signs of clinical mastitis with the alternating magnetic field of the magnetotherapy apparatus AMnp-02 “Sun” in combination with the drug mastoxidine.

The device АМнп-02 “Sun” - is intended for therapeutic effect on various parts of the human body with an alternating magnetic field in medical, sanatorium and resort institutions, as well as at home on the recommendation of a doctor. It has a low-frequency variable and a magnetic field of influence that automatically changes in frequency and is based on the therapeutic effect of a pulsed magnetic field that changes in frequency. It has a variety of therapeutic effects: neurostimulating, analgesic, decongestant, anti-inflammatory, vasoactive, stimulating regeneration in damaged tissues. Magnetotherapy improves microcirculation, restores blood coagulability, stimulates the outflow of secrets from internal organs, stimulates regenerative and regenerative processes in tissues (instructions for using the magnetotherapy apparatus with a low-frequency alternating magnetic field of exposure AMNp-02 “Sun”. Approved by Order of Roszdravnadzor No. 9642-Pr / 09 December 01, 2009).

Mastoxidine 1% solution - has a wide spectrum of antibacterial action, is active against gram-negative and gram-positive microorganisms - Proteus, Pseudomonas aeruginosa and Klebsiella (Friedlander's coli), Salmonella, staphylococci, streptococci, as well as pathogenic anaerobes. The active substance is dioxidine, which selectively inhibits DNA synthesis in a microbial cell, without affecting the synthesis of RNA and protein; causes structural changes in the cell wall and bacterial nucleotides, inhibits the activity of extracellular bacterial nuclease and α-toxin. Used for the treatment and prevention of clinical and latent mastitis, as well as for prophylactic sanitizing treatments of the udder at the beginning of the dry period in cows (instructions for use of Mastoxidine 1% solution for the prevention and treatment of mastitis in cows).

Our method of treating clinical mastitis in cows is carried out as follows: after evening milking, the magnetotherapy apparatus AMnp-02 “Sun” is applied to the udder lobes with signs of clinical mastitis, the duration of the magnetic field is 10 minutes, the course of magnetotherapy is 4 days. Additionally, mastoxidine, heated to a temperature of 40 ° C, at a dose of 20 ml for three consecutive days is administered intracisternally.

Photo 1 shows the fixation of the magnetotherapy apparatus AMnp-02 “Sun”.

Example 1. For the experiment, 60 cattle goals were selected with a diagnosis of chronic purulent-catarrhal mastitis, which, according to the principle of pairs of analogues, were divided into the experimental and control groups (n = 30).

The cows of the first group were treated in a known manner: LTC "Zorka" externally to the affected area in regime No. 2, exposure 2 minutes, morning and evening after milking - 5 days, in combination with the drug Mastiet-forte, intracestrally, at a dose of 8 g, once per day after milking until recovery. The cows of the second group were treated with the new proposed method: magnetic radiation using the apparatus "Sun" AMnp-02 externally to the affected area within 10 minutes in the evening after milking for 4 days in combination with mastoxidine, heated to 40 ° C, in a dose 20 ml intracisternally in the affected lobe for 3 days. The results of the effectiveness of these treatment regimens are summarized in table 1.

Table 1 Comparative effectiveness of the integrated use of a magnetic field and mastoxidine in mastitis Group Number of goals The number of affected shares of the udder The number of days of treatment Recovered Cured goals % share udder % First thirty 60 5.5 ± 0.6 25 83.3 46 76.7 Second thirty 65 3.8 ± 0.85 thirty one hundred 60 one hundred

As a result of treatment in a new way, all cows recovered in the second group, and in the first, where the known method of treatment was used, only 83.3% recovered, which is 16.7% less than in the first group. The therapeutic course in the second group was shorter by 1.5 days.

Example 2. In cows of the first and second groups (from Example 1), the presence of the species composition of microflora in the secretion of the udder of the lobes with signs of clinical mastitis was revealed and determined before treatment and on the last day of treatment (AD Tretyakov, 1981. Tests were carried out according to GOST 53430-2009, GOST 52814-2007, GOST 30347-97, GOST 10444.12-88). The results of studies of the secretion of affected udder lobes are presented in table 2.

table 2 The presence of the species composition of microflora in the secretion of the udder of the lobes with signs of purulent-catarrhal mastitis Selected microflora Indicators first group second group on the 1st day of treatment on the 4th day of treatment on the 1st day of treatment on the 5th day of treatment qty % qty % qty % qty % Total Samples Investigated 65 65 60 60 The number of samples in which mastitis pathogens were detected, including: 62 95.4 0 0 55 91.7 fourteen 23.3 Streptococcus agalactiae twenty 32,2 0 0 17 31,0 four 28.6 Staphylococcus aureus 27 43.5 0 0 24 43.6 7 50,0 Candida mushrooms 5 8.1 0 0 four 7.3 one 7.1 Proteus vulgaris 2 3.2 0 0 3 5,4 0 0 Escherichia coli 8 13.0 0 0 7 12.7 2 14.3

According to the results of a bacteriological study, in the second group of cows on the fourth day of treatment, samples with mastitis pathogens were not found in comparison with the first group, this indicates that in the treatment with the magnetotherapy apparatus AMnp-02 “Sun” in combination with mastoxidine, the suppression of pathogenic microflora is 100 %

Claims (1)

A method for the treatment of clinical mastitis, including exposure to an udder of animals with signs of clinical mastitis with the magnetotherapy apparatus AMnp-02 “Sun” after evening milking for 4 days, exposure duration 10 minutes and additional intracisternal administration of mastoxidine heated to a temperature of 40 ° C , at a dose of 20 ml for three consecutive days.

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